A comparison of mindfulness-based stress reduction and an active control in modulation of neurogenic inflammation

Rosenkranz, Melissa A.; Davidson, Richard J.; MacCoon, Donal G.; Sheridan, John F.; Kalin, Ned H.; Lutz, Antoine

doi:10.1016/j.bbi.2012.10.013

Cited by 307Mindfulness and Compassion InterventionsStress Responses and CortisolVagus Nerve Stimulation Research

A comparison of mindfulness-based stress reduction and an active control in modulation of neurogenic inflammation

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Rosenkranz, Melissa A., Davidson, Richard J., MacCoon, Donal G., Sheridan, John F., Kalin, Ned H., Lutz, Antoine·2013·Brain, Behavior, and Immunity

DOI 10.1016/j.bbi.2012.10.013PMC PMC3518553

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Abstract

Psychological stress is a major provocative factor of symptoms in chronic inflammatory conditions. In recent years, interest in addressing stress responsivity through meditation training in health-related domains has increased astoundingly, despite a paucity of evidence that reported benefits are specific to meditation practice. We designed the present study to rigorously compare an 8-week Mindfulness-Based Stress Reduction (MBSR) intervention to a well-matched active control intervention, the Health Enhancement Program (HEP) in ability to reduce psychological stress and experimentally-induced inflammation. The Trier Social Stress Test (TSST) was used to induce psychological stress and inflammation was produced using topical application of capsaicin cream to forearm skin. Immune and endocrine measures of inflammation and stress were collected both before and after MBSR training. Results show those randomized to MBSR and HEP training had comparable post-training stress-evoked cortisol responses, as well as equivalent reductions in self-reported psychological distress and physical symptoms. However, MBSR training resulted in a significantly smaller post-stress inflammatory response compared to HEP, despite equivalent levels of stress hormones. These results suggest behavioral interventions designed to reduce emotional reactivity may be of therapeutic benefit in chronic inflammatory conditions. Moreover, mindfulness practice, in particular, may be more efficacious in symptom relief than the well-being promoting activities cultivated in the HEP program.

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Other longitudinal RCTs showed no sustained attention differences between MBSR and HEP, comparable post-training stress-evoked cortisol responses, and equivalent reductions in self-reported psychological distress and physical symptoms.
“Other longitudinal Rcts also showed no sustained attention differences between MBsR and heP, MBsR and heP had comparable post-training stress-evoked cortisol responses, as well as equivalent reductions in self-reported psychological distress and physical symptoms (Davidson, 2010;Maccoon et al., 2012;2014;Rosenkranz et al., 2013).”
From Salivary testosterone and cortisol response in acute stress modulated by seven sessions of mindfulness meditation in young males (2024) · cites this paper as Rosenkranz et al., 2013
The Results (Cortisol) report no significant MBSR–HEP difference in stress-evoked cortisol response, and the Discussion reports comparable reductions in psychological distress and medical symptoms. The Methods (Participants) say attention outcomes belonged to a larger set of experiments whose results would be reported elsewhere; this paper does not establish the claimed absence of sustained-attention differences. Page numbers are unavailable in our copy. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Later rigorous RCT studies using an active control failed to replicate the positive results of meditation versus waitlist control.
“however, later rigorous Rct studies using an active control failed to replicate these results.”
From Salivary testosterone and cortisol response in acute stress modulated by seven sessions of mindfulness meditation in young males (2024) · cites this paper as Rosenkranz et al., 2013
The Methods (Interventions) describe random assignment to MBSR or an active control. The paper reports comparable reductions in psychological distress, consistent with no added benefit for that outcome, but the Results (Primary analyses: Effects of the intervention) find a significantly smaller post-training inflammatory flare in the MBSR group. It therefore does not support the unqualified claim that active-control studies failed to replicate positive results. (LLM, conf=0.85)
Experimental — accuracy not yet measured
The waitlist control has been intensively investigated in the meditation field.
“the waitlist control has been intensively investigated in the meditation field (Davidson, 2010;Maccoon, Maclean, Davidson, saron, & lutz, 2014;Maccoon et al., 2012;Rosenkranz et al., 2013;terburg et al., 2009).”
From Salivary testosterone and cortisol response in acute stress modulated by seven sessions of mindfulness meditation in young males (2024) · cites this paper as Rosenkranz et al., 2013
For the past 10 years, more and more meditation studies have used longitudinal RCT design with active controls such as relaxation training, health education or enhancement programs, physical exercise, and cognitive tasks.
