Important Flavonoids and Their Role as a Therapeutic Agent

Ullah, Asad; Munir, Sidra; Badshah, Syed Lal; Khan, Noreen; Ghani, Lubna; Poulson, Benjamin Gabriel; Emwas, Abdul-Hamid; Jaremko, Mariusz

doi:10.3390/molecules25225243

Cited by 1,696Bioactive natural compoundsFlavonoids in Medical ResearchPhytochemicals and Antioxidant Activities

Important Flavonoids and Their Role as a Therapeutic Agent

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Ullah, Asad, Munir, Sidra, Badshah, Syed Lal, Khan, Noreen, Ghani, Lubna, Poulson, Benjamin Gabriel, Emwas, Abdul-Hamid, Jaremko, Mariusz·2020·Molecules

DOI 10.3390/molecules25225243PMC PMC7697716

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Abstract

Flavonoids are phytochemical compounds present in many plants, fruits, vegetables, and leaves, with potential applications in medicinal chemistry. Flavonoids possess a number of medicinal benefits, including anticancer, antioxidant, anti-inflammatory, and antiviral properties. They also have neuroprotective and cardio-protective effects. These biological activities depend upon the type of flavonoid, its (possible) mode of action, and its bioavailability. These cost-effective medicinal components have significant biological activities, and their effectiveness has been proved for a variety of diseases. The most recent work is focused on their isolation, synthesis of their analogs, and their effects on human health using a variety of techniques and animal models. Thousands of flavonoids have been successfully isolated, and this number increases steadily. We have therefore made an effort to summarize the isolated flavonoids with useful activities in order to gain a better understanding of their effects on human health.

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Chalcones and quinones are known for their redox properties, which neutralize free radicals and reduce oxidative stress.
“These compounds are known for their redox properties, which neutralize free radicals and reduce oxidative stress [48,49,50].”
From Comparative Analysis of Infusions and Ethanolic Extracts of Annona muricata Leaves from Colima, Mexico: Phytochemical Profile and Antioxidant Activity (2024) · cites this paper as [50]
Section 2.7 (Stroke Prevention; page not provided) reports that several dihydroxy chalcones suppressed reactive oxygen species and oxidative stress. Section 2.2 (Antioxidant Activity; page not provided) describes flavonoids reacting with radicals, but the cited passages do not establish the claimed redox and antioxidant properties for quinones. The chalcone evidence also concerns specific compounds rather than chalcones generally. (LLM, conf=0.86)
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Authors: Ullah, A., Munir, S., Badshah, S. L., Khan, N., Ghani, L., Poulson, B. G., Emwas, A.-H., & Jaremko, M.
Affiliations: Islamia College University (PK)
University of Azad Jammu and Kashmir (PK)
King Abdullah University of Science and Technology (SA)
Corresponding author: Badshah, Syed Lal
Jaremko, Mariusz
ORCID: Ullah, Asad
Munir, Sidra
Badshah, Syed Lal
Ghani, Lubna
Poulson, Benjamin Gabriel
Emwas, Abdul-Hamid
Jaremko, Mariusz
Venue: Molecules
Publisher: MDPI AG
Published: 2020-11-11
Volume: 25
Issue: 22
Pages: 5243
ISSN: 1420-3049 (ISSN-L)
DOI: 10.3390/molecules25225243
PMC: PMC7697716
OpenAlex: W3100994999
Cited by: 1,696
References: 290
Citations by year: 2026: 272 · 2025: 466 · 2024: 420 · 2023: 326 · 2022: 159 · 2021: 51 · 2014: 1
FWCI: 12.83
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Molecules (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
King Abdullah University of Science and Technology Repository (King Abdullah University of Science and Technology) (submittedVersion, other-oa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
Health Sciences › Medicine › Pharmacology › Flavonoids in Medical Research
Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords: flavonoids, phytochemicals, anticancer activity, antioxidant activity, anti-inflammatory activity, antiviral activity, neuroprotection, cardioprotection, bioavailability, flavonoid analogs, flavonoid isolation, medicinal plants
MeSH terms: Alzheimer Disease, Animals, Anti-Inflammatory Agents, Antifungal Agents, Antimalarials, Antineoplastic Agents, Antioxidants, Antiviral Agents, Cardiovascular System, Flavonoids, Humans, Hypoglycemic Agents, Nervous System, Neurons, Plant Extracts, Plants, Quercetin, Rats, Sprague-Dawley, Rats, Wistar, Plant Leaves, Neuroprotective Agents, Stroke, Mice, Rats, Polyphenols

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