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Cited by 344

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Third-Line Nivolumab Monotherapy in Recurrent SCLC: CheckMate 032

Open access
Ready, Neal, Farago, Anna F., de Braud, Filippo, Atmaca, Akin, Hellmann, Matthew D., Schneider, Jeffrey G., Spigel, David R., Moreno, Victor, Chau, Ian, Hann, Christine L., Eder, Joseph Paul, Steele, Nicola L., Pieters, Anne, Fairchild, Justin, Antonia, Scott J.·2019·Journal of Thoracic Oncology
DOI 10.1016/j.jtho.2018.10.003
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Abstract

INTRODUCTION: For patients with recurrent SCLC, topotecan remains the only approved second-line treatment, and the outcomes are poor. CheckMate 032 is a phase 1/2, multicenter, open-label study of nivolumab or nivolumab plus ipilimumab in SCLC or other advanced/metastatic solid tumors previously treated with one or more platinum-based chemotherapies. We report results of third- or later-line nivolumab monotherapy treatment in SCLC. METHODS: In this analysis, patients with limited-stage or extensive-stage SCLC and disease progression after two or more chemotherapy regimens received nivolumab monotherapy, 3 mg/kg every 2 weeks, until disease progression or unacceptable toxicity. The primary end point was objective response rate. Secondary end points included duration of response, progression-free survival, overall survival, and safety. RESULTS: Between December 4, 2013, and November 30, 2016, 109 patients began receiving third- or later-line nivolumab monotherapy. At a median follow-up of 28.3 months (from first dose to database lock), the objective response rate was 11.9% (95% confidence interval: 6.5-19.5) with a median duration of response of 17.9 months (range 3.0-42.1). At 6 months, 17.2% of patients were progression-free. The 12-month and 18-month overall survival rates were 28.3% and 20.0%, respectively. Grade 3 to 4 treatment-related adverse events occurred in 11.9% of patients. Three patients (2.8%) discontinued because of treatment-related adverse events. CONCLUSIONS: Nivolumab monotherapy provided durable responses and was well tolerated as a third- or later-line treatment for recurrent SCLC. These results suggest that nivolumab monotherapy is an effective third- or later-line treatment for this patient population.

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Metadata

Authors
Ready, N., Farago, A. F., de Braud, F., Atmaca, A., Hellmann, M. D., Schneider, J. G., Spigel, D. R., Moreno, V., Chau, I., Hann, C. L., Eder, J. P., Steele, N. L., Pieters, A., Fairchild, J., & Antonia, S. J.
Venue
Journal of Thoracic Oncology
Publisher
Elsevier BV
Published
2019-02
Volume
14
Issue
2
Pages
237-244
ISSN
1556-0864 (ISSN-L)
DOI
10.1016/j.jtho.2018.10.003
OpenAlex
W2897191292
Cited by
344
References
29
FWCI
15.42
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Third-Line Nivolumab Monotherapy in Recurrent SCLC: CheckMate 032. https://app.cochat.ai/papers/10.1016/j.jtho.2018.10.003
The paper
Ready, N., Farago, A. F., de Braud, F., Atmaca, A., Hellmann, M. D., Schneider, J. G., Spigel, D. R., Moreno, V., Chau, I., Hann, C. L., Eder, J. P., Steele, N. L., Pieters, A., Fairchild, J., & Antonia, S. J. (2019). Third-Line Nivolumab Monotherapy in Recurrent SCLC: CheckMate 032. Journal of Thoracic Oncology. https://doi.org/10.1016/j.jtho.2018.10.003

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.