Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 1,253

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

The Pharmacological Potential of Rutin

Ganeshpurkar, Aditya, Saluja, Ajay K.·2017·Saudi Pharmaceutical Journal
DOI 10.1016/j.jsps.2016.04.025PMC PMC5355559
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.jsps.2016.04.025

Cites

3 of 3 references verified0 citation errors · 0 not checkable

Statistics

Figures

Figure 1 Chemical structure of rutin.
Figure 1 Chemical structure of rutin.CC BY-NC-ND · PubMed Central

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 3 references

Research works printed but not linked: 166

  1. Abarikwu, 2012, Rutin ameliorates cyclophosphamide-induced reproductive toxicity in male rats, Toxicol. Int., 19, 207, 10.4103/0971-6580.97224 · DOI
  2. Abdel-Raheem, 2010, Gastroprotective effect of rutin against indomethacin-induced ulcers in rats, Basic Clin. Pharmacol. Toxicol., 107, 742, 10.1111/j.1742-7843.2010.00568.x · DOI
  3. Akondi, 2011, Protective effects of rutin and naringin in testicular ischemia-reperfusion induced oxidative stress in rats, J. Reprod. Infertility, 12, 209
  4. Alarcón-Alonso, 2012, Pharmacological characterization of the diuretic effect of Hibiscus sabdariffa Linn (Malvaceae) extract, J. Ethnopharmacol., 139, 751, 10.1016/j.jep.2011.12.005 · DOI
  5. Ali, 2009, Cardioprotective effect of tetrahydrocurcumin and rutin on lipid peroxides and antioxidants in experimentally induced myocardial infarction in rats, Pharmazie, 64, 132
  6. Almeida, 2012, Hydrogels containing rutin intended for cutaneous administration: efficacy in wound healing in rats, Drug Dev. Ind. Pharm., 38, 792, 10.3109/03639045.2011.628676 · DOI
  7. Alonso, 2014, Antioxidative effects and percutaneous absorption of five polyphenols, Free Radic. Biol. Med., 75, 149, 10.1016/j.freeradbiomed.2014.07.014 · DOI
  8. Alonso-Castro, 2013, Rutin exerts antitumor effects on nude mice bearing SW480 tumor, Arch. Med. Res., 44, 346, 10.1016/j.arcmed.2013.06.002 · DOI
  9. Al-Rejaie, 2013, Protective effect of rutin on the antioxidant genes expression in hypercholestrolemic male Wistar rat, BMC Complement. Altern. Med., 13, 136, 10.1186/1472-6882-13-136 · DOI
  10. Andlauer, 2001, Intestinal absorption of rutin in free and conjugated forms, Biochem. Pharmacol., 62, 369, 10.1016/S0006-2952(01)00638-4 · DOI
  11. Annapurna, 2009, Cardioprotective actions of two bioflavonoids, quercetin and rutin, in experimental myocardial infarction in both normal and streptozotocin-induced type I diabetic rats, J. Pharm. Pharmacol., 61, 1365, 10.1211/jpp.61.10.0014 · DOI
  12. Araruna, 2012, Evaluation of antibiotic & antibiotic modifying activity of pilocarpine & rutin, Indian J. Med. Res., 135, 252
  13. Araújo, 2011, Chemopreventive effect of dietary polyphenols in colorectal cancer cell lines, Nutr. Res., 31, 77, 10.1016/j.nutres.2011.01.006 · DOI
  14. Arima, 2002, Rutin-enhanced antibacterial activities of flavonoids against Bacillus cereus and Salmonella enteritidis, Biosci. Biotechnol. Biochem., 66, 1009, 10.1271/bbb.66.1009 · DOI
  15. Arjumand, 2011, Rutin attenuates cisplatin induced renal inflammation and apoptosis by reducing NFκB, TNF-α and caspase-3 expression in wistar rats, Food Chem. Toxicol., 49, 2013, 10.1016/j.fct.2011.05.012 · DOI
  16. Arora, 2005, Radioprotection by plant products: present status and future prospects, Phytother. Res., 19, 1, 10.1002/ptr.1605 · DOI
  17. Azevedo, 2013, The antioxidant effects of the flavonoids rutin and quercetin inhibit oxaliplatin-induced chronic painful peripheral neuropathy, Mol. Pain, 9, 53, 10.1186/1744-8069-9-53 · DOI
  18. Bernard, 1997, Glycosylated flavones as selective inhibitors of topoisomerase IV, Antimicrob. Agents Chemother., 41, 992, 10.1128/AAC.41.5.992 · DOI
