Myeloid-derived-suppressor cells as regulators of the immune system

Gabrilovich, Dmitry I.; Nagaraj, Srinivas

doi:10.1038/nri2506

Cited by 6,753Immune cells in cancerImmunotherapy and Immune ResponsesPhagocytosis and Immune Regulation

Myeloid-derived-suppressor cells as regulators of the immune system

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Gabrilovich, Dmitry I., Nagaraj, Srinivas·2009·Nature Reviews Immunology

DOI 10.1038/nri2506PMC PMC2828349

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Abstract

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that expand during cancer, inflammation and infection, and that have a remarkable ability to suppress T-cell responses. These cells constitute a unique component of the immune system that regulates immune responses in healthy individuals and in the context of various diseases. In this Review, we discuss the origin, mechanisms of expansion and suppressive functions of MDSCs, as well as the potential to target these cells for therapeutic benefit.

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CD11b+Gr1+ myeloid cells are a heterogeneous group with known roles in tumor angiogenesis and T cell immunosuppression.
“CD11b+Gr1+ myeloid cells are a heterogeneous group with previously identified roles in tumor angiogenesis and T cell immunosuppression (Gabrilovich and Nagaraj, 2009; Ostrand-Rosenberg and Sinha, 2009; Shojaei et al., 2007).”
From A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis (2012) · cites this paper as Gabrilovich and Nagaraj, 2009
Myeloid-derived suppressor cells suppress T-cell activity.
“MDSCs play a role in the immune system through their suppressive action on T cells (116).”
From The Role of Immune and Inflammatory Cells in Idiopathic Pulmonary Fibrosis (2018) · cites this paper as [116]
MDSCs attenuate Teff and NK cell activity via arginase 1, iNOS, ROS, and peroxynitrite, regulate Treg differentiation, and induce immunosuppressive macrophages.
“Through different mediators such as arginase 1, Inducible nitric oxide synthase (iNOS), reactive oxygen species (ROS), and peroxynitrite, MDSCs attenuate the activity of Teffs and NK cells (Gabrilovich and Nagaraj, 2009), regulate the differentiation of Tregs (Huang et al., 2006), and induce an immunosuppressive phenotype in macrophages (Sinha et al., 2007).”
From Hallmarks of response, resistance, and toxicity to immune checkpoint blockade (2021) · cites this paper as Gabrilovich and Nagaraj, 2009
Immunosuppressive myeloid cells can be differentiated/polarized for anti-tumor phenotypes.
“On a similar note, immunosuppressive myeloid cells can be differentiated/polarized for anti‐tumor phenotypes [88, 89].”
From Tumor microenvironment signaling and therapeutics in cancer progression (2023) · cites this paper as [89]

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[99]Fricke I Treatment of cancer patients with VEGF-Trap overcomes defects in DC differentiation but is insufficient to improve antigen-specific immune responses Clin Cancer Res 13 4840 4848 2007 17699863

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“…system by targeting Gr-1 + CD11b + cells or the cytokines that regulate their differentiation. comprised of precursors to macrophages, dendritic cells, and granulocytes at earlier stages of differentiation (Gabrilovich and Nagaraj, 2009; Ostrand-Rosenberg and Sinha, 2009; Peranzoni et al., 2010).”
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Self-citation

Authors: Gabrilovich, D. I., & Nagaraj, S.
Affiliations: University of South Florida (US)
Corresponding author: Gabrilovich, Dmitry I.
ORCID: Gabrilovich, Dmitry I.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2009-03
Volume: 9
Issue: 3
Pages: 162-174
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri2506
PMC: PMC2828349
OpenAlex: W2004150448
Cited by: 6,753
References: 133
Citations by year: 2026: 267 · 2025: 335 · 2024: 384 · 2023: 418 · 2022: 488 · 2021: 537 · 2020: 498 · 2019: 384 · 2018: 433 · 2017: 409 · 2016: 405 · 2015: 422 · 2014: 403 · 2013: 430 · 2012: 378
FWCI: 24.43
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Repositorio Institucional E-DocUR (Universidad Del Rosario) (submittedVersion)
Funders: National Cancer Institute (R01CA084488, R01CA100062)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Keywords: myeloid-derived suppressor cells, T cell suppression, tumor immunosuppression, inflammation, infection, immune regulation
MeSH terms: Animals, Cell Movement, Communicable Diseases, Humans, Immune System, Immune Tolerance, Inflammation, Lymphocyte Activation, Neoplasms, Stem Cells, T-Lymphocytes, Myeloid Cells, Myelopoiesis, T-Lymphocytes, Regulatory

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Myeloid-derived-suppressor cells as regulators of the immune system

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