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Intraoperative extracorporeal membrane oxygenation and the possibility of postoperative prolongation improve survival in bilateral lung transplantation
Open accessAbstract
Objectives The value of intraoperative extracorporeal membrane oxygenation (ECMO) in lung transplantation remains controversial. In our department, ECMO has been used routinely for intraoperatively unstable patients for more than 15 years. Recently, we have extended its indication to a preemptive application in almost all cases. In addition, we prolong ECMO into the early postoperative period whenever graft function does not meet certain quality criteria or in patients with primary pulmonary hypertension. The objective of this study was to review the results of this strategy.Methods All standard bilateral lung transplantations performed between January 2010 and June 2016 were included in this single-center, retrospective analysis. Patients were divided into 3 groups: group I-no ECMO (n = 116), group II-intraoperative ECMO (n = 343), and group III-intraoperative and prolonged postoperative ECMO (n = 123). The impact of different ECMO strategies on primary graft function, short-term outcomes, and patient survival were analyzed.Results The use of intraoperative ECMO was associated with improved 1-, 3-, and 5-year survival compared with non-ECMO patients (91% vs 82%, 85% vs 76%, and 80% vs 74%; log-rank P = .041). This effect was still evident after propensity score matching of both cohorts. Despite the high number of complex patients in group III, outcome was excellent with higher survival rates than in the non-ECMO group at all time points.Conclusions Intraoperative ECMO results in superior survival when compared with transplantation without any extracorporeal support. The concept of prophylactic postoperative ECMO prolongation is associated with excellent outcomes in recipients with pulmonary hypertension and in patients with questionable graft function at the end of implantation.
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“While VA ECMO offers hemodynamic stability and adequate gas exchange, and facilitates controlled allograft reperfusion,3,8,18,28 several reports have demonstrated higher rates of grade 3 PGD among patients who underwent BOLT with versus without ECMO support.9,10,13”
From Textbook outcome in lung transplantation: Planned venoarterial extracorporeal membrane oxygenation versus off-pump support for patients without pulmonary hypertension (2022) · cites this paper as [9]
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“In this context, our findings suggest that previously reported associations between planned VA ECMO and increased grade 3 PGD are likely confounded by differences in underlying physiology and illness severity between planned support strata.”
From Textbook outcome in lung transplantation: Planned venoarterial extracorporeal membrane oxygenation versus off-pump support for patients without pulmonary hypertension (2022) · cites this paper as [9]
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Normothermic Ex Vivo Lung Perfusion in Clinical Lung Transplantation
Cypel, M., Yeung, J. C., Liu, M., Anraku, M., Chen, F., Karolak, W., Sato, M., Laratta, J., Azad, S., Madonik, M. M., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1014597 · Cited by 1,112
Ischemia–Reperfusion–induced Lung Injury
de Perrot, M. E., Liu, M., Waddell, T. K., & Keshavjee, S. H. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200207-670so · Cited by 962
Christie, J. D., Carby, M. R., Bag, R., Corris, P. A., Hertz, M. I., & Weill, D. (2005) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2004.11.049 · Cited by 761
Snell, G. I., Yusen, R. D., Weill, D., Strueber, M., Garrity, E. R., Reed, A. K., Peláez, A., Whelan, T. P. M., Perch, M., Bag, R., et al. (2017) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2017.07.021 · Cited by 736
Clinical risk factors for primary graft dysfunction after lung transplantation
Diamond, J. M., Lee, J. C., Kawut, S. M., Shah, R. J., Localio, A. R., Bellamy, S. L., Lederer, D. J., Cantu, E., Kohl, B. A., Lama, V. N., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201210-1865oc · Cited by 687
Functional Repair of Human Donor Lungs by IL-10 Gene Therapy
Cypel, M., Liu, M., Rubacha, M., Yeung, J. C., Hirayama, S., Anraku, M., Sato, M., Medin, J. A., Davidson, B. L., de Perrot, M. E., et al. (2009) · Science Translational Medicine · doi:10.1126/scitranslmed.3000266 · Cited by 326
Cypel, M., Rubacha, M., Yeung, J. C., Hirayama, S., Torbicki, K., Madonik, M. M., Fischer, S., Hwang, D., Pierre, A. F., Waddell, T. K., et al. (2009) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2009.02775.x · Cited by 275
Machuca, T., Collaud, S., Mercier, O. M., Cheung, M., Cunningham, V., Kim, S. J., Azad, S., Singer, L. G., Yasufuku, K., de Perrot, M. E., et al. (2014) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2014.11.039 · Cited by 253