  19. Bhutani, 2013, Emerging therapies for the treatment of osteoporosis, J. Midlife Health, 4, 147
  20. Bishnoi, 2007, Protective effect of rutin, a polyphenolic flavonoid against haloperidol-induced orofacial dyskinesia and associated behavioural, biochemical and neurochemical changes, Fundam. Clin. Pharmacol., 21, 521, 10.1111/j.1472-8206.2007.00512.x · DOI
  21. Burton, 1984, Myocardial alteration due to free radical generation, Am. J. Physiol., 84, H776
  22. Butchi Akondi, 2011, Protective effect of rutin and naringin on sperm quality in streptozotocin (STZ) induced type 1 diabetic rats, Iran J. Pharm. Res., 10, 585
  23. Carbonaro, 2005, Absorption of quercetin and rutin in rat small intestine, Ann. Nutr. Metab., 49, 178, 10.1159/000086882 · DOI
  24. Carelli, 2012, A specific combination of zeaxanthin, spermidine and rutin prevents apoptosis in human dermal papilla cells, Exp. Dermatol., 21, 953, 10.1111/exd.12029 · DOI
  25. Carvalho, 2013, In vitro inhibition of canine distemper virus by flavonoids and phenolic acids: implications of structural differences for antiviral design, Res. Vet. Sci., 95, 717, 10.1016/j.rvsc.2013.04.013 · DOI
  26. Chan, 2009, Effect of rutin on warfarin anticoagulation and pharmacokinetics of warfarin enantiomers in rats, J. Pharm. Pharmacol., 61, 451, 10.1211/jpp.61.04.0006 · DOI
  27. Chattopadhyay, 1993, Hypoglycemic effect of Ocimum sanctum leaf in normal and streptozotocin diabetic rats, Indian J. Exp. Biol., 31, 891
  28. Chen, 2013, Antioxidant activity and components of a traditional Chinese medicine formula consisting of Crataegus pinnatifida and Salvia miltiorrhiza, BMC Complement Altern. Med., 13, 99, 10.1186/1472-6882-13-99 · DOI
  29. Chen, 2013, Anti-tumor effect of rutin on human neuroblastoma cell lines through inducing G2/M cell cycle arrest and promoting apoptosis, Sci. World J., 20
  30. Chen, 2010, Lymphatic absorption of quercetin and rutin in rat and their pharmacokinetics in systemic plasma, J. Agric. Food Chem., 58, 546, 10.1021/jf9026124 · DOI
  31. Chen, 2002, Experimental study on inhibitory effect of rutin against platelet activation induced by platelet activating factor in rabbits, Zhongguo Zhong Xi Yi Jie He Za Zhi, 22, 283
  32. Chen, 2014, Protective effect of rutin on LPS-induced acute lung injury via down-regulation of MIP-2 expression and MMP-9 activation through inhibition of Akt phosphorylation, Int. Immunopharmacol., 22, 409, 10.1016/j.intimp.2014.07.026 · DOI
  33. Chen, 2013, Beneficial effect of rutin on oxonate-induced hyperuricemia and renal dysfunction in mice, Pharmacology, 92, 75, 10.1159/000351703 · DOI
  34. Chiou, 2004, Effects of some natural flavonoids on retinal function recovery after ischemic insult in the rat, J. Ocul. Pharmacol. Ther., 20, 107, 10.1089/108076804773710777 · DOI
  35. Choi, 2013, Rutin suppresses atopic dermatitis and allergic contact dermatitis, Exp. Biol. Med. (Maywood), 238, 410, 10.1177/1535370213477975 · DOI
  36. Choi, 2014, Rutin inhibits UV-B radiation-induced expression of COX-2 and iNOS in hairless mouse skin: p38 MAP kinase and JNK as potential targets, Arch. Biochem. Biophys., 559, 38, 10.1016/j.abb.2014.05.016 · DOI
  37. Choquenet, 2008, Quercetin and rutin as potential sunscreen agents: determination of efficacy by anin vitromethod, J. Nat. Prod., 71, 1117, 10.1021/np7007297 · DOI
  38. Choudhury, 1999, Urinary excretion of hydroxycinnamates and flavonoids after oral and intravenous administration, Free Radic. Biol. Med., 27, 278, 10.1016/S0891-5849(99)00054-4 · DOI
  39. Coombes, 2002, Effects of vitamin E deficiency on fatigue and muscle contractile properties, Eur. J. Appl., Physiol., 87, 272, 10.1007/s00421-002-0631-3 · DOI
