Transdermal Testosterone Gel Improves Sexual Function, Mood, Muscle Strength, and Body Composition Parameters in Hypogonadal Men

Wang, C.

doi:10.1210/jc.85.8.2839

Cited by 403Hormonal and reproductive studiesMenopause: Health Impacts and TreatmentsSexual function and dysfunction studies

Transdermal Testosterone Gel Improves Sexual Function, Mood, Muscle Strength, and Body Composition Parameters in Hypogonadal Men

Wang, C.·2000·Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jc.85.8.2839

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Effects of testosterone on sexual interest appear after 3 weeks and plateau at 6 weeks, with no further increments expected beyond that.
“Effects on sexual interest appear after 3 weeks plateauing at 6 weeks, with no further increments expected beyond.”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [14]
Effects of testosterone on erythropoiesis are evident at 3 months and peak at 9-12 months.
“Effects on erythropoiesis are evident at 3 months, peaking at 9–12 months.”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [14]
Changes in fat mass, lean body mass, and muscle strength stabilize at 6-12 months of testosterone treatment.
“Changes in fat mass, lean body mass, and muscle strength occur within 12–16 weeks, stabilize at 6–12 months, but can marginally continue over years.”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [14]
Upon testosterone administration, fat mass decreases and lean body mass increases, with total body weight often but not always showing no major changes.
“Upon testosterone administration there is a decrease in fat mass and an increase in lean body mass and the net result is often, but not always, that total body weight does not show major changes.”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [14]
Effects of testosterone on muscle strength are demonstrable after 12-20 weeks, and maximum effects are attained after 6 or 12 months depending on the achieved testosterone levels.
“It can be concluded that the effects of testosterone on muscle strength are demonstrable after 12–20 weeks and that depending on the achieved testosterone levels, the maximum effects are attained after 6 or 12 months.”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [14]

In 180 days of treatment with a 1% testosterone gel preparation (50 or 100 mg/day), mean leg press muscle strength increases by 90 days and does not improve further at 180 days.
“In a study of 180 days of treatment with a 1% testosterone gel preparation (50 or 100 mg/day, contained in 5 or 10 g gel), mean muscle strength in the leg press exercise increased by 90 days and had not improved further at 180 days (14).”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [14]
Effects of testosterone on libido, sexual desire, sexual thoughts and fantasies, and satisfaction with sexual life manifest after 3 weeks or 30 days.
“Effects on libido, sexual desire, sexual thoughts and fantasies and satisfaction with sexual life manifest themselves rather rapidly: after 3 weeks (68) or 30 days (14).”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [14]
The percentage of full erections, sexual performance, and satisfaction with erections increase after 30 days of testosterone treatment.
“An increase in percentage of full erections and sexual performance and satisfaction with erections was noticed after 30 days (14, 69)”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [14]
Increase in good mood and decrease in bad mood occur after 3 weeks or 30 days of testosterone treatment.
“Increase in good mood and a decrease in bad mood were noted after 3 weeks (68) or after 30 days (14).”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [14]
Increase in motivation occurs after 30 days of testosterone treatment and is maintained thereafter.
“There was also an increase in motivation after 30 days which was maintained thereafter (14).”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [14]
Effects of testosterone on red blood cell formation (hemoglobin and hematocrit) are dose dependent.
“The effects of testosterone on red blood cell formation (hemoglobin and hematocrit) are dose dependent (14, 82, 83) while higher age is also a factor (44).”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [14]

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Authors: Wang, C.
Corresponding author: Wang, C.
Venue: Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 2000-08-01
Volume: 85
Issue: 8
Pages: 2839-2853
ISSN: 0021-972X (ISSN-L)
DOI: 10.1210/jc.85.8.2839
OpenAlex: W4246208375
Cited by: 359
References: 0
Citations by year: 2026: 1 · 2025: 2 · 2024: 6 · 2023: 8 · 2022: 9 · 2021: 7 · 2020: 7 · 2019: 5 · 2018: 9 · 2017: 10 · 2016: 7 · 2015: 9 · 2014: 8 · 2013: 21 · 2012: 16
FWCI: 18.67
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
Keywords: transdermal testosterone gel, hypogonadism, male hypogonadism, testosterone replacement therapy, sexual function, mood, muscle strength, body composition

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Transdermal Testosterone Gel Improves Sexual Function, Mood, Muscle Strength, and Body Composition Parameters in Hypogonadal Men

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