Vitamin D in the treatment of pulmonary tuberculosis
Abstract
Vitamin D was used to treat tuberculosis in the pre-antibiotic era. New insights into the immunomodulatory properties of 1alpha,25-dihydroxy-vitamin D have rekindled interest in vitamin D as an adjunct to antituberculous therapy. We describe the historical use of vitamin D in tuberculosis treatment; discuss the mechanisms by which it may modulate host response to infection with Mycobacterium tuberculosis; and review three clinical trials and ten case series in which vitamin D has been used in the treatment of pulmonary tuberculosis.
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The blue lamp has been shown to form more photo-oxidation products and cause more severe cellular damage and apoptosis in the presence of bilirubin as compared to the green lamp.
“Although the mechanism is not related to apoptosis, the blue lamp has been shown to form more photo-oxidation products and cause more severe cellular damage and apoptosis in the presence of bilirubin as compared to the green lamp [93].”
From Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy (2013) · cites this paper as [93]
Cites
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Self-citationYamshchikov, A. V., Desai, N. S., Blumberg, H. M., Ziegler, T. R., & Tangpricha, V. (2009) · Endocrine Practice · doi:10.4158/ep09101.orr · Cited by 307 · see citing works
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- Authors
- Martineau, A. R., Honecker, F. U., Wilkinson, R. J., & Griffiths, C. J.
- Affiliations
- University of Cape Town (ZA)
- University Medical Center Hamburg-Eppendorf (DE)
- Corresponding author
- Martineau, Adrian R.
- Venue
- The Journal of Steroid Biochemistry and Molecular Biology
- Publisher
- Elsevier BV
- Published
- 2007-03
- Volume
- 103
- Issue
- 3-5
- Pages
- 793-798
- ISSN
- 0960-0760 (ISSN-L)
- OpenAlex
- W2023635033
- Cited by
- 216
- References
- 2
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 7 · 2022: 8 · 2021: 3 · 2020: 8 · 2019: 7 · 2018: 6 · 2017: 10 · 2016: 8 · 2015: 12 · 2014: 6 · 2013: 18 · 2012: 18
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Steroid Biochemistry and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (072070)
- British Lung Foundation
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
- Keywords
- vitamin D, pulmonary tuberculosis, 1,25-dihydroxyvitamin D, Mycobacterium tuberculosis, immunomodulation, adjunctive therapy, tuberculosis treatment, history of tuberculosis treatment, host response to infection
- MeSH terms
- Dose-Response Relationship, Drug, Humans, Macrophages, Tuberculosis, Pulmonary, Vitamin D
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