  40. Corcostegui, 1998, Protective effect of hidrosmin against cisplatin induced acute nephrotoxicity in rats, Pharm. Pharmacol. Commun., 4, 465
  41. Cristina Marcarini, 2011, Investigation of cytotoxic, apoptosis-inducing, genotoxic and protective effects of the flavonoid rutin in HTC hepatic cells, Exp. Toxicol. Pathol., 63, 459, 10.1016/j.etp.2010.03.005 · DOI
  42. da Cruz, 2012, In vitro antimycobacterial activity and HPLC-DAD screening of phenolics from Ficus benjamina L. and Ficus luschnathiana (Miq.) Miq. leaves, Nat. Prod. Res., 26, 2251, 10.1080/14786419.2011.650637 · DOI
  43. da Silva, 2001, Hypocholesterolemic effect of naringin and rutin flavonoids, Arch. Latinoam. Nutr., 51, 258
  44. De Clercq, 2006, Antiviral prodrugs-the development of successful prodrug strategies for antiviral chemotherapy, Br. J. Pharmacol., 10, 1, 10.1038/sj.bjp.0706446 · DOI
  45. De Sarmento, 1957, Treatment of whooping cough with vitamins C & K combined with rutin, intravenous administration, Pediatr. Prat., 28, 51
  46. Deb, 2010, Pathophysiologic mechanisms of acute ischemic stroke: an overview with emphasis on therapeutic significance beyond thromlolysis, Pathophysiology, 17, 197, 10.1016/j.pathophys.2009.12.001 · DOI
  47. Draelos, 2000, Cosmetics and skin care products. A historical perspective, Dermatol. Clin., 18, 557, 10.1016/S0733-8635(05)70206-0 · DOI
  48. Drewa, 1998, The influence of rutin on the weight, metastasis and melanin content of B16 melanotic melanoma in C57BL/6 mice, Neoplasma, 45, 266
  49. Dubey, 2013, Experimental studies on bioactive potential of rutin, Chron. Young Sci., 4, 153, 10.4103/2229-5186.115556 · DOI
  50. Dubey, 2013, Rutin exerts antiulcer effect by inhibiting the gastric proton pump, Indian J. Pharmacol., 45, 415, 10.4103/0253-7613.115011 · DOI
  51. Fernandes, 2010, Influence of rutin treatment on biochemical alterations in experimental diabetes, Biomed. Pharmacother., 64, 214, 10.1016/j.biopha.2009.08.007 · DOI
  52. Fernández, 2006, Central nervous system depressant action of flavonoid glycosides, Eur. J. Pharmacol., 539, 168, 10.1016/j.ejphar.2006.04.004 · DOI
  53. Ganesh, 2012, Antiplasmodial activity of flavonol quercetin and its analogues in Plasmodium falciparum: evidence from clinical isolates in Bangladesh and standardized parasite clones, Parasitol. Res., 110, 2289, 10.1007/s00436-011-2763-z · DOI
  54. Gonçalves, 2013, Flavonoid rutin increases thyroid iodide uptake in rats, PLoS One, 8, e73908, 10.1371/journal.pone.0073908 · DOI
  55. Gould, 2004, The medical management of idiopathic chylothorax in a domestic long-haired cat, Can. Vet. J., 45, 51
  56. Grdina, 2002, Radioprotectants: current status and new directions, Oncology, 63, 2, 10.1159/000067146 · DOI
  57. Griffiths, 1972, Metabolism of flavonoid compounds in germ-free rats, Biochem. J., 130, 1161, 10.1042/bj1301161 · DOI
  58. Guardia, 2001, Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat, Farmaco, 56, 683, 10.1016/S0014-827X(01)01111-9 · DOI
  59. Hammad, 1997, Pharmacological effects of selected flavonoids on rat isolated ileum: structure-activity relationship, Gen. Pharmacol., 28, 767, 10.1016/S0306-3623(96)00299-6 · DOI
  60. Han, 2009, Rutin has therapeutic effect on septic arthritis caused by Candida albicans, Int. Immunopharmacol., 9, 207, 10.1016/j.intimp.2008.11.002 · DOI
  61. Harborne, 1986, Nature, distribution and function of plant flavonoids, Prog. Clin. Biol. Res., 213, 15
  62. Hodsman, 2005, Parathyroid hormone and teriparatide for the treatment of osteoporosis: a review of the evidence and suggested guidelines for its use, Endocr. Rev., 26, 688, 10.1210/er.2004-0006 · DOI
  63. Horcajada, 2014, Oleuropein or rutin consumption decreases the spontaneous development of osteoarthritis in the Hartley guinea pig, Osteoarthritis Cartilage, 10.1016/j.joca.2014.02.879 · DOI
