An epigenetic basis for an omnigenic model of psychiatric disorders
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Epigenetics is a molecular mechanism that helps explain the biological impact of environmental factors.
“Epigenetics is a molecular mechanism that has attracted attention as it helps explain the biological impact of environmental factors.28,29”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [28]
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Epigenetics and gene expression
Gibney, E. R., & Nolan, C. M. (2010) · Heredity · doi:10.1038/hdy.2010.54 · Cited by 1,109 · cited 3× · see citing works
“Gene expression also varies temporally and is influenced by the environment (Gibney & Nolan, 2010).”
BackgroundSex-specific transcriptional signatures in human depression
Labonté, B., Engmann, O., Purushothaman, I., Menard, C., Wang, J., Tan, C., Scarpa, J. R., Moy, G., Loh, Y.-H. E., Cahill, M., et al. (2017) · Nature Medicine · doi:10.1038/nm.4386 · Cited by 748 · see citing works
Hannon, E., Dempster, E., Viana, J., Burrage, J., Smith, A. R., Macdonald, R., St Clair, D., Mustard, C., Breen, G., Therman, S., et al. (2016) · Genome Biology · doi:10.1186/s13059-016-1041-x · Cited by 349 · see citing works
MiR-137: an important player in neural development and neoplastic transformation
Mahmoudi, E., & Cairns, M. J. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.150 · Cited by 198 · see citing works
Akula, N., Barb, J., Jiang, X., Wendland, J. R., Choi, K. H., Sen, S. K., Hou, L., Chen, D. T. W., Laje, G., Johnson, K., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.170 · Cited by 116 · see citing works
Viana, J., Hannon, E., Dempster, E., Pidsley, R., Macdonald, R., Knox, O., Spiers, H., Troakes, C., Al-Saraj, S., Turecki, G., et al. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw373 · Cited by 105 · see citing works
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Research works printed but not linked: 18
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Cited by
Sorted by citations
Yuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246 · see citing works
“28,29 Epigenetics refers to short-and long-term gene expression variations that are caused by non-DNA-encoded mechanisms.”
Background
- Authors
- Peedicayil, J., & Grayson, D. R.
- Affiliations
- Christian Medical College, Vellore (IN)
- University of Illinois Chicago (US)
- Corresponding author
- Peedicayil, Jacob
- Venue
- Journal of Theoretical Biology
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 443
- Pages
- 52-55
- ISSN
- 0022-5193 (ISSN-L)
- PMC
- PMC6512988
- OpenAlex
- W2793639703
- Cited by
- 35
- References
- 6
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 7 · 2022: 2 · 2021: 4 · 2020: 6 · 2019: 6 · 2018: 1
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Theoretical Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Figshare (submittedVersion, cc-by-nc-nd)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (P50AA022538)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- omnigenic model, epigenetics, gene expression regulation, mental illness, schizophrenia, bipolar disorder, major depressive disorder, heritability
- MeSH terms
- Mental Disorders, Humans, Models, Genetic, Models, Neurological, Mutation, DNA Methylation, Epigenesis, Genetic
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