Cited by 595Cardiac, Anesthesia and Surgical OutcomesLipoproteins and Cardiovascular HealthCardiac and Coronary Surgery Techniques

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Reduction in cardiovascular events after vascular surgery with atorvastatin: a randomized trial

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Durazzo, Anai E.S, Machado, Fábio S, Ikeoka, Dimas T, De Bernoche, Cláudia, Monachini, Maristela C, Puech-Leão, Pedro, Caramelli, Bruno·2004·Journal of Vascular Surgery

DOI 10.1016/j.jvs.2004.01.004

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Abstract

Objectives This prospective, randomized, placebo-controlled, double-blind clinical trial was performed to analyze the effect of atorvastatin compared with placebo on the occurrence of a 6-month composite of cardiovascular events after vascular surgery. Cardiovascular complications are the most important cause of perioperative morbidity and mortality among patients undergoing vascular surgery. Statin therapy may reduce perioperative cardiac events through stabilization of coronary plaques.Methods One hundred patients were randomly assigned to receive 20 mg atorvastatin or placebo once a day for 45 days, irrespective of their serum cholesterol concentration. Vascular surgery was performed on average 30 days after randomization, and patients were prospectively followed up over 6 months. The cardiovascular events studied were death from cardiac cause, nonfatal myocardial infarction, unstable angina, and stroke.Results Fifty patients received atorvastatin, and 50 received placebo. During the 6-month follow-up primary end points occurred in 17 patients, 4 in the atorvastatin group and 13 in the placebo group. The incidence of cardiac events was more than three times higher with placebo (26.0%) compared with atorvastatin (8.0%; P =.031). The risk for an event was compared between the groups with the Kaplan-Meier method, as event-free survival after vascular surgery. Patients given atorvastatin exhibited a significant decrease in the rate of cardiac events, compared with the placebo group, within 6 months after vascular surgery (P =.018).Conclusion Short-term treatment with atorvastatin significantly reduces the incidence of major adverse cardiovascular events after vascular surgery.

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Authors: Durazzo, A. E. S., Machado, F. S., Ikeoka, D. T., De Bernoche, C., Monachini, M. C., Puech-Leão, P., & Caramelli, B.
Affiliations: Universidade de São Paulo (BR)
Corresponding author: Durazzo, Anai E.S
ORCID: Durazzo, Anai E.S
Machado, Fábio S
Ikeoka, Dimas T
Caramelli, Bruno
Venue: Journal of Vascular Surgery
Publisher: Elsevier BV
Published: 2004-05
Volume: 39
Issue: 5
Pages: 967-975
ISSN: 0741-5214 (ISSN-L)
DOI: 10.1016/j.jvs.2004.01.004
OpenAlex: W2030475349
Cited by: 595
References: 34
Citations by year: 2026: 4 · 2025: 3 · 2024: 12 · 2023: 11 · 2022: 6 · 2021: 15 · 2020: 19 · 2019: 11 · 2018: 17 · 2017: 18 · 2016: 27 · 2015: 23 · 2014: 36 · 2013: 27 · 2012: 33
FWCI: 33.54
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3364 d)
Locations: Journal of Vascular Surgery (publishedVersion)
PubMed (publishedVersion)
Funders: Fundação de Amparo à Pesquisa do Estado de São Paulo
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac, Anesthesia and Surgical Outcomes
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Surgery › Cardiac and Coronary Surgery Techniques
Keywords: atorvastatin, vascular surgery, perioperative cardiovascular events, statin therapy, myocardial infarction, unstable angina, stroke, cardiac mortality, event-free survival
MeSH terms: Atorvastatin, Aged, Cardiovascular Diseases, Double-Blind Method, Female, Follow-Up Studies, Heptanoic Acids, Humans, Cholesterol, LDL, Male, Patient Compliance, Postoperative Complications, Prospective Studies, Pyrroles, Risk Factors, Time Factors, Vascular Surgical Procedures, Incidence, Hydroxymethylglutaryl-CoA Reductase Inhibitors

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Reduction in cardiovascular events after vascular surgery with atorvastatin: a randomized trial

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