No response of plasma substance P, but delayed increase of interleukin-1 receptor antagonist to acute psychosocial stress
Abstract
Psychosocial stress has been shown to induce inflammatory reactions, followed by the release of immunosuppressive glucocorticoids. This may be mediated by catecholamines or other stress reactive substances such as neuropeptides or cytokines. We here set out to explore the effects of acute psychosocial stress on plasma levels of substance P (SP), a possible mediator of stress-induced inflammatory reactions, and interleukin-1 receptor antagonist (IL-1ra). Twelve healthy male subjects (mean age 27 yrs.) were subjected to the psychosocial stress test "Trier Social Stress Test" (TSST) and a resting control condition. Blood and saliva samples were taken before, as well as 1, 20, 45, and 90 min after TSST or rest, respectively. Salivary cortisol and plasma SP and IL-1ra were measured using immunoassays, salivary alpha-amylase (sAA) was measured by an enzyme kinetic method, and plasma epinephrine (E) and norepinephrine (NE) were measured by HPLC. The TSST induced immediate increases of E, NE, and sAA, and a delayed increase of free cortisol. Plasma IL-1ra showed an even further delayed peak at 90 min after stress. Plasma levels of SP did not respond to stress. No significant associations between changes of stress hormones and IL-1ra or SP were found. We conclude that substance P, epinephrine, and norepinephrine are probably not involved in mediating peripheral inflammation following psychosocial stress, at least with respect to IL-1ra. Further studies have to reveal the mechanisms in…
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There is evidence that cytokines do not routinely change across an hour in the absence of an intervention.
“However, there is evidence that cytokines do not routinely change across an hour in the absence of an intervention [43–45].”
From Singing modulates mood, stress, cortisol, cytokine and neuropeptide activity in cancer patients and carers (2016) · cites this paper as [44]
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A mechanism converting psychosocial stress into mononuclear cell activation
Bierhaus, A., Wolf, J., Andrassy, M., Rohleder, N., Humpert, P. M., Petrov, D., Ferstl, R., von Eynatten, M., Wendt, T., Rudofsky, G., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0438019100 · Cited by 926 · see citing works
Self-citationNater, U. M., La Marca, R., Florin, L., Moses, A., Langhans, W., Koller, M. M., & Ehlert, U. (2006) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.05.010 · Cited by 630 · cited 1× · see citing works
“However, it is highly unlikely that subjects experienced stress on day one, as this would have raised the activity of the salivary enzyme alpha-amylase (sAA), which is highly sensitive to acute stress (Nater et al., 2005; Rohleder et al., 2004).”
BackgroundSalivary alpha amylase as marker for adrenergic activity during stress: Effect of betablockade
van Stegeren, A., Rohleder, N., Everaerd, W., & Wolf, O. T. (2006) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.05.012 · Cited by 419 · see citing works
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Nater, U. M., & Rohleder, N. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.01.014 · Cited by 1,370 · see citing works
Self-citationSteptoe, A., Hamer, M., & Chida, Y. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.03.011 · Cited by 1,278 · see citing works
Marsland, A. L., Walsh, C., Lockwood, K., & John-Henderson, N. A. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.01.011 · Cited by 691 · see citing works
Rohleder, N., Wolf, J. M., Maldonado, E. F., & Kirschbaum, C. (2006) · Psychophysiology · doi:10.1111/j.1469-8986.2006.00457.x · Cited by 321 · see citing works
Self-citationRosenkranz, M. A., Davidson, R. J., MacCoon, D. G., Sheridan, J. F., Kalin, N. H., & Lutz, A. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.10.013 · Cited by 307 · see citing works
Fancourt, D., Williamon, A., Carvalho, L. A., Steptoe, A., Dow, R., & Lewis, I. (2016) · ecancermedicalscience · doi:10.3332/ecancer.2016.631 · Cited by 201 · see citing works
Hope, S., Ueland, T., Steen, N. E., Dieset, I., Lorentzen, S., Berg, A. O., Agartz, I., Aukrust, P., & Andreassen, O. A. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2012.12.023 · Cited by 131 · see citing works
- Authors
- Rohleder, N., Wolf, J. M., Herpfer, I., Fiebich, B. L., Kirschbaum, C., & Lieb, K.
- Affiliations
- Technische Universität Dresden (DE)
- University of Freiburg (DE)
- Corresponding author
- Rohleder, Nicolas
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 2006-05
- Volume
- 78
- Issue
- 26
- Pages
- 3082-3089
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W2140637925
- Cited by
- 39
- References
- 3
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 4 · 2013: 1 · 2012: 4
- FWCI
- 1.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Life Sciences (publishedVersion)
- PubMed (publishedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- psychosocial stress, substance P, interleukin-1 receptor antagonist, Trier Social Stress Test, stress-induced inflammation, epinephrine, norepinephrine, salivary cortisol, salivary amylase, catecholamines, neuropeptides, cytokines
- MeSH terms
- Acute Disease, Adult, Affect, alpha-Amylases, Endocrine Glands, Epinephrine, Humans, Hydrocortisone, Inflammation, Male, Norepinephrine, Saliva, Sialoglycoproteins, Social Environment, Stress, Psychological, Substance P, Biomarkers, Area Under Curve, Interleukin 1 Receptor Antagonist Protein
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