“consequently, for the past 10 years, more and more meditation studies have used longitudinal Rct design with active controls such as relaxation training, health education or enhancement programs, physical exercise, and cognitive tasks (Davidson, 2010;Maccoon et al., 2012;2014;Rosenkranz et al., 2013;terburg et al., 2009).”
From Salivary testosterone and cortisol response in acute stress modulated by seven sessions of mindfulness meditation in young males (2024) · cites this paper as Rosenkranz et al., 2013
A series of studies used MBSR versus HEP to validate the active control in meditation.
“For example, a series of studies used MBsR vs. health enhancement Program (heP) to validate the active control in meditation (Davidson, 2010;Maccoon et al., 2012;2014;Rosenkranz et al., 2013).”
From Salivary testosterone and cortisol response in acute stress modulated by seven sessions of mindfulness meditation in young males (2024) · cites this paper as Rosenkranz et al., 2013

Mindfulness practices are associated with supporting physical health.
“Mindfulness practices have been associated with benefits for coping with stress, anxiety, and depression [23,25,26,27], improving compassion and increasing prosocial (e.g., helping or relationship-promoting) behaviors [28,29,30], bolstering attention and working (e.g., short-term) memory [31,32], improving self-regulatory abilities (e.g., self-control) [33], and supporting physical health [34,35,”
From Being in the moment so you can keep moving forward: Mindfulness and rumination mediate the relationship between attachment orientations and negative conflict styles (2020) · cites this paper as [36]
Although the HEP and mindfulness conditions were effective at improving mood, stress, and cognition, they did not significantly differ.
“Although the HEP and mindfulness conditions were effective at improving mood, stress, and cognition, they did not significantly differ.”
From The neural mechanisms of mindfulness-based pain relief: a functional magnetic resonance imaging-based review and primer (2019) · cites this paper as [95]
The mindfulness program was more effective at reducing inflammatory markers in response to a social stress test and pain.
“However, the mindfulness program was more effective at reducing inflammatory markers in response to a social stress test95 and pain.74”
From The neural mechanisms of mindfulness-based pain relief: a functional magnetic resonance imaging-based review and primer (2019) · cites this paper as [95]
MBSR outperformed HEP in lowering inflammatory responses after social stress and in reducing experimentally induced pain ratings.
“However, the MBSR program was more effective at reducing inflammatory responses following social stress141 and experimentally-induced pain ratings.139”
From Mindfulness meditation-based pain relief: a mechanistic account (2016) · cites this paper as [141]
Mindfulness training has a specific effect on a broad range of affective and physical health outcomes, as indicated by studies that controlled for nonspecific factors or lacked group support.
“Still, there is evidence that mindfulness training studies that either control for these factors or lack these intervention elements (e.g., group support) have been linked with affective and physical health outcomes (e.g., Kabat-Zinn et al., 1998; Polusny et al., 2015; Rosenkranz et al., 2013; Taren et al., 2015), suggesting a mindfulness-specific impact on a broad array of outcomes.”
From Mechanisms of mindfulness training: Monitor and Acceptance Theory (MAT (2017) · cites this paper as Rosenkranz et al., 2013

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Background
Histamine is released in the wheal but not the flare following challenge of human skin in vivo: a microdialysis study
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Adrenergic excitation of cutaneous nociceptors in chronically inflamed rats
Sato, J., Suzuki, S., Iseki, T., et al. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90897-t · Cited by 110 · see citing works
Altered distribution of leukocyte subsets and cytokine production in response to acute psychosocial stress in patients with psoriasis vulgaris
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Stress sensitivity in metastatic breast cancer: Analysis of hypothalamic–pituitary–adrenal axis function
Spiegel, D., Giese‐Davis, J., Taylor, C. B., & KRAEMER, H. C. (2006) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2006.09.004 · Cited by 99 · see citing works
Noradrenaline increases hyperalgesia to heat in skin sensitized by capsaicin
Drummond, P. D. (1995) · Pain · doi:10.1016/0304-3959(94)00130-7 · Cited by 96 · see citing works
Endocrine stress responses in TH1-mediated chronic inflammatory skin disease (psoriasis vulgaris)—do they parallel stress-induced endocrine changes in TH2-mediated inflammatory dermatoses (atopic dermatitis)?
