Epigenetics and gene expression

Gibney, E R; Nolan, C M

doi:10.1038/hdy.2010.54

Cited by 1,109Epigenetics and DNA MethylationGenomics and Chromatin DynamicsGenetic Syndromes and Imprinting

Epigenetics and gene expression

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Gibney, E R, Nolan, C M·2010·Heredity

DOI 10.1038/hdy.2010.54

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Abstract

Transcription, translation and subsequent protein modification represent the transfer of genetic information from the archival copy of DNA to the short-lived messenger RNA, usually with subsequent production of protein. Although all cells in an organism contain essentially the same DNA, cell types and functions differ because of qualitative and quantitative differences in their gene expression. Thus, control of gene expression is at the heart of differentiation and development. Epigenetic processes, including DNA methylation, histone modification and various RNA-mediated processes, are thought to influence gene expression chiefly at the level of transcription; however, other steps in the process (for example, translation) may also be regulated epigenetically. The following paper will outline the role epigenetics is believed to have in influencing gene expression.

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There are three main types of epigenetic modifications: DNA methylation, histone modifications, and various RNA-mediated processes.
“There are three main types of epigenetic modifications: DNA methylation, histone modifications, and various RNA-mediated processes (39, 40).”
From Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma (2019) · cites this paper as [40]
It is not sufficient to study only differences in single DNA methylation loci.
“As these modifications accumulate and interact with one-another to produce tightly regulated changes in gene expression, it is not sufficient to only study differences in single DNA methylation loci.9”
From The role of epigenetics in psychological resilience (2021) · cites this paper as [9]
Epigenetic modifications accumulate and interact with one another to produce tightly regulated changes in gene expression.
“As these modifications accumulate and interact with one-another to produce tightly regulated changes in gene expression, it is not sufficient to only study differences in single DNA methylation loci.9”
From The role of epigenetics in psychological resilience (2021) · cites this paper as [9]

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Cutting Edge: Ectopic Expression of CD40 Ligand on B Cells Induces Lupus-Like Autoimmune Disease
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Regulation of Interferon-γ Gene Expression
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Defective T-cell ERK signaling induces interferon-regulated gene expression and overexpression of methylation-sensitive genes similar to lupus patients
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Epigenetics and SLE: RFX1 downregulation causes CD11a and CD70 overexpression by altering epigenetic modifications in lupus CD4+ T cells
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Maternal Cocaine Administration in Mice Alters DNA Methylation and Gene Expression in Hippocampal Neurons of Neonatal and Prepubertal Offspring
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Site-specific DNA methylation by a complex of PU.1 and Dnmt3a/b
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Changes in Presenilin 1 gene methylation pattern in diet-induced B vitamin deficiency
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Environment and lupus-related diseases
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The cell biology of DNA methylation in mammals
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Epigenetic mechanisms and gastrointestinal development
Waterland, R. A. (2006) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2006.06.064 · Cited by 103 · see citing works
Prediction of regulatory elements in mammalian genomes using chromatin signatures
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Functional Connection between Deimination and Deacetylation of Histones
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DNA methyltransferase-3a interacts with p53 and represses p53-mediated gene expression
Wang, Y., Kamarova, Y., Shen, K. C., Jiang, Z., Hahn, M., Wang, Y., & Brooks, S. C. (2005) · Cancer Biology & Therapy · doi:10.4161/cbt.4.10.2073 · Cited by 92 · see citing works
Quantitative changes in T cell DNA methylation occur during differentiation and ageing
Golbus, J., Palella, T. D., & Richardson, B. C. (1990) · European Journal of Immunology · doi:10.1002/eji.1830200836 · Cited by 91 · see citing works
Age-dependent decreases in DNA methyltransferase levels and low transmethylation micronutrient levels synergize to promote overexpression of genes implicated in autoimmunity and acute coronary syndromes
Li, Y., Liu, Y., Strickland, F. M., & Richardson, B. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.12.008 · Cited by 91 · see citing works
Inhibited expression of hematopoietic progenitor kinase 1 associated with loss of jumonji domain containing 3 promoter binding contributes to autoimmunity in systemic lupus erythematosus
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Histone modifications and methyl-CpG-binding domain protein levels at the TNFSF7 (CD70) promoter in SLE CD4+ T cells
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Key role of ERK pathway signaling in lupus
Gorelik, G. J., & Richardson, B. (2009) · Autoimmunity · doi:10.3109/08916930903374832 · Cited by 86 · see citing works
DNA methylation inhibition increases T cell KIR expression through effects on both promoter methylation and transcription factors
Liu, Y., Kuick, R. D., Hanash, S., & Richardson, B. (2008) · Clinical Immunology · doi:10.1016/j.clim.2008.08.009 · Cited by 84 · see citing works
RFX1 regulates CD70 and CD11a expression in lupus T cells by recruiting the histone methyltransferase SUV39H1
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Stimulatory and Inhibitory Killer Ig-Like Receptor Molecules Are Expressed and Functional on Lupus T Cells
Basu, D., Liu, Y., Wu, A., Yarlagadda, S., Gorelik, G. J., Kaplan, M. J., Hewagama, A., Hinderer, R., Strickland, F. M., & Richardson, B. C. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900034 · Cited by 80 · see citing works
The biology of nitric oxide and other reactive intermediates in systemic lupus erythematosus
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Promoter Hypomethylation Results in Increased Expression of Protein Phosphatase 2A in T Cells from Patients with Systemic Lupus Erythematosus
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The Site Specific Demethylation in the 5′-Regulatory Area of NMDA Receptor 2B Subunit Gene Associated with CIE-Induced Up-Regulation of Transcription
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Transcriptional control: Repression by local chromatin modification
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Early life, the epigenome and human health
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Research works printed but not linked: 2

Allis CD, Jenuwein T, Reinberg D (2007). Overview and concepts. In: Allis CD, Jenuwein T, Reinberg D (eds). Epigenetics. CSHL Press: New York. pp 23-61.
Kouzarides T, Berger SL (2007). Chromatin modifications and their mechanism of action. In: Allis CD, Jenuwein T, Reinberg D (eds). Epigenetics. CSHL Press: New York. pp 191-209.

Sorted by citations

T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development
Ohkura, N., Hamaguchi, M., Morikawa, H., Sugimura, K., Tanaka, A., Ito, Y., Osaki, M., Tanaka, Y., Yamashita, R., Nakano, N., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.09.010 · Cited by 756 · see citing works
“It has been postulated that DNA methylation inhibits the recognition of DNA by some proteins (Prokhortchouk and Defossez, 2008), and is generally associated with gene repression (Gibney and Nolan, 2010).”
Background
Development and Maintenance of Regulatory T cells
Ohkura, N., Kitagawa, Y., & Sakaguchi, S. (2013) · Immunity · doi:10.1016/j.immuni.2013.03.002 · Cited by 728 · see citing works
“Epigenetic Changes in Treg Cells Epigenetic modifications, which include histone modifications, DNA methylation, microRNAs, nucleosome positioning, chromatin interaction, and chromosome conformational changes, play indispensable roles in cell differentiation, especially for cell-lineage stabilization (Gibney and Nolan…”
Background
A Six Months Exercise Intervention Influences the Genome-wide DNA Methylation Pattern in Human Adipose Tissue
Rönn, T., Volkov, P., Davegårdh, C., Dayeh, T., Hall, E., Olsson, A. H., Nilsson, E., Tornberg, Å. B., Nitert, M. D., Eriksson, K., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003572 · Cited by 619 · see citing works
“It should be noted that epigenetic processes are likely to influence more aspects of gene expression, including accessibility of the gene, posttranscriptional RNA processing and stability, splicing and also translation [49].”
Temperature-responsive smart nanocarriers for delivery of therapeutic agents: applications and recent advances
Karimi, M., Sahandi Zangabad, P., Ghasemi, A., Amiri, M., Bahrami, M., Malekzad, H., Ghahramanzadeh Asl, H., Mahdieh, Z., Bozorgomid, M., Ghasemi, A., et al. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b00371 · Cited by 500 · see citing works
Micronuclei in genotoxicity assessment: from genetics to epigenetics and beyond
Luzhna, L., Kathiria, P., & Kovalchuk, O. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00131 · Cited by 454 · see citing works
“Epigenetic regulation includes at least four outlined mechanisms: DNA methylation, histone modifications, chromatin remodeling, and non-coding RNA expression (Bonasio et al., 2010; Gibney and Nolan, 2010).”
Background
The many faces of estrogen signaling
Vrtačnik, P., Ostanek, B., Mencej-Bedrač, S., & Marc, J. (2014) · Biochemia Medica · doi:10.11613/bm.2014.035 · Cited by 403 · see citing works
Recommendations for the design and analysis of epigenome-wide association studies
Michels, K. B., Binder, A. M., Dedeurwaerder, S., Epstein, C. B., Greally, J. M., Gut, I., Houseman, E. A., Izzi, B., Kelsey, K. T., Meissner, A., et al. (2013) · Nature Methods · doi:10.1038/nmeth.2632 · Cited by 378 · see citing works
CD133 as a biomarker for putative cancer stem cells in solid tumours: limitations, problems and challenges
Grosse‐Gehling, P., Fargeas, C. A., Dittfeld, C., Garbe, Y., Alison, M. R., Corbeil, D., & Kunz‐Schughart, L. A. (2012) · The Journal of Pathology · doi:10.1002/path.4086 · Cited by 299 · see citing works
“G lio bl as to m a, m ed ul lo bl as to m a CD 13 3/ 1, 29 3C 3 (M B) × × × – Ye s Ye s [1 19 ]”
BackgroundInfluential
Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma
Jiang, S., Postovit, L., Cattaneo, A., Binder, E. B., & Aitchison, K. J. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00808 · Cited by 288 · see citing works
“There are three main types of epigenetic modifications: DNA methylation, histone modifications, and various RNA-mediated processes (39, 40).”
Background
Epigenetic Mechanisms of Depression and Antidepressant Action
Vialou, V., Feng, J., Robison, A. J., & Nestler, E. J. (2013) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010611-134540 · Cited by 277 · see citing works
“Numerous mechanisms that underlie epigenetic regulation have been described, including (a) direct modification of DNA’s transcriptional potential by methylation of cytosine bases and (b) indirect regulation of DNA’s accessibility through several types of chemical modification of the proteins involved in chromatin stru…”
Background
The central role of RNA in human development and cognition
Mattick, J. S. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.05.001 · Cited by 274 · see citing works
“ment [165–170], long-term responses to environmental variables [171,172], and brain function [173–179].”
Background
Parental Advisory: Maternal and Paternal Stress Can Impact Offspring Neurodevelopment
Chan, J. C., Nugent, B. M., & Bale, T. L. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.10.005 · Cited by 241 · see citing works
“Epigenetic control of gene expression, including DNA methylation, histone posttranslational modifications (PTMs), and noncoding RNAs, evolved to regulate and establish cell- and tissue-specific gene expression programs and to control normal cellular functions (8,9).”
Background
Epigenetic switch from repressive to permissive chromatin in response to cold stress
Park, J., Lim, C. J., Shen, M., Park, H. J., Cha, J., Iniesto, E., Rubio, V., Mengiste, T. D., Zhu, J., Bressan, R. A., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1721241115 · Cited by 232 · see citing works
“The factors controlling how chromatin remodeling enzymes are targeted to specific loci is an area of intense research (59), and the extension of our model to other gene regulons could explain in mechanistic terms how specific chromatin sites are chosen to be remodeled for transcriptional regulation.”
Background
Epigenetics in Prostate Cancer: Biologic and Clinical Relevance
Jerónimo, C., Bastian, P. J., Bjartell, A. S., Carbone, G. M., Catto, J. W. F., Clark, S. J., Henrique, R., Nelson, W. G., & Shariat, S. F. (2011) · European Urology · doi:10.1016/j.eururo.2011.06.035 · Cited by 226 · see citing works
“Structurally, histones possess a flexible ‘‘tail’’ that is susceptible to post-translation biochemical modification (such as acetylation, methylation, and phosphorylation) [13–17].”
Background
The RdDM Pathway Is Required for Basal Heat Tolerance in Arabidopsis
Popova, O. V., Dinh, H. Q., Aufsatz, W., & Jonak, C. (2013) · Molecular Plant · doi:10.1093/mp/sst023 · Cited by 219 · see citing works
“The transcriptional capacity of genes is intimately connected to their epigenetic states (Bonasio et al., 2010; Gibney and Nolan, 2010).”
Epigenetics: Principles and Practice
Hamilton, J. P. (2011) · Digestive Diseases · doi:10.1159/000323874 · Cited by 215 · see citing works
Mechanisms Underlying T Cell Immunosenescence: Aging and Cytomegalovirus Infection
Tu, W., & Rao, S. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.02111 · Cited by 189 · see citing works
Epigenetic Control of Skeletal Development by the Histone Methyltransferase Ezh2
Dudakovic, A., Camilleri, E. T., Xu, F., Riester, S. M., McGee‐Lawrence, M. E., Bradley, E. W., Paradise, C. R., Lewallen, E. A., Thaler, R., Deyle, D. R., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.672345 · Cited by 181 · see citing works
Genetic and epigenetic basis of Treg cell development and function: from a FoxP3‐centered view to an epigenome‐defined view of natural Treg cells
Morikawa, H., & Sakaguchi, S. (2014) · Immunological Reviews · doi:10.1111/imr.12174 · Cited by 176 · see citing works
Review of applications of high-throughput sequencing in personalized medicine: barriers and facilitators of future progress in research and clinical application
Lightbody, G., Haberland, V., Browne, F., Taggart, L., Zheng, H., Parkes, E., & Blayney, J. K. (2019) · Briefings in Bioinformatics · doi:10.1093/bib/bby051 · Cited by 173 · see citing works
“These levels are connected via genetic data transfer processes, including transcription, translation, binding and protein modification [23, 24].”
Background
HIF-1-Independent Mechanisms Regulating Metabolic Adaptation in Hypoxic Cancer Cells
Lee, S.-H., Golinska, M., & Griffiths, J. R. (2021) · Cells · doi:10.3390/cells10092371 · Cited by 169 · see citing works
Methotrexate Restores Regulatory T Cell Function Through Demethylation of the FoxP3 Upstream Enhancer in Patients With Rheumatoid Arthritis
Cribbs, A. P., Kennedy, A., Penn, H., Amjadi, P., Green, P. A., Read, J. E., Brennan, F. M., Gregory, B., & Williams, R. O. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39031 · Cited by 166 · see citing works
Gene regulatory network inference resources: A practical overview
Mercatelli, D., Scalambra, L., Triboli, L., Ray, F., & Giorgi, F. M. (2019) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2019.194430 · Cited by 157 · see citing works
Epigenetic Drug Discovery: Targeting DNA Methyltransferases
Foulks, J. M., Parnell, K. M., Nix, R. N., Chau, S., Świerczek, K., Saunders, M. J., Wright, K., Hendrickson, T. F., Ho, K.-K., McCullar, M. V., et al. (2011) · SLAS DISCOVERY · doi:10.1177/1087057111421212 · Cited by 160 · see citing works
Plant Volatile Organic Compounds Evolution: Transcriptional Regulation, Epigenetics and Polyploidy
Picazo-Aragonés, J., Terrab, A., & Balao, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21238956 · Cited by 153 · see citing works
“VOCs are differentially—both temporally and spatially—synthesized throughout the development of the plant, due to differences in gene expression in distinct cell types [26].”
Background
Determinants and Consequences of Dispersal in Vertebrates with Complex Life Cycles: A Review of Pond-Breeding Amphibians
Cayuela, H., Valenzuela‐Sánchez, A., Teulier, L., Martínez-Solano, Í., Léna, J., Merilä, J., Muths, E., Shine, R., Quay, L., Denoël, M., et al. (2020) · The Quarterly Review of Biology · doi:10.1086/707862 · Cited by 148 · see citing works
Eukaryotic mRNA Decay: Methodologies, Pathways, and Links to Other Stages of Gene Expression
Pérez-Ortín, J. E., Alepuz, P. M., Chávez, S., & Choder, M. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.02.029 · Cited by 142 · see citing works
“[mRNA] = [mRNA]0 + e-kd t [7]”
Facial Genetics: A Brief Overview
Richmond, S., Howe, L. J., Lewis, S. J., Stergiakouli, E., & Zhurov, A. I. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00462 · Cited by 141 · see citing works
The Association of Gut Microbiota With Osteoporosis Is Mediated by Amino Acid Metabolism: Multiomics in a Large Cohort
Ling, C.-W., Miao, Z., Xiao, M.-L., Zhou, H., Jiang, Z., Fu, Y., Xiong, F., Zuo, L.-S.-Y., Liu, Y.-P., Wu, Y.-Y., et al. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab492 · Cited by 138 · see citing works
Genome-wide analysis reveals distinct patterns of epigenetic features in long non-coding RNA loci
Sati, S., Ghosh, S., Jain, V., Scaria, V., & Sengupta, S. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks776 · Cited by 133 · see citing works
“The methylation architecture in and around the protein-coding genes affects their expression and hence influence cell identity (38).”
Background
Cancer immune escape: the role of antigen presentation machinery
Kallingal, A., Olszewski, M., Maciejewska, N., Brankiewicz, W., & Bagiński, M. (2023) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-023-04737-8 · Cited by 133 · see citing works
“Epigenetic modulation of antitumor immunity has been an active area of research in recent years and has been found to have potential applications in cancer immunotherapy (Gibney and Nolan 2010).”
Background
Posttraumatic Stress Disorder and Inflammation: Untangling Issues of Bidirectionality
Sumner, J. A., Nishimi, K. M., Koenen, K. C., Roberts, A. L., & Kubzansky, L. D. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.11.005 · Cited by 131 · see citing works
A mutation screen in patients with Kabuki syndrome
Li, Y., Bögershausen, N., Alanay, Y., Şimşek‐Kiper, P. Ö., Plume, N., Keupp, K., Pohl, E., Pawlik, B., Rachwalski, M., Milz, E., et al. (2011) · Human Genetics · doi:10.1007/s00439-011-1004-y · Cited by 130 · see citing works
“Introduction Epigenetic control of developmental processes is a fascinating mechanism by which spatial and temporal expression of distinct genes and pathways are regulated (Gibney and Nolan 2010).”
Background
Induction of the neural crest state: Control of stem cell attributes by gene regulatory, post-transcriptional and epigenetic interactions
Prasad, M. S., Sauka‐Spengler, T., & LaBonne, C. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.03.014 · Cited by 126 · see citing works
“non-covalent proline isomerization (Gibney and Nolan, 2010).”
Background
The role of DNA methylation in the pathogenesis of type 2 diabetes mellitus
Ahmed, S. A. H., Ansari, S. A., Mensah‐Brown, E. P. K., & Emerald, B. S. (2020) · Clinical Epigenetics · doi:10.1186/s13148-020-00896-4 · Cited by 126 · see citing works
CD133: to be or not to be, is this the real question?
Irollo, E., & Pirozzi, G. (2013) · Europe PMC (PubMed Central) · Cited by 122 · see citing works
Epigenetic Mechanisms in Bone Biology and Osteoporosis: Can They Drive Therapeutic Choices?
Marini, F., Cianferotti, L., & Brandi, M. L. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17081329 · Cited by 121 · see citing works
“Post-translational histone modifications include a large number of histone changes, such as methylation, acetylation, phosphorylation, ubiquitination, ADP ribosylation, sumoylation, deamination, and non-covalent proline isomerisation [2].”
Background
Epigenetic correlates of plant phenotypic plasticity: DNA methylation differs between prickly and nonprickly leaves in heterophyllousIlex aquifolium(Aquifoliaceae) trees
Herrera, C. M., & Bazaga, P. (2012) · Botanical Journal of the Linnean Society · doi:10.1111/boj.12007 · Cited by 118 · see citing works
Epigenetic Mechanisms of Aging and Aging-Associated Diseases
la Torre, A., Vecchio, F. L., & Greco, A. (2023) · Cells · doi:10.3390/cells12081163 · Cited by 120 · see citing works
The polycomb repressive complex 2 governs life and death of peripheral T cells
Zhang, Y., Kinkel, S., Maksimovic, J., Bandala‐Sanchez, E., Tanzer, M. C., Naselli, G., Zhang, J., Zhan, Y., Lew, A. M., Silke, J., et al. (2014) · Blood · doi:10.1182/blood-2013-12-544106 · Cited by 115 · see citing works
Quantitative epigenetics and evolution
Banta, J. A., & Richards, C. L. (2018) · Heredity · doi:10.1038/s41437-018-0114-x · Cited by 114 · see citing works
Molecular Mechanisms of Muscle Plasticity with Exercise
Hoppeler, H. H., Baum, O., Lurman, G. J., & Mueller, M. (2011) · Comprehensive physiology · doi:10.1002/cphy.c100042 · Cited by 120 · see citing works
Biomarkers Associated With Migraine and Their Potential Role in Migraine Management
Durham, P. L., & Papapetropoulos, S. (2013) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12174 · Cited by 109 · see citing works
“alterations in gene expression that are not caused by changes in DNA sequence; as heritable changes in gene activity and expression; and as stable, long-term alterations in the transcriptional potential of a cell that are not necessarily heritable.(83,84) Epigenetic mechanisms that can stably influence gene expression…”
Background
The role of epigenetics in psychological resilience
Smeeth, D., Beck, S., Karam, E. G., & Pluess, M. (2021) · The Lancet Psychiatry · doi:10.1016/s2215-0366(20)30515-0 · Cited by 108 · see citing works
Vitamin D and the risk for cancer: A molecular analysis
Carlberg, C., & Velleuer, E. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114735 · Cited by 110 · see citing works
Epigenetic modifications of Nrf2-mediated glutamate–cysteine ligase: implications for the development of diabetic retinopathy and the metabolic memory phenomenon associated with its continued progression
Mishra, M., Zhong, Q. P. W., & Kowluru, R. A. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.07.001 · Cited by 108 · see citing works
“the genes and these modifications, in addition to allowing cells to quickly respond to the changing stimuli, also result in long-lasting changes in gene activity (17, 30, 31).”
BackgroundInfluential
Pharmacophore-based virtual screening, 3D QSAR, Docking, ADMET, and MD simulation studies: An in silico perspective for the identification of new potential HDAC3 inhibitors
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Histone Deacetylase Inhibition Promotes Osteoblast Maturation by Altering the Histone H4 Epigenome and Reduces Akt Phosphorylation
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Interpreting omics data with pathway enrichment analysis
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Epigenetic reprogramming in cancer: From diagnosis to treatment
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Gene Polymorphisms and Fiber-Type Composition of Human Skeletal Muscle
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Molecular Regulatory Mechanisms Affecting Fruit Aroma
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Authors: Gibney, E. R., & Nolan, C. M.
Affiliations: University College Dublin (IE)
Corresponding author: Nolan, C M
ORCID: Gibney, E R
Nolan, C M
Venue: Heredity
Publisher: Springer Science and Business Media LLC
Published: 2010-05-12
Volume: 105
Issue: 1
Pages: 4-13
ISSN: 0018-067X (ISSN-L)
1365-2540
DOI: 10.1038/hdy.2010.54
OpenAlex: W1974450480
Cited by: 1,109
References: 119
Citations by year: 2026: 68 · 2025: 148 · 2024: 175 · 2023: 147 · 2022: 115 · 2021: 102 · 2020: 70 · 2019: 33 · 2018: 42 · 2017: 28 · 2016: 32 · 2015: 22 · 2014: 29 · 2013: 32 · 2012: 31
FWCI: 2.72
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Heredity (publishedVersion)
PubMed (publishedVersion)
Funders: Science Foundation Ireland (RFP06)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
Keywords: epigenetics, gene expression regulation, transcriptional regulation, DNA methylation, histone modifications, RNA-mediated gene regulation, cell differentiation, development (biology), translational regulation, protein modification
MeSH terms: Animals, Cell Differentiation, Humans, DNA Modification Methylases, Gene Expression, Cell Lineage, Heredity, Epigenesis, Genetic

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