The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
The dynamics of acute inflammation
Abstract
When the body is infected, it mounts an acute inflammatory response to rid itself of the pathogens and restore health. Uncontrolled acute inflammation due to infection is defined clinically as sepsis and can culminate in organ failure and death. We consider a three-dimensional ordinary differential equation model of inflammation consisting of a pathogen, and two inflammatory mediators. The model reproduces the healthy outcome and diverse negative outcomes, depending on initial conditions and parameters. We analyze the various bifurcations between the different outcomes when key parameters are changed and suggest various therapeutic strategies. We suggest that the clinical condition of sepsis can arise from several distinct physiological states, each of which requires a different treatment approach.
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Cites
de Waal Malefyt, R., Abrams, J., Bennett, B., Figdor, C. G., & de Vries, J. E. (1991) · The Journal of experimental medicine · doi:10.1084/jem.174.5.1209 · Cited by 3,762
Nitric oxide and the immune response
Bogdan, C. (2001) · Nature Immunology · doi:10.1038/ni1001-907 · Cited by 3,447
Opal, S. M., & DePalo, V. A. (2000) · Chest · doi:10.1378/chest.117.4.1162 · Cited by 1,752
Bone, R. C. (1996) · Annals of Internal Medicine · doi:10.7326/0003-4819-125-8-199610150-00009 · Cited by 718 · cited 2×
“With the advent and improvement of antibiotics and organ support therapy, the condition has become increasingly relevant (Bone, 1996).”
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Cited by
Mcdade, T. W., Tallman, P. S., Madimenos, F. C., Liebert, M. A., Cepon, T. J., Sugiyama, L. S., & Snodgrass, J. J. (2012) · American Journal of Human Biology · doi:10.1002/ajhb.22296 · Cited by 113
McDade, T. W., Hoke, M., Borja, J. B., Adair, L. S., & Kuzawa, C. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.08.010 · Cited by 83
Multiscale Modeling in the Clinic: Drug Design and Development
Clancy, C. E., An, G., Cannon, W. R., Liu, Y., May, E. E., Ortoleva, P., Popel, A. S., Sluka, J. P., Su, J., Vicini, P., et al. (2016) · Annals of Biomedical Engineering · doi:10.1007/s10439-016-1563-0 · Cited by 62
Dynamics of the HPA axis and inflammatory cytokines: Insights from mathematical modeling
Malek, H., Ebadzadeh, M. M., Safabakhsh, R., Razavi, A., & Zaringhalam, J. (2015) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2015.09.018 · Cited by 63
Metadata
- Authors
- Kumar, R., Clermont, G., Vodovotz, Y., & Chow, C. C.
- Venue
- Journal of Theoretical Biology
- Publisher
- Elsevier BV
- Published
- 2004-09
- Volume
- 230
- Issue
- 2
- Pages
- 145-155
- ISSN
- 0022-5193 (ISSN-L)
- OpenAlex
- W2156661166
- Cited by
- 322
- References
- 4
- FWCI
- 5.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kumar, R., Clermont, G., Vodovotz, Y., & Chow, C. C. (2004). The dynamics of acute inflammation. Journal of Theoretical Biology. https://doi.org/10.1016/j.jtbi.2004.04.044
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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