Statins: an essential component in the management of carotid artery disease

Paraskevas, Kosmas I.; Hamilton, George; Mikhailidis, Dimitri P.

doi:10.1016/j.jvs.2007.03.035

Cited by 77Cerebrovascular and Carotid Artery DiseasesLipoproteins and Cardiovascular HealthAcute Ischemic Stroke Management

Statins: an essential component in the management of carotid artery disease

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Paraskevas, Kosmas I., Hamilton, George, Mikhailidis, Dimitri P.·2007·Journal of Vascular Surgery

DOI 10.1016/j.jvs.2007.03.035

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Abstract

Objective We aimed to define the role of treatment using statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) in the management of patients with carotid artery disease.Literature search methods We searched PubMed for studies evaluating the effect of statins on carotid IMT and the occurrence of cerebrovascular events.Literature search results Current evidence indicates that routine statin therapy reduces carotid intima-media thickness progression and stroke risk. Additionally, statin treatment significantly reduces perioperative as well as long-term morbidity and mortality in patients undergoing carotid surgery or endovascular interventions. It would also be expected that statins would reduce coronary events in this high-risk population.Conclusions Statins should be considered as an essential component of the therapeutic approach of patients with carotid artery stenosis.

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A more recent systematic review showed significant carotid intima-media thickness regression after statin therapy.
“and a more recent systematic review also showed a significant CIMT regression after statin therapy.204”
From ESC/EAS Guidelines for the management of dyslipidaemias (2011) · cites this paper as [204]
Two systematic reviews, mostly based on retrospective nonrandomized studies, found inconclusive evidence that statin therapy reduces perioperative cardiovascular morbidity and mortality in abdominal aortic aneurysm patients.
“Two systematic reviews, 204,207 mostly based on retrospective nonrandomized studies, reported that there is still inconclusive evidence that statin therapy reduces the perioperative CV morbidity and mortality in these patients.”
From ESC/EAS Guidelines for the management of dyslipidaemias (2011) · cites this paper as [204]

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More on PROSPER
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2 of the 169 references couldn’t be matched to a known paper.

Research works printed but not linked: 5

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Authors: Paraskevas, K. I., Hamilton, G., & Mikhailidis, D. P.
Affiliations: The Royal Free Hospital (GB)
Corresponding author: Mikhailidis, Dimitri P.
ORCID: Paraskevas, Kosmas I.
Hamilton, George
Mikhailidis, Dimitri P.
Venue: Journal of Vascular Surgery
Publisher: Elsevier BV
Published: 2007-08
Volume: 46
Issue: 2
Pages: 373-386.e9
ISSN: 0741-5214 (ISSN-L)
DOI: 10.1016/j.jvs.2007.03.035
OpenAlex: W2103876289
Cited by: 77
References: 169
Citations by year: 2025: 4 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 6 · 2016: 5 · 2015: 4 · 2014: 3 · 2013: 2 · 2012: 1
FWCI: 1.58
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2213 d)
Locations: Journal of Vascular Surgery (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cerebrovascular and Carotid Artery Diseases
Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
Keywords: statins, carotid artery stenosis, carotid intima-media thickness, stroke risk, cerebrovascular events, carotid endarterectomy, coronary events
MeSH terms: Carotid Arteries, Coronary Disease, Humans, Risk Factors, Carotid Stenosis, Treatment Outcome, Practice Guidelines as Topic, Tunica Intima, Tunica Media, Risk Assessment, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Stroke

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Statins: an essential component in the management of carotid artery disease

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