Antiphospholipid antibody solid phase–based assays: problems and proposed solutions for the 2023 ACR/EULAR classification criteria for antiphospholipid syndrome
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The choice of 40 units as the cut-off is questionable.
“In addition, as pinpointed by other authors [3, 4], the choice of 40 units as the cut-off is questionable.”
From Insights into the 2023 ACR/EULAR antiphospholipid syndrome classification criteria: findings from a cohort of 205 patients with primary APS (2025) · cites this paper as [3]
The 99th percentile may vary depending on the ELISA supplier and should be determined locally.
“Huisman et al. [3] stated that it seems more convincing to consider the 99th percentile, which may vary depending on the ELISA supplier and which should be determined locally.”
From Insights into the 2023 ACR/EULAR antiphospholipid syndrome classification criteria: findings from a cohort of 205 patients with primary APS (2025) · cites this paper as [3]
Different results were obtained with the same sample depending on the choice of ELISA method, challenging the defensibility of a fixed cut-off.
“In fact, different results were obtained with the same sample depending on the choice of ELISA method, challenging the defensibility of a ‘fixed’ cut off.”
From Insights into the 2023 ACR/EULAR antiphospholipid syndrome classification criteria: findings from a cohort of 205 patients with primary APS (2025) · cites this paper as [3]
Cited by
Sorted by citations
Devreese, K. M. J., Bertolaccini, M. L., Branch, D. W., de Laat, B., Erkan, D., Favaloro, E. J., Pengo, V., Ortel, T. L., Wahl, D., & Cohen, H. (2025) · Journal of Thrombosis and Haemostasis · doi:10.1016/j.jtha.2024.10.022 · Cited by 92 · see citing works
Zen, M., Tonello, M., Carta, F., Calligaro, A., Favaro, M., Del Ross, T., Hulej, G., Rahmé, Z., Ruffatti, A., & Doria, A. (2025) · Rheumatology · doi:10.1093/rheumatology/keae665 · Cited by 7 · see citing works
- Authors
- Huisman, A., Urbanus, R. T., & Meijer, P.
- Affiliations
- Utrecht University (NL)
- Corresponding author
- Huisman, Albert
- Venue
- Journal of Thrombosis and Haemostasis
- Publisher
- Elsevier BV
- Published
- 2024-03
- Volume
- 22
- Issue
- 3
- Pages
- 874-876
- ISSN
- 1538-7836 (ISSN-L)
- OpenAlex
- W4390129351
- Cited by
- 10
- References
- 0
- Citations by year
- 2025: 3 · 2024: 7
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Thrombosis and Haemostasis (publishedVersion)
- PubMed (publishedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vasculitis and related conditions
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Keywords
- antiphospholipid syndrome, antiphospholipid antibodies, solid-phase immunoassay, ELISA, anticardiolipin antibodies, anti-beta2-glycoprotein I antibodies, laboratory criteria
- MeSH terms
- Humans, Sensitivity and Specificity, Antiphospholipid Syndrome, Antibodies, Antiphospholipid
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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