  64. Horcajada-Molteni, 2000, Rutin inhibits ovariectomy-induced osteopenia in rats, J. Bone Miner. Res., 15, 2251, 10.1359/jbmr.2000.15.11.2251 · DOI
  65. Hsieh, 2008, Effects of rutin from Toona sinensis on the immune and physiological responses of white shrimp (Litopenaeus vannamei) under Vibrio alginolyticus challenge, Fish Shellfish Immunol., 25, 581, 10.1016/j.fsi.2008.07.014 · DOI
  66. Hsu, 2014, Rutin potentiates insulin receptor kinase to enhance insulin-dependent glucose transporter 4 translocation, Mol. Nutr. Food Res., 58, 1168, 10.1002/mnfr.201300691 · DOI
  67. Hu, 2009, Allopurinol, rutin, and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: renal organic ion transporter involvement, Am. J. Physiol. Renal Physiol., 297, F1080, 10.1152/ajprenal.90767.2008 · DOI
  68. Hu, 2012, Allopurinol, quercetin and rutin ameliorate renal NLRP3 inflammasome activation and lipid accumulation in fructose-fed rats, Biochem. Pharmacol., 84, 113, 10.1016/j.bcp.2012.03.005 · DOI
  69. Huang, 2014, Rutin improves endotoxin-induced acute lung injury via inhibition of iNOS and VCAM-1 expression, Environ. Toxicol., 107, 742
  70. Hyun, 2014, Effects of watercress containing rutin and rutin alone on the proliferation and osteogenic differentiation of human osteoblast-like MG-63 cells, Korean J. Physiol. Pharmacol., 18, 347, 10.4196/kjpp.2014.18.4.347 · DOI
  71. Ibrahim, 2013, Anti-H5N1 virus flavonoids from Capparis sinaica Veill, Nat. Prod. Res., 27, 2149, 10.1080/14786419.2013.790027 · DOI
  72. Isai, 2009, Prevention of selenite-induced cataractogenesis by rutin in Wistar rats, Mol. Vis., 15, 2570
  73. Iwu, 1986, Biochemical mechanism of the antimalarial activity of Azadirachta indica leaf extract, Pharmacol. Res. Commun., 18, 81, 10.1016/0031-6989(86)90161-X · DOI
  74. Janbaz, 2002, Protective effect of rutin on paracetamol and CCl4-induced hepatotoxicity in rodents, Fitoterapia, 73, 557, 10.1016/S0367-326X(02)00217-4 · DOI
  75. Javed, 2012, Rutin prevents cognitive impairments by ameliorating oxidative stress and neuroinflammation in rat model of sporadic dementia of Alzheimer type, Neuroscience, 17, 340, 10.1016/j.neuroscience.2012.02.046 · DOI
  76. Johann, 2011, Antifungal activity of five species of Polygala, Braz. J. Microbiol., 42, 1065, 10.1590/S1517-83822011000300027 · DOI
  77. Jung, 2007, Anti-asthmatic action of quercetin and rutin in conscious guinea-pigs challenged with aerosolized ovalbumin, Arch. Pharm. Res., 30, 1599, 10.1007/BF02977330 · DOI
  78. Kalgaonkar, 2010, Effects of a flavonol-rich diet on select cardiovascular parameters in a Golden Syrian hamster model, J. Med. Food, 13, 108, 10.1089/jmf.2008.0295 · DOI
  79. Kamalakkannan, 2006, Antihyperglycaemic and antioxidant effect of rutin, a polyphenolic flavonoid, in streptozotocin-induced diabetic wistar rats, Basic Clin. Pharmacol. Toxicol., 98, 97, 10.1111/j.1742-7843.2006.pto_241.x · DOI
  80. Kamalakkannan, 2006, The influence of rutin on the extracellular matrix in streptozotocin-induced diabetic rat kidney, J. Pharm. Pharmacol., 58, 1091, 10.1211/jpp.58.8.0010 · DOI
  81. Kamel, 2014, Hesperidin and rutin, antioxidant citrus flavonoids, attenuate cisplatin-induced nephrotoxicity in rats, J. Biochem. Mol. Toxicol., 28, 312, 10.1002/jbt.21567 · DOI
  82. Kanashiro, 2009, Modulatory effects of rutin on biochemical and hematological parameters in hypercholesterolemic Golden Syrian hamsters, An. Acad. Bras. Cienc., 81, 67, 10.1590/S0001-37652009000100009 · DOI
  83. Kappel, 2013, Rutin potentiates calcium uptake via voltage-dependent calcium channel associated with stimulation of glucose uptake in skeletal muscle, Arch Biochem. Biophys., 532, 55, 10.1016/j.abb.2013.01.008 · DOI
