Is basic research providing answers if adjuvant anti-estrogen treatment of breast cancer can induce cognitive impairment?

Conjugated Equine Estrogens and Incidence of Probable Dementia and Mild Cognitive Impairment in Postmenopausal Women Women's Health Initiative Memory Study

Shumaker, S. A. (2004) · JAMA · doi:10.1001/jama.291.24.2947 · Cited by 1,360 · see citing works

Estrogen and the Risk of Breast Cancer

Clemons, M., & Goss, P. E. (2001) · New England Journal of Medicine · doi:10.1056/nejm200101253440407 · Cited by 1,100 · see citing works

Selective Estrogen-Receptor Modulators — Mechanisms of Action and Application to Clinical Practice

Riggs, B. L., & Hartmann, L. C. (2003) · New England Journal of Medicine · doi:10.1056/nejmra022219 · Cited by 972 · see citing works

Tamoxifen: a most unlikely pioneering medicine

Jordan, V. C. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1031 · Cited by 832 · see citing works

Conjugated Equine Estrogens and Global Cognitive Function in Postmenopausal Women Women's Health Initiative Memory Study

Espeland, M. A. (2004) · JAMA · doi:10.1001/jama.291.24.2959 · Cited by 794 · see citing works

Effects of estrogen on memory function in surgically menopausal women

Phillips, S. M. (1992) · Psychoneuroendocrinology · doi:10.1016/0306-4530(92)90007-t · Cited by 737 · see citing works

Estradiol Increases the Sensitivity of Hippocampal CA1 Pyramidal Cells to NMDA Receptor-Mediated Synaptic Input: Correlation with Dendritic Spine Density

Woolley, C., Weiland, N., McEwen, B., & Schwartzkroin, P. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-05-01848.1997 · Cited by 711 · see citing works

Cancer- and Cancer Treatment–Associated Cognitive Change: An Update on the State of the Science

Ahles, T. A., Root, J. C., & Ryan, E. L. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2012.43.0116 · Cited by 706 · see citing works

Estradiol regulates hippocampal dendritic spine density via an N-methyl- D-aspartate receptor-dependent mechanism

Woolley, C. S., & McEwen, B. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-12-07680.1994 · Cited by 679 · see citing works

Tumor Characteristics and Clinical Outcome of Elderly Women With Breast Cancer

Diab, S. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.7.550 · Cited by 676 · see citing works

Invited Review: Estrogens effects on the brain: multiple sites and molecular mechanisms

McEwen, B. S. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.6.2785 · Cited by 653 · see citing works

Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017α and P450 aromatase localized in neurons

Hojo, Y., Hattori, T.-A., Enami, T., Furukawa, A., Suzuki, K., Ishii, H.-T., Mukai, H., Morrison, J. H., Janssen, W. G. M., Kominami, S., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2630225100 · Cited by 644 · see citing works

NEUROSTEROIDS: A NOVEL FUNCTION OF THE BRAIN

Baulieu, E. E. (1998) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00071-7 · Cited by 624 · see citing works

Vascular Actions of Estrogens: Functional Implications

Miller, V. M., & DUCKLES, S. P. (2008) · Pharmacological Reviews · doi:10.1124/pr.107.08002 · Cited by 592 · see citing works

Estrogen Receptor Breast Cancer Phenotypes in the Surveillance, Epidemiology, and End Results Database

Anderson, W. F., Chatterjee, N., Ershler, W. B., & Brawley, O. W. (2002) · Breast Cancer Research and Treatment · doi:10.1023/a:1020299707510 · Cited by 589 · see citing works

Estrogen receptor α, not β, is a critical link in estradiol-mediated protection against brain injury

Dubal, D. B., Zhu, H., Yu, J., Rau, S. W., Shughrue, P. J., Merchenthaler, I. J., Kindy, M. S., & Wise, P. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1952 · Cited by 550 · see citing works

Longitudinal Assessment of Cognitive Changes Associated With Adjuvant Treatment for Breast Cancer: Impact of Age and Cognitive Reserve

Ahles, T. A., Saykin, A. J., McDonald, B. C., Li, Y., Furstenberg, C. T., Hanscom, B. S., Mulrooney, T. J., Schwartz, G. N., & Kaufman, P. A. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.27.0827 · Cited by 536 · see citing works

Estradiol increases choline acetyltransferase activity in specific basal forebrain nuclei and projection areas of female rats

