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Cited by 34Aluminum toxicity and tolerance in plants and animalsLipid Membrane Structure and BehaviorErythrocyte Function and Pathophysiology

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In vitro effect of AlCl3 on human erythrocytes: Changes in membrane morphology and functionality

Lukyanenko, Ludmila Michaylovna, Skarabahatava, Aliasksandra Sergeevna, Slobozhanina, Ekaterina Ivanovna, Kovaliova, Svetlana Anatolievna, Falcioni, Maria Letizia, Falcioni, Giancarlo·2013·Journal of Trace Elements in Medicine and Biology
DOI 10.1016/j.jtemb.2012.10.003
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Abstract

Aluminum belongs to a group of potential toxic elements capable of penetrating the human body. In this paper, the effect of aluminum concentrations on red blood cell membranes using different fluorescent probes able to localize in various parts of the phospholipid bilayer (TMA-DPH, laurdan and pyrene) were studied. Our results confirm that human erythrocytes exposed to aluminum undergo physico-chemical modifications at the membrane level. A decrease in fluorescence anisotropy of TMA-DPH and in the polarity of the lipid bilayer with a concomitant shift toward a gel phase was observed, and the pyrene excimerization coefficient (kex) increased. Furthermore, the presence of aluminum induced lipid peroxidation and reduced the activity of erythrocyte antioxidant enzymes (SOD, CAT and GSHPx). Al-induced morphological changes on the erythrocyte membrane surface were monitored using atomic force microscopy. These results provide further information on the target of action of different aluminum amounts.

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  • Al-induced change in erythrocyte size may be accompanied by change in erythrocyte shape resulting in formation of echinocytes, acanthocytes and stomatocytes in vitro due to altered membrane morphology.

    “The Al-induced change in erythrocyte size may also be accompanied by change in erythrocyte shape resulting in the formation of echinocytes (Suwalsky et al., 2004), acanthocytes and stomatocytes (Vittori et al., 2002) in vitro, due to altered membrane morphology (Lukyanenko et al., 2013).”

    From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Lukyanenko et al., 2013

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Research works printed but not linked: 58