  84. Karami, 2014, Nephroprotective effects of Feijoa Sellowiana leaves extract on renal injury induced by acute dose of ecstasy (MDMA) in mice, Iran J. Basic Med. Sci., 17, 69
  85. Khan, 2009, Rutin protects the neural damage induced by transient focal ischemia in rats, Brain Res., 1292, 123, 10.1016/j.brainres.2009.07.026 · DOI
  86. Khan, 2012, CCl4-induced hepatotoxicity: protective effect of rutin on p53, CYP2E1 and the antioxidative status in rat, BMC Complement. Altern. Med., 12, 178, 10.1186/1472-6882-12-178 · DOI
  87. Khan, 2012, Protective effects of rutin against potassium bromate induced nephrotoxicity in rats, BMC Complement. Altern. Med., 12, 204, 10.1186/1472-6882-12-204 · DOI
  88. Kim, 2009, Germinated Buckwheat extract decreases blood pressure and nitrotyrosine immunoreactivity in aortic endothelial cells in spontaneously hypertensive rats, Phytother. Res., 23, 993, 10.1002/ptr.2739 · DOI
  89. Kopko, 2005, The use of rutin in a cat with idiopathic chylothorax, Can. Vet. J., 46, 729
  90. Korkmaz, 2013, Inhibiting inducible nitric oxide synthase with rutin reduces renal ischemia/reperfusion injury, Can. J. Surg., 56, 6, 10.1503/cjs.004811 · DOI
  91. Korkmaz, 2010, Protective effect of rutin on the ischemia/reperfusion induced damage in rat kidney, J. Surg. Res., 164, 309, 10.1016/j.jss.2009.03.022 · DOI
  92. Kourounakis, 1986, Effect of benzopyrone derivatives on drug activity and metabolism, Eur. J. Drug Metab. Pharmacokinet., 11, 269, 10.1007/BF03189111 · DOI
  93. Kreft, 1997, Extraction of rutin from buckwheat (Fagopyrum esculentum Moench) seeds and determination by capillary electrophoresis, J. Agric. Food Chem., 47, 4649, 10.1021/jf990186p · DOI
  94. Krishna, 2005, Partial reversal by rutin and quercetin of impaired cardiac function in streptozotocin-induced diabetic rats, Can. J. Physiol. Pharmacol., 83, 343, 10.1139/y05-009 · DOI
  95. Kumar, 2015, Pharmacokinetic drug interactions between apigenin, rutin and paclitaxel mediated by P-glycoprotein in rats, Eur. J. Drug Metab. Pharmacokinet., 40, 267, 10.1007/s13318-014-0203-z · DOI
  96. Kyung, 2008, Rutin inhibits osteoclast formation by decreasing reactive oxygen species and TNF-alpha by inhibiting activation of NF-kappaB, Exp. Mol. Med., 40, 52, 10.3858/emm.2008.40.1.52 · DOI
  97. La Casa, 2000, Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesions, J. Ethnopharmacol., 71, 45, 10.1016/S0378-8741(99)00174-9 · DOI
  98. Lau, 2011, A review on current osteoporosis research: with special focus on disuse bone loss, J. Osteoporos., 5
  99. Li, 2002, Reactive species mechanisms of cellular hypoxia-reoxygenation injury, Am. J. Physiol. Cell Physiol., 282, C227, 10.1152/ajpcell.00112.2001 · DOI
  100. Li, 2013, Quercetin provides greater cardioprotective effect than its glycoside derivative rutin on isoproterenol-induced cardiac fibrosis in the rat, Can. J. Physiol. Pharmacol., 91, 951, 10.1139/cjpp-2012-0432 · DOI
  101. Lin, 2012, Rutin inhibits human leukemia tumor growth in a murine xenograft model in vivo, Environ. Toxicol., 27, 480, 10.1002/tox.20662 · DOI
  102. Lin, 2009, Rutin inhibits the proliferation of murine leukemia WEHI-3 cells in vivo and promotes immune response in vivo, Leuk. Res., 33, 823, 10.1016/j.leukres.2008.09.032 · DOI
  103. Lindahl, 1997, Flavonoids as phospholipase A2 inhibitors: importance of their structure for selective inhibition of group II phospholipase A2, Inflammation, 21, 347, 10.1023/A:1027306118026 · DOI
  104. Lloyd-Jones, 2009, Heart disease and stroke statistics 2009 update: a report from the American heart association statistics committee and stroke statistics subcommittee, Circulation, 11, e71