Luine, V. N. (1985) · Experimental Neurology · doi:10.1016/0014-4886(85)90108-6 · Cited by 523 · see citing works

Activation of estrogen receptor-β regulates hippocampal synaptic plasticity and improves memory

Liu, F., Day, M., Muñiz, L., Bitran, D., Arias, R. L., Revilla-Sanchez, R., Grauer, S. M., Zhang, G., Kelley, C., Pulito, V. L., et al. (2008) · Nature Neuroscience · doi:10.1038/nn2057 · Cited by 504 · see citing works

Breast Cancer after Use of Estrogen plus Progestin in Postmenopausal Women

Chlebowski, R. T., Kuller, L. H., Prentice, R. L., Stefanick, M. L., Manson, J. E., Gass, M. L. S., Aragaki, A. K., Ockene, J. K., Lane, D. S., Sarto, G. E., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0807684 · Cited by 468 · see citing works

Estradiol Enhances Learning and Memory in a Spatial Memory Task and Effects Levels of Monoaminergic Neurotransmitters

Luine, V. N., Richards, S. T., Wu, V., & Beck, K. D. (1998) · Hormones and Behavior · doi:10.1006/hbeh.1998.1473 · Cited by 445 · see citing works

Novel Actions of Estrogen Receptor-β on Anxiety-Related Behaviors

Lund, T. D., Rovis, T., Chung, W. C. J., & Handa, R. J. (2005) · Endocrinology · doi:10.1210/en.2004-1158 · Cited by 436 · see citing works

Hippocampal Synapses Depend on Hippocampal Estrogen Synthesis

Kretz, O., Fester, L., Wehrenberg, U., Zhou, L., Brauckmann, S., Zhao, S., Prange‐Kiel, J., Naumann, T., Jarry, H., Frotscher, M., et al. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5186-03.2004 · Cited by 412 · see citing works

Meta-Analysis of Cognitive Functioning in Breast Cancer Survivors Previously Treated With Standard-Dose Chemotherapy

Jim, H., Phillips, K. M., Chait, S. R., Faul, L. A., Popa, M. A., Lee, Y., Cases, M. G., Jacobsen, P. B., & Small, B. J. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.39.5640 · Cited by 411 · see citing works

Long-term treatment with estrogen and progesterone enhances acquisition of a spatial memory task by ovariectomized aged rats☆

Gibbs, R. B. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00103-2 · Cited by 404 · see citing works

Chemotherapy-Related Cognitive Dysfunction

Wefel, J. S., & Schagen, S. B. (2012) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-012-0264-9 · Cited by 400 · see citing works

Effect of gonadal steroids on activities of monoamine oxidase and choline acetylase in rat brain

Luine, V. N., Khylchevskaya, R. I., & McEwen, B. S. (1975) · Brain Research · doi:10.1016/0006-8993(75)90704-0 · Cited by 344 · see citing works

Estrogen effects on the brain: Actions beyond the hypothalamus via novel mechanisms.

McEwen, B. S., Akama, K. T., Spencer-Segal, J. L., Milner, T. A., & Waters, E. M. (2012) · Behavioral Neuroscience · doi:10.1037/a0026708 · Cited by 302 · see citing works

Hormone Therapy and Risk of Alzheimer Disease

Resnick, S. M., & Henderson, V. W. (2002) · JAMA · doi:10.1001/jama.288.17.2170 · Cited by 286 · see citing works

Estrogen and Aging Affect the Subcellular Distribution of Estrogen Receptor-α in the Hippocampus of Female Rats

Adams, M. M., Fink, S. E., Shah, R. A., Janssen, W. G. M., Hayashi, S., Milner, T. A., McEwen, B. S., & Morrison, J. H. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03608.2002 · Cited by 271 · see citing works

Effects of Tamoxifen and Exemestane on Cognitive Functioning of Postmenopausal Patients With Breast Cancer: Results From the Neuropsychological Side Study of the Tamoxifen and Exemestane Adjuvant Multinational Trial

Schilder, C. M. T., Seynaeve, C., Beex, L. V. A. M., Boogerd, W. J., Linn, S. C., Gundy, C. M., Huizenga, H. M., Nortier, J. W. R., van de Velde, C. J., van Dam, F. S. A. M., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2008.21.3553 · Cited by 270 · see citing works

Estradiol Replacement Enhances Working Memory in Middle-Aged Rats When Initiated Immediately after Ovariectomy But Not after a Long-Term Period of Ovarian Hormone Deprivation

Daniel, J. M., Hulst, J. L., & Berbling, J. L. (2005) · Endocrinology · doi:10.1210/en.2005-0998 · Cited by 263 · see citing works

Acetylcholine Mediates the Estrogen-Induced Increase in NMDA Receptor Binding in CA1 of the Hippocampus and the Associated Improvement in Working Memory

Daniel, J. M., & Dohanich, G. P. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-17-06949.2001 · Cited by 263 · see citing works

Aromatase inhibitors for treatment of advanced breast cancer in postmenopausal women

Gibson, L. J., Lawrence, D., Dawson, C., & Bliss, J. M. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003370.pub3 · Cited by 250 · see citing works

Disruption of estrogen receptor β gene impairs spatial learning in female mice

Rissman, E. F., Heck, A. L., Leonard, J. E., Shupnik, M. A., & Gustafsson, J.-Α. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012032699 · Cited by 245 · see citing works

Estrogen Attenuates Ischemic Oxidative Damage via an Estrogen Receptor α-Mediated Inhibition of NADPH Oxidase Activation

Zhang, Q.-G., Raz, L., Wang, R., Han, D. K., Sevilla, L. M. D., Yang, F., Vadlamudi, R. K., & Brann, D. W. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3574-09.2009 · Cited by 242 · see citing works

Neuroprotective actions of sex steroids in Parkinson’s disease

Bourque, M., Dluzen, D. E., & Paolo, T. D. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.04.014 · Cited by 239 · see citing works

Role of estrogen receptor alpha and beta expression and signaling on cognitive function during aging

Foster, T. C. (2012) · Hippocampus · doi:10.1002/hipo.20935 · Cited by 231 · see citing works

Preliminary Assessment of Cognitive Function in Breast Cancer Patients Treated with Tamoxifen

Paganini‐Hill, A., & Clark, L. J. (2000) · Breast Cancer Research and Treatment · doi:10.1023/a:1006426132338 · Cited by 227 · see citing works

Does hormone therapy for the treatment of breast cancer have a detrimental effect on memory and cognition? A pilot study

Jenkins, V. A., Shilling, V. M., Fallowfield, L. J., Howell, A., & Hutton, S. B. (2003) · Psycho-Oncology · doi:10.1002/pon.709 · Cited by 227 · see citing works

Different modes of hippocampal plasticity in response to estrogen in young and aged female rats

Adams, M. M., Shah, R. A., Janssen, W. G. M., & Morrison, J. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.141215898 · Cited by 222 · see citing works

Estradiol synthesis within the human brain

Azcoitia, Í., Yagüe, J. G., & García‐Segura, L. M. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.02.012 · Cited by 219 · see citing works

Estrogen binding and estrogen receptor characterization (ERα and ERβ) in the cholinergic neurons of the rat basal forebrain

Shughrue, P. J., Scrimo, P. J., & Merchenthaler, I. J. (2000) · Neuroscience · doi:10.1016/s0306-4522(99)00520-5 · Cited by 215 · see citing works

Para/autocrine regulation of estrogen receptors in hippocampal neurons

Prange‐Kiel, J., Wehrenberg, U., Jarry, H., & Rune, G. M. (2003) · Hippocampus · doi:10.1002/hipo.10075 · Cited by 210 · see citing works

Estrogen Replacement Therapy and Cognitive Decline in Older Community Women

Matthews, K. A., Cauley, J. A., Yaffe, K. S., & Zmuda, J. M. (1999) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1999.tb02563.x · Cited by 208 · see citing works

Cognitive Function in Postmenopausal Women Treated with Raloxifene

Yaffe, K. S., Krueger, K., Sarkar, S., Grady, D., Barrett-Connor, E. L., Cox, D. A., & Nickélsen, T. (2001) · New England Journal of Medicine · doi:10.1056/nejm200104193441604 · Cited by 204 · see citing works

Estrogen Replacement Increases Spinophilin-immunoreactive Spine Number in the Prefrontal Cortex of Female Rhesus Monkeys

Tang, Y. C. (2003) · Cerebral Cortex · doi:10.1093/cercor/bhg121 · Cited by 197 · see citing works

Cognitive Function in Postmenopausal Women Treated With Raloxifene

Yaffe, K. S., Krueger, K. A., Sarkar, S., Grady, D. G., Barrett-Connor, E. L., Cox, D. A., & Nickélsen, T. (2001) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-200109000-00018 · Cited by 197 · see citing works

Effects of estrogen on basal forebrain cholinergic neurons vary as a function of dose and duration of treatment

Gibbs, R. B. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01432-1 · Cited by 187 · see citing works

Estrogen and cognitive functioning in women: Lessons we have learned.

Sherwin, B. B. (2011) · Behavioral Neuroscience · doi:10.1037/a0025539 · Cited by 178 · see citing works

Estrogen exposures and memory at midlife

Henderson, V. W., Guthrie, J. R., DUDLEY, E. C., Burger, H., & Dennerstein, L. (2003) · Neurology · doi:10.1212/01.wnl.0000059413.75888.be · Cited by 174 · see citing works

Intra-hippocampal estradiol infusion enhances memory in ovariectomized rats

Packard, M. G., & Teather, L. A. (1997) · Neuroreport · doi:10.1097/00001756-199709290-00004 · Cited by 170 · see citing works

Aromatase Inhibition Abolishes LTP Generation in Female But Not in Male Mice

Vierk, R., Glassmeier, G., Zhou, L., Brandt, N., Fester, L., Dudzinski, D., Wilkars, W., Bender, R. A., Lewerenz, M., Gloger, S., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5319-11.2012 · Cited by 169 · see citing works

Distribution patterns of estrogen receptor α and β in the human cortex and hippocampus during development and adulthood

González, M., Cabrera‐Socorro, A., Pérez‐García, C. G., Fraser, J. D., López, F. J., Alonso, R., & Meyer, G. (2007) · Journal of Comparative Neurology · doi:10.1002/cne.21419 · Cited by 167 · see citing works

Hormone therapy and cognitive function: Is there a critical period for benefit?

Maki, P. M. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.01.001 · Cited by 161 · see citing works

Sex Steroids and Cognitive Function

Luine, V. N. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01710.x · Cited by 159 · see citing works

Memory impairments with adjuvant anastrozole versus tamoxifen in women with early-stage breast cancer

Bender, C. M., Sereika, S. M., Brufsky, A., Ryan, C. M., Vogel, V. G., Rastogi, P., Cohen, S. M., Casillo, F. E., & Berga, S. L. (2007) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e318148b28b · Cited by 159 · see citing works

Effects of tamoxifen on serotonin transporter and 5-hydroxytryptamine2A receptor binding sites and mRNA levels in the brain of ovariectomized rats with or without acute estradiol replacement

SUMNER, B. E. H., Grant, K. E., Rosie, R., Hegele-Hartung, C., Fritzemeier, K.-H., & Fink, G. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00243-0 · Cited by 154 · see citing works

Estrogen modulates learning in female rats by acting directly at distinct memory systems

Zurkovsky, L., Brown, S. L., Boyd, S. E., Fell, J. A., & Korol, D. L. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.09.002 · Cited by 150 · see citing works

Estradiol-Induced Object Memory Consolidation in Middle-Aged Female Mice Requires Dorsal Hippocampal Extracellular Signal-Regulated Kinase and Phosphatidylinositol 3-Kinase Activation

Fan, L., Zhao, Z., Orr, P. T., Chambers, C. H., Lewis, M. C., & Frick, K. M. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4333-09.2010 · Cited by 150 · see citing works

Sex Differences in Cholinergic Enzymes of Diagonal Band Nuclei in the Rat Preoptic Area

Luine, V. N., & McEwen, B. S. (2008) · Neuroendocrinology · doi:10.1159/000123501 · Cited by 146 · see citing works

Neuroprotection by Estrogen in Animal Models of Global and Focal Ischemia

Merchenthaler, I. J., Dellovade, T., & Shughrue, P. J. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1286.009 · Cited by 146 · see citing works

Cognitive effects of hormonal therapy in early stage breast cancer patients: a prospective study

Collins, B., MacKenzie, J., Stewart, A., Bielajew, C. H., & Verma, S. (2008) · Psycho-Oncology · doi:10.1002/pon.1453 · Cited by 142 · see citing works

Novel effects of estradiol and estrogen receptor α and β on cognitive function

Fugger, H. N., Foster, T. C., Gustafsson, J.-Å., & Rissman, E. F. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02993-0 · Cited by 140 · see citing works

Minireview: Endocannabinoids and Gonadal Hormones: Bidirectional Interactions in Physiology and Behavior

Gorzalka, B. B., & Dang, S. S. (2011) · Endocrinology · doi:10.1210/en.2011-1643 · Cited by 139 · see citing works

Neuroprotective actions of estradiol revisited

Azcoitia, Í., Arévalo, M., Nicola, A. F. D., & García‐Segura, L. M. (2011) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2011.08.002 · Cited by 138 · see citing works

17β-Estradiol replacement in young, adult and middle-aged female ovariectomized rats promotes improvement of spatial reference memory and an antidepressant effect and alters monoamines and BDNF levels in memory- and depression-related brain areas

Kiss, Á., Delattre, A. M., Pereira, S. I. R., Carolino, R. O. G., Szawka, R. E., Anselmo-Franci, J. A., Zanata, S. M., & Ferraz, A. C. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.10.047 · Cited by 137 · see citing works

Sex, Sex Steroids, and Brain Injury

Herson, P. S., Koerner, I. P., & Hurn, P. D. (2009) · Seminars in Reproductive Medicine · doi:10.1055/s-0029-1216276 · Cited by 136 · see citing works

Aromatase Inhibitors Induce Spine Synapse Loss in the Hippocampus of Ovariectomized Mice

Zhou, L., Fester, L., von Blittersdorff, B., Hassu, B., Nogens, H., Prange‐Kiel, J., Jarry, H., Wegscheider, K., & Rune, G. M. (2010) · Endocrinology · doi:10.1210/en.2009-0254 · Cited by 136 · see citing works

Estradiol acts via estrogen receptors alpha and beta on pathways important for synaptic plasticity in the mouse hippocampal formation

Spencer-Segal, J. L., Tsuda, M. C., Mattei, L., Waters, E. M., Romeo, R. D., Milner, T. A., McEwen, B. S., & Ogawa, S. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.11.035 · Cited by 133 · see citing works

Posttraining intrahippocampal estradiol injections enhance spatial memory in male rats: Interaction with cholinergic systems.

Packard, M. G., Kohlmaier, J. R., & Alexander, G. M. (1996) · Behavioral Neuroscience · doi:10.1037//0735-7044.110.3.626 · Cited by 133 · see citing works

Direct and indirect effects of estrogen on rat hippocampus

Prange‐Kiel, J., & Rune, G. M. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.05.061 · Cited by 132 · see citing works

Perimenopausal use of hormone therapy is associated with enhanced memory and hippocampal function later in life

Maki, P. M., Dennerstein, L., Clark, M., Guthrie, J. R., LaMontagne, P., Fornelli, D., Little, D. M., Henderson, V. W., & Resnick, S. M. (2010) · Brain Research · doi:10.1016/j.brainres.2010.11.030 · Cited by 131 · see citing works

Gonadotropin-releasing hormone regulates spine density via its regulatory role in hippocampal estrogen synthesis

Prange‐Kiel, J., Jarry, H., Schoen, M., Kohlmann, P., Lohse, C., Zhou, L., & Rune, G. M. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200707043 · Cited by 130 · see citing works

Steroidogenic factor‐1 expression in marmoset and rat hippocampus: co‐localization with StAR and aromatase

Wehrenberg, U., Prange‐Kiel, J., & Rune, G. M. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00207.x · Cited by 128 · see citing works

Estrogen receptor beta (ERβ) mRNA and protein in serotonin neurons of macaques

Gundlah, C., Lu, N. Z., Mirkes, S. J., & Bethea, C. L. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00108-5 · Cited by 128 · see citing works

Estrogen receptor α and β immunoreactive neurons in normal adult and aged female rat hippocampus: A qualitative and quantitative study

Mehra, R. D., Sharma, K., Nyakas, C. J., & Vij, U. (2005) · Brain Research · doi:10.1016/j.brainres.2005.06.073 · Cited by 127 · see citing works

Estrogens, estrogen receptors, and female cognitive aging: The impact of timing

Daniel, J. M. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.05.003 · Cited by 126 · see citing works

Effects of anastrozole on cognitive performance in postmenopausal women: a randomised, double-blind chemoprevention trial (IBIS II)

Jenkins, V. A., Ambroisine, L., Atkins, L., Cuzick, J. M., Howell, A., & Fallowfield, L. J. (2008) · The Lancet Oncology · doi:10.1016/s1470-2045(08)70207-9 · Cited by 120 · see citing works

Estradiol or diarylpropionitrile decrease anxiety-like behavior of wildtype, but not estrogen receptor beta knockout, mice

Walf, A., Koonce, C. J., & Frye, C. (2008) · Behavioral Neuroscience · doi:10.1037/a0012749 · Cited by 118 · see citing works

Posttraining intrahippocampal estradiol injections enhance spatial memory in male rats: Interaction with cholinergic systems.

Packard, M. G., Kohlmaier, J. R., & Alexander, G. M. (1996) · Behavioral Neuroscience · doi:10.1037/0735-7044.110.3.626 · Cited by 118 · see citing works

Sex differences in emotional and cognitive behaviour in mammals including man: Adaptive and neural bases

Gray, J. A., & Buffery, A. W. H. (1971) · Acta Psychologica · doi:10.1016/0001-6918(71)90014-x · Cited by 117 · see citing works

Androgens with activity at estrogen receptor beta have anxiolytic and cognitive-enhancing effects in male rats and mice

Frye, C. A., Koonce, C. J., Edinger, K. L., Osborne, D. M., & Walf, A. A. (2008) · Hormones and Behavior · doi:10.1016/j.yhbeh.2008.07.013 · Cited by 117 · see citing works

Differential effects of estrogen on hippocampal- and striatal-dependent learning

Davis, D. M., Jacobson, T. K., Aliakbari, S., & Mizumori, S. J. Y. (2005) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2005.06.004 · Cited by 113 · see citing works

Fast, convenient, and effective method to transiently transfect primary hippocampal neurons

Köhrmann, M., Haubensak, W. E., Hemraj, I., Kaether, C., Leßmann, V., & Kiebler, M. A. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19991215)58:6 · Cited by 111 · see citing works

Selective estrogen receptor modulators protect hippocampal neurons from kainic acid excitotoxicity: Differences with the effect of estradiol

Ciriza, I., Carrero, P., Azcoitia, Í., Lundeen, S. G., & García‐Segura, L. M. (2004) · Journal of Neurobiology · doi:10.1002/neu.20043 · Cited by 109 · see citing works

Raloxifene and estradiol benzoate both fully restore hippocampal choline acetyltransferase activity in ovariectomized rats

Wu, X., Glinn, M. A., Ostrowski, N. L., Su, Y., Ni, B., Cole, H. W., Bryant, H. U., & Paul, S. M. (1999) · Brain Research · doi:10.1016/s0006-8993(99)02062-4 · Cited by 106 · see citing works

Estradiol reduces anxiety- and depression-like behavior of aged female mice

Walf, A. A., & Frye, C. A. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.09.017 · Cited by 106 · see citing works

Estrogen-regulated synaptogenesis in the hippocampus: Sexual dimorphism in vivo but not in vitro

Fester, L., Prange‐Kiel, J., Zhou, L., von Blittersdorff, B., Böhm, J. W., Jarry, H., Schumacher, M., & Rune, G. M. (2011) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2011.11.010 · Cited by 106 · see citing works

Selective estrogen receptor modulators as brain therapeutic agents

Arévalo, M., Santos‐Galindo, M., Lagunas, N., Azcoitia, Í., & García‐Segura, L. M. (2010) · Journal of Molecular Endocrinology · doi:10.1677/jme-10-0122 · Cited by 106 · see citing works

Estradiol interacts with the cholinergic system to affect verbal memory in postmenopausal women: Evidence for the critical period hypothesis

Dumas, J. A., Hancur-Bucci, C., Naylor, M. R., Sites, C. K., & NEWHOUSE, P. A. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2007.09.011 · Cited by 105 · see citing works

Selective Estrogen Receptor Modulators Decrease Reactive Astrogliosis in the Injured Brain: Effects of Aging and Prolonged Depletion of Ovarian Hormones

Barreto, G. E., Santos‐Galindo, M., Diz-Chaves, Y., Pernía, O., Carrero, P., Azcoitia, Í., & García‐Segura, L. M. (2009) · Endocrinology · doi:10.1210/en.2009-0352 · Cited by 103 · see citing works

Estrogen Receptor β Activates the Human Retinoic Acid Receptorα -1 Promoter in Response to Tamoxifen and Other Estrogen Receptor Antagonists, but Not in Response to Estrogen

Zou, A., Marschke, K. B., Arnold, K. E., Berger, E. M., Fitzgerald, P., Mais, D. E., & Allegretto, E. A. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.3.0253 · Cited by 103 · see citing works

Effects of Hormone Replacement Therapy on Cognitive and Brain Aging

Resnick, S. M., & Maki, P. M. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb04023.x · Cited by 102 · see citing works

Effects of selective estrogen receptor modulators on allocentric working memory performance and on dendritic spines in medial prefrontal cortex pyramidal neurons of ovariectomized rats

Velázquez-Zamora, D. A., García‐Segura, L. M., & González‐Burgos, I. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.01.010 · Cited by 101 · see citing works

Transient Estradiol Exposure during Middle Age in Ovariectomized Rats Exerts Lasting Effects on Cognitive Function and the Hippocampus

Rodgers, S. P., Bohacek, J., & Daniel, J. M. (2010) · Endocrinology · doi:10.1210/en.2009-1245 · Cited by 101 · see citing works

Effects of raloxifene and estradiol on hippocampal acetylcholine release and spatial learning in the rat

Gibbs, R. B., Gabor, R., Cox, T., & Johnson, D. A. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(03)00118-5 · Cited by 95 · see citing works

Estrogen and the aging brain: an elixir for the weary cortical network

Dumitriu, D., Rapp, P. R., McEwen, B. S., & Morrison, J. H. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05529.x · Cited by 92 · see citing works

Estrogen prevents the loss of CA1 hippocampal neurons in gerbils after ischemic injury

Shughrue, P. J., & Merchenthaler, I. J. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00790-x · Cited by 90 · see citing works

Duration of estrogen deprivation, not chronological age, prevents estrogen's ability to enhance hippocampal synaptic physiology

Smith, C. C., Vedder, L. C., Nelson, A. R., Bredemann, T. M., & McMahon, L. L. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009307107 · Cited by 90 · see citing works

Systemic and local administration of estradiol into the prefrontal cortex or hippocampus differentially alters working memory

Sinopoli, K. J., Floresco, S., & Galea, L. A. M. (2006) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2006.04.003 · Cited by 88 · see citing works

Estrogen synthesis in the hippocampus

Fester, L., Prange‐Kiel, J., Jarry, H., & Rune, G. M. (2011) · Cell and Tissue Research · doi:10.1007/s00441-011-1221-7 · Cited by 87 · see citing works

Effects of oral estrogen, raloxifene and arzoxifene on gene expression in serotonin neurons of macaques

Bethea, C. L., Mirkes, S. J., Su, A., & Michelson, D. (2002) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00054-3 · Cited by 86 · see citing works

Neuroprotective actions of selective estrogen receptor modulators

DonCarlos, L. L., Azcoitia, Í., & García‐Segura, L. M. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.04.012 · Cited by 86 · see citing works

Cognitive function in postmenopausal women receiving adjuvant letrozole or tamoxifen for breast cancer in the BIG 1-98 randomized trial

Phillips, K., Ribi, K., Sun, Z., Stephens, A. J., Thompson, A. M., Harvey, V. J., Thurlimann, B. J. K., Cardoso, F., Pagani, O., Coates, A. S., et al. (2010) · The Breast · doi:10.1016/j.breast.2010.03.025 · Cited by 83 · see citing works

Estrogen and Tamoxifen Protect against Mn-Induced Toxicity in Rat Cortical Primary Cultures of Neurons and Astrocytes

Lee, E.-S. Y., Yin, Z., Milatović, D., Jiang, H., & Aschner, M. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfp081 · Cited by 83 · see citing works

Impact of the selective estrogen receptor modulator, raloxifene, on neuronal survival and outgrowth following toxic insults associated with aging and Alzheimer's disease

O’Neill, K. E., Chen, S., & Brinton, R. D. (2003) · Experimental Neurology · doi:10.1016/j.expneurol.2003.09.005 · Cited by 82 · see citing works

Anastrozole improved testosterone-induced impairment acquisition of spatial learning and memory in the hippocampal CA1 region in adult male rats.

Moradpour, F., Naghdi, N., & Fathollahi, Y. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.08.037 · Cited by 79 · see citing works

Estrogen–Growth Factor Interactions and Their Contributions to Neurological Disorders

Scharfman, H. E., & MacLusky, N. J. (2008) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2008.01200.x · Cited by 78 · see citing works

Estrogen-like Activity of Tamoxifen and Raloxifene on NMDA Receptor Binding and Expression of its Subunits in Rat Brain

Cyr, M. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00233-0 · Cited by 78 · see citing works

Estrogen induces rapid translocation of estrogen receptor β, but not estrogen receptor α, to the neuronal plasma membrane

Sheldahl, L. C., Shapiro, R. A., Bryant, D. N., Koerner, I. P., & Dorsa, D. M. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.02.035 · Cited by 77 · see citing works

Synaptic Plasticity in the Hippocampus: Effects of Estrogen from the Gonads or Hippocampus?

Rune, G. M., Lohse, C., Prange‐Kiel, J., Fester, L., & Frotscher, M. (2006) · Neurochemical Research · doi:10.1007/s11064-005-9004-8 · Cited by 77 · see citing works

Cognitive limitations associated with tamoxifen and aromatase inhibitors in employed breast cancer survivors

Breckenridge, L. M., Bruns, G. L., Todd, B. L., & Feuerstein, M. (2010) · Psycho-Oncology · doi:10.1002/pon.1860 · Cited by 75 · see citing works

Beta estrogen receptor knockout (BERKO) mice present attenuated hippocampal CA1 long-term potentiation and related memory deficits in contextual fear conditioning

Day, M., Sung, A., Logue, S. F., Bowlby, M. R., & Arias, R. L. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.05.011 · Cited by 74 · see citing works

Protective actions of ovarian hormones in the serotonin system of macaques

Bethea, C. L., Reddy, A. P., Tokuyama, Y., Henderson, J. A., & Lima, F. B. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.04.003 · Cited by 73 · see citing works

Enhancing effects of estrogen on inhibitory avoidance performance may be in part independent of intracellular estrogen receptors in the hippocampus

Frye, C. A., & Rhodes, M. E. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03559-x · Cited by 73 · see citing works

Estrogen modulates place learning through estrogen receptors in the hippocampus

Zurkovsky, L., BROWN, S., & Korol, D. L. (2006) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2006.07.008 · Cited by 72 · see citing works

The Ability of Oestradiol Administration to Regulate Protein Levels of Oestrogen Receptor Alpha in the Hippocampus and Prefrontal Cortex of Middle‐Aged Rats is Altered Following Long‐Term Ovarian Hormone Deprivation

Bohacek, J., & Daniel, J. M. (2009) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2009.01882.x · Cited by 72 · see citing works

Tamoxifen and toremifene cause impairment of learning and memory function in mice

Chen, D., Wu, C. F., Shi, B., & Xu, Y. M. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00656-6 · Cited by 69 · see citing works

Tamoxifen alleviates irradiation-induced brain injury by attenuating microglial inflammatory response in vitro and in vivo

Liu, J., Tian, D., Li, Z., Qu, W., Zhan, Y., Xie, M.-J., Yu, Z., Wang, W., & Wu, G. (2010) · Brain Research · doi:10.1016/j.brainres.2009.12.055 · Cited by 68 · see citing works

Oestrogen Synthesis in the Hippocampus: Role in Axon Outgrowth

Schassen, C. V., Fester, L., Prange‐Kiel, J., Lohse, C., Huber, C., Böttner, M., & Rune, G. M. (2006) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01484.x · Cited by 67 · see citing works

Self‐reported cognitive functioning in postmenopausal breast cancer patients before and during endocrine treatment: findings from the neuropsychological TEAM side‐study

Schilder, C. M. T., Seynaeve, C., Linn, S., Boogerd, W. J., Beex, L. V. A. M., Gundy, C. M., Nortier, J. W. R., van de Velde, C. J. �., van Dam, F. S. A. M., & Schagen, S. B. (2011) · Psycho-Oncology · doi:10.1002/pon.1928 · Cited by 66 · see citing works

Selective Estrogen Receptor Modulator Effects in the Rat Brain

Zhou, W., Koldzic‐Zivanovic, N., Clarke, C. H., Beun, R. D., Wassermann, K., Bury, P. S., Cunningham, K. A., & Thomas, M. L. (2002) · Neuroendocrinology · doi:10.1159/000048218 · Cited by 63 · see citing works

Cognitive function in postmenopausal breast cancer patients one year after completing adjuvant endocrine therapy with letrozole and/or tamoxifen in the BIG 1-98 trial

Phillips, K., Aldridge, J., Ribi, K., Sun, Z., Thompson, A. M., Harvey, V. J., Thurlimann, B. J. K., Cardoso, F., