Erectile dysfunction
Open accessAbstract
Erectile dysfunction is a multidimensional but common male sexual dysfunction that involves an alteration in any of the components of the erectile response, including organic, relational and psychological. Roles for nonendocrine (neurogenic, vasculogenic and iatrogenic) and endocrine pathways have been proposed. Owing to its strong association with metabolic syndrome and cardiovascular disease, cardiac assessment may be warranted in men with symptoms of erectile dysfunction. Minimally invasive interventions to relieve the symptoms of erectile dysfunction include lifestyle modifications, oral drugs, injected vasodilator agents and vacuum erection devices. Surgical therapies are reserved for the subset of patients who have contraindications to these nonsurgical interventions, those who experience adverse effects from (or are refractory to) medical therapy and those who also have penile fibrosis or penile vascular insufficiency. Erectile dysfunction can have deleterious effects on a man's quality of life; most patients have symptoms of depression and anxiety related to sexual performance. These symptoms, in turn, affect his partner's sexual experience and the couple's quality of life. This Primer highlights numerous aspects of erectile dysfunction, summarizes new treatment targets and ongoing preclinical studies that evaluate new pharmacotherapies, and covers the topic of regenerative medicine, which represents the future of sexual medicine.
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In other important causes of ED, the combination of drugs and feelings of inadequacy along with fear and psychological distress due to body image perturbation (eg, obesity) can profoundly negatively affect sexual function and well-being.
“Similar considerations can be made regarding other important causes of ED where the combination of drugs and feelings of inadequacy along with fear and psychological distress due to body image perturbation (eg, obesity) can profoundly negatively affect sexual function and well-being.78”
From A Psychosocial Approach to Erectile Dysfunction: Position Statements from the European Society of Sexual Medicine (ESSM) (2021) · cites this paper as [78]
The Mechanisms/pathophysiology section links various medications to erectile dysfunction, and the Quality of life section describes shame, fear, anxiety and reduced sexual confidence. The Risk factors section associates obesity with erectile dysfunction. The copy does not establish the claimed combination of drugs and distress caused by obesity-related body-image changes as a cause of impaired sexual function and well-being. The supplied passages have no page numbers. (LLM, conf=0.85)
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Cites
Impotence and Its Medical and Psychosocial Correlates: Results of the Massachusetts Male Aging Study
Feldman, H. A., Goldstein, I., Hatzichristou, D. G., Krane, R. J., & McKinlay, J. B. (1994) · Journal of Urology · doi:10.1016/s0022-5347(17)34871-1 · Cited by 5,074 · see citing works
Dong, Y., Hao, L., Shi, Z., Wang, G., Zhang, Z., & Han, C. (2013) · Urologia Internationalis · doi:10.1159/000351405 · Cited by 4,557 · see citing works
Organic Causes of Erectile Dysfunction in Men Under 40
Ludwig, W. W., & Phillips, M. (2013) · Urologia Internationalis · doi:10.1159/000354931 · Cited by 2,156 · see citing works
Oral Sildenafil in the Treatment of Erectile Dysfunction
Goldstein, I., Lue, T. F., Padma-Nathan, H., Rosen, R. C., Steers, W. D., & Wicker, P. A. (1998) · New England Journal of Medicine · doi:10.1056/nejm199805143382001 · Cited by 2,120 · see citing works
Letter: Grading of angina pectoris.
CAMPEAU, L. A. (1976) · Circulation · doi:10.1161/circ.54.3.947585 · Cited by 1,607 · see citing works
Laumann, E. O., Nicolosi, A., Glasser, D. B., Paik, A., Gingell, C., Moreira, E., Wang, T., & for the GSSAB Investigators' Group (2005) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901250 · Cited by 1,415 · see citing works
Lue, T. F. (2000) · New England Journal of Medicine · doi:10.1056/nejm200006153422407 · Cited by 1,261 · see citing works
Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation
Hatzimouratidis, K., Amar, E., Eardley, I., Giuliano, F., Hatzichristou, D., Montorsi, F., Vardi, Y., & Wespes, E. (2010) · European Urology · doi:10.1016/j.eururo.2010.02.020 · Cited by 1,223 · see citing works
JOHANNES, C. B., ARAUJO, A. B., FELDMAN, H. A., DERBY, C. A., KLEINMAN, K. P., & McKINLAY, J. B. (2000) · Journal of Urology · doi:10.1016/s0022-5347(05)67900-1 · Cited by 1,158 · see citing works
Andersson, K. E., & Wagner, G. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.1.191 · Cited by 1,119 · see citing works
Rosen, R., Altwein, J., Boyle, P., Kirby, R. S., Lukacs, B., Meuleman, E., O’Leary, M. P., Puppo, P., Robertson, C., & Giuliano, F. (2003) · European Urology · doi:10.1016/j.eururo.2003.08.015 · Cited by 1,118 · see citing works
Increased Risk of Non-Fatal Myocardial Infarction Following Testosterone Therapy Prescription in Men
Finkle, W. D., Greenland, S., Ridgeway, G. K., Adams, J. L., Frasco, M. A., Cook, M. B., Fraumeni, J. F., & Hoover, R. N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085805 · Cited by 735 · see citing works
Management of erectile impotence Use of implantable inflatable prosthesis
Scott, F. B., Bradley, W. E., & Timm, G. W. (1973) · Urology · doi:10.1016/0090-4295(73)90224-0 · Cited by 606 · see citing works
Tajar, A., Forti, G., O'Neill, T. W., Lee, D. M., Silman, A. J., Finn, J. D., Bartfai, G., Boonen, S., Casanueva, F. F., Giwercman, A., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1796 · Cited by 604 · see citing works
Nicolosi, A., Laumann, E. O., Glasser, D. B., Moreira, E. D., Paik, A., & Gingell, C. (2004) · Urology · doi:10.1016/j.urology.2004.06.055 · Cited by 591 · see citing works
Ballard, S. A., Gingell, C., Tang, K., TURNER, L. A., Price, M. E., & NAYLOR, A. M. (1998) · The Journal of Urology · doi:10.1016/s0022-5347(01)63299-3 · Cited by 590 · see citing works
Araujo, A. B., Durante, R., Feldman, H. A., Goldstein, I., & McKinlay, J. B. (1998) · Psychosomatic Medicine · doi:10.1097/00006842-199807000-00011 · Cited by 576 · see citing works
Treatment of Men with Erectile Dysfunction with Transurethral Alprostadil
Padma-Nathan, H., Hellstrom, W. J. G., Kaiser, F. E., Labasky, R. F., Lue, T. F., Nolten, W. E., Norwood, P. C., Peterson, C. A., Shabsigh, R., Tam, P. Y., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199701023360101 · Cited by 574 · see citing works
Physiology of Erection and Pharmacological Management of Impotence
Lue, T. F., & Tanagho, E. A. (1987) · The Journal of Urology · doi:10.1016/s0022-5347(17)44267-4 · Cited by 566 · see citing works
Corona, G., Lee, D. M., Forti, G., O'Connor, D. B., Maggi, M., O’Neill, T. W., Pendleton, N., Bártfai, G., Boonen, S., Casanueva, F. F., et al. (2009) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2009.01601.x · Cited by 545 · see citing works
A Systematic Review of the Association Between Erectile Dysfunction and Cardiovascular Disease
Gandaglia, G., Briganti, A., Jackson, G., Kloner, R. A., Montorsi, F., Montorsi, P., & Vlachopoulos, C. V. (2013) · European Urology · doi:10.1016/j.eururo.2013.08.023 · Cited by 517 · see citing works
Cavernosal Alpha-Blockade: A New Technique for Investigating and Treating Erectile Impotence
Brindley, G. S. (1983) · The British Journal of Psychiatry · doi:10.1192/bjp.143.4.332 · Cited by 497 · see citing works
Efficacy and Safety of Intracavernosal Alprostadil in Men with Erectile Dysfunction
Linet, O. I., & Ogrinc, F. G. (1996) · New England Journal of Medicine · doi:10.1056/nejm199604043341401 · Cited by 494 · see citing works
Nehra, A. X., Jackson, G., Miner, M. M., Billups, K. L., Burnett, A. L. “., Buvat, J., Carson, C. C., Cunningham, G. R., Ganz, P., Goldstein, I., et al. (2012) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2012.06.015 · Cited by 472 · see citing works
Grimm, R. H., Grandits, G. A., Prineas, R. J., McDonald, R. H., Lewis, C. E., Flack, J. M., Yunis, C., Svendsen, K. H., Liebson, P. R., Elmer, P. J., et al. (1997) · Hypertension · doi:10.1161/01.hyp.29.1.8 · Cited by 459 · see citing works
Erectile Dysfunction and Risk of Cardiovascular Disease
Dong, J.-Y., Zhang, Y., & Qin, L.-Q. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.06.024 · Cited by 450 · see citing works