  105. Machado, 2008, Antidepressant-like effect of rutin isolated from the ethanolic extract from Schinus molle L. in mice: evidence for the involvement of the serotonergic and noradrenergic systems, Eur. J. Pharmacol., 587, 163, 10.1016/j.ejphar.2008.03.021 · DOI
  106. Markert, 1968, Neoplasia: a disease of differentiation, Cancer Res., 28, 1908
  107. Martínez Conesa, 2005, Treatment of metastatic melanoma B16F10 by the flavonoids tangeretin, rutin, and diosmin, J. Agric. Food Chem., 53, 6791, 10.1021/jf058050g · DOI
  108. Mellou, 2006, Enzymatic esterification of flavonoids with unsaturated fatty acids: effect of the novel esters on vascular endothelial growth factor release from K562 cells, Process Biochem., 41, 2029, 10.1016/j.procbio.2006.05.002 · DOI
  109. Mendes-Junior, 2013, Oral supplementation with the rutin improves cardiovagal baroreflex sensitivity and vascular reactivity in hypertensive rats, Appl. Physiol. Nutr. Metab., 38, 1099, 10.1139/apnm-2013-0091 · DOI
  110. Moretti, 2012, Effect of quercetin, rutin, naringenin and epicatechin on lipid peroxidation induced in human sperm, Reprod. Toxicol., 34, 651, 10.1016/j.reprotox.2012.10.002 · DOI
  111. Morino, 1982, Carcinogenicity test of quercetin and rutin in golden hamsters by oral administration, Carcinogenesis, 3, 93, 10.1093/carcin/3.1.93 · DOI
  112. Mouria, 2002, Food-derived polyphenols inhibit pancreatic cancer growth through mitochondrial cytochrome C release and apoptosis, Int. J. Cancer, 98, 761, 10.1002/ijc.10202 · DOI
  113. Muthenna, 2010, Inhibition of advanced glycation end-product formation on eye lens protein by rutin, Br. J. Nutr., 107, 941, 10.1017/S0007114511004077 · DOI
  114. Nassiri-Asl, 2010, The effects of rutin on the development of pentylenetetrazole kindling and memory retrieval in rats, Epilepsy Behav., 18, 50, 10.1016/j.yebeh.2010.03.005 · DOI
  115. Nebbioso, 2013, Treatment of glaucomatous patients by means of food supplement to reduce the ocular discomfort: a double blind randomized trial, Eur. Rev. Med. Pharmacol. Sci., 17, 1117
  116. Nieoczym, 2014, Effect of quercetin and rutin in some acute seizure models in mice, Prog. Neuropsychopharmacol. Biol. Psychiatry, 54, 50, 10.1016/j.pnpbp.2014.05.007 · DOI
  117. Nones, 2012, The flavonoids hesperidin and rutin promote neural crest cell survival, Cell Tissue Res., 350, 305, 10.1007/s00441-012-1472-y · DOI
  118. Oates, 1988, Studies on the mechanism of ethanol-induced gastric damage in rat, Gastroenterology, 94, 10, 10.1016/0016-5085(88)90604-X · DOI
  119. O’Connell, 2008, Curcumin: potential for hepatic fibrosis therapy?, Br. J. Pharmacol., 153, 403, 10.1038/sj.bjp.0707580 · DOI
  120. Odetti, 1990, Prevention of diabetes-increased aging effect on rat collagen-linked fluorescence by aminoguanidine and rutin, Diabetes, 39, 796, 10.2337/diab.39.7.796 · DOI
  121. Ogeturk, 2005, Caffeic acid phenethyl ester protects kidneys against carbon tetrachloride toxicity in rats, J. Ethnopharmacol., 97, 273, 10.1016/j.jep.2004.11.019 · DOI
  122. Ortolani, 1995, Protection from ischemia-reperfusion damage in patients with stroke: the role of rutin and GSH, Transplant. Proc., 27, 2877
  123. Ortolani, 2000, Protective effects of N-acetylcysteine and rutin on the lipid peroxidation of the lung epithelium during the adult respiratory distress syndrome, Shock, 13, 14, 10.1097/00024382-200013010-00003 · DOI
  124. Pashikanti, 2010, Rutin metabolites: novel inhibitors of nonoxidative advanced glycation end products, Free Radic. Biol. Med., 48, 656, 10.1016/j.freeradbiomed.2009.11.019 · DOI
  125. Patil, 2013, Antioxidative and radioprotective potential of rutin and quercetin in Swiss albino mice exposed to gamma radiation, J. Med. Phys., 38, 87, 10.4103/0971-6203.111321 · DOI
  126. Patil, 2012, Radiomodulatory role of rutin and quercetin in swiss albino mice exposed to the whole body gamma radiation, Indian J. Nucl. Med., 27, 237, 10.4103/0972-3919.115394 · DOI
  127. Pihan, 1987, Free radicals and lipid peroxidation in ethanol- and aspirin-induced gastric mucosal injury, Dig. Dis. Sci., 32, 1395, 10.1007/BF01296666 · DOI
  128. Pimentel, 2013, Antimicrobial activity and rutin identification of honey produced by the stingless bee Melipona compressipes manaosensis and commercial honey, BMC Complement. Altern. Med., 13, 151, 10.1186/1472-6882-13-151 · DOI
  129. Pozin, 1996, Changes in the vascular wall and ischemic damages to the myocardium in reversible episodes of heart muscle ischemia, Fiziol. Zh., 42, 10
  130. Pu, 2007, Neuroprotective effects of quercetin and rutin on spatial memory impairment in an 8-arm radial maze task and neuronal death induced by repeated cerebral ischemia in rats, J. Pharmacol. Sci., 104, 329, 10.1254/jphs.FP0070247 · DOI
  131. Ratty, 1988, Effects of flavonoids on nonenzymatic lipid peroxidation: structure-activity relationship, Biochem. Med. Metab. Biol., 39, 69, 10.1016/0885-4505(88)90060-6 · DOI
  132. Richetti, 2011, Quercetin and rutin prevent scopolamine-induced memory impairment in zebrafish, Behav. Brain Res., 217, 10, 10.1016/j.bbr.2010.09.027 · DOI
  133. Roseghini, 2007, Flavonoid rutin alters the viability and function of mitogen-stimulated splenocytes and thymocytes compared with non stimulated cells, Immunopharmacol. Immunotoxicol., 29, 271, 10.1080/08923970701512940 · DOI
  134. Roux, 2010, New treatment targets in osteoporosis, Joint Bone Spine, 77, 222, 10.1016/j.jbspin.2010.02.004 · DOI
  135. Rylski, 1979, The analgesic action of some flavonoids in the hot plate test, Acta Physiol. Pol., 30, 385
  136. Scambia, 1990, Synergistic antiproliferative activity of quercetin and cisplatin on ovarian cancer cell growth, Anticancer Drugs, 1, 45, 10.1097/00001813-199010000-00008 · DOI
  137. Schuller, 2011, Idiopathic chylothorax and lymphedema in 2 whippet littermates, Can. Vet. J., 52, 1243
  138. Schwedhelm, 2003, Clinical pharmacokinetics of antioxidants and their impact on systemic oxidative stress, Clin. Pharmacokinet., 42, 437, 10.2165/00003088-200342050-00003 · DOI
  139. Schwingel, 2014, Effects of the compounds resveratrol, rutin, quercetin, and quercetin nanoemulsion on oxaliplatin-induced hepatotoxicity and neurotoxicity in mice, Naunyn. Schmiedebergs Arch. Pharmacol., 387, 837, 10.1007/s00210-014-0994-0 · DOI
  140. Selvaraj, 2014, Anti-nociceptive effect in mice of thillai flavonoid rutin, Biomed. Environ. Sci., 27, 295
  141. Shen, 2008, Illustrated pharmacology memory cards: pharmnemonics, Minireview, 5
  142. Silveira, 2009, Effect of rutin and chloroquine on White Leghorn chickens infected with Plasmodium (Bennettinia) juxtanucleare, Trop. Anim. Health Prod., 41, 1319, 10.1007/s11250-009-9317-8 · DOI
  143. Sonkar, 2014, An experimental evaluation of nephroprotective potential of Butea monosperma extract in albino rats, Indian J. Pharmacol., 46, 109, 10.4103/0253-7613.125190 · DOI
  144. Srinivasan, 2005, Partial protective effect of rutin on multiple low dose streptozotocin-induced diabetes in mice, Indian J. Pharmacol., 37, 327, 10.4103/0253-7613.16859 · DOI
  145. Stanley Mainzen Prince, 2006, Rutin improves glucose homeostasis in streptozotocin diabetic tissues by altering glycolytic and gluconeogenic enzymes, J. Biochem. Mol. Toxicol., 20, 96, 10.1002/jbt.20117 · DOI
  146. Stojković, 2013, In situ antioxidant and antimicrobial activities of naturally occurring caffeic acid, p-coumaric acid and rutin, using food systems, J. Sci. Food Agric., 93, 3205, 10.1002/jsfa.6156 · DOI
  147. Su, 2014, Rutin, a flavonoid and principal component of Saussurea involucrata, attenuates physical fatigue in a forced swimming mouse model, Int. J. Med. Sci., 11, 528, 10.7150/ijms.8220 · DOI