Buske-Kirschbaum, A., Ebrecht, M., Kern, S., & Hellhammer, D. H. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.10.006 · Cited by 91 · see citing works
Neurogenic flare responses following topical application of capsaicin in humans
Helme, R. D., & McKernan, S. (1985) · Annals of Neurology · doi:10.1002/ana.410180414 · Cited by 90 · see citing works
Acute Stress Results in Skin Corticotropin-Releasing Hormone Secretion, Mast Cell Activation and Vascular Permeability, an Effect Mimicked by Intradermal Corticotropin-Releasing Hormone and Inhibited by Histamine-1 Receptor Antagonists
Lytinas, M., Kempuraj, D., Huang, M., Boucher, W. S., Esposito, P., & Theoharides, T. C. (2003) · International Archives of Allergy and Immunology · doi:10.1159/000069516 · Cited by 84 · see citing works
Endocrine and Immune Responses to Stress in Chronic Inflammatory Skin Disorders
Buske-Kirschbaum, A., & Hellhammer, D. H. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb03153.x · Cited by 84 · see citing works
Substance P at the nexus of mind and body in chronic inflammation and affective disorders.
Rosenkranz, M. A. (2007) · Psychological Bulletin · doi:10.1037/0033-2909.133.6.1007 · Cited by 81 · see citing works
Self-citation
Atopic eczema in children: another harmful sequel of divorce
Bockelbrink, A., Heinrich, J., Schäfer, I., Zutavern, A., Borte, M., Herbarth, O., Schaaf, B., Berg, A. V., Schäfer, T., & for the LISA Study Group (2006) · Allergy · doi:10.1111/j.1398-9995.2006.01186.x · Cited by 81 · see citing works
Mast cells, neuropeptides and inflammation
Church, M. K., Lowman, M. A., Rees, P., et al. (1989) · Inflammation Research · doi:10.1007/bf02222185 · Cited by 79 · see citing works
Role of substance P and calcitonin gene‐related peptide in the regulation of interleukin‐8 and monocyte chemotactic protein‐1 expression in human dental pulp
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Effect of substance P on superoxide anion and IL-8 production by human PMNL.
Serra, M. C., Calzetti, F., Ceska, M., & Cassatella, M. A. (1994) · PubMed Central · Cited by 75 · see citing works
Associations Between Cognitive Function and Naturally Occurring Daily Cortisol During Middle Adulthood: Timing Is Everything
Stawski, R. S., Almeida, D. M., Lachman, M. E., Tun, P. A., Rosnick, C. B., & Seeman, T. E. (2011) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbq094 · Cited by 68 · see citing works
Human skin mast cells: in vitro and in vivo studies
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The Effects of Acute Social Stress on Epidermal Langerhans' Cell Frequency and Expression of Cutaneous Neuropeptides
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Sympathetic Modulation of Acute Cutaneous Flare Induced by Intradermal Injection of Capsaicin in Anesthetized Rats
Lin, Q., Zou, X., Li, F., et al. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00568.2002 · Cited by 57 · see citing works
Human Skin Mast Cells Produce TNF-α by Substance P
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Immunoreactivity of corticotropin-releasing hormone, adrenocorticotropic hormone andα-melanocyte-stimulating hormone in alopecia areata
Kim, H. S., Cho, D. H., Kim, H. J., Lee, J. Y., Cho, B. K., & Park, H. J. (2006) · Experimental Dermatology · doi:10.1111/j.1600-0625.2006.00443.x · Cited by 49 · see citing works
Acute Stress Induces Proinflammatory Signaling at Chronic Inflammation Sites
Weik, U., Herforth, A., Kolb-Bachofen, V., & Deinzer, R. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181835bf3 · Cited by 47 · see citing works
Chronic urticaria: importance of a medical-psychological approach.
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Immunoreactivity of corticotropin‐releasing hormone, adrenocorticotropic hormone and α‐melanocyte‐stimulating hormone in alopecia areata
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No response of plasma substance P, but delayed increase of interleukin-1 receptor antagonist to acute psychosocial stress
Rohleder, N., Wolf, J. M., Herpfer, I., Fiebich, B. L., Kirschbaum, C., & Lieb, K. (2006) · Life Sciences · doi:10.1016/j.lfs.2005.12.016 · Cited by 39 · see citing works
The impact of meteorological conditions on patch test results with 12 standard series allergens (fragrances, biocides, topical ingredients)
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A quantitative comparison of the effect of local analgesics on argon laser induced cutaneous pain and on histamine induced wheal, flare and itch.
