The DOI matches its Crossref record.
ES28.04 Emerging Mechanisms to Target KRAS Directly
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mRNA-5671/V941 targets the G12D, G12V, G13D and G12C KRAS variants and has a strong mechanistic rationale.
“mRNA-5671/V941, a liquid nanoparticle-formulated mRNA neoantigen vaccine that targets the G12D, G12V, G13D and G12C variants of KRAS, has been developed and has strong mechanistic rationale196.”
From The current state of the art and future trends in RAS-targeted cancer therapies (2022) · cites this paper as [196]
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The current state of the art and future trends in RAS-targeted cancer therapies
Punekar, S. R., Velcheti, V., Neel, B. G., & Wong, K.-K. (2022) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00671-9 · Cited by 549
Metadata
- Authors
- Nagasaka, M.
- Affiliations
- The Barbara Ann Karmanos Cancer Institute (US)
- Corresponding author
- Nagasaka, M.
- ORCID
- Nagasaka, M.
- Venue
- Journal of Thoracic Oncology
- Publisher
- Elsevier BV
- Published
- 2021-03
- Volume
- 16
- Issue
- 3
- Pages
- S96-S97
- ISSN
- 1556-0864 (ISSN-L)
- OpenAlex
- W3138837374
- Cited by
- 15
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 3 · 2021: 1
- Type
- conference abstract
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Thoracic Oncology (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Keywords
- KRAS mutation, non-small cell lung cancer, KRAS G12C inhibitors, covalent KRAS inhibitor, PROTACs, CRISPR/Cas9, adoptive T cell therapy, cancer vaccines, KRAS-targeted therapy
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