The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Effect of Testosterone Solution 2% on Testosterone Concentration, Sex Drive and Energy in Hypogonadal Men: Results of a Placebo Controlled Study
Abstract
PURPOSE: We determined the effect of testosterone solution 2% on total testosterone level and the 2 symptoms of hypogonadism, sex drive and energy level. MATERIALS AND METHODS: This was a randomized, multicenter, double-blind, placebo controlled, 16-week study to compare the effect of testosterone and placebo on the proportion of men with a testosterone level within the normal range (300 to 1,050 ng/dl) upon treatment completion. We also assessed the impact of testosterone on sex drive and energy level measured using SAID (Sexual Arousal, Interest and Drive scale) and HED (Hypogonadism Energy Diary), respectively. A total of 715 males 18 years old or older with total testosterone less than 300 ng/dl and at least 1 symptom of testosterone deficiency (decreased energy and/or decreased sexual drive) were randomized to 60 mg topical testosterone solution 2% or placebo once daily. RESULTS: Of study completers 73% in the testosterone vs 15% in the placebo group had a testosterone level within the normal range at study end point (p <0.001). Participants assigned to testosterone showed greater baseline to end point improvement in SAID scores (low sex drive subset p <0.001 vs placebo) and HED scores (low energy subset p = 0.02 vs placebo, not significant at prespecified p <0.01). No major adverse cardiovascular or venous thrombotic events were reported in the testosterone group. The incidence of increased hematocrit was higher with testosterone vs placebo (p = 0.04). CONCLUSIONS: Once daily testosterone solution 2% for 12 weeks was efficacious in restoring normal testosterone levels and improving sexual drive in hypogonadal men. Improvement was also seen in energy levels on HED though not at the prespecified p <0.01. No new safety signals were identified.
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In the citing paper
“Randomized controlled trials have shown that there is not a significant increase in the rate of a prostate cancer diagnosis in older, testosterone deficient men who were treated with testosterone compared to placebo.”
From Evaluation and Management of Testosterone Deficiency: AUA Guideline (2018) · cites this paper as [30]
In the citing paper
“The evidence is less conclusive as to whether or not testosterone therapy improves cognitive function, 28 measures of diabetes, 29 energy, 30 fatigue, 30 lipid profiles, 29 and quality of life measures. 31”
From Evaluation and Management of Testosterone Deficiency: AUA Guideline (2018) · cites this paper as [30]
In the citing paper
“there is accumulating evidence against a link between testosterone therapy and prostate cancer development.”
From Evaluation and Management of Testosterone Deficiency: AUA Guideline (2018) · cites this paper as [30]
In the citing paper
“Though testosterone therapy improves bone mineral density, lean body mass, erectile function, and anemia, there is inconclusive evidence on the benefits of testosterone therapy on cognitive function, energy levels, blood glucose or lipid levels, and controversy remains around whether testosterone therapy affects the risk of cardiovascular events (6-13).”
From Non-testosterone management of male hypogonadism: an examination of the existing literature (2020) · cites this paper as [10]
In the citing paper
“Though testosterone therapy improves bone mineral density, lean body mass, erectile function, and anemia, there is inconclusive evidence on the benefits of testosterone therapy on cognitive function, energy levels, blood glucose or lipid levels, and controversy remains around whether testosterone therapy affects the risk of cardiovascular events (6-13).”
From Non-testosterone management of male hypogonadism: an examination of the existing literature (2020) · cites this paper as [10]
In the citing paper
“Though testosterone therapy improves bone mineral density, lean body mass, erectile function, and anemia, there is inconclusive evidence on the benefits of testosterone therapy on cognitive function, energy levels, blood glucose or lipid levels, and controversy remains around whether testosterone therapy affects the risk of cardiovascular events (6-13).”
From Non-testosterone management of male hypogonadism: an examination of the existing literature (2020) · cites this paper as [10]
Citations
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Increased Risk of Non-Fatal Myocardial Infarction Following Testosterone Therapy Prescription in Men
Finkle, W. D., Greenland, S., Ridgeway, G. K., Adams, J. L., Frasco, M. A., Cook, M. B., Fraumeni, J. F., & Hoover, R. N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085805 · Cited by 735
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Effects of testosterone on sexual function in men: results of a meta‐analysis
Isidori, A. M., Giannetta, E., Gianfrilli, D., Greco, E. A., Bonifacio, V., Aversa, A., Isidori, A., Fabbri, A., & Lenzi, A. (2005) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2005.02350.x · Cited by 492
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Testosterone Therapy: a Panacea for Sexual Dysfunction in Men?
Helo, S., Thomas, P., & Tadros, N. N. (2018) · Current Sexual Health Reports · doi:10.1007/s11930-018-0151-8
Erythrocytosis in Patients on Testosterone Therapy
Desai, A. P., & Go, R. S. (2021) · Springer eBooks · doi:10.1007/978-3-030-77111-9_2
Неспецифический реактивный гепатит у больных желчнокаменной болезнью
Бычков, С. А. (2007) · Electronic Kharkiv National University Institutional Repository (Kharkiv National University)
Testosterone Therapy in Oncologic Patients
Solsrud, E., Louters, M. M., & Pearlman, A. M. (2023) · Current Sexual Health Reports · doi:10.1007/s11930-022-00351-w
Cardiovascular safety of testosterone replacement therapy
Čapka, D. (2023) · Urologie pro praxi · doi:10.36290/uro.2023.070
Unveiling The Effect of Testosterone Therapy on Sexual Dysfunction
Wijaya, P. G. P. M., Putra, I. G. A. T. S., & Sanjaya, I. G. W. (2024) · Journal Of Social Research · doi:10.55324/josr.v3i2.1948
Reproductive and nonreproductive actions of testosterone
Gagliano‐Jucá, T., Jain, A., Jasuja, R., & Bhasin, S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-13825-6.00198-9
Braga, M., Travison, T. G., Taplin, M., Habtemariam, D. A., Dufour, A. B., McDonnell, M. E., Simonson, D. C., Lin, A. P., Borwick, E., Chammas, L., et al. (2026) · Andrology · doi:10.1111/andr.70194
Endocrine Support for the Aesthetic Patient
Parsa, A. A., & Parsa, F. D. (2026) · Springer eBooks · doi:10.1007/978-3-032-03840-1_46
Metadata
- Authors
- Brock, G., Heiselman, D., Maggi, M., Kim, S. W., Rodríguez Vallejo, J. M., Behre, H. M., McGettigan, J., Dowsett, S. A., Hayes, R. P., Knorr, J., Ni, X., & Kinchen, K.
- Affiliations
- Western University (CA)
- Eli Lilly (United States) (US)
- University of Florence (IT)
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- Urology Service, Hospital Infanta Leonor, Madrid, Spain
- University Hospital in Halle (DE)
- Quality of Life Medical and Research Center, Tucson, Arizona
- Venue
- Journal of Urology
- Published
- 2016-03
- Volume
- 195
- Issue
- 3
- Pages
- 699-705
- ISSN
- 0022-5347 (ISSN-L)
- 1527-3792
- OpenAlex
- W1818591415
- Cited by
- 109
- References
- 30
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 12 · 2023: 7 · 2022: 11 · 2021: 12 · 2020: 9 · 2019: 10 · 2018: 13 · 2017: 13 · 2016: 10
- FWCI
- 10.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Urology (publishedVersion)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Keywords
- testosterone replacement therapy, hypogonadism, androgen deficiency, sexual desire, energy levels, hematocrit, cardiovascular safety
- MeSH terms
- Double-Blind Method, Humans, Hypogonadism, Libido, Male, Middle Aged, Solutions, Testosterone
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