  1. Zafar, 1999, Aluminum intake and it's toxic effects on health, Int J Agric Biol, 01, 188
  2. Konoha, 2007, Neurotoxicity of aluminum hydroxyl polimer on primary cultured neutons of rat cerebral cortez, Biomed Res Trace Elem, 18, 395
  3. Gomez, 2008, Aluminium exposure through the diet: metal levels in Abeta PP trangenic mice, a model for Alzheimer's disease, Toxicology, 249, 214, 10.1016/j.tox.2008.05.004 · DOI
  4. Exley, 2009, Darwin, natural selection and the biological esentiality of aluminium and silicon, Trends Biochem Sci, 34, 589, 10.1016/j.tibs.2009.07.006 · DOI
  5. Maton, 1999, Antacids revisited, a review of their clinical pharmacology and recommended therapeutic use, Drugs, 57, 855, 10.2165/00003495-199957060-00003 · DOI
  6. Flaten, 1996, Status an future concems of clinical and environmental aluminum toxicology, J Toxicol Environ Health, 48, 527, 10.1080/009841096161050 · DOI
  7. Bondy, 2010, The neurotoxicity of environmental aluminium is still an issue, Neurotoxicology, 31, 575, 10.1016/j.neuro.2010.05.009 · DOI
  8. Jaffe, 2005, Frequence of elevated serum aluminium levels in adult dialysis patients, Am J Kidney Dis, 46, 316, 10.1053/j.ajkd.2005.04.020 · DOI
  9. Jeffery, 1996, Systemic aluminum toxicity: effect on bone, hematopoietic tissue and kidney, J Toxicol Environ Health, 48, 649, 10.1080/009841096161122 · DOI
  10. Wu, 2012, Aluminum induces neurodegeneration and its toxicity arises from increased iron accumulation and reactive oxygen species (ROS) production, Neurobiol Aging, 33, 199, 10.1016/j.neurobiolaging.2010.06.018 · DOI
  11. Ward, 2001, Aluminium toxicity and iron homeostasis, J Inorg Biochem, 87, 9, 10.1016/S0162-0134(01)00308-7 · DOI
  12. Kim, 2007, Aluminium stimulates uptake of non-tansferrin bound iron and tranferrin bound iron in human glial cells, Toxicol Appl Pharmacol, 220, 349, 10.1016/j.taap.2007.02.001 · DOI
  13. Prousek, 2007, Fenton chemistry in biology and medicine, Pure Appl Chem, 79, 2325, 10.1351/pac200779122325 · DOI
  14. Dobson, 1998, Location of aluminium and gallium in human neuroblastoma cells treated with metal-chelating agent complexes, Toxicol Appl Pharmacol, 152, 145, 10.1006/taap.1998.8489 · DOI
  15. Barker, 1990, Development of 26Al accelerator mass spectrometry for biological and toxicological applications, Nucl Instr Methods Phys Res Sect B, 52, 540, 10.1016/0168-583X(90)90473-8 · DOI
  16. Day, 1994, Biological chemistry of aluminum studied using 26Al and accelerator mass spectrometry, Nucl Instr Meth Phys Res, 92, 463, 10.1016/0168-583X(94)96055-0 · DOI
  17. Fifield, 1997, Study of the kinetics of aluminum absorption and excretion in humans, Dept Nucl Phys Annu Rep, 97
  18. Priest, 1998, Industry-sponsored studies on the biokinetics and bioavailability of aluminum in man, Health Aluminum Ind, 105
  19. Kinnunen, 1991, On the principles of functional ordering in biological membranes, Chem Phys Lipids, 57, 375, 10.1016/0009-3084(91)90087-R · DOI
  20. Abreo, 1989, Application of an erythrocyte aluminium assay in the diagnosis of aluminium-associated microcytic anemia in patients undergoing dialysis and response to deferoxamine therapy, J Lab Clin Med, 113, 50
  21. Wills, 1983, Aluminium poisoning:dialysis encephalopathy, osteomalacia, and anaemia, Lancet, 2, 29, 10.1016/S0140-6736(83)90014-4 · DOI
  22. Eschbach, 1985, Anaemia of end-stage renal disease (ESRD), Kidney Int, 28, 1, 10.1038/ki.1985.109 · DOI
  23. Altmann, 1988, Aluminium chelation therapy in dialysis patients: evidence for inhibition of haemoglobin synthesis by low levels of aluminium, Lancet, 1, 1012, 10.1016/S0140-6736(88)91840-5 · DOI
  24. Rabini, 2002, Reduced susceptibility to peroxidation of erythrocyte membranes from centenarians, Exp Gerontol, 3, 657, 10.1016/S0531-5565(02)00006-2 · DOI
  25. Dodge, 1963, The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes, Arch Biochem Biophys, 100, 119, 10.1016/0003-9861(63)90042-0 · DOI
  26. Lowry, 1951, Protein measurement with the Folin phenol reagent, J Biol Chem, 193, 265, 10.1016/S0021-9258(19)52451-6 · DOI
  27. Strauss, 1988, Malonaldehyde formation is not a suitable screening test to detect oxidation in human neutrophils, J Clin Pathol, 34, 800, 10.1136/jcp.34.7.800 · DOI
  28. Kuhry, 1985, Plasma membrane fluidity measurements on whole living cells by fluorescence anisotropy of trimethylammoniumdiphenylhexatriene, Biochim Biophys Acta, 845, 60, 10.1016/0167-4889(85)90055-2 · DOI
  29. Engel, 1981, Values for and significance of order parameters and “cone angles” of fluorophore rotation in lipid bilayers, Biochemistry, 20, 7338, 10.1021/bi00529a003 · DOI
  30. Cranney, 1983, Fluorescence lifetime and quenching studies on some interesting diphenilhexatriene membrane probes, BBA, 735, 418, 10.1016/0005-2736(83)90156-6 · DOI
  31. Parasassi, 1990, Phase fluctuation in phospholipid membranes revealed by laurdan fluorescence, Biophys J, 57, 1179, 10.1016/S0006-3495(90)82637-0 · DOI
  32. Galla, 1974, Lateral diffusion in the hydrophobic region of membranes: use of pyrene excimers as optical probes, Biochim Biophys Acta, 339, 103, 10.1016/0005-2736(74)90336-8 · DOI
  33. Moin, 1986, Simple and specific method detection of glutathione peroxidase activity in erythrocytes, Lab Sci, 12, 724
  34. Kostuk, 1990, Simple and specific method detection of superoxide dismutase activity based on reaction of quercetine, Quest Med Chem, 36, 88
  35. Koroluk, 1988, Method detection of catalase activity, Lab Sci, 1, 16
  36. Board, 1981, Transport of glutathione S-conjugate from human erythrocytes, FEBS Lett, 124, 163, 10.1016/0014-5793(81)80127-5 · DOI
  37. Habig, 1974, Glutathione S-transferases. The first enzymatic step in mercapturic acid formation, J Biol Chem, 249, 7130, 10.1016/S0021-9258(19)42083-8 · DOI
  38. Wahllander, 1979, GlutathioneS-coniugate formation from 1-chloro-2,4-dinitrobenzene and biliaryS-coniugate excretion in the perfused rat liver, Eur J Biochem, 96, 441, 10.1111/j.1432-1033.1979.tb13056.x · DOI
  39. Proudfoot, 2009, Aluminium and zinc phosphide poisoning, Clin Toxicol, 47, 89, 10.1080/15563650802520675 · DOI
  40. Priest, 1990, The distribution and behavior of metals in the skeleton and body: studies with bone-seeking radionuclides, Trace Met Fluoride Bones Teeth, 83
  41. Tamada, 2004, Fluorimetric determination of aluminum in human serum and whole blood, Bunseki Kagaku, 53, 435, 10.2116/bunsekikagaku.53.435 · DOI
  42. Lukyanenko, 2010, Aluminum ions influence on biophysics parameters of erythrocyte membranes, Proc Natl Acad Sci Belarus-Biol Sci, 2, 52
  43. Abreo, 1990, Aluminum inhibits hemoglobin synthesis but enhance iron uptake in Friend erythroleukemia cells, Kidney Int, 37, 677, 10.1038/ki.1990.33 · DOI
  44. Iacopetta, 1983, The kinetics of transferrin endocytosis and iron uptake from transferrin in rabbit reticulocytes, J Biol Chem, 258, 9108, 10.1016/S0021-9258(17)44637-0 · DOI
  45. Kuhry, 1983, TMA-DPH: a suitable fluorescence polarization probe for specific plasma membrane fluidity studies in intact living cells, Cell Biophys, 5, 129, 10.1007/BF02796139 · DOI
  46. Parasassi, 1991, Quantitation of lipid phases in phospholipid vesicles by the generalized polarization of laurdan fluorescence, Biophys J, 60, 179, 10.1016/S0006-3495(91)82041-0 · DOI
  47. Parasassi, 1994, Influence of cholesterol on phospholipid bilayers phase domains as detected by laurdan fluorescence, Biophys J, 66, 120, 10.1016/S0006-3495(94)80763-5 · DOI
  48. Bulat, 2008, Lipid peroxidation and antioxidative enzyme activity in erythrocytes of workers occupationally exposed to aluminium, Arh Hig Rada Toksikol, 59, 81, 10.2478/10004-1254-59-2008-1853 · DOI
  49. Exley, 2004, The pro-oxidant activity of aluminum, Free Radic Biol Med, 36, 380, 10.1016/j.freeradbiomed.2003.11.017 · DOI
  50. Mujika, 2011, Pro-oxidant activity of aluminium: stabilization of the aluminium superoxide radical ion, J Phys Chem, 115, 6717, 10.1021/jp203290b · DOI
  51. Kumar, 2009, Aluminium neurotoxicity: neurobehavioural and oxidative aspects, Arch Toxicol, 83, 965, 10.1007/s00204-009-0455-6 · DOI
  52. Gonzales, 2004, Biliary secretory function in rats chronically intoxicated with aluminum, Toxicol Sci, 79, 189, 10.1093/toxsci/kfh085 · DOI
  53. Suwalsky, 2001, Effects of AlCl3 on toad skin, human erythrocytes, and model cell membranes, Brain Res Bull, 55, 205, 10.1016/S0361-9230(01)00505-6 · DOI
  54. Vota, 2012, Oxidative stress due to aluminium exposure induces eryptosis which is prevented by erythropoietin, J Cell Biochem, 10.1002/jcb.24026 · DOI
  55. Jin, 2010, Detection of eythrocytes influenced by aging and type 2 diabetes using atomic force microscope, Biochem Biophys Res Commun, 391, 1698, 10.1016/j.bbrc.2009.12.133 · DOI
  56. Stolz, 2009, Adhesively-tensed cellmembranes: lysis kinetics and atomic force microscopy probing, Biophys J, 85, 2746
  57. Muller, 2008, Atomic force microscopy as a multifunctional molecular toolbox in nanobiotechnology, Nat Nanotechnol, 3, 261, 10.1038/nnano.2008.100 · DOI
  58. Khairullina AYa, 2008, Study of optical and nanostructural metal-induced changes in erythrocyte membranes by scattering and atomic force microscopy, Opt Spectrosc, 105, 154, 10.1134/S0030400X08070242 · DOI

Cited by

Sorted by citations

  • Aluminium toxicosis: a review of toxic actions and effects

    Igbokwe, I. O., Igwenagu, E., & Igbokwe, N. A. (2019) · Interdisciplinary Toxicology · doi:10.2478/intox-2019-0007 · Cited by 395

    “The additional causes of anemia appear to be multi-factorial and include defective hemoglobin production due to inhibition of the enzymes of heme synthesis, altered erythrocyte membrane structure and fragility, shortening of red blood cell life span due to eryptotic and oncotic injuries, and inadequate iron utilizatio…”
    BackgroundInfluential

Metadata

Authors
Lukyanenko, L. M., Skarabahatava, A. S., Slobozhanina, E. I., Kovaliova, S. A., Falcioni, M. L., & Falcioni, G.
Affiliations
  • National Academy of Sciences of Belarus (BY)
  • Università di Camerino (IT)
Corresponding author
Falcioni, Giancarlo
ORCID
Kovaliova, Svetlana Anatolievna
Venue
Journal of Trace Elements in Medicine and Biology
Publisher
Elsevier BV
Published
2013-04
Volume
27
Issue
2
Pages
160-167
ISSN
0946-672X (ISSN-L)
DOI
10.1016/j.jtemb.2012.10.003
OpenAlex
W2084883559
Cited by
34
References
1
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 3 · 2015: 8 · 2014: 3
FWCI
4.02
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Trace Elements in Medicine and Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Unicam Scientific Publications (University of Camerino) (submittedVersion)
Funders
Belarusian Republican Foundation for Fundamental Research
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
  • Health Sciences › Medicine › Physiology (medical) › Erythrocyte Function and Pathophysiology
Keywords
aluminum toxicity, aluminum chloride, erythrocyte membrane, lipid bilayers, fluorescence anisotropy, TMA-DPH, Laurdan, lipid peroxidation, antioxidant enzymes, superoxide dismutase, catalase, glutathione peroxidase, atomic force microscopy
MeSH terms
Aluminum Chloride, Adult, Antioxidants, Biological Transport, Chlorides, Diphenylhexatriene, Erythrocyte Membrane, Fluorescence Polarization, Glutathione, Humans, Middle Aged, Lipid Peroxidation, Aluminum Compounds, Microscopy, Atomic Force

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