Nichols, D. J., Muirhead, G. J., & Harness, J. A. (2002) · British Journal of Clinical Pharmacology · doi:10.1046/j.0306-5251.2001.00027.x · Cited by 354 · see citing works
KWAN, M., GREENLEAF, W. J., MANN, J., CRAPO, L., & DAVIDSON, J. M. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-57-3-557 · Cited by 339 · see citing works
Androgens Regulate Phosphodiesterase Type 5 Expression and Functional Activity in Corpora Cavernosa
Morelli, A., Filippi, S., Mancina, R., Luconi, M., Vignozzi, L., Marini, M., Orlando, C., Vannelli, G. B., Aversa, A., Natali, A., et al. (2004) · Endocrinology · doi:10.1210/en.2003-1699 · Cited by 337 · see citing works
Fisher, W. A., Rosen, R. C., Eardley, I., Sand, M., & Goldstein, I. (2005) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2005.00118.x · Cited by 335 · see citing works
Moreland, R. B. (1998) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3900328 · Cited by 331 · see citing works
A Prospective Study of Risk Factors for Erectile Dysfunction
Bacon, C. G., Mittleman, M. A., Kawachi, I. I., Giovannucci, E. L., Glasser, D. B., & Rimm, E. B. (2006) · The Journal of Urology · doi:10.1016/s0022-5347(06)00589-1 · Cited by 331 · see citing works
Hormone-neurotransmitter interactions in the control of sexual behavior
Hull, E. M., Lorrain, D. S., Du, J., Matuszewich, L., Lumley, L. A., Putnam, S. K., & Moses, J. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00086-8 · Cited by 329 · see citing works
CHAPTER 1: THE MANAGEMENT OF ERECTILE DYSFUNCTION: AN AUA UPDATE
D, D. K. M. M., Jarow, J. P., Broderick, G. A., Dmochowski, R. R., Heaton, J. P. W., Lue, T. F., MILBANK, A. J., Nehra, A. X., Sharlip, I. D., & PANEL), (. O. T. E. D. G. U. (2005) · The Journal of Urology · doi:10.1097/01.ju.0000164463.19239.19 · Cited by 323 · see citing works
Bivalacqua, T. J., Champion, H. C., Usta, M. F., Cellek, S., Chitaley, K., Webb, R. C., Lewis, R. L., MILLS, T. M., Hellstrom, W. J. G., & Kadowitz, P. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400520101 · Cited by 317 · see citing works
Isidori, A. M., Buvat, J., Corona, G., Goldstein, I., Jannini, E. A., Lenzi, A., Porst, H., Salonia, A., Traish, A. M., & Maggi, M. (2013) · European Urology · doi:10.1016/j.eururo.2013.08.048 · Cited by 313 · see citing works
Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway
Chitaley, K., Wingard, C. J., Webb, R. C., Branam, H., Stopper, V. S., Lewis, R. W., & MILLS, T. M. (2001) · Nature Medicine · doi:10.1038/83258 · Cited by 309 · see citing works
Defining sexual outcomes after treatment for localized prostate carcinoma
Schover, L. R., Fouladi, R. T., Warneke, C. L., Neese, L., Klein, E. A., Zippe, C., & Kupelian, P. A. (2002) · Cancer · doi:10.1002/cncr.10848 · Cited by 305 · see citing works
Effects of Castration and Androgen Replacement on Erectile Function in a Rabbit Model1
Traish, A. M., Park, K., Dhir, V., Kim, N. N., Moreland, R. B., & Goldstein, I. (1999) · Endocrinology · doi:10.1210/endo.140.4.6655 · Cited by 305 · see citing works
Sharma, R., Oni, O. A., Gupta, K., Chen, G., Sharma, M., Dawn, B., Sharma, R., Parashara, D., Savin, V. J., Ambrose, J. A., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv346 · Cited by 302 · see citing works
Increased incidence of depressive symptoms in men with erectile dysfunction
Shabsigh, R., Klein, L. T., Seidman, S., Kaplan, S. A., Lehrhoff, B. J., & Ritter, J. S. (1998) · Urology · doi:10.1016/s0090-4295(98)00292-1 · Cited by 296 · see citing works
Prediction of Cardiovascular Events and All-Cause Mortality With Erectile Dysfunction
Vlachopoulos, C. V., Terentes-Printzios, D. G., Ioakeimidis, N., Aznaouridis, K. A., & Stefanadis, C. (2013) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.112.966903 · Cited by 296 · see citing works
Padma-Nathan, H., McCullough, A., Levine, L. A., Lipshultz, L. I., Siegel, R. L., Montorsi, F., Giuliano, F., Brock, G. B., & on behalf of the Study Group (2008) · International Journal of Impotence Research · doi:10.1038/ijir.2008.33 · Cited by 291 · see citing works
Changes in erectile responsiveness during androgen replacement therapy
Bancroft, J., & Wu, F. C. W. (1983) · Archives of Sexual Behavior · doi:10.1007/bf01542116 · Cited by 288 · see citing works
Cavernous Neurotomy Causes Hypoxia and Fibrosis in Rat Corpus Cavernosum
Leungwattanakij, S., Bivalacqua, T. J., Usta, M. F., Yang, D. Y., Hyun, J., Champion, H. C., Abdel‐Mageed, A. B., & Hellstrom, W. J. G. (2003) · Journal of Andrology · doi:10.1002/j.1939-4640.2003.tb02668.x · Cited by 287 · see citing works
Buvat, J., Maggi, M., Guay, A. T., & Torres, L. O. (2012) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2012.02783.x · Cited by 281 · see citing works
Gacci, M., Eardley, I., Giuliano, F., Hatzichristou, D., Kaplan, S., Maggi, M., McVary, K., Mirone, V., Porst, H., & Roehrborn, C. (2011) · European Urology · doi:10.1016/j.eururo.2011.06.037 · Cited by 274 · see citing works
Nehra, A. X., Goldstein, I., Pabby, A., Nugent, M. A., Huang, Y.-H., Morenas, A. D. L., Krane, R. J., Udelson, D., de Tejada, I. S., & Moreland, R. B. (1996) · The Journal of Urology · doi:10.1016/s0022-5347(01)65578-2 · Cited by 268 · see citing works
Basaria, S., Harman, S. M., Travison, T. G., Hodis, H., Tsitouras, P., Budoff, M., Pencina, K. M., Vita, J., Dzekov, C., Mazer, N. A., et al. (2015) · JAMA · doi:10.1001/jama.2015.8881 · Cited by 268 · see citing works
Wei, M., Macera, C. A., Davis, D. R., Hornung, C. A., Nankin, H. R., & Blair, S. N. (1994) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a117181 · Cited by 264 · see citing works
Testosterone supplementation and sexual function: A meta-analysis study
Corona, G., Isidori, A. M., Buvat, J., Aversa, A., Rastrelli, G., Hackett, G., Rochira, V., Sforza, A., Lenzi, A., Mannucci, E., et al. (2014) · The Journal of Sexual Medicine · doi:10.1111/jsm.12536 · Cited by 263 · see citing works
Yuan, J., Zhang, R., Yang, Z., Lee, J., Liu, Y., Tian, J., Qin, X., Ren, Z., Ding, H., Chen, Q., et al. (2013) · European Urology · doi:10.1016/j.eururo.2013.01.012 · Cited by 260 · see citing works
Mechanisms of action of PDE5 inhibition in erectile dysfunction
Corbin, J. D. (2004) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901205 · Cited by 248 · see citing works
A new treatment for Peyronie's disease: modeling the penis over an inflatable penile prosthesis.
Wilson, S., & Delk, J. (1994) · Journal of Urology · doi:10.1016/s0022-5347(17)32519-3 · Cited by 246 · see citing works
Moreland, R. B., Traish, A. M., McMillin, M. A., Smith, B. D., Goldstein, I., & de Tejada, I. S. (1995) · The Journal of Urology · doi:10.1016/s0022-5347(01)67730-9 · Cited by 246 · see citing works
Onset of effects of testosterone treatment and time span until maximum effects are achieved
Saad, F., Aversa, A., Isidori, A. M., Zafalon, L., Zitzmann, M., & Gooren, L. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0221 · Cited by 232 · see citing works
Boas, M., Boisen, K. A., Virtanen, H., Kaleva, M., Suomi, A.-M., Schmidt, I. M., Damgaard, I., Kai, C. M., Chellakooty, M., Skakkebaek, N., et al. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02066 · Cited by 226 · see citing works
Raina, R., Agarwal, A. K., Ausmundson, S., Lakin, M. M., Nandipati, K. C., D, D. K. M. M., Mansour, D., & Zippe, C. D. (2005) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901380 · Cited by 223 · see citing works
Buena, F., Swerdloff, R. S., Steiner, B. S., Lutchmansingh, P., Peterson, M. A., Pandian, M. R., Galmarini, M., & Bhasin, S. (1993) · Fertility and Sterility · doi:10.1016/s0015-0282(16)55938-x · Cited by 215 · see citing works
SOP Conservative (Medical and Mechanical) Treatment of Erectile Dysfunction
Porst, H., Burnett, A. L. “., Brock, G. B., Ghanem, H. M., Giuliano, F., Glina, S., Hellstrom, W. J. G., Martín‐Morales, A., Salonia, A., & Sharlip, I. D. (2013) · The Journal of Sexual Medicine · doi:10.1111/jsm.12023 · Cited by 213 · see citing works
A SURGICAL ALGORITHM FOR THE TREATMENT OF PEYRONIE'S DISEASE
Levine, L. A., & Lenting, E. L. (1997) · Journal of Urology · doi:10.1016/s0022-5347(01)68184-9 · Cited by 209 · see citing works
Ferrini, M. G., Davila, H. H., Kovanecz, I., Sanchez, S. P., González-Cadavid, N. F., & Rajfer, J. (2006) · Urology · doi:10.1016/j.urology.2006.05.011 · Cited by 204 · see citing works