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Differences between the Lewis and Sprague–Dawley rats in chronic inflammation induced norepinephrine sensitivity of cutaneous C-fiber nociceptors
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The effect of capsaicin application on mast cells in normal human skin
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Axon Reflex Flare Evoked by Nicotine in Human Skin.
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Interactions of bradykinin and norepinephrine on rat cutaneous nociceptors in both normal and inflamed conditions in vitro
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Body Surface Area
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TOWARD THE STUDY OF VERNACULAR INTELLECTUALISM: A RESPONSE
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The Neuroscience of Mindfulness Meditation
Tang, Y.-Y., Hölzel, B. K., & Posner, M. I. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn3916 · Cited by 2,889 · see citing works
Mindfulness Interventions
Creswell, J. D. (2017) · Annual Review of Psychology · doi:10.1146/annurev-psych-042716-051139 · Cited by 1,702 · see citing works
Mechanisms of mindfulness training: Monitor and Acceptance Theory (MAT
Lindsay, E. K., & Creswell, J. D. (2017) · Clinical Psychology Review · doi:10.1016/j.cpr.2016.10.011 · Cited by 919 · see citing works
“…factors or lack these intervention elements (e.g., group support) have been linked with affective and physical health outcomes (e.g., Kabat-Zinn et al., 1998; Polusny et al., 2015; Rosenkranz et al., 2013; Taren et al., 2015), suggesting a mindfulness-specific impact on a broad array of outcomes.”
Background
Conceptual and methodological issues in research on mindfulness and meditation.
Davidson, R. J., & Kaszniak, A. W. (2015) · American Psychologist · doi:10.1037/a0039512 · Cited by 773 · see citing works
Self-citation
Biological and psychological markers of stress in humans: Focus on the Trier Social Stress Test
Allen, A. P., Kennedy, P. J., Cryan, J. F., Dinan, T. G., & Clarke, G. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.11.005 · Cited by 734 · see citing works
Investigating the phenomenological matrix of mindfulness-related practices from a neurocognitive perspective.
Lutz, A., Jha, A. P., Dunne, J. D., & Saron, C. D. (2015) · American Psychologist · doi:10.1037/a0039585 · Cited by 697 · see citing works
“In addition, the diurnal slope of cortisol responses was steeper in the MBSR compared with HEP groups after training, a pattern associated with improved cognitive and psychological functioning (Rosenkranz et al., 2013).”
BackgroundResult
Mindfulness meditation and the immune system: a systematic review of randomized controlled trials
Black, D. S., & Slavich, G. M. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12998 · Cited by 599 · see citing works
How Does Mindfulness Training Affect Health? A Mindfulness Stress Buffering Account
Creswell, J. D., & Lindsay, E. K. (2014) · Current Directions in Psychological Science · doi:10.1177/0963721414547415 · Cited by 543 · see citing works
Mindfulness Meditation and Psychopathology
Wielgosz, J., Goldberg, S. B., Kral, T. R. A., Dunne, J. D., & Davidson, R. J. (2019) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-021815-093423 · Cited by 435 · see citing works
Self-citation
Brief mindfulness meditation training alters psychological and neuroendocrine responses to social evaluative stress
Creswell, J. D., Pacilio, L. E., Lindsay, E. K., & Brown, K. W. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.02.007 · Cited by 376 · see citing works
Meditation and Cardiovascular Risk Reduction: A Scientific Statement From the American Heart Association
Levine, G. N., Lange, R. A., Bairey‐Merz, C. N., Davidson, R. J., Jamerson, K., Mehta, P. K., Michos, E. D., Norris, K., Ray, I. B., Saban, K. L., et al. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.002218 · Cited by 330 · see citing works
Self-citation
Mindfulness-based programmes for mental health promotion in adults in nonclinical settings: A systematic review and meta-analysis of randomised controlled trials
Galante, J., Friedrich, C., Dawson, A. F., Modrego-Alarcón, M., Gebbing, P., Delgado-Suárez, I., Gupta, R., Dean, L., Dalgleish, T., White, I. R., et al. (2021) · PLOS Medicine · doi:10.1371/journal.pmed.1003481 · Cited by 319 · see citing works
Alterations in resting-state functional connectivity link mindfulness meditation with reduced interleukin-6: a randomized controlled trial
Creswell, J. D., Taren, A. A., Lindsay, E. K., Greco, C. M., Gianaros, P. J., Fairgrieve, A., Marsland, A. L., Brown, K. W., Way, B. M., Rosen, R. K., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.01.008 · Cited by 299 · see citing works
Mindfulness meditation-based pain relief: a mechanistic account
Zeidan, F., & Vago, D. R. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13153 · Cited by 300 · see citing works
Prospects for a clinical science of mindfulness-based intervention
Dimidjian, S., & Segal, Z. V. (2015) · American Psychologist · doi:10.1037/a0039589 · Cited by 291 · see citing works
Rapid changes in histone deacetylases and inflammatory gene expression in expert meditators
Kaliman, P., Álvarez-López, M. J., Cosín-Tomás, M., Rosenkranz, M. A., Lutz, A., & Davidson, R. J. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.11.004 · Cited by 300 · see citing works
Self-citation
The Effects of Mind-Body Therapies on the Immune System: Meta-Analysis
Morgan, N., Irwin, M. R., Chung, M., & Wang, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100903 · Cited by 294 · see citing works
“For IL-8, three studies [36,45,63,65] with a total of 158 participants were identified.”
Background
Yoga, Meditation and Mind-Body Health: Increased BDNF, Cortisol Awakening Response, and Altered Inflammatory Marker Expression after a 3-Month Yoga and Meditation Retreat
Cahn, B. R., Goodman, M. S., Peterson, C. T., Maturi, R., & Mills, P. J. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00315 · Cited by 292 · see citing works
Mindfulness Training and Physical Health: Mechanisms and Outcomes
Creswell, J. D., Lindsay, E. K., Villalba, D. K., & Chin, B. (2019) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000675 · Cited by 252 · see citing works
“For example, one methodologically strong trial showed that mindfulness training buffered stress-induced inflammatory responses in the skin (43).”
How mindfulness training promotes positive emotions: Dismantling acceptance skills training in two randomized controlled trials.
Lindsay, E. K., Chin, B., Greco, C. M., Young, S., Brown, K. W., Wright, A. G. C., Smyth, J. M., Burkett, D., & Creswell, J. D. (2018) · Journal of Personality and Social Psychology · doi:10.1037/pspa0000134 · Cited by 218 · see citing works
“…although there is ample evidence that mindfulness interventions can reduce negative affect (for reviews, see Keng et al., 2011; Khoury et al., 2013), some questions remain about whether mindfulness programs are more effective than active placebo controlled programs (e.g., Rosenkranz et al., 2013).”
Mindfulness-based stress reduction (MBSR) for improving health, quality of life and social functioning in adults: a systematic review and meta-analysis
deVibe, M., Bjørndal, A., Fattah, S., Dyrdal, G. M., Halland, E., & Tanner-Smith, E. E. (2017) · Campbell Systematic Reviews: Better Evidence for a Better World · doi:10.4073/csr.2017.11 · Cited by 198 · see citing works
Self-compassion as a predictor of interleukin-6 response to acute psychosocial stress
Breines, J. G., Thoma, M. V., Gianferante, D., Hanlin, L., Chen, X., & Rohleder, N. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.11.006 · Cited by 181 · see citing works
Effects of psychotropic drugs on inflammation:Consequence or mediator of therapeutic effects in psychiatric treatment?
Baumeister, D., Ciufolini, S., & Mondelli, V. (2016) · Psychopharmacology · doi:10.1007/s00213-015-4044-5 · Cited by 183 · see citing works
Does the Five Facet Mindfulness Questionnaire measure what we think it does? Construct validity evidence from an active controlled randomized clinical trial.
Goldberg, S. B., Wielgosz, J., Dahl, C., Schuyler, B., MacCoon, D. S., Rosenkranz, M., Lutz, A., Sebranek, C. A., & Davidson, R. J. (2016) · Psychological Assessment · doi:10.1037/pas0000233 · Cited by 172 · see citing works
Self-citation
Expression of toll-like receptors in peripheral blood mononuclear cells and response to cognitive-behavioral therapy in major depressive disorder
Kéri, S., Szabó, C., & Kelemen, O. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.03.020 · Cited by 165 · see citing works
Mindfulness Meditation for Primary Headache Pain: A Meta-Analysis
Gu, Q., Hou, J.-C., & Fang, X.-M. (2018) · Chinese Medical Journal · doi:10.4103/0366-6999.228242 · Cited by 162 · see citing works
Effects of mindfulness-based interventions on salivary cortisol in healthy adults: a meta-analytical review
Sanada, K., Montero-Marin, J., Alda Díez, M., Salas-Valero, M., Pérez-Yus, M. C., Morillo, H., Demarzo, M. M. P., García-Toro, M., & García-Campayo, J. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00471 · Cited by 161 · see citing works
Specific reduction in cortisol stress reactivity after social but not attention-based mental training
Engert, V., Kok, B. E., Papassotiriou, I., Chrousos, G. P., & Singer, T. (2017) · Science Advances · doi:10.1126/sciadv.1700495 · Cited by 151 · see citing works
The neural mechanisms of mindfulness-based pain relief: a functional magnetic resonance imaging-based review and primer
Zeidan, F., Baumgartner, J. N., & Coghill, R. C. (2019) · PAIN Reports · doi:10.1097/pr9.0000000000000759 · Cited by 115 · see citing works
Mindfulness in the maintenance of cognitive capacities in Alzheimer’s disease: a randomized clinical trial.
Quintana-Hernández, D. J., Miró-Barrachina, M. T., Ibáñez-Fernández, I. J., Pino, A. S.-D., Quintana-Montesdeoca, M. P., Rodríguez-de Vera, B., Morales-Casanova, D., Pérez-Vieitez, M. D. C., Rodríguez-García, J., & Bravo-Caraduje, N. (2016) · Journal of Alzheimer's Disease · doi:10.3233/jad-143009 · Cited by 107 · see citing works
Does Mindfulness‐Based Cognitive Therapy for Migraine Reduce Migraine‐Related Disability in People with Episodic and Chronic Migraine? A Phase 2b Pilot Randomized Clinical Trial
Seng, E. K., Singer, A. B., Metts, C., Grinberg, A. S., Patel, Z. S., Marzouk, M., Rosenberg, L., Day, M., Minen, M. T., Lipton, R. B., et al. (2019) · Headache: The Journal of Head and Face Pain · doi:10.1111/head.13657 · Cited by 103 · see citing works
Psychological mechanisms driving stress resilience in mindfulness training: A randomized controlled trial.
Chin, B., Lindsay, E. K., Greco, C. M., Brown, K. W., Smyth, J. M., Wright, A. G. C., & Creswell, J. D. (2019) · Health Psychology · doi:10.1037/hea0000763 · Cited by 103 · see citing works
Potential benefits of mindfulness-based interventions in mild cognitive impairment and Alzheimer’s disease: an interdisciplinary perspective.
Larouche, E., Hudon, C., & Goulet, S. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.05.058 · Cited by 93 · see citing works
Mindfulness-based cognitive therapy in COPD: a cluster randomised controlled trial
Farver-Vestergaard, I., O'Toole, M. S., O'Connor, M., Løkke, A., Bendstrup, E., Basdeo, S. A., Cox, D. J., Dunne, P. J., Ruggeri, K., Early, F., et al. (2018) · European Respiratory Journal · doi:10.1183/13993003.02082-2017 · Cited by 86 · see citing works
Mindfulness-based stress reduction for long-term physical conditions: a systematic review.
Crowe, M., Jordan, J., Burrell, B., Jones, V., Gillon, D., & Harris, S. (2016) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867415607984 · Cited by 85 · see citing works
Effectiveness of stress management interventions to change cortisol levels: a systematic review and meta-analysis.
Rogerson, O., Wilding, S., Prudenzi, A., & O’Connor, D. B. (2024) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2023.106415 · Cited by 87 · see citing works
“Although for Rosenkranz et al. (2013) the average SE was first calculated across the 5 measures.”
Relapse prevention in major depressive disorder: Mindfulness-based cognitive therapy versus an active control condition.
Shallcross, A. J., Gross, J. J., Visvanathan, P. D., Kumar, N., Palfrey, A., Ford, B. Q., Dimidjian, S., Shirk, S., Holm-Denoma, J., Goode, K. M., et al. (2015) · Journal of Consulting and Clinical Psychology · doi:10.1037/ccp0000050 · Cited by 81 · see citing works
Heart rate variability is enhanced in controls but not maladaptive perfectionists during brief mindfulness meditation following stress-induction: A stratified-randomized trial
Azam, M. A., Katz, J., Fashler, S. R., Changoor, T., Azargive, S., & Ritvo, P. (2015) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2015.06.005 · Cited by 78 · see citing works
Mindfulness-Based Stress Reduction to Enhance Psychological Functioning and Improve Inflammatory Biomarkers in Trauma-Exposed Women: A Pilot Study
Gallegos, A. M., Lytle, M. C., Moynihan, J. A., & Talbot, N. L. (2015) · Psychological Trauma Theory Research Practice and Policy · doi:10.1037/tra0000053 · Cited by 79 · see citing works
The Contribution of Common and Specific Therapeutic Factors to Mindfulness-Based Intervention Outcomes
Canby, N. K., Eichel, K., Lindahl, J., Chau, S., Cordova, J., & Britton, W. B. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.603394 · Cited by 71 · see citing works
Mindfulness training for healthy aging: impact on attention, well-being, and inflammation.
