The DOI matches its Crossref record; 180 of the 184 references it cites were found in a registry or an index.
Immune Checkpoint Inhibitors in EGFR-Mutated NSCLC: Dusk or Dawn?
Open accessAbstract
Although immune checkpoint inhibitors (ICIs) that target programmed cell death protein-1/programmed cell death ligand-1 axis have significantly shifted the treatment paradigm in advanced NSCLC, clinical benefits of these agents are limited in patients with EGFR-mutated NSCLC. Several predictive biomarkers (e.g., programmed cell death ligand-1 expression, tumor mutation burden), which have been validated in EGFR-wild type NSCLC, however, are not efficacious in EGFR-mutated tumors, suggesting the unique characteristics of tumor microenvironment of EGFR-mutated NSCLC. Here, we first summarized the clinical evidence on the efficacy of ICIs in patients with EGFR-mutated NSCLC. Then, the cancer immunogram features of EGFR-mutated NSCLC was depicted to visualize the state of cancer-immune system interactions, including tumor foreignness, tumor sensitivity to immune effectors, metabolism, general immune status, immune cell infiltration, cytokines, and soluble molecules. We further discussed the potential subpopulations with EGFR mutations that could benefit from ICI treatment. Lastly, we put forward future strategies to adequately maximize the efficacy of ICI treatment in patients with EGFR-mutated NSCLC in the upcoming era of combination immunotherapies.
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“Generally believed, the efficacy of α-PD-1/PD-L1 is modest in EGFR-mutated patients [184, 185]”
From Combination strategies with PD-1/PD-L1 blockade: current advances and future directions (2022) · cites this paper as [184]
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Cites
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Cited by
Sorted by citations
Combination strategies with PD-1/PD-L1 blockade: current advances and future directions
Yi, M., Zheng, X., Niu, M., Zhu, S., Ge, H., & Wu, K. (2022) · Molecular Cancer · doi:10.1186/s12943-021-01489-2 · Cited by 1,445
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Self-citation
Metadata
- Authors
- Qiao, M., Jiang, T., Liu, X., Mao, S., Zhou, F., Li, X., Zhao, C., Chen, X., Su, C., Ren, S., & Zhou, C.
- Affiliations
- Tongji University (CN)
- Corresponding author
- Zhou, Caicun
- ORCID
- Venue
- Journal of Thoracic Oncology
- Publisher
- Elsevier BV
- Published
- 2021-08
- Volume
- 16
- Issue
- 8
- Pages
- 1267-1288
- ISSN
- 1556-0864 (ISSN-L)
- OpenAlex
- W3159640891
- Cited by
- 186
- References
- 184
- Citations by year
- 2026: 24 · 2025: 39 · 2024: 39 · 2023: 35 · 2022: 35 · 2021: 14
- FWCI
- 3.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Thoracic Oncology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81871865, 81972167)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
- Keywords
- immune checkpoint inhibitors, EGFR-mutant non-small cell lung cancer, PD-1/PD-L1 axis, predictive biomarkers, tumor mutational burden, PD-L1 expression, tumor microenvironment, immune cell infiltration, cytokines, combination immunotherapy, treatment response
- MeSH terms
- Immune Checkpoint Inhibitors, Carcinoma, Non-Small-Cell Lung, Humans, Lung Neoplasms, Mutation, Biomarkers, Tumor, Tumor Microenvironment, B7-H1 Antigen, ErbB Receptors
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