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Cited by 83Stress Responses and CortisolHealth disparities and outcomesBirth, Development, and Health

Do environments in infancy moderate the association between stress and inflammation in adulthood? Initial evidence from a birth cohort in the Philippines

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McDade, Thomas W., Hoke, Morgan, Borja, Judith B., Adair, Linda S., Kuzawa, Christopher·2013·Brain, Behavior, and Immunity
DOI 10.1016/j.bbi.2012.08.010PMC PMC3541465
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Abstract

Chronic inflammation is a potentially important pathway through which psychosocial stressors increase risk for cardiovascular disease. However, prior research on stress and inflammation has been conducted almost exclusively in high income, industrialized populations with low levels of infectious disease. In this study we test the hypothesis that psychosocial stressors are associated with elevated concentrations of C-reactive protein (CRP) among young adults in the Philippines (n=1622), who have grown up in an ecological and epidemiological setting that differs substantially from that of the US. In addition, we apply a developmental, ecological perspective to consider whether microbial and nutritional environments in infancy alter patterns of association between stressors and CRP. Data come from the Cebu Longitudinal Health and Nutrition Survey, a prospective cohort study that began collecting data in 1983-1984 when participants were in utero. A series of regression models indicate trends toward significant interactions between perceived stress and environmental factors in infancy, including exposure to animal feces, season of birth, and birth weight. Parental absence in childhood was a significant predictor of CRP in adulthood in interaction with exposure to animal feces in infancy. Positive associations between stressors and CRP were only evident for individuals with lower levels of microbial exposure in infancy, or lower birth weight. These results suggest that early environments influence the development of inflammatory phenotypes in ways that moderate sensitivity to psychosocial stressors in adulthood, and they underscore the value of a comparative, developmental approach to research on social environments, inflammation, and disease.

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  • Parental separation in early childhood is associated with increased CRP in adulthood.

    “Parental separation in early childhood is also associated with increased CRP in adulthood (Lacey et al, 2013;McDade et al, 2013).”

    From Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond (2017) · cites this paper as McDade et al, 2013

    The Results (§3.2; page not supplied) report that prolonged parental absence before about age 11 predicted higher CRP in young adulthood in an unadjusted model, but the association weakened after adjustment and differed by infant microbial exposure. The Methods (§2.3; page not supplied) show that parental absence was broader than separation: maternal absences also included employment-related absences and death. The paper therefore supports an association for parental absence, not an unqualified finding specifically about parental separation. (LLM, conf=0.87)

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  1. Greene WH Econometric Analysis 2000 Prentice Hall New Jersey 4th edition

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Authors
McDade, T. W., Hoke, M., Borja, J. B., Adair, L. S., & Kuzawa, C.
Affiliations
  • Northwestern University (US)
  • University of San Carlos (PH)
  • University of North Carolina at Chapel Hill (US)
Corresponding author
McDade, Thomas W.
ORCID
Venue
Brain, Behavior, and Immunity
Publisher
Elsevier BV
Published
2013-07
Volume
31
Pages
23-30
ISSN
0889-1591 (ISSN-L)
DOI
10.1016/j.bbi.2012.08.010
PMC
PMC3541465
OpenAlex
W2086005446
Cited by
83
References
70
Citations by year
2026: 3 · 2024: 2 · 2023: 9 · 2022: 2 · 2021: 2 · 2020: 10 · 2019: 7 · 2018: 5 · 2017: 9 · 2016: 9 · 2015: 11 · 2014: 8 · 2013: 4 · 2012: 1
FWCI
3.18
Type
journal article
Language
en
Open access
Licence
Locations
  • Brain Behavior and Immunity (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
  • UNC Libraries
Funders
  • National Institutes of Health (2r24hd050924-06, 5p20rr020649-03, ES10126, RR20649)
  • National Heart, Lung, and Blood Institute (R01HL085144)
  • Fogarty International Center (R01TW005596, 5R01TW05596, R03TW008133)
  • National Institute of Environmental Health Sciences (ES 10126, P30ES010126)
  • National Center for Research Resources (RR20649, P20-RR020649)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R24 HD-050924)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Social Sciences › Health › Health disparities and outcomes
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords
psychosocial stress, chronic inflammation, C-reactive protein, infancy, microbial exposure, birth weight, season of birth, parental absence, developmental origins of health and disease, cardiovascular risk, Philippines, Cebu Longitudinal Health and Nutrition Survey
MeSH terms
Adaptation, Psychological, Adult, Birth Weight, C-Reactive Protein, Female, Health Surveys, Humans, Immunity, Innate, Infant, Inflammation, Male, Maternal Deprivation, Philippines, Prospective Studies, Surveys and Questionnaires, Social Environment, Stress, Psychological, Cohort Studies

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