  148. Szabo, 1990, Experimental pathogenesis: drugs and chemical lesions in the gastric mucosa, Scand. J. Gastroenterol., 1, 10.3109/00365529009091924 · DOI
  149. Szelenyi, 1988, Possible role of oxygen free radicals in ethanol-induced gastric mucosal damage in rats, Dig. Dis. Sci., 33, 865, 10.1007/BF01550977 · DOI
  150. Tao, 2007, In vitro anti-HIV and -HSV activity and safety of sodium rutin sulfate as a microbicide candidate, Antiviral Res., 75, 227, 10.1016/j.antiviral.2007.03.008 · DOI
  151. Tongjaroenbuangam, 2011, Neuroprotective effects of quercetin, rutin and okra (Abelmoschus esculentus Linn.) in dexamethasone-treated mice, Neurochem. Int., 59, 677, 10.1016/j.neuint.2011.06.014 · DOI
  152. Tran, 2011, In situ forming and rutin-releasing chitosan hydrogels as injectable dressings for dermal wound healing, Biomacromolecules, 12, 2872, 10.1021/bm200326g · DOI
  153. Trumbeckaite, 2006, The effect of flavonoids on rat heart mitochondrial function, Biomed. Pharmacother., 60, 245, 10.1016/j.biopha.2006.04.003 · DOI
  154. Ugusman, 2014, Role of rutin on nitric oxide synthesis in human umbilical vein endothelial cells, Sci. World J., 10.1155/2014/169370 · DOI
  155. Vetrugno, 2012, Oral administration of forskolin and rutin contributes to intraocular pressure control in primary open angle glaucoma patients under maximum tolerated medical therapy, J. Ocul. Pharmacol. Ther., 28, 536, 10.1089/jop.2012.0021 · DOI
  156. Wacker, 1978, Antiviral activity of plant components. 1st communication: Flavonoids (author’s transl), Arzneimittelforschung, 28, 347
  157. Wang, S., Nagrath, D., 2010. Liver tissue engineering. In: Biomaterials for Tissue Engineering Applications: A Review of the Past and Future Trends, 14, 389. · DOI
  158. Wang, 2012, Rutin inhibits β-amyloid aggregation and cytotoxicity, attenuates oxidative stress, and decreases the production of nitric oxide and proinflammatory cytokines, Neurotoxicology, 33, 482, 10.1016/j.neuro.2012.03.003 · DOI
  159. Weiss, 2003, Protection against ionizing radiation by antioxidant nutrients and phytochemicals, Toxicology, 189, 1, 10.1016/S0300-483X(03)00149-5 · DOI
  160. Xie, 2014, Inhibition of flavonoids on acetylcholine esterase: binding and structure-activity relationship, Food Funct., 5, 2582, 10.1039/C4FO00287C · DOI
  161. Xu, 2007, Structure-activity relationships of flavonoids for vascular relaxation in porcine coronary artery, Phytochemistry, 68, 1179, 10.1016/j.phytochem.2007.02.013 · DOI
  162. Yang, 2006, Comparative study on effects of rutin and quercetin on metabolism in osteoblast cells, Zhong Yao Cai, 29, 467
  163. Yeh, 2014, Rutin decreases lipopolysaccharide-induced acute lung injury via inhibition of oxidative stress and the MAPK-NF-κB pathway, Free Radic. Biol. Med., 69, 249, 10.1016/j.freeradbiomed.2014.01.028 · DOI
  164. You, 2011, In vitro antioxidant activity and in vivo anti-fatigue effect of loach (Misgurnus anguillicaudatus) peptides prepared by papain digestion, Food Chem., 124, 188, 10.1016/j.foodchem.2010.06.007 · DOI
  165. Yu, 2010, Fatigue among older people: a review of the research literature, Int. J. Nursing Stud., 47, 216, 10.1016/j.ijnurstu.2009.05.009 · DOI
  166. Zhang, 1993, Role of mitochondria in Cisplatin-induced oxidative damage exhibited by rat renal cortical slices, Biochem. Pharmacol., 45, 2215, 10.1016/0006-2952(93)90192-Y · DOI

Cited by

Metadata

Authors
Ganeshpurkar, A., & Saluja, A. K.
Venue
Saudi Pharmaceutical Journal
Publisher
Springer Science and Business Media LLC
Published
2017-02
Volume
25
Issue
2
Pages
149-164
ISSN
1319-0164
DOI
10.1016/j.jsps.2016.04.025
PMC
PMC5355559
Cited by
1,253
References
3
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.