Institutional experience with extracorporeal membrane oxygenation in lung transplantation☆
Aigner, C., Wisser, W., Taghavi, S., Láng, G., Jaksch, P., Czyżewski, D., & Klepetko, W. (2007) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/j.ejcts.2006.11.049 · Cited by 237
Self-citationIus, F., Kuehn, C., Tudorache, I., Sommer, W., Avsar, M., Boethig, D., Fuehner, T., Gottlieb, J., Hoeper, M. M., Haverich, A., et al. (2012) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2012.07.095 · Cited by 226
Bermudez, C. A., Shiose, A., Esper, S. A., Shigemura, N., D’Cunha, J., Bhama, J. K., Richards, T. J., Arlia, P., Crespo, M. M., & Pilewski, J. M. (2014) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2014.06.072 · Cited by 186
Clinical Ex Vivo Lung Perfusion—Pushing the Limits
Aigner, C., Slama, A., Höetzenecker, K., Scheed, A., Urbanek, B., Schmid, W., Nierscher, F. J., Láng, G., & Klepetko, W. (2012) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2012.04027.x · Cited by 182
Self-citationBiscotti, M., Yang, J. A., Sonett, J. R., & Bacchetta, M. D. (2014) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2014.07.061 · Cited by 181
Tudorache, I., Sommer, W., Kühn, C., Wiesner, O., Hadem, J., Fuehner, T., Ius, F., Avsar, M., Schwerk, N., Böthig, D., et al. (2014) · Transplantation · doi:10.1097/tp.0000000000000348 · Cited by 176
Bermudez, C. A., Adusumilli, P. S., McCurry, K. R., Zaldonis, D. B., Crespo, M. M., Pilewski, J. M., & Toyoda, Y. (2009) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2008.11.036 · Cited by 147
Slama, A., Schillab, L., Barta, M., Benedek, A., Mitterbauer, A., Höetzenecker, K., Taghavi, S., Láng, G., Matilla, J. R., Ankersmit, H. J., et al. (2017) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2017.02.011 · Cited by 147
Self-citationShort- and long-term outcomes of 1000 adult lung transplant recipients at a single center
Kreisel, D., Krupnick, A. S., Puri, V., Guthrie, T. J., Trulock, E. P., Meyers, B. F., & Patterson, G. A. (2010) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2010.09.009 · Cited by 146
Consequences of Vascular Flow on Lung Injury Induced by Mechanical Ventilation
Broccard, A. F., Hotchkiss, J. R., Kuwayama, N., OLSON, D. A., JAMAL, S., Wangensteen, D., & Marini, J. J. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.6.9612006 · Cited by 146
Pereszlenyi, A. (2002) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/s1010-7940(02)00058-1 · Cited by 146
Hartwig, M. G., Walczak, R., Lin, S. S., & Davis, R. D. (2011) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2011.05.017 · Cited by 122
Ius, F., Sommer, W., Tudorache, I., Avsar, M., Siemeni, T., Salman, J., Molitoris, U., Gras, C., Juettner, B., Puntigam, J., et al. (2016) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2015.08.016 · Cited by 115
Mordant, P., Nakajima, D., Mussi, R. K., İskender, İ., Maahs, L., Behrens, P., Coutinho, R., Iyer, R. K., Davies, J. E., Cypel, M., et al. (2016) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2016.04.017 · Cited by 115
Wigfield, C. H., Lindsey, J. D., Steffens, T. G., Edwards, N. M., & Love, R. B. (2007) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2006.12.010 · Cited by 108
Triantafillou, A. N., Pasque, M. K., Huddleston, C. B., Pond, C. G., Cerza, R. F., Forstot, R. M., Cooper, J. D., Patterson, G. A., & Lappas, D. G. (1994) · The Annals of Thoracic Surgery · doi:10.1016/0003-4975(94)91367-6 · Cited by 83
Halldorsson, A., Kronon, M. T., Allen, B. S., Bolling, K. S., Wang, T., Rahman, S., & Feinberg, H. (1998) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(98)70286-7 · Cited by 79
İskender, İ., Sakamoto, J., Nakajima, D., Lin, H., Chen, M., Kim, H., Guan, Z., Sorbo, L. D., Hwang, D. M., Waddell, T. K., et al. (2016) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2016.03.006 · Cited by 71
Preoperative prediction for the use of cardiopulmonary bypass in lung transplantation
de Hoyos, A., Demajo, W., Snell, G. I., Miller, J. D., Winton, T. L., MAURER, J. R., & Patterson, G. A. (1993) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(19)34031-0 · Cited by 71
Fiser, S. M., Kron, I. L., Long, S. M., Kaza, A. K., Kern, J. A., & Tribble, C. G. (2001) · The Journal of Heart and Lung Transplantation · doi:10.1016/s1053-2498(01)00249-2 · Cited by 67
Ko, W., Chen, Y., & Lee, Y. (2001) · Artificial Organs · doi:10.1046/j.1525-1594.2001.025008607.x · Cited by 54
Lower-extremity complications with femoral extracorporeal life support
Vallabhajosyula, P., Kramer, M., Lazar, S., McCarthy, F. H., Rame, J. E., Wald, J. W., Szeto, W. Y., Williams, M. L., Atluri, P., Desai, N. D., et al. (2016) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2015.11.044 · Cited by 51
Samano, M. N., Fernandes, L. M., Baranauskas, J. C. B., Correia, A. T., Afonso, J. E., Teixeira, R. H. D. O. B., Caramori, M. L., Pêgo‐Fernandes, P. M., & Jatene, F. B. (2012) · Transplantation Proceedings · doi:10.1016/j.transproceed.2012.07.134 · Cited by 38
Clark, S. C., Sudarshan, C., Khanna, R., Roughan, J., Flecknell, P. A., & Dark, J. H. (1998) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(98)70217-x · Cited by 29
Verbelen, T., Cromphaut, S. J. V., Rega, F., & Meyns, B. P. (2012) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2012.10.020 · Cited by 29
McFadden, P. M., & Greene, C. L. (2014) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2014.12.020 · Cited by 22
Láng, G., Aigner, C., Winkler, G., Shkirdladze, K., Wisser, W., Dekan, G., Tamura, M., Heinze, G., Raemdonck, D. E. V., & Klepetko, W. (2009) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2008.11.064 · Cited by 9
Self-citationWisser, W., Marta, G. M., Şenbaklavacı, Ö., Neuhauser, P., Mares, P., & Klepetko, W. (2001) · The Journal of Heart and Lung Transplantation · doi:10.1016/s1053-2498(00)00495-2 · Cited by 8
Self-citationEffect of controlled reperfusion techniques in human lung transplantation
Alvarado, C., Poston, R. S., Hattler, B. G. J., Keenan, R. J., Dauber, J. A., Griffith, B. P., & McCurry, K. R. (2001) · The Journal of Heart and Lung Transplantation · doi:10.1016/s1053-2498(00)00377-6 · Cited by 7
Lung Transplantation for PPH: Postoperatively Prolonged ECMO Improves Early Outcome
Moser, B., Jaksch, P., Muraközy, G., Nierlich, P., Láng, G., Taghavi, S., Aigner, C., Matilla, J. R., & Klepetko, W. (2015) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2015.01.435 · Cited by 4
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Hoeper, M. M., Benza, R. L., Corris, P., de Perrot, M., Fadel, E., Keogh, A. M., Kühn, C., Savale, L., & Klepetko, W. (2019) · European Respiratory Journal · doi:10.1183/13993003.01906-2018 · Cited by 216
“…has almost completely replaced the use of conventional cardiopulmonary bypass as it has been associated with a reduction of peri-operative complications including renal failure, a reduced need for transfusions of blood products and (in some, but not all, series) with better survival [49, 59 – 63].”
Self-citationHoetzenecker, K., Benazzo, A., Stork, T., Sinn, K., Schwarz, S., Schweiger, T., Klepetko, W., Kifjak, D., Baron, D. M., Hager, H., et al. (2020) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2019.10.155 · Cited by 157
Self-citationTwenty-year experience with extracorporeal life support as bridge to lung transplantation
Benazzo, A., Schwarz, S., Frommlet, F., Schweiger, T., Jaksch, P., Schellongowski, P., Staudinger, T., Klepetko, W., Lang, G., Hoetzenecker, K., et al. (2019) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2019.02.048 · Cited by 126
Self-citationHartwig, M. G., van Berkel, V. H., Bharat, A., Cypel, M., Date, H., Erasmus, M. E., Höetzenecker, K., Klepetko, W., Kon, Z. N., Kukreja, J., et al. (2022) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2022.06.024 · Cited by 85
Self-citationEffect of mode of intraoperative support on primary graft dysfunction after lung transplant
Loor, G., Huddleston, S. J., Hartwig, M. G., Bottiger, B., Daoud, D., Wei, Q., Zhang, Q., Ius, F., Warnecke, G., Villavicencio, M. A., et al. (2022) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2021.10.076 · Cited by 76
Metadata
- Authors
- Hoetzenecker, K., Schwarz, S., Muckenhuber, M., Benazzo, A., Frommlet, F., Schweiger, T., Bata, O., Jaksch, P., Ahmadi, N., Muraközy, G., Prosch, H., Hager, H., Roth, G., Lang, G., Taghavi, S., & Klepetko, W.
- Affiliations
- Medical University of Vienna (AT)
- National Institute of Oncology (HU)
- University of Ottawa (CA)
- Corresponding author
- Klepetko, Walter
- ORCID
- Venue
- The Journal of Thoracic and Cardiovascular Surgery
- Publisher
- Elsevier BV
- Published
- 2018-05
- Volume
- 155
- Issue
- 5
- Pages
- 2193-2206.e3
- ISSN
- 0022-5223 (ISSN-L)
- OpenAlex
- W2772602769
- Cited by
- 242
- References
- 38
- Citations by year
- 2026: 13 · 2025: 18 · 2024: 36 · 2023: 26 · 2022: 40 · 2021: 38 · 2020: 39 · 2019: 23 · 2018: 9
- FWCI
- 19.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Thoracic and Cardiovascular Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Mechanical Circulatory Support Devices
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Keywords
- extracorporeal membrane oxygenation, intraoperative ECMO, bilateral lung transplantation, primary graft function, patient survival, idiopathic pulmonary arterial hypertension, graft function
- MeSH terms
- Adult, Female, Graft Survival, Humans, Hypertension, Pulmonary, Intraoperative Care, Lung Diseases, Male, Middle Aged, Retrospective Studies, Risk Factors, Time Factors, Extracorporeal Membrane Oxygenation, Lung Transplantation, Treatment Outcome, Risk Assessment, Primary Graft Dysfunction
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