CoChat
Sign Up
Cited by 105Sexual function and dysfunction studiesPeriodontal Regeneration and TreatmentsUrological Disorders and Treatments

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Platelet-Rich Plasma (PRP) Improves Erectile Function: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial

Poulios, Evangelos, Mykoniatis, Ioannis, Pyrgidis, Nikolaos, Zilotis, Filimon, Kapoteli, Paraskevi, Kotsiris, Dimitrios, Kalyvianakis, Dimitrios, Hatzichristou, Dimitrios·2021·The Journal of Sexual Medicine
DOI 10.1016/j.jsxm.2021.03.008
Open this paper in CoChat — free account

Abstract

BACKGROUND: Animal studies postulate that platelet-rich plasma (PRP) injections improve key elements of the pathophysiologic mechanisms leading to erectile dysfunction (ED). AIM: To conduct the first double-blind, randomized, placebo-controlled trial assessing the efficacy and safety of PRP injections in patients with mild and moderate ED. METHODS: Sixty sexually active patients with mild and moderate ED were randomly assigned to two sessions, with a one-month difference, of 10 mL PRP (n = 30) or placebo (n = 30) intracavernosal injections. An FDA-approved separation system was used. Patients were evaluated at 1, 3 and 6 months after completion of the treatment protocol. A per-protocol analysis was applied. All participants withheld any ED treatment during the trial. OUTCOMES: The achievement of minimal clinically important difference (MCID) in the International Index of Erectile Function - Erectile Domain (IIEF-EF) from baseline to 6 months after final treatment. Erectile function at all time points, as well as safety of PRP injections, were also evaluated. RESULTS: At 6 months, a MCID was achieved by 20/29 (69%) patients in the PRP group compared to 7/26 (27%) in the placebo group. The risk difference between the two groups was 42% (95%CI: 18-66), P < 0.001 and the baseline-adjusted mean between-group-difference in the IIEF-EF score was 3.9 points (95%CI: 1.8-5.9). Similarly, a statistically significant difference of both the number of participants attaining a MCID and the IIEF-EF score was also observed at the 1- and 3-month evaluation between the two groups. Accordingly, patients receiving PRP were more satisfied with the treatment. No adverse events were observed during the study period. CLINICAL IMPLICATIONS: Intracavernosal PRP injection therapy used as outlined in this trial appears to be a safe and effective short-term treatment for the management of mild to moderate ED. STRENGTHS & LIMITATIONS: We conducted the first clinical trial exploring the role of PRP in the management of ED. Conversely, our findings lack external validity due to single-center design. Furthermore, our results cannot be extrapolated to other PRP separation systems. CONCLUSIONS: PRP intracavernosal injections may be a promising addition to the urologist's armamentarium for the management of ED. Still, further high-quality studies are warranted to corroborate our findings. Evangelos P, Mykoniatis I, Pyrgidis N, et al. Platelet-Rich Plasma (PRP) Improves Erectile Function: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial. J Sex Med 2021;18:926-935.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.jsxm.2021.03.008

Cites

43 of 43 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 43 references

Research works printed but not linked: 2

  1. Salonia, 2020, EAU guidelines on sexual and reproductive health 2020, Eur Assoc Urol Guidel
  2. Akakpo, 2020, Biotherapies for erectile dysfunction and Peyronie's disease: where are we now?, Progres En Urol J Assoc Francaise Urol Soc Francaise Urol

Cited by

Sorted by citations

See all 105

Related

Metadata

Authors
Poulios, E., Mykoniatis, I., Pyrgidis, N., Zilotis, F., Kapoteli, P., Kotsiris, D., Kalyvianakis, D., & Hatzichristou, D.
Affiliations
Aristotle University of Thessaloniki (GR)
Corresponding author
Mykoniatis, Ioannis
ORCID
Venue
The Journal of Sexual Medicine
Publisher
Oxford University Press (OUP)
Published
2021-05
Volume
18
Issue
5
Pages
926-935
ISSN
1743-6095 (ISSN-L)
DOI
10.1016/j.jsxm.2021.03.008
OpenAlex
W3158399656
Cited by
105
References
43
Citations by year
2026: 26 · 2025: 16 · 2024: 29 · 2023: 20 · 2022: 10 · 2021: 4
FWCI
11.29
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Journal of Sexual Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
  • Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
  • Health Sciences › Medicine › Urology › Urological Disorders and Treatments
Keywords
platelet-rich plasma, erectile dysfunction, intracavernous injection, IIEF-EF, treatment efficacy, treatment safety, patient satisfaction, minimal clinically important difference, adverse events
MeSH terms
Double-Blind Method, Humans, Erectile Dysfunction, Male, Penile Erection, Treatment Outcome, Platelet-Rich Plasma

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review