Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a “Kidney Disease: Improving Global Outcomes” (KDIGO) Controversies Conference

Goodship, Timothy H.J.; Cook, H. Terence; Fakhouri, Fadi; Fervenza, Fernando C.; Frémeaux-Bacchi, Véronique; Kavanagh, David; Nester, Carla M.; Noris, Marina; Pickering, Matthew C.; Rodríguez de Córdoba, Santiago; Roumenina, Lubka T.; Sethi, Sanjeev; Smith, Richard J.H.; Alpers, Charlie E.; Appel, Gerald B.; Ardissino, Gianluigi; Ariceta, Gema; Arici, Mustafa; Bagga, Arvind; Bajema, Ingeborg M.; Blasco, Miguel; Burke, Linda; Cairns, Thomas D.; Carratala, Mireya; D'Agati, Vivette D.; Daha, Mohamed R.; De Vriese, An S.; Dragon-Durey, Marie-Agnès; Fogo, Agnes B.; Galbusera, Miriam; Gale, Daniel P.; Haller, Hermann; Johnson, Sally; Józsi, Mihály; Karpman, Diana; Lanning, Lynne; Le Quintrec, Moglie; Licht, Christoph; Loirat, Chantal; Monfort, Francisco; Morgan, B. Paul; Noël, Laure-Hélène; O'Shaughnessy, Michelle M.; Rabant, Marion; Rondeau, Eric; Ruggenenti, Piero; Sheerin, Neil S.; Smith, Jenna; Spoleti, Fabrizio; Thurman, Joshua M.

doi:10.1016/j.kint.2016.10.005

Cited by 701

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a “Kidney Disease: Improving Global Outcomes” (KDIGO) Controversies Conference

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Goodship, Timothy H.J., Cook, H. Terence, Fakhouri, Fadi, Fervenza, Fernando C., Frémeaux-Bacchi, Véronique, Kavanagh, David, Nester, Carla M., Noris, Marina, Pickering, Matthew C., Rodríguez de Córdoba, Santiago, Roumenina, Lubka T., Sethi, Sanjeev, Smith, Richard J.H., Alpers, Charlie E., Appel, Gerald B., Ardissino, Gianluigi, Ariceta, Gema, Arici, Mustafa, Bagga, Arvind, Bajema, Ingeborg M., Blasco, Miguel, Burke, Linda, Cairns, Thomas D., Carratala, Mireya, D'Agati, Vivette D., Daha, Mohamed R., De Vriese, An S., Dragon-Durey, Marie-Agnès, Fogo, Agnes B., Galbusera, Miriam, Gale, Daniel P., Haller, Hermann, Johnson, Sally, Józsi, Mihály, Karpman, Diana, Lanning, Lynne, Le Quintrec, Moglie, Licht, Christoph, Loirat, Chantal, Monfort, Francisco, Morgan, B. Paul, Noël, Laure-Hélène, O'Shaughnessy, Michelle M., Rabant, Marion, Rondeau, Eric, Ruggenenti, Piero, Sheerin, Neil S., Smith, Jenna, Spoleti, Fabrizio, Thurman, Joshua M., van de Kar, Nicole C.A.J., Vivarelli, Marina, Zipfel, Peter F.·2017·Kidney International

DOI 10.1016/j.kint.2016.10.005

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Abstract

In both atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G) complement plays a primary role in disease pathogenesis. Herein we report the outcome of a 2015 Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference where key issues in the management of these 2 diseases were considered by a global panel of experts. Areas addressed included renal pathology, clinical phenotype and assessment, genetic drivers of disease, acquired drivers of disease, and treatment strategies. In order to help guide clinicians who are caring for such patients, recommendations for best treatment strategies were discussed at length, providing the evidence base underpinning current treatment options. Knowledge gaps were identified and a prioritized research agenda was proposed to resolve outstanding controversial issues.

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Smith, R. J. H., Appel, G. B., Blom, A. M., Cook, H. T., D’Agati, V. D., Fakhouri, F., Fremeaux-Bacchi, V., Józsi, M., Kavanagh, D., Lambris, J. D., et al. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0107-2 · Cited by 409
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Brocklebank, V., Wood, K. M., & Kavanagh, D. (2018) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.00620117 · Cited by 373
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Cserhalmi, M., Papp, A., Brandus, B., Uzonyi, B., & Józsi, M. (2019) · Seminars in Immunology · doi:10.1016/j.smim.2019.101341 · Cited by 131
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Diseases of complement dysregulation-an overview
Wong, E. K. S., & Kavanagh, D. (2018) · Seminars in Immunopathology · doi:10.1007/s00281-017-0663-8 · Cited by 115
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Revisiting the role of factor H in age-related macular degeneration: Insights from complement-mediated renal disease and rare genetic variants
Tzoumas, N., Hallam, D., Harris, C. L., Lako, M., Kavanagh, D., & Steel, D. H. W. (2021) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2020.10.008 · Cited by 33
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Authors: Goodship, T. H. J., Cook, H. T., Fakhouri, F., Fervenza, F. C., Frémeaux-Bacchi, V., Kavanagh, D., Nester, C. M., Noris, M., Pickering, M. C., Rodríguez de Córdoba, S., Roumenina, L. T., Sethi, S., Smith, R. J. H., Alpers, C. E., Appel, G. B., Ardissino, G., Ariceta, G., Arici, M., Bagga, A., Bajema, I. M., Blasco, M., Burke, L., Cairns, T. D., Carratala, M., D'Agati, V. D., Daha, M. R., De Vriese, A. S., Dragon-Durey, M.-A., Fogo, A. B., Galbusera, M., Gale, D. P., Haller, H., Johnson, S., Józsi, M., Karpman, D., Lanning, L., Le Quintrec, M., Licht, C., Loirat, C., Monfort, F., Morgan, B. P., Noël, L.-H., O'Shaughnessy, M. M., Rabant, M., Rondeau, E., Ruggenenti, P., Sheerin, N. S., Smith, J., Spoleti, F., Thurman, J. M., van de Kar, N. C. A. J., Vivarelli, M., & Zipfel, P. F.
Venue: Kidney International
Publisher: Elsevier BV
Published: 2017-03
Volume: 91
Issue: 3
Pages: 539-551
ISSN: 0085-2538 (ISSN-L)
DOI: 10.1016/j.kint.2016.10.005
OpenAlex: W2565152113
Cited by: 701
References: 2
FWCI: 28.77
Type: journal article
Language: en
Open access: hybrid

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This page: CoChat. (2026). Citation check: Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a “Kidney Disease: Improving Global Outcomes” (KDIGO) Controversies Conference. https://app.cochat.ai/papers/10.1016/j.kint.2016.10.005
The paper: Goodship, T. H. J., Cook, H. T., Fakhouri, F., Fervenza, F. C., Frémeaux-Bacchi, V., Kavanagh, D., Nester, C. M., Noris, M., Pickering, M. C., Rodríguez de Córdoba, S., Roumenina, L. T., Sethi, S., Smith, R. J. H., Alpers, C. E., Appel, G. B., Ardissino, G., Ariceta, G., Arici, M., Bagga, A., . . . Zipfel, P. F. (2017). Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a “Kidney Disease: Improving Global Outcomes” (KDIGO) Controversies Conference. Kidney International. https://doi.org/10.1016/j.kint.2016.10.005

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Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a “Kidney Disease: Improving Global Outcomes” (KDIGO) Controversies Conference

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