Gray, P. B., Singh, A. B., Woodhouse, L. J., Storer, T. W., Casaburi, R. H., Dzekov, J., Dzekov, C., Sinha‐Hikim, I., & Bhasin, S. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0247 · Cited by 203 · see citing works
Standardization of Vascular Assessment of Erectile Dysfunction
Sikka, S. C., Hellstrom, W. J. G., Brock, G. B., & Morales, A. M. (2012) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2012.02825.x · Cited by 197 · see citing works
Zhang, X., Morelli, A., Luconi, M., Vignozzi, L., Filippi, S., Marini, M., Vannelli, G. B., Mancina, R., Forti, G., & Maggi, M. (2004) · European Urology · doi:10.1016/j.eururo.2004.10.021 · Cited by 193 · see citing works
Implants, Mechanical Devices, and Vascular Surgery for Erectile Dysfunction
Hellstrom, W. J. G., D, D. K. M. M., Moncada, I., Carson, C. C., Minhas, S., Faria, G. E., & Krishnamurti, S. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2009.01626.x · Cited by 186 · see citing works
Hackett, G., Cole, N., Bhartia, M., Kennedy, D., Raju, J., & Wilkinson, P. (2013) · The Journal of Sexual Medicine · doi:10.1111/jsm.12146 · Cited by 182 · see citing works
Rajpurkar, A. D., & Dhabuwala, C. B. (2003) · The Journal of Urology · doi:10.1097/01.ju.0000072524.82345.6d · Cited by 181 · see citing works
Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P
Ohmori, T., Yatomi, Y., OSADA, M., Kazama, F., Takafuta, T., IKEDA, H., & OZAKI, Y. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(03)00260-8 · Cited by 180 · see citing works
Capogrosso, P., Colicchia, M., Ventimiglia, E., Castagna, G., Clementi, M. C., Suardi, N., Castiglione, F., Briganti, A., Cantiello, F., Damiano, R., et al. (2013) · The Journal of Sexual Medicine · doi:10.1111/jsm.12179 · Cited by 167 · see citing works
Filippi, S., Vignozzi, L., Morelli, A., Chavalmane, A. K., Sarchielli, E., Fibbi, B., Saad, F., Sandner, P., Ruggiano, P., Vannelli, G. B., et al. (2009) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2009.01467.x · Cited by 166 · see citing works
Giuliano, F., Jackson, G., Montorsi, F., Martín‐Morales, A., & Raillard, P. (2009) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2009.02254.x · Cited by 165 · see citing works
Goldstein, I., Fisher, W. A., Sand, M. S., Rosen, R. C., Mollen, M. D., Brock, G. B., KARLIN, G. S., Pommerville, P. J., Bangerter, K., Bandel, T.-J., et al. (2005) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2005.00147.x · Cited by 163 · see citing works
Synthesis of Scientific Disciplines in Pursuit of Health: The Interactive Biopsychosocial Model
Lindau, S. T., Laumann, E. O., Levinson, W. S., & Waite, L. J. (2003) · Perspectives in biology and medicine · doi:10.1353/pbm.2003.0055 · Cited by 162 · see citing works
SMOKING AND ERECTILE DYSFUNCTION: EVIDENCE BASED ANALYSIS
McVARY, K. T., CARRIER, S., WESSELLS, H., & the SUBCOMMITTEE ON SMOKING AND ERECTILE DYSFUNCTION SOCIOECONOMIC COMMITTEE, S. M. S. O. N. A. (2001) · Journal of Urology · doi:10.1016/s0022-5347(05)65641-8 · Cited by 160 · see citing works
Sildenafil citrate for the treatment of erectile dysfunction in men with Type II diabetes mellitus
Boulton, A. J. M., Selam, J. L., Sweeney, M. T., & Ziegler, D. (2001) · Diabetologia · doi:10.1007/s001250100656 · Cited by 159 · see citing works
Moreira, E. D., Lôbo, C. F. L., Diament, A., Nicolosi, A., & Glasser, D. B. (2003) · Urology · doi:10.1016/s0090-4295(02)02158-1 · Cited by 156 · see citing works
Levine, L. A., Estrada, C. R., & Morgentaler, A. (2001) · The Journal of Urology · doi:10.1016/s0022-5347(05)65867-3 · Cited by 155 · see citing works
Regulation of Adrenergic Activity in Penile Corpus Cavernosum
de Tejada, I. S., Kim, N. N., Lagan, I., Krane, R. J., & Goldstein, I. (1989) · The Journal of Urology · doi:10.1016/s0022-5347(17)39009-2 · Cited by 155 · see citing works
Phosphodiesterase-5 (PDE5) Inhibitors In the Management of Erectile Dysfunction.
Huang, S. A., & Lie, J. D. (2013) · PubMed · Cited by 154 · see citing works
Bahk, J. Y., Jung, J. H., Han, H. J., Min, S. K., & Lee, Y. S. (2010) · PubMed · Cited by 154 · see citing works
Corona, G., Fagioli, G., Mannucci, E., Romeo, A., Rossi, M., Lotti, F., Sforza, A., Morittu, S., Chiarini, V., Casella, G., et al. (2008) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2008.00982.x · Cited by 150 · see citing works
Standard Operating Procedures for Taking a Sexual History
Althof, S. E., Rosen, R. C., Perelman, M. A., & Aurioles, E. R. (2012) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2012.02823.x · Cited by 150 · see citing works
Traish, A. M., Toselli, P. A., Jeong, S., & Kim, N. N. (2005) · Journal of Andrology · doi:10.1002/j.1939-4640.2005.tb01091.x · Cited by 148 · see citing works
Fisher, W. A., Rosen, R. C., Mollen, M. D., Brock, G. B., KARLIN, G. S., Pommerville, P. J., Goldstein, I., Bangerter, K., Bandel, T.-J., Derogatis, L. R., et al. (2005) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2005.00119.x · Cited by 147 · see citing works
Sildenafil Citrate for Treatment of Erectile Dysfunction in Men With Type 1 Diabetes
Stuckey, B. G. A., Jadzinsky, M. N., Murphy, L. J., Montorsi, F., Kadıoğlu, A., Filho, F. F., Manzano, P., & Deerochanawong, C. (2003) · Diabetes Care · doi:10.2337/diacare.26.2.279 · Cited by 141 · see citing works
Giltay, E. J., Tishova, Y. A., Mskhalaya, G. J., Gooren, L. J. G., Saad, F., & Kalinchenko, S. Y. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01859.x · Cited by 140 · see citing works
McCabe, M. P., & Althof, S. E. (2014) · The Journal of Sexual Medicine · doi:10.1111/jsm.12374 · Cited by 140 · see citing works
Yiou, R., Hamidou, L., Birebent, B., Bitari, D., Lecorvoisier, P., Contremoulins, I., Khodari, M., Rodriguez, A., Augustin, D., roudot-Thoraval, F., et al. (2016) · European Urology · doi:10.1016/j.eururo.2015.09.026 · Cited by 140 · see citing works
Mulhall, J. P., Müller, A., Donohue, J. F., Mullerad, M., Kobylarz, K. A., Paduch, D. A., Tal, R., Li, P. S., Cohen‐Gould, L., & Scardino, P. T. (2008) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2008.00794.x · Cited by 139 · see citing works
Lifestyle modifications and erectile dysfunction: what can be expected?
Esposito, K., Maiorino, M. I., & Bellastella, G. (2014) · Asian Journal of Andrology · doi:10.4103/1008-682x.137687 · Cited by 138 · see citing works
Salonia, A., Castagna, G., Saccà, A., Ferrari, M., Umberto Capitanio, A., Castiglione, F., Rocchini, L., Briganti, A., Rigatti, P., & Montorsi, F. (2012) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2012.02869.x · Cited by 136 · see citing works
Corona, G., Giorda, C. B., Cucinotta, D., Guida, P., & Nada, E. (2014) · The Journal of Sexual Medicine · doi:10.1111/jsm.12601 · Cited by 136 · see citing works
Virag, R., Shoukry, K., Floresco, J., Nollet, F., & Greco, E. (1991) · The Journal of Urology · doi:10.1016/s0022-5347(17)38316-7 · Cited by 134 · see citing works
Bidirectional relationship between depression and erectile dysfunction.
Shiri, R., Koskimäki, J., Tammela, T., Häkkinen, J. T., Auvinen, A., & Hakama, M. (2007) · Journal of Urology · doi:10.1016/j.juro.2006.09.030 · Cited by 134 · see citing works
Male Sexuality and Cardiovascular Risk. A Cohort Study in Patients with Erectile Dysfunction
Corona, G., Monami, M., Boddi, V., Cameron-Smith, M., Lotti, F., De Vita, G., Melani, C., Balzi, D., Sforza, A., Forti, G., et al. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01744.x · Cited by 134 · see citing works
Ferrini, M. G., Kovanecz, I., Sanchez, S. P., Umeh, C., Rajfer, J., & González-Cadavid, N. F. (2008) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2008.01105.x · Cited by 129 · see citing works
Ferrini, M., Kovanecz, I., Nolazco, G., Rajfer, J., & Gonzalez-Cadavid, N. (2006) · BJU International · doi:10.1111/j.1464-410x.2006.05955.x · Cited by 129 · see citing works
Health issues of men: prevalence and correlates of erectile dysfunction
SHABSIGH, R., PERELMAN, M. A., LOCKHART, D. C., LUE, T. F., & BRODERICK, G. A. (2005) · Journal of Urology · doi:10.1097/01.ju.0000165389.73148.d1 · Cited by 126 · see citing works
Nelson, C. J., Mulhall, J. P., & Roth, A. J. (2011) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.02127.x · Cited by 123 · see citing works
Testosterone Regulates RhoA/Rho-Kinase Signaling in Two Distinct Animal Models of Chemical Diabetes
Vignozzi, L., Morelli, A., Filippi, S., Ambrosini, S., Mancina, R., Luconi, M., Mungai, S., Vannelli, G. B., Zhang, X., Forti, G., et al. (2007) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2007.00440.x · Cited by 122 · see citing works
Sexual function of the ageing male
Corona, G., Rastrelli, G., Maseroli, E., Forti, G., & Maggi, M. (2013) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2013.05.007 · Cited by 121 · see citing works
Treatment of infertility in men with spinal cord injury
Brackett, N. L., Lynne, C. M., Ibrahim, E., Ohl, D. A., & Sønksen, J. (2010) · Nature Reviews Urology · doi:10.1038/nrurol.2010.7 · Cited by 119 · see citing works
Isidori, A. M., Balercia, G., Calogero, A. E., Corona, G., Ferlin, A., Francavilla, S., Santi, D., & Maggi, M. (2014) · Journal of Endocrinological Investigation · doi:10.1007/s40618-014-0155-9 · Cited by 118 · see citing works
Vasculogenic Impotence: A Review of 92 Cases With 54 Surgical Operations
Virag, R., Zwang, G., Dermange, H., & Legman, M. (1981) · Vascular Surgery · doi:10.1177/153857448101500102 · Cited by 117 · see citing works
Guo, W., Liao, C., Zou, Y.-G., Li, F. Y., Li, T., Zhou, Q.-Z., Cao, Y., & Mao, X. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01792.x · Cited by 116 · see citing works
Do cigarette smokers with erectile dysfunction benefit from stopping?: a prospective study
Pourmand, G., Alidaee, M. R., Rasuli, S., Maleki, A., & Mehrsai, A. (2004) · BJU International · doi:10.1111/j.1464-410x.2004.05162.x · Cited by 113 · see citing works
Anxiety and erectile dysfunction: a global approach to ED enhances results and quality of life
Hedon, F. (2003) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3900994 · Cited by 113 · see citing works
Costabile, R. A., Spevak, M., Fishman, I. J., Govier, F. E., Hellstrom, W. J. G., Shabsigh, R., Nemo, K. J., RAPPORT, J. L., Tam, P. Y., WELDON, K. L. M., et al. (1998) · The Journal of Urology · doi:10.1016/s0022-5347(01)62527-8 · Cited by 113 · see citing works
Erectile dysfunction and central obesity: an Italian perspective
Maggi, M., Corona, G., Rastrelli, G., Filippi, S., Vignozzi, L., & Mannucci, E. (2014) · Asian Journal of Andrology · doi:10.4103/1008-682x.126386 · Cited by 110 · see citing works
Prevalence of sexual dysfunction in male subjects with alcohol dependence
Benegal, V., & Arackal, B. (2007) · Indian Journal of Psychiatry · doi:10.4103/0019-5545.33257 · Cited by 108 · see citing works
Penile Prosthetic Surgery in Neurologically Impaired Patients: Long-Term Followup
Zermann, D., Kutzenberger, J., Sauerwein, D., Schubert, J., & Loeffler, U. (2006) · The Journal of Urology · doi:10.1016/s0022-5347(05)00344-7 · Cited by 108 · see citing works
Bosshardt, R., Farwerk, R., Sikora, R., Sohn, M. H. H., & Jakse, G. (1995) · British Journal of Urology · doi:10.1111/j.1464-410x.1995.tb07392.x · Cited by 107 · see citing works
Managing the Difficult Penile Prosthesis Patient
Trost, L. W., Baum, N. H., & Hellstrom, W. J. G. (2013) · The Journal of Sexual Medicine · doi:10.1111/jsm.12115 · Cited by 106 · see citing works
Montorsi, F., Guazzoni, G. F., Bergamaschi, F. A. M., & Rigatti, P. (1993) · The Journal of Urology · doi:10.1016/s0022-5347(17)35904-9 · Cited by 106 · see citing works
Seftel, A. D., de la Rosette, J. J. M. C. H., Birt, J. A., Porter, V., Zarotsky, V., & Viktrup, L. (2012) · International Journal of Clinical Practice · doi:10.1111/ijcp.12044 · Cited by 105 · see citing works
Physical activity and erectile dysfunction: meta-analysis of population-based studies
Cheng, J. Y. W., Ng, E. M. L., Ko, J. S. N., & Chen, R. Y. L. (2006) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901521 · Cited by 105 · see citing works
Kupelian, V. A., Link, C. L., & McKinlay, J. B. (2007) · European Urology · doi:10.1016/j.eururo.2007.03.015 · Cited by 105 · see citing works
Jannini, E. A., Sternbach, N., Limoncin, E., Ciocca, G., Gravina, G. L., Tripodi, F. M., Petruccelli, I., Keijzer, S., Isherwood, G., Wiedemann, B., et al. (2013) · The Journal of Sexual Medicine · doi:10.1111/jsm.12344 · Cited by 104 · see citing works
Jin, L., Liu, T., Lagoda, G. A., Champion, H. C., Bivalacqua, T. J., & Burnett, A. L. “. (2006) · The FASEB Journal · doi:10.1096/fj.05-4232fje · Cited by 104 · see citing works
McCullough, A., Hellstrom, W. J. G., Wang, R., Lepor, H., Wagner, K. R., & Engel, J. D. (2010) · The Journal of Urology · doi:10.1016/j.juro.2010.01.062 · Cited by 101 · see citing works
Phosphodiesterase Type 5 Inhibitors: The Day After
Hatzimouratidis, K., & Hatzichristou, D. G. (2006) · European Urology · doi:10.1016/j.eururo.2006.07.020 · Cited by 100 · see citing works
Jannini, E. A., McCabe, M. P., Salonia, A., Montorsi, F., & Sachs, B. D. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01824.x · Cited by 99 · see citing works
Reilly, C. M., Stopper, V. S., & MILLS, T. M. (1997) · PubMed · Cited by 95 · see citing works
Penile Prosthesis Surgery in Patients with Corporal Fibrosis: A State of the Art Review
Martínez‐Salamanca, J. I., Mueller, A., Moncada, I., Carballido, J., & Mulhall, J. P. (2011) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2011.02281.x · Cited by 94 · see citing works
Curran, M. P., & Keating, G. M. (2003) · Drugs · doi:10.2165/00003495-200363200-00004 · Cited by 94 · see citing works
Efficacy and safety of transurethral alprostadil therapy in men with erectile dysfunction
Williams, Abbou, Amar, A., Desvaux, Flam, Nijeholt, L. À., Lynch, Morgan, MÜller, Porst, et al. (1998) · British Journal of Urology · doi:10.1046/j.1464-410x.1998.00703.x · Cited by 93 · see citing works
Belardinelli, R., Lacalaprice, F., Faccenda, E., Purcaro, A., & Perna, G. (2004) · International Journal of Cardiology · doi:10.1016/j.ijcard.2004.05.020 · Cited by 91 · see citing works
The future is today: emerging drugs for the treatment of erectile dysfunction
Albersen, M., Shindel, A. W., Mwamukonda, K. B., & Lue, T. F. (2010) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.2010.480973 · Cited by 91 · see citing works
VACCUM CONSTRICTION AND EXTERNAL ERECTION DEVICES IN ERECTILE DYSFUNCTION
Levine, L. A., & Dimitriou, R. J. (2001) · Urologic Clinics of North America · doi:10.1016/s0094-0143(05)70142-7 · Cited by 90 · see citing works
Understanding and targeting the Rho kinase pathway in erectile dysfunction
Sopko, N. A., Hannan, J. L., & Bivalacqua, T. J. (2014) · Nature Reviews Urology · doi:10.1038/nrurol.2014.278 · Cited by 89 · see citing works
Compliance of sildenafil treatment for erectile dysfunction and factors affecting it
Jiann, B.-P., Yu, C.-C., Su, C.-C., & Tsai, J.-Y. (2005) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901379 · Cited by 88 · see citing works
Evaluation of young men with organic erectile dysfunction
Papagiannopoulos, D., Khare, N., & Nehra, A. X. (2014) · Asian Journal of Andrology · doi:10.4103/1008-682x.139253 · Cited by 88 · see citing works
THE CAUSES OF PATIENT DROPOUT FROM PENILE SELF-INJECTION THERAPY FOR IMPOTENCE
Mulhall, J. P., JAHODA, A. E., CAIRNEY, M., Goldstein, B. H., LEITZES, R., WOODS, J., Payton, T. R., Krane, R. J., & Goldstein, I. (1999) · The Journal of Urology · doi:10.1016/s0022-5347(05)68269-9 · Cited by 88 · see citing works
Endocrine evaluation of erectile dysfunction
Sansone, A., Romanelli, F., Gianfrilli, D., & Lenzi, A. (2014) · Endocrine · doi:10.1007/s12020-014-0254-6 · Cited by 87 · see citing works
Why do so many people drop out from auto-injection therapy for impotence?
Althof, S. E., Turner, L. A., Levine, S. B., Risen, C., Kursh, E., Bodner, D., & Resnick, M. (1989) · Journal of Sex & Marital Therapy · doi:10.1080/00926238908403816 · Cited by 86 · see citing works
Schmidt, H. M., Munder, T., Gerger, H., Frühauf, S., & Barth, J. (2014) · The Journal of Sexual Medicine · doi:10.1111/jsm.12520 · Cited by 84 · see citing works
Schouten, B., Bosch, J. L. H. R., Bernsen, R. M. D., Blanker, M. H., Thomas, S., & Bohnen, A. M. (2004) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901264 · Cited by 83 · see citing works
Androgenic Maintenance of the Rat Erectile Response Via a Non‐Nitric‐Oxide‐Dependent Pathway
Reilly, C. M., Lewis, R. W., Stopper, V., & MILLS, T. M. (1997) · Journal of Andrology · doi:10.1002/j.1939-4640.1997.tb02435.x · Cited by 82 · see citing works
Potential of Adipose-Derived Stem Cells for Treatment of Erectile Dysfunction
Lin, G., Banie, L., Ning, H., Bella, A. J., Lin, C., & Lue, T. F. (2009) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2008.01190.x · Cited by 82 · see citing works
Why do patients with erectile dysfunction abandon effective therapy with sildenafil (Viagra)?
Klotz, T., Mathers, M., Klotz, R., & Sommer, F. (2005) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901252 · Cited by 81 · see citing works
Testosterone Therapy in Erectile Dysfunction and Hypogonadism
Shabsigh, R. (2005) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2005.00139.x · Cited by 81 · see citing works
Vignozzi, L., Filippi, S., Comeglio, P., Cellai, I., Sarchielli, E., Morelli, A., Rastrelli, G., Maneschi, E., Galli, A., Vannelli, G. B., et al. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.01.014 · Cited by 81 · see citing works
Erectile Function Rehabilitation After Radical Prostatectomy: Practice Patterns Among AUA Members
Tal, R., Telöken, P., & Mulhall, J. P. (2011) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2011.02355.x · Cited by 80 · see citing works
Androgenic Maintenance of Inflow and Veno-Occlusion during Erection in the Rat
MILLS, T. M., Lewis, R. W., & Stopper, V. (1998) · Biology of Reproduction · doi:10.1095/biolreprod59.6.1413 · Cited by 80 · see citing works
Zeléfsky, M. J., Shasha, D., Branco, R. D., Kollmeier, M. A., Baser, R. E., Pei, X., Ennis, R. D., Stock, R. G., Bar-Chama, N. C., & Mulhall, J. P. (2014) · The Journal of Urology · doi:10.1016/j.juro.2014.02.097 · Cited by 79 · see citing works
Yamada, T., Hara, K., Umematsu, H., Suzuki, R., & Kadowaki, T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043673 · Cited by 78 · see citing works
Cao, S., Gan, Y., Dong, X., Liu, J., & Lu, Z. (2014) · The Journal of Sexual Medicine · doi:10.1111/jsm.12641 · Cited by 77 · see citing works
Intracavernosal alprostadil is effective for the treatment of erectile dysfunction in diabetic men
Heaton, J. P. W., Lording, D. W., Liu, S.-N., Litonjua, A., Li, G., KIM, S. C., Kim, J., Zhizhou, S., Israr, D., Niazi, D., et al. (2001) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3900760 · Cited by 76 · see citing works
Prevalence of Erectile Dysfunction Among Young Adults: Results of a Large-Scale Survey
Heruti, R. J., Shochat, T., Tekes-Manova, D., Ashkenazi, I., & Justo, D. (2004) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.04041.x · Cited by 76 · see citing works
Giannetta, E., Gianfrilli, D., Barbagallo, F., Isidori, A. M., & Lenzi, A. (2012) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2011.12.005 · Cited by 76 · see citing works
Long-term follow-up of patients receiving injection therapy for erectile dysfunction
Sundaram, C. P., Thomas, W. J., Pryor, L. E., Sidi, A. A., Billups, K. L., & Pryor, J. L. (1997) · Urology · doi:10.1016/s0090-4295(97)00079-4 · Cited by 76 · see citing works
The Management of Impotence in Diabetic Men by Vacuum Tumescence Therapy
Price, D. E., Cooksey, G., Jehu, D., Bentley, S., Hearnshaw, J. R., & OSBORN, D. E. (1991) · Diabetic Medicine · doi:10.1111/j.1464-5491.1991.tb01538.x · Cited by 75 · see citing works
The role of anxiety on sexual arousal
Hale, V. E., & Strassberg, D. S. (1990) · Archives of Sexual Behavior · doi:10.1007/bf01542466 · Cited by 75 · see citing works
SOP: Physical Examination and Laboratory Testing for Men with Erectile Dysfunction
Ghanem, H. M., Salonia, A., & Martín‐Morales, A. (2012) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2012.02734.x · Cited by 74 · see citing works
The use of phosphodiesterase 5 inhibitors with concomitant medications
Corona, G., Razzoli, E., Forti, G., & Maggi, M. (2008) · Journal of Endocrinological Investigation · doi:10.1007/bf03349261 · Cited by 74 · see citing works
The effects of anxiety and attentional focus on sexual responding—II
Beck, J. G., & Barlow, D. H. (1986) · Behaviour Research and Therapy · doi:10.1016/0005-7967(86)90145-2 · Cited by 74 · see citing works
Prostaglandin E2 inhibits Na-K-2Cl cotransport in medullary thick ascending limb cells
Kaji, D. M., Chase, H. S., Eng, J. P., & Diaz, J. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.1.c354 · Cited by 74 · see citing works
Long-term outcomes of penile prostheses for the treatment of erectile dysfunction
Trost, L. W., McCaslin, R., Linder, B. J., & Hellstrom, W. J. G. (2013) · Expert Review of Medical Devices · doi:10.1586/erd.12.92 · Cited by 73 · see citing works
Corona, G., Mannucci, E., Lotti, F., Boddi, V., Jannini, E. A., Fisher, A. D., Monami, M., Sforza, A., Forti, G., & Maggi, M. (2009) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2009.01352.x · Cited by 72 · see citing works
Is female sexual function related to the male partners’ erectile function?
Jiann, B.-P., Su, C.-C., & Tsai, J.-Y. (2013) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2012.03007.x · Cited by 71 · see citing works
The Effect of Testosterone on Androgen Receptors and Human Penile Growth
Baskin, L. S., Sutherland, R. S., DiSandro, M., Hayward, S. W., Lipschutz, J. H., & Cunha, G. R. (1997) · The Journal of Urology · doi:10.1097/00005392-199709000-00108 · Cited by 71 · see citing works
Autonomie Control of Penile Erection: Modulation by Testosterone in the Rat
Giuliano, F., Rampint, O., SCHIRAR, A., Jardin, A., & Rousseau, J.-P. (1993) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1993.tb00539.x · Cited by 71 · see citing works
Flaccid Penile Acceleration as a Marker of Cardiovascular Risk in Men without Classical Risk Factors
Rastrelli, G., Corona, G., Lotti, F., Aversa, A., Bartolini, M., Mancini, M., Mannucci, E., & Maggi, M. (2013) · The Journal of Sexual Medicine · doi:10.1111/jsm.12342 · Cited by 70 · see citing works
Jung, J., Choi, S.-M., Cho, S., Ghim, J., Hwang, A.-K., Kim, U.-J., Kim, B. S., Koguchi, A., Miyoshi, S., Okabe, H., et al. (2010) · Clinical Therapeutics · doi:10.1016/j.clinthera.2010.06.011 · Cited by 70 · see citing works
Long-Term Mechanical Reliability of AMS 700CX™/CXM Inflatable Penile Prosthesis
Dhar, N. B., Angermeier, K. W., & Montague, D. K. (2006) · The Journal of Urology · doi:10.1016/j.juro.2006.08.012 · Cited by 70 · see citing works
Melman, A., Bar-Chama, N. C., McCullough, A., Davies, K. P., & Christ, G. J. (2005) · European Urology · doi:10.1016/j.eururo.2005.05.005 · Cited by 70 · see citing works
The Effect of Testosterone on Androgen Receptors and Human Penile Growth
Baskin, L. S., Sutherland, R. S., DiSandro, M., Hayward, S. W., Lipschutz, J. H., & Cunha, G. R. (1997) · The Journal of Urology · doi:10.1016/s0022-5347(01)64400-8 · Cited by 70 · see citing works
Baltacı, S., Aydos, K., Koşar, A., & Anafarta, K. (1995) · British Journal of Urology · doi:10.1111/j.1464-410x.1995.tb00769.x · Cited by 69 · see citing works
Corona, G., Rastrelli, G., Balercia, G., Lotti, F., Sforza, A., Monami, M., Forti, G., Mannucci, E., & Maggi, M. (2012) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2012.02717.x · Cited by 69 · see citing works
Andrić, S. A., Janjic, M. M., Stojkov, N. J., & Kostic, T. S. (2010) · Biology of Reproduction · doi:10.1095/biolreprod.110.083626 · Cited by 69 · see citing works
Francis, M. E., Kusek, J. W., Nyberg, L. M., & Eggers, P. W. (2007) · The Journal of Urology · doi:10.1016/j.juro.2007.03.127 · Cited by 69 · see citing works
PSYCHIATRIC MORBIDITY IS FREQUENTLY UNDETECTED IN PATIENTS WITH ERECTILE DYSFUNCTION
Mallis, D., Moysidis, K., Nakopoulou, E., Papaharitou, S., Konstantinos Hatzimouratidis, A., & Hatzichristou, D. G. (2005) · The Journal of Urology · doi:10.1097/01.ju.0000176746.73667.3c · Cited by 63 · see citing works
Kupelian, V., Araujo, A. B., Chiu, G. R., Rosen, R. C., & McKinlay, J. B. (2010) · Preventive Medicine · doi:10.1016/j.ypmed.2009.11.006 · Cited by 62 · see citing works
Dietary factors in erectile dysfunction
Esposito, K., Giugliano, F. M., SIO, M. D., Carleo, D., Palo, C. D., D’Armiento, M., & Giugliano, D. (2006) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901438 · Cited by 62 · see citing works
Tal, R., Valenzuela, R. G., Aviv, N., Parker, M., Waters, W. B., Flanigan, R. C., & Mulhall, J. P. (2009) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2009.01437.x · Cited by 61 · see citing works
Cavernosal nerve stimulation in the rat reverses castration-induced decrease in penile NOS activity
Lugg, J., Ng, C. S., Rajfer, J., & González-Cadavid, N. F. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.271.2.e354 · Cited by 59 · see citing works
Smoking and other lifestyle factors in relation to erectile dysfunction
Polsky, J. Y., Aronson, K. J., Heaton, J. P. W., & Adams, M. A. (2005) · British Journal of Urology · doi:10.1111/j.1464-410x.2005.05820.x · Cited by 58 · see citing works
Activated RhoA/Rho Kinase Impairs Erectile Function After Cavernous Nerve Injury in Rats
Gratzke, C., Strong, T. D., Gebska, M. A., Champion, H. C., Stief, C. G., Burnett, A. L. “., & Bivalacqua, T. J. (2010) · The Journal of Urology · doi:10.1016/j.juro.2010.06.094 · Cited by 58 · see citing works
Erectile Dysfunction and Fruit/Vegetable Consumption Among Diabetic Canadian Men
Wang, F., Dai, S., Wang, M., & MORRISON, H. I. (2013) · Urology · doi:10.1016/j.urology.2013.07.061 · Cited by 56 · see citing works
The SUBITO-DE study: sexual dysfunction in newly diagnosed type 2 diabetes male patients.
Corona, G., Giorda, C. B., Cucinotta, D., Guida, P., & Nada, E. (2013) · PubMed · doi:10.3275/8969 · Cited by 55 · see citing works
Reasons for high drop-out rate with self-injection therapy for impotence.
Jn, W., Badlani, G. H., Ravalli, R., & BRETTSCHNEIDER, N. (1994) · PubMed · Cited by 55 · see citing works
Zhang, X.-H., Melman, A., & DiSanto, M. E. (2011) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2011.02218.x · Cited by 51 · see citing works
Guay, A. T., Perez, J. U. S. B., squez, E. V. A., Newton, R., & Jacobson, J. (2000) · European Urology · doi:10.1159/000020360 · Cited by 51 · see citing works
LONG-TERM FOLLOWUP AND SELECTION CRITERIA FOR PENILE REVASCULARIZATION IN ERECTILE FAILURE
Manning, M., Jünemann, K., Scheepe, J. R., Braun, P., KRAUTSCHICK, A. W., & Alken, P. M. (1998) · The Journal of Urology · doi:10.1016/s0022-5347(01)62382-6 · Cited by 50 · see citing works
The Prevalence of Bother, Acceptance, and Need for Help in Men with Erectile Dysfunction
de Boer, B.-J., Bots, M. L., Nijeholt, A. A. B. L. À., & Verheij, T. J. M. (2005) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2005.20364.x · Cited by 49 · see citing works
Improvements in sexual quality of life after moderate weight loss
Kolotkin, R. L., Binks, M., Crosby, R. D., Østbye, T., Mitchell, J. E., & Hartley, G. G. (2008) · International Journal of Impotence Research · doi:10.1038/ijir.2008.32 · Cited by 48 · see citing works
Unusual Complications of the Vacuum Erection Device
GANEM, J. P., Lucey, D. T., Janosko, E. O., & Carson, C. C. (1998) · Urology · doi:10.1016/s0090-4295(97)00706-1 · Cited by 46 · see citing works
Yao, F., Liu, L., Zhang, Y., Huang, Y., Liu, D., Lin, H., Liu, Y., Fan, R., Li, C., & Deng, C. (2013) · Clinical Research in Cardiology · doi:10.1007/s00392-013-0577-y · Cited by 44 · see citing works
Alcohol Consumption and Male Erectile Dysfunction: An Unfounded Reputation for Risk?
Chew, K.-K. (2009) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2009.01333.x · Cited by 43 · see citing works
Emerging tools for erectile dysfunction: a role for regenerative medicine
Hakim, L., der Aa, F. V., Bivalacqua, T. J., Hedlund, P., & Albersen, M. (2012) · Nature Reviews Urology · doi:10.1038/nrurol.2012.143 · Cited by 40 · see citing works
Psychobiological correlates of smoking in patients with erectile dysfunction
Corona, G., Mannucci, E., Petrone, L., Ricca, V., Mansani, R., Cilotti, A., Balercia, G., Chiarini, V., Giommi, R., Forti, G., et al. (2005) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901351 · Cited by 40 · see citing works
Priapus is Happier with Venus than with Bacchus
Boddi, V., Corona, G., Monami, M., Fisher, A. D., Bandini, E., Melani, C., Balzi, D., Sforza, A., Patussi, V., Forti, G., et al. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01887.x · Cited by 39 · see citing works
Nelson, C. J., Lacey, S., Kenowitz, J., Pessin, H., Shuk, E., Roth, A. J., & Mulhall, J. P. (2015) · Psycho-Oncology · doi:10.1002/pon.3771 · Cited by 37 · see citing works
Bianca, R. D. D. V., Sorrentino, R., Sorrentino, R., Imbimbo, C., Palmieri, A., Fusco, F., Maggi, M., Palma, R. D., Cirino, G., & Mirone, V. G. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.093419 · Cited by 37 · see citing works
The Place of Surgery for Vascular Impotence in the Third Millennium
Wespes, E., WILDSCHUTZ, T., Roumeguère, T., & Schulman, C. C. (2003) · The Journal of Urology · doi:10.1097/01.ju.0000086160.63566.11 · Cited by 36 · see citing works
Albersen, M., Linsen, L., Tinel, H., Sandner, P., & van Renterghem, K. (2013) · The Journal of Sexual Medicine · doi:10.1111/jsm.12095 · Cited by 35 · see citing works
Evaluation of penile revascularization for erectile dysfunction: a 10-year follow-up
Vardi, Y., Gruenwald, I., Gedalia, U., Nassar, S., Engel, A., & Har-Shai, Y. (2004) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901120 · Cited by 35 · see citing works
Functional prostaglandin E (EP) receptors in human penile corpus cavernosum
Moreland, R. B., Kim, N. N., Nehra, A. X., Goldstein, I., & Traish, A. M. (2003) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901042 · Cited by 34 · see citing works
Oudot, A., Behr‐Roussel, D., Poirier, S., Sandner, P., Bernabé, J., Alexandre, L., & Giuliano, F. (2011) · European Urology · doi:10.1016/j.eururo.2011.07.052 · Cited by 34 · see citing works
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Salonia, A., Bettocchi, C., Boeri, L., Capogrosso, P., Carvalho, J., Çilesiz, N. C., Cocci, A., Corona, G., Dimitropoulos, K., Gül, M., et al. (2021) · European Urology · doi:10.1016/j.eururo.2021.06.007 · Cited by 858 · see citing works
Sexual dysfunction and male infertility
Lotti, F., & Maggi, M. (2018) · Nature Reviews Urology · doi:10.1038/nrurol.2018.20 · Cited by 350 · see citing works
Erectile Dysfunction in Young Men—A Review of the Prevalence and Risk Factors
Nguyen, H. M. T., Gabrielson, A. T., & Hellstrom, W. J. G. (2017) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2017.05.004 · Cited by 352 · see citing works
Erectile dysfunction and diabetes: A melting pot of circumstances and treatments
Defeudis, G., Mazzilli, R., Tenuta, M., Rossini, G., Zamponi, V., Olana, S., Faggiano, A., Pozzilli, P., Isidori, A. M., & Gianfrilli, D. (2021) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3494 · Cited by 295 · see citing works
Onion (Allium cepa L.) peels: A review on bioactive compounds and biomedical activities
Kumar, M., Barbhai, M. D., Hasan, M., Punia, S., Dhumal, S., Radha, Rais, N., Chandran, D., Pandiselvam, R., Kothakota, A., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112498 · Cited by 240 · see citing works
Addressing male sexual and reproductive health in the wake of COVID-19 outbreak
Sansone, A., Mollaioli, D., Ciocca, G., Limoncin, E., Colonnello, E., Vena, W., & Jannini, E. A. (2020) · Journal of Endocrinological Investigation · doi:10.1007/s40618-020-01350-1 · Cited by 166 · see citing works
Interactions between erectile dysfunction, cardiovascular disease and cardiovascular drugs
Terentes-Printzios, D. G., Ioakeimidis, N., Rokkas, K., & Vlachopoulos, C. V. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00593-6 · Cited by 166 · see citing works
Ma, C., Su, H., & Li, H. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.627891 · Cited by 147 · see citing works
Estimating the Prevalence of Sexual Dysfunction Using the New ICD-11 Guidelines
Briken, P., Matthiesen, S., Pietras, L., Wiessner, C., Klein, V., Reed, G. M., & Dekker, A. (2020) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2020.0653 · Cited by 145 · see citing works
Sexual Health Implications of COVID-19 Pandemic
Pennanen-Iire, C., Prereira-Lourenço, M., Padoa, A., Ribeirinho, A., Samico, A., Gressler, M., Jatoi, N.-A., Mehrad, M., & Girard, A. (2020) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2020.10.004 · Cited by 155 · see citing works
Corona, G., Cucinotta, D., Lorenzo, G. D., Ferlin, A., Giagulli, V. A., Gnessi, L., Isidori, A. M., Maiorino, M. I., Miserendino, P., Murrone, A., et al. (2023) · Journal of Endocrinological Investigation · doi:10.1007/s40618-023-02015-5 · Cited by 125 · see citing works
Erectile dysfunction in fit and healthy young men: psychological or pathological?
Rastrelli, G., & Maggi, M. (2017) · Translational Andrology and Urology · doi:10.21037/tau.2016.09.06 · Cited by 123 · see citing works
Zhu, L., Huang, X., Yu, W., Chen, H., Chen, Y., & Dai, Y. (2017) · Andrologia · doi:10.1111/and.12871 · Cited by 120 · see citing works
Roychoudhury, S., Chakraborty, S., Choudhury, A. P., Das, A., Jha, N. K., Sláma, P., Nath, M., Massányi, P., Ruokolainen, J., & Kesari, K. K. (2021) · Antioxidants · doi:10.3390/antiox10060837 · Cited by 118 · see citing works
Bovijn, J., Jackson, L. M., Censin, J. C., Chen, C., Laisk, T., Laber, S., Ferreira, T. C., Pulit, S. L., Glastonbury, C. A., Smoller, J. W., et al. (2018) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2018.11.004 · Cited by 113 · see citing works
Management of male erectile dysfunction: From the past to the future
Wang, C., Wu, B.-R., Xiang, P., Xiao, J., & Hu, X. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1148834 · Cited by 108 · see citing works
Poulios, E., Mykoniatis, I., Pyrgidis, N., Zilotis, F., Kapoteli, P., Kotsiris, D., Kalyvianakis, D., & Hatzichristou, D. (2021) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2021.03.008 · Cited by 105 · see citing works
Yafi, F. A., Sharlip, I. D., & Becher, E. F. (2017) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2017.08.001 · Cited by 102 · see citing works
A genome-wide association study to identify candidate genes for erectile dysfunction
Kazemi, E., Zargooshi, J., Kaboudi, M., Heidari, P., Kahrizi, D., Mahaki, B., Mohammadian, Y., Khazaei, H., & Ahmed, K. (2020) · Briefings in Bioinformatics · doi:10.1093/bib/bbaa338 · Cited by 102 · see citing works
Salonia, A., Adaikan, G., Buvat, J., Carrier, S., El-Meliegy, A., Hatzimouratidis, K., McCullough, A., Morgentaler, A., Torres, L. O., & Khera, M. (2017) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2016.11.324 · Cited by 100 · see citing works
Sansone, A., Mollaioli, D., Ciocca, G., Colonnello, E., Limoncin, E., Balercia, G., & Jannini, E. A. (2021) · Andrology · doi:10.1111/andr.13003 · Cited by 102 · see citing works
Feng, H., Liu, Q., Deng, Z., Li, H., Zhang, H., Song, J., Liu, X., Liu, J., Wen, B., & Wang, T. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03147-w · Cited by 101 · see citing works
Dewitte, M., Bettocchi, C., Carvalho, J., Corona, G., Flink, I., Limoncin, E., Pascoal, P., Reisman, Y., & Van Lankveld, J. (2021) · Sexual Medicine · doi:10.1016/j.esxm.2021.100434 · Cited by 97 · see citing works
Xiong, Y., Zhang, F., Zhang, Y., Wang, W., Ran, Y., Wu, C., Zhu, S., Qin, F., & Yuan, J. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.05.008 · Cited by 93 · see citing works
The role of testosterone in male sexual function
Corona, G., & Maggi, M. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09748-3 · Cited by 104 · see citing works
Maiuolo, J., Gliozzi, M., Musolino, V., Carresi, C., Nucera, S., Macrì, R., Scicchitano, M., Bosco, F., Scarano, F., Ruga, S., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20123022 · Cited by 83 · see citing works
Etiology of Male Infertility: an Update
Bhattacharya, I., Sharma, S. S., & Majumdar, S. (2023) · Reproductive Sciences · doi:10.1007/s43032-023-01401-x · Cited by 81 · see citing works
Novel Emerging Therapies for Erectile Dysfunction
Kim, S., Cho, M. C., Cho, S. Y., Chung, H., & Rajasekaran, M. R. (2020) · The World Journal of Men s Health · doi:10.5534/wjmh.200007 · Cited by 78 · see citing works
Yannas, D., Frizza, F., Vignozzi, L., Corona, G., Maggi, M., & Rastrelli, G. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10102221 · Cited by 68 · see citing works
Salonia, A., Adaikan, G., Buvat, J., A., C. S., El-Meliegy, A., Hatzimouratidis, K., McCullough, A., Morgentaler, A., Torres, L. O., & Khera, M. (2017) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2016.11.325 · Cited by 71 · see citing works
The mechanisms and potential of stem cell therapy for penile fibrosis
Milenkovic, U., Albersen, M., & Castiglione, F. (2018) · Nature reviews. Urology · doi:10.1038/s41585-018-0109-7 · Cited by 61 · see citing works
Effects of Environmental and Pathological Hypoxia on Male Fertility
Li, Z., Wang, S., Gong, C., Hu, Y., Liu, J., Wang, W., Chen, Y., Liao, Q., He, B., Huang, Y., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.725933 · Cited by 70 · see citing works
Sansone, A., Mollaioli, D., Limoncin, E., Ciocca, G., Bắc, N. H., Thắng, N. C., Hou, G., Yuan, J., Zitzmann, M., Giraldi, A. G. E., et al. (2021) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2021.11.001 · Cited by 70 · see citing works
Relationship Between Cannabis Use and Erectile Dysfunction: A Systematic Review and Meta-Analysis
Pizzol, D., Demurtas, J., Stubbs, B., Soysal, P., Mason, C., Işık, A. T., Solmi, M., Smith, L., & Veronese, N. (2019) · American Journal of Men s Health · doi:10.1177/1557988319892464 · Cited by 68 · see citing works
Penile Doppler Ultrasound for Erectile Dysfunction: Technique and Interpretation
Varela, C. G., Yeguas, L. M., Rodríguez, I. C., & Vila, M. D. D. (2020) · American Journal of Roentgenology · doi:10.2214/ajr.19.22141 · Cited by 66 · see citing works
Reproductive axis ageing and fertility in men
da Silva, S. M., & Anderson, R. A. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09759-0 · Cited by 71 · see citing works
Anderson, D., Laforge, J., M. Ross, M., Vanlangendonck, R., Hasoon, J., Viswanath, O., D. Kaye, A., & Urits, I. (2022) · Health Psychology Research · doi:10.52965/001c.37533 · Cited by 66 · see citing works
Sexual Quality of Life and Satisfaction With Penile Prostheses
Barton, G. J., Carlos, E. C., & Lentz, A. (2018) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2018.10.003 · Cited by 65 · see citing works
Nanotechnology in reproductive medicine: Opportunities for clinical translation
Shandilya, R., Pathak, N., Lohiya, N. K., Sharma, R. S., & Mishra, P. K. (2020) · Daehan saengsik uihak hoeji/Clinical and experimental reproductive medicine · doi:10.5653/cerm.2020.03650 · Cited by 61 · see citing works
Bossio, J. A., Basson, R., Driscoll, M., Correia, S., & Brotto, L. A. (2018) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2018.08.013 · Cited by 60 · see citing works
Kharazi, U., & Badalzadeh, R. (2020) · Reproductive Biology · doi:10.1016/j.repbio.2020.07.002 · Cited by 58 · see citing works
Palanichamy, C., Pavadai, P., Theivendren, P., Arunachalam, S., Babkiewicz, E., Pandian, S. R. K., Kabilan, S. J., Ammunje, D. N., Suthendran, K., Chandrasekaran, J., et al. (2022) · Molecules · doi:10.3390/molecules27123799 · Cited by 58 · see citing works
Impact of hypoxia on male reproductive functions
Oyedokun, P. A., Akhigbe, R. E., Ajayi, L. O., & Ajayi, A. F. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04559-1 · Cited by 58 · see citing works
Erectile Dysfunction: Key Role of Cavernous Smooth Muscle Cells
de Souza, I. L. L., Ferreira, E. D. S., Vasconcelos, L. H. C., Cavalcante, F. D. A., & da Silva, B. A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.895044 · Cited by 57 · see citing works
Cao, S., Hu, X., Shao, Y., Wang, Y., Tang, Y., Ren, S., & Li, X. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1128076 · Cited by 56 · see citing works
An In-Depth Bibliometric Analysis and Current Perspective on Male infertility Research
Baskaran, S., Agarwal, A. K., Leisegang, K., Pushparaj, P. N., Selvam, M. K. P., & Henkel, R. (2019) · The World Journal of Men s Health · doi:10.5534/wjmh.180114 · Cited by 57 · see citing works
Promising role of medicinal plants in the regulation and management of male erectile dysfunction
Masuku, N. P., Unuofin, J. O., & Lebelo, S. L. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110555 · Cited by 57 · see citing works
HIV and Sexual Dysfunction in Men
Vincentis, S. D., Tartaro, G., Rochira, V., & Santi, D. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10051088 · Cited by 55 · see citing works
Clinckaert, A., Callens, K., Cooreman, A., Bijnens, A., Moris, L., Calster, C. V., Geraerts, I., Joniau, S., & Everaerts, W. (2022) · Cancers · doi:10.3390/cancers14225667 · Cited by 55 · see citing works
Ye, K., Li, Z., Yin, Y., Zhou, J., Li, D., Gan, Y., Peng, D., Xiao, M., Zhao, L., Dai, Y., et al. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14256 · Cited by 55 · see citing works
Erectile Dysfunction: Treatments, Advances and New Therapeutic Strategies
Argiolas, A., Argiolas, F. M., Argiolas, G., & Melis, M. R. (2023) · Brain Sciences · doi:10.3390/brainsci13050802 · Cited by 55 · see citing works
Elim, D., Fitri, A. M. N., Mahfud, M. A. S., Afika, N., Sultan, N. A. F., Hijrah, Asri, R. M., & Permana, A. D. (2022) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2022.113018 · Cited by 54 · see citing works
Kalyvianakis, D., Memmos, E., Mykoniatis, I., Kapoteli, P., Memmos, D., & Hatzichristou, D. G. (2018) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2018.01.003 · Cited by 54 · see citing works
Implications of Exposure to Air Pollution on Male Reproduction: The Role of Oxidative Stress
Omolaoye, T. S., Skosana, B. T., Ferguson, L. M., Ramsunder, Y., Ayad, B. M., & du Plessis, S. S. (2024) · Antioxidants · doi:10.3390/antiox13010064 · Cited by 53 · see citing works
Shaher, H., Fathi, A., Elbashir, S., Abdelbaki, S. A., & Soliman, T. T. (2023) · Urology · doi:10.1016/j.urology.2023.01.028 · Cited by 52 · see citing works
Campbell, J. D., & Burnett, A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18081794 · Cited by 54 · see citing works
Ala, M., Jafari, R. M., & Dehpour, A. R. (2020) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12633 · Cited by 52 · see citing works
Erectile Dysfunction and Oxidative Stress: A Narrative Review
Zhu, D., Pham, Q. M., Wang, C., Colonnello, E., Yannas, D., Hoai, B. N., Zhang, Y., Jannini, E. A., & Sansone, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073073 · Cited by 51 · see citing works
Sexual impairment in patients with hidradenitis suppurativa: a systematic review
Cuenca‐Barrales, C., Montero‐Vílchez, T., Szepietowski, J. C., Matusiak, Ł., & Molina‐Leyva, A. (2020) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.16726 · Cited by 48 · see citing works
Anatomy and Physiology of the Hypothalamic-Pituitary-Gonadal (HPG) Axis
Dwyer, A. A., & Quinton, R. (2019) · Springer eBooks · doi:10.1007/978-3-319-99817-6_43 · Cited by 47 · see citing works
Leisegang, K., & Finelli, R. (2021) · Arab Journal of Urology · doi:10.1080/2090598x.2021.1926753 · Cited by 47 · see citing works
The Psychology of Erectile Dysfunction
Allen, M. S., Wood, A. M., & Sheffield, D. (2023) · Current Directions in Psychological Science · doi:10.1177/09637214231192269 · Cited by 46 · see citing works
GPX4 Alleviates Diabetes Mellitus-Induced Erectile Dysfunction by Inhibiting Ferroptosis
Xu, W., Sun, T., Wang, J., Wang, T., Wang, S., Liu, J., & Li, H. (2022) · Antioxidants · doi:10.3390/antiox11101896 · Cited by 45 · see citing works
Vasculogenic Erectile Dysfunction: The Impact of Diet and Lifestyle
Ostfeld, R. J., Allen, K., Aspry, K. E., Brandt, E. J., Spitz, A., Liberman, J. N., Belardo, D., O’Keefe, J. H., Aggarwal, M., Miller, M. J., et al. (2020) · The American Journal of Medicine · doi:10.1016/j.amjmed.2020.09.033 · Cited by 51 · see citing works
Pozzi, E., Fallara, G., Capogrosso, P., Boeri, L., Belladelli, F., Corsini, C., da Costa, A. G., Candela, L., Cignoli, D., Cazzaniga, W., et al. (2022) · Andrology · doi:10.1111/andr.13212 · Cited by 43 · see citing works
Xiao, Y., Xie, T., Peng, J., Zhou, X., Long, J., Yang, M., Zhu, H., & Yang, J. Y. (2023) · BMC Psychology · doi:10.1186/s40359-023-01074-w · Cited by 48 · see citing works
Paternostro, R., Heinisch, B. B., Reiberger, T., Mandorfer, M., Schwarzer, R., Seeland, B., Trauner, M. A., Peck‐Radosavljevic, M., & Ferlitsch, A. (2018) · Liver International · doi:10.1111/liv.13704 · Cited by 43 · see citing works
Wang, S., Wang, Z., Zang, Z., Liang, X., Jia, B., Tan, Y., Lan, Y., & Shi, X. (2024) · Advanced Materials · doi:10.1002/adma.202413287 · Cited by 42 · see citing works
Current and future trends in men’s health clinics
Houman, J., Eleswarapu, S. V., & Mills, J. N. (2020) · Translational Andrology and Urology · doi:10.21037/tau.2019.08.33 · Cited by 41 · see citing works
The 2018 Revision to the Process of Care Model for Evaluation of Erectile Dysfunction
Mulhall, J. P., Giraldi, A., Hackett, G., Hellstrom, W. J. G., Jannini, E. A., Rubio-Aurioles, E., Trost, L., & Hassan, T. A. (2018) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2018.06.005 · Cited by 40 · see citing works
Male Obesity Associated Gonadal Dysfunction and the Role of Bariatric Surgery
Sultan, S., Patel, A. G., El-Hassani, S., Whitelaw, B., Leca, B. M., Vincent, R. P., le Roux, C. W., Rubino, F., Aywlin, S. J. B., & Dimitriadis, G. K. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00408 · Cited by 39 · see citing works
Cantone, E., Massanova, M., Crocetto, F., Barone, B., Esposito, F., Arcaniolo, D., Corlianò, F., Romano, L., Motta, G., & Celia, A. (2022) · Andrologia · doi:10.1111/and.14504 · Cited by 36 · see citing works
Razdan, S., Siegal, A. R., Brewer, Y., Sljivich, M., & Valenzuela, R. J. (2023) · International Journal of Impotence Research · doi:10.1038/s41443-023-00797-z · Cited by 37 · see citing works
Goldstein, I., Goren, A., Li, V. W., Maculaitis, M. C., Tang, W. Y., & Hassan, T. A. (2019) · International Journal of Clinical Practice · doi:10.1111/ijcp.13384 · Cited by 42 · see citing works
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Sansone, A., Limoncin, E., Colonnello, E., Mollaioli, D., Ciocca, G., Corona, G., & Jannini, E. A. (2021) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2021.01.005 · Cited by 37 · see citing works
Corpora cavernosa fibroblasts mediate penile erection
Guimarães, E. L. M., Dias, D. O., Hau, W. F., Julien, A., Holl, D., Garcia-Collado, M., Savant, S., Vågesjö, E., Phillipson, M., Jakobsson, L., et al. (2024) · Science · doi:10.1126/science.ade8064 · Cited by 36 · see citing works
Sansone, A., Cuzin, B., & Jannini, E. A. (2021) · Sexual Medicine · doi:10.1016/j.esxm.2021.100437 · Cited by 35 · see citing works
Increased odds ratio for erectile dysfunction in COVID-19 patients
Katz, J., Yue, S., Xue, W., & Gao, H. (2021) · Journal of Endocrinological Investigation · doi:10.1007/s40618-021-01717-y · Cited by 37 · see citing works
Allen, M. S., & Tostes, R. C. (2023) · Sexual Medicine Reviews · doi:10.1093/sxmrev/qeac007 · Cited by 34 · see citing works
dos Reis, F. M., & dos Reis, A. M. (2020) · Clinical Science · doi:10.1042/cs20200865 · Cited by 34 · see citing works
Abdelrahman, I. F. S., Raheem, A. A., Elkhiat, Y., Aburahma, A. A., Abdel-Raheem, T. M., & Ghanem, H. M. (2021) · Andrology · doi:10.1111/andr.13104 · Cited by 33 · see citing works
Pozzi, E., Capogrosso, P., Boeri, L., Belladelli, F., Baudo, A., Schifano, N., Abbate, C., Dehò, F., Montorsi, F., & Salonia, A. (2020) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2020.03.012 · Cited by 33 · see citing works
Nascimento, B., Miranda, E., Terrier, J., Carneiro, F., & Mulhall, J. P. (2020) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2020.05.023 · Cited by 33 · see citing works
Anastasiadis, E., Ahmed, R., Khoja, A. K., & Yap, T. (2022) · Frontiers in Reproductive Health · doi:10.3389/frph.2022.944765 · Cited by 34 · see citing works
Bajic, P., Mahon, J., Faraday, M. M., Sadeghi‐Nejad, H., Hakim, L., & McVary, K. T. (2019) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2019.05.003 · Cited by 32 · see citing works
Sansone, A., Cignarelli, A., Sansone, M., Romanelli, F., Corona, G., Gianfrilli, D., Isidori, A. M., Giorgino, F., & Lenzi, A. (2018) · International Journal of Endocrinology · doi:10.1155/2018/7424792 · Cited by 32 · see citing works
Exploring the Multifaceted Potential of Sildenafil in Medicine
Pușcașu, C., Zanfirescu, A., Negreș, S., & Șeremet, O. C. (2023) · Medicina · doi:10.3390/medicina59122190 · Cited by 31 · see citing works
Stridh, A., Pontén, M., Arver, S., Kirsch, I., Abé, C., & Jensen, K. B. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.1423 · Cited by 32 · see citing works
Rodler, S., von Büren, J., Büchner, A., Stief, C. G., Elkhanova, K., Wülfing, C., & Jungmann, S. (2020) · Sexual Medicine · doi:10.1016/j.esxm.2020.04.001 · Cited by 31 · see citing works
Relationship between hyperuricemia with deposition and sexual dysfunction in males and females
Sansone, A., Reisman, Y., & Jannini, E. A. (2022) · Journal of Endocrinological Investigation · doi:10.1007/s40618-021-01719-w · Cited by 31 · see citing works
Leitão, A. E., Vieira, M. C. D. S., Pelegrini, A., da Silva, E. L., & Guimarães, A. C. D. A. (2021) · Maturitas · doi:10.1016/j.maturitas.2020.12.002 · Cited by 30 · see citing works
Xu, W., Sun, T., Wang, J., Wang, T., Wang, S., Liu, J., Liu, K., & Li, H. (2022) · Andrology · doi:10.1111/andr.13291 · Cited by 30 · see citing works
Yang, Y., Chien, W., Chung, C., Hong, K.-T., Yu, Y.-L., Hueng, D., Chen, Y.-H., Ma, H., Chang, H., Kao, Y., et al. (2018) · American Journal of Men s Health · doi:10.1177/1557988317750970 · Cited by 29 · see citing works
Aldawsari, M. F., Anwer, M. K., Ahmed, M. M., Fatima, F., Soliman, G. A., Bhatia, S., Zafar, A., & Aboudzadeh, M. A. (2021) · Polymers · doi:10.3390/polym13203512 · Cited by 30 · see citing works
Koga, S., & Horiguchi, Y. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17072 · Cited by 30 · see citing works
Ng, Y.-F., Chen, C. Y.-T., Chia, G. T.-H., Tan, B. B. J.-W., Chan, L. L., & Tan, E. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101665 · Cited by 30 · see citing works
Different levels of estradiol are correlated with sexual dysfunction in adult men
Chen, T., Wu, F., Wang, X., Ma, G., Xuan, X., Tang, R., Ding, S., & Lü, J. (2020) · Scientific Reports · doi:10.1038/s41598-020-69712-6 · Cited by 29 · see citing works
Qinyu-Zeng, Shuhua-He, Fengzhi-Chen, LiWang, Liren-Zhong, Hui, J., Wei-Ding, Junhong-Fan, Haibo-Zhang, & Anyang-Wei (2020) · Nitric Oxide · doi:10.1016/j.niox.2020.11.003 · Cited by 29 · see citing works
D-(+)-Galactose-induced aging: A novel experimental model of erectile dysfunction
Rezende, M. S. D. A., de Almeida, A. J. P. O., Gonçalves, T. A. F., de Azevedo, F. D. L. A. A., Dantas, S. H., Silva, S. D. L., Soares, E. M. C., Alves, H. F., Lima, T. T., Júnior, J. F. D. S., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0249487 · Cited by 29 · see citing works
Ginseng for erectile dysfunction
Lee, H. W., Lee, M. S., Kim, T., Alræk, T., Zaslawski, C., Kim, J. W., & Moon, D. G. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012654.pub2 · Cited by 29 · see citing works
- Authors
- Yafi, F. A., Jenkins, L., Albersen, M., Corona, G., Isidori, A. M., Goldfarb, S., Maggi, M., Nelson, C. J., Parish, S., Salonia, A., Tan, R., Mulhall, J. P., & Hellstrom, W. J. G.
- Affiliations
- Tulane University (US)
- Memorial Sloan Kettering Cancer Center (US)
- KU Leuven (BE)
- Ospedale Bellaria (IT)
- Sapienza University of Rome (IT)
- University of Florence (IT)
- Albert Einstein College of Medicine (US)
- IRCCS Ospedale San Raffaele (IT)
- Tan Tock Seng Hospital (SG)
- Corresponding author
- Mulhall, John P.
- Hellstrom, Wayne J. G.
- ORCID
- Venue
- Nature Reviews Disease Primers
- Published
- 2016-02-04
- Volume
- 2
- Issue
- 1
- Pages
- 16003-16003
- ISSN
- 2056-676X (ISSN-L)
- PMC
- PMC5027992
- OpenAlex
- W4211157510
- Cited by
- 853
- References
- 217
- Citations by year
- 2026: 87 · 2025: 139 · 2024: 134 · 2023: 133 · 2022: 113 · 2021: 98 · 2020: 67 · 2019: 35 · 2018: 33 · 2017: 12
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature Reviews Disease Primers (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Funders
- National Cancer Institute (P30CA008748)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Health Sciences › Medicine › Urology › Urological Disorders and Treatments
- Health Sciences › Medicine › Rheumatology › Dupuytren's Contracture and Treatments
- Keywords
- erectile dysfunction, male sexual dysfunction, erectile response, metabolic syndrome, cardiovascular disease, cardiac evaluation, lifestyle modification, intracavernous injection, vacuum erection devices, penile fibrosis, anxiety and depression, quality of life, regenerative medicine, sexual medicine
- MeSH terms
- Aging, Alcohol Drinking, Endocrine System Diseases, Humans, Erectile Dysfunction, Male, Penis, Quality of Life, Risk Factors, Smoking
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