1,25-dihydroxyvitamin D3 reduces systolic blood pressure in hypertensive adults: a pilot feasibility study
Open accessAbstract
Vitamin D has been reported to lower blood pressure in vivo by regulating the renin-angiotensin system; however, there are limited clinical studies to support this finding in humans. We investigated the effect of vitamin D treatment on hypertension in a three-arm randomized placebo controlled pilot and feasibility study. We tested placebo with two forms of vitamin D: cholecalciferol (vitamin D(3)) and the active form of vitamin D, calcitriol. Subjects were recruited from the Atlanta Veterans Affairs Medical Center in Decatur, GA between April and August 2008. Subjects received 200,000IU of vitamin D(3) (n=3) weekly for 3 weeks or matching placebo (n=3) weekly for 3 weeks (n=3) or 0.5mug calcitriol (n=2) taken twice daily for one week. Our primary endpoint was blood pressure measured by 24h ambulatory blood pressure monitor. Subjects receiving calcitriol experienced a 9% decrease in mean systolic blood pressure (SBP) compared placebo (p<0.001). One week after conclusion of calcitriol therapy SBP returned to pre-treatment levels. There was no reduction in blood pressure in the placebo or vitamin D(3) groups. Results from this pilot study suggests that active vitamin D therapy may be an effective short-term intervention for reducing blood pressure and needs to be explored further in larger controlled studies.
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1,25(OH)2D3 is reported to protect against oxidative stress and to modulate DNA damage/repair systems, as well as Nrf2 activation.
“Interestingly, the active form of vitamin D, 1,25(OH)2D3, is reported to protect against oxidative stress [34,35] and to modulate DNA damage/repair systems [[36], [37], [38]], as well as Nrf2 activation [34,39].”
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- Authors
- Judd, S. E., Raiser, S. N., Kumari, M., & Tangpricha, V.
- Affiliations
- University of Alabama at Birmingham (US)
- Emory University (US)
- Corresponding author
- Judd, Suzanne E.
- Venue
- The Journal of Steroid Biochemistry and Molecular Biology
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 121
- Issue
- 1-2
- Pages
- 445-447
- ISSN
- 0960-0760 (ISSN-L)
- PMC
- PMC3037009
- OpenAlex
- W2076031587
- Cited by
- 66
- References
- 20
- Citations by year
- 2024: 2 · 2022: 2 · 2021: 11 · 2020: 2 · 2019: 2 · 2018: 6 · 2017: 4 · 2016: 7 · 2015: 6 · 2014: 3 · 2013: 6 · 2012: 8
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Steroid Biochemistry and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (K23AR054334)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Keywords
- 1,25-dihydroxyvitamin D3, vitamin D, hypertension, systolic blood pressure, vitamin D3, renin-angiotensin system, ambulatory blood pressure, veterans
- MeSH terms
- Adult, Black or African American, Blood Pressure, Calcitriol, Cholecalciferol, Feasibility Studies, Humans, Hypertension, Middle Aged, Pilot Projects, Placebos, Renin, Systole, Biomarkers
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