Fountain-Zaragoza, S., & Prakash, R. S. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00011 · Cited by 66 · see citing works
Insight meditation and telomere biology: The effects of intensive retreat and the moderating role of personality
Conklin, Q. A., King, B. G., Zanesco, A. P., Lin, J., Hamidi, A. B., Pokorny, J. J., Álvarez-López, M. J., Cosín-Tomás, M., Huang, C., Kaliman, P., et al. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.03.003 · Cited by 66 · see citing works
Critical Analysis of the Efficacy of Meditation Therapies for Acute and Subacute Phase Treatment of Depressive Disorders: A Systematic Review
Jain, F. A., Walsh, R. N., Eisendrath, S. J., Christensen, S., & Rael Cahn, B. (2015) · Psychosomatics · doi:10.1016/j.psym.2014.10.007 · Cited by 64 · see citing works
Can mindfulness in health care professionals improve patient care? An integrative review and proposed model
Braun, S. E., Kinser, P. A., & Rybarczyk, B. (2019) · Translational Behavioral Medicine · doi:10.1093/tbm/iby059 · Cited by 56 · see citing works
Revue des effets de la méditation de pleine conscience sur la santé mentale et physique et sur ses mécanismes d'action.
Ngô, T.-L. (2014) · Sante Mentale au Quebec · doi:10.7202/1023988ar · Cited by 54 · see citing works
Brief Mindfulness Meditation Induces Gray Matter Changes in a Brain Hub.
Tang, R., Friston, K. J., & Tang, Y.-Y. (2020) · Neural Plasticity · doi:10.1155/2020/8830005 · Cited by 54 · see citing works
Comparison of the effects of <scp>K</scp>orean mindfulness‐based stress reduction, walking, and patient education in diabetes mellitus
Jung, H. Y., Lee, H., & Park, J. (2015) · Nursing & Health Sciences · doi:10.1111/nhs.12229 · Cited by 48 · see citing works
Epigenetic Response to Mindfulness in Peripheral Blood Leukocytes Involves Genes Linked to Common Human Diseases
García-Campayo, J., Puebla-Guedea, M., Labarga, A., Urdánoz, A., Roldán, M., Pulido, L., de Morentin, X. M., Perdones-Montero, Á., Montero-Marín, J., & Mendioroz, M. (2018) · Mindfulness · doi:10.1007/s12671-017-0851-6 · Cited by 42 · see citing works
A Preliminary Randomized Controlled Trial of a Mindful Eating Intervention for Post-menopausal Obese Women
Smith, B. W., Shelley, B. M., Sloan, A. L., Colleran, K., & Erickson, K. (2018) · Mindfulness · doi:10.1007/s12671-017-0824-9 · Cited by 37 · see citing works
Mindfulness-Based Stress Reduction Triggers a Long-Term Shift toward More Positive Appraisals of Emotional Ambiguity
Harp, N. R., Freeman, J. B., & Neta, M. (2022) · Journal of Experimental Psychology General · doi:10.1037/xge0001173 · Cited by 38 · see citing works
“As such, altering our maladaptive stress responses, such as in chronic or uncontrolled stress, via stress reduction techniques can have downstream benefits for both physical (Rosenkranz et al., 2013) and psychological (Britton et al., 2012) well-being.”
Background
Dispositional mindfulness predicts cortisol, cardiovascular, and psychological stress responses in adolescence
Lucas-Thompson, R. G., Miller, R. L., Seiter, N. S., & Prince, M. A. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104405 · Cited by 34 · see citing works
The beneficial effects of meditation: contribution of the anterior cingulate and locus coeruleus.
Craigmyle, N. A. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2013.00731 · Cited by 32 · see citing works
Dispositional mindfulness moderates the effect of a brief mindfulness induction on physiological stress responses
Laurent, H. K., Laurent, S. M., Nelson, B., Wright, D. B., & De Araujo Sanchez, M.-A. (2015) · Mindfulness · doi:10.1007/s12671-014-0377-0 · Cited by 31 · see citing works
A Randomized Controlled Trial of a Mindfulness-Based Weight Loss Intervention on Cardiovascular Reactivity to Social-Evaluative Threat Among Adults with Obesity
Daubenmier, J., Epel, E. S., Moran, P. J., Thompson, J., Mason, A. E., Acree, M., Goldman, V., Kristeller, J., Hecht, F. M., & Mendes, W. B. (2019) · Mindfulness · doi:10.1007/s12671-019-01232-5 · Cited by 27 · see citing works
Salivary testosterone and cortisol response in acute stress modulated by seven sessions of mindfulness meditation in young males
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“…has been intensively investigated in the meditation field (Davidson, 2010; Maccoon, Maclean, Davidson, saron, & lutz, 2014; Maccoon et al., 2012; Rosenkranz et al., 2013; terburg et al., 2009). early meditation research often used meditation intervention vs. waitlist control and demonstrated…”
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“The significant within-subjects effects observed for psychological outcomes suggest gradual improvements in response to MM exposures with changes similar to those found in prior studies of MM and psychological status (Oman et al., 2008; Rosenkranz et al., 2013; Tang et al., 2007).”
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“…in brain regions involved in how we respond to negative and/or stressful events (Davidson et al. 2003; Farb et al. 2013), changes in associated somatic measures including immune function (Davidson et al. 2003; Rosenkranz et al. 2013) and blood pressure (Hughes et al. 2013; Nyklicek et al. 2013).”
Background
Plasma oxytocin is modulated by mental training, but does not mediate its stress-buffering effect
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The Mindfulness-Based Stress Reduction Program (MBSR) Reduces Stress-Related Psychological Distress in Healthcare Professionals
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To Investigate the Effectiveness of Mindfulness-Based Stress Reduction Program (MBSR) on Reducing the Symptoms of Patients with Social Anxiety
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Interest in mindfulness based stress reduction (MBSR) programs
Burke, K. D., & Way, B. M. (2014) · PsycEXTRA Dataset · doi:10.1037/e578192014-909
MINDFULNESS-BASED STRESS REDUCTION (MBSR) AS AN INTERVENTION FOR CANCER PATIENTS
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Authors: Rosenkranz, M. A., Davidson, R. J., MacCoon, D. G., Sheridan, J. F., Kalin, N. H., & Lutz, A.
Affiliations: University of Wisconsin–Madison (US)
The Ohio State University (US)
ORCID: Rosenkranz, Melissa A.
Davidson, Richard J.
Sheridan, John F.
Kalin, Ned H.
Venue: Brain, Behavior, and Immunity
Publisher: Elsevier BV
Published: 2013-01
Volume: 27
Issue: 1
Pages: 174-184
ISSN: 0889-1591 (ISSN-L)
DOI: 10.1016/j.bbi.2012.10.013
PMC: PMC3518553
OpenAlex: W2133206720
Cited by: 307
References: 93
Citations by year: 2026: 13 · 2025: 18 · 2024: 12 · 2023: 33 · 2022: 20 · 2021: 30 · 2020: 19 · 2019: 27 · 2018: 23 · 2017: 26 · 2016: 26 · 2015: 27 · 2014: 24 · 2013: 9
FWCI: 21.72
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Brain Behavior and Immunity (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (5u01at002114-03)
National Institute of Mental Health (P50MH069315)
National Center for Complementary and Alternative Medicine
National Center for Complementary and Integrative Health (U01-AT002114, P01AT004952, U01AT002114-01A1)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD003352)
Topics: Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Keywords: mindfulness-based stress reduction, neurogenic inflammation, psychological stress, meditation training, Trier Social Stress Test, cortisol response, psychological distress, chronic inflammatory diseases
MeSH terms: Adult, Analysis of Variance, Blister, Capsaicin, Female, Humans, Hydrocortisone, Male, Middle Aged, Saliva, Stress, Psychological, Tumor Necrosis Factor-alpha, Interleukin-8, Treatment Outcome, Sensory System Agents, Meditation, Neurogenic Inflammation, Mind-Body Therapies, Young Adult, Self Report

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A comparison of mindfulness-based stress reduction and an active control in modulation of neurogenic inflammation

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