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Cited by 160Pain Mechanisms and TreatmentsPhytochemistry and Biological ActivitiesInflammatory mediators and NSAID effects

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

(-)-Linalool inhibits in vitro NO formation. Probable involvement in the antinociceptive activity of this monoterpene compound

Peana, Alessandra T., Marzocco, Stefania, Popolo, Ada, Pinto, Aldo·2006·Life Sciences
DOI 10.1016/j.lfs.2005.05.065
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Abstract

Recent studies performed in our laboratory have shown that (-)-linalool, the natural occurring enantiomer in essential oils, possesses anti-inflammatory, antihyperalgesic and antinociceptive effects in different animal models. The antinociceptive and antihyperalgesic effect of (-)-linalool has been ascribed to the stimulation of the cholinergic, opioidergic and dopaminergic systems, to its local anaesthetic activity and to the blockade of N-Methyl-d-aspartate receptors (NMDA). Since nitric oxide (NO) and prostaglandin E(2) (PGE(2)) play an important role in oedema formation and hyperalgesia and nociception development, to investigate the mechanism of these actions of the (-)-linalool, we examined the effects of this compound on lipopolysaccharide (LPS)-induced responses in macrophage cell line J774.A1. Exposure of LPS-stimulated cells to (-)-linalool significantly inhibited nitrite accumulation in the culture medium without inhibiting the LPS-stimulated increase of inducible nitric oxide synthase (iNOS) expression, suggesting that the inhibitory activity of (-)-linalool is mainly due to the iNOS enzyme activity. In contrast, exposure of LPS-stimulated cells to (-)-linalool failed, if not at the highest concentration, both in inhibiting PGE(2) release and in inhibiting increase of inducible cyclooxygenase-2 (COX(2)) expression in the culture medium. Collectively, these results indicate that the reduction of NO production/release is responsible, at least partially, for the molecular mechanisms of (-)-linalool antinociceptive effect, probably through mechanisms where cholinergic and glutamatergic systems are involved.

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Metadata

Authors
Peana, A. T., Marzocco, S., Popolo, A., & Pinto, A.
Affiliations
  • University of Sassari (IT)
  • University of Salerno (IT)
Corresponding author
Peana, Alessandra T.
ORCID
Venue
Life Sciences
Publisher
Elsevier BV
Published
2006-01
Volume
78
Issue
7
Pages
719-723
ISSN
0024-3205 (ISSN-L)
DOI
10.1016/j.lfs.2005.05.065
OpenAlex
W2073572798
Cited by
160
References
31
Citations by year
2026: 2 · 2025: 4 · 2024: 7 · 2023: 13 · 2022: 11 · 2021: 11 · 2020: 14 · 2019: 6 · 2018: 11 · 2017: 7 · 2016: 10 · 2015: 10 · 2014: 9 · 2013: 5 · 2012: 8
FWCI
1.98
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Life Sciences (publishedVersion)
  • PubMed (publishedVersion)
  • UnissResearch (Università degli Studi di Sassari) (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
  • Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Keywords
linalool, nitric oxide, inducible nitric oxide synthase, antinociceptive activity, hyperalgesia, prostaglandin E2, cyclooxygenase-2, lipopolysaccharide, macrophages, monoterpenes, cholinergic system, glutamatergic system, anti-inflammatory activity
MeSH terms
Acyclic Monoterpenes, Analgesics, Animals, Cell Line, Dose-Response Relationship, Drug, Drug Combinations, Insecticides, Lipopolysaccharides, Macrophages, Nitric Oxide, Nitrites, Dinoprostone, Culture Media, Conditioned, Monoterpenes, Cyclooxygenase 2, Nitric Oxide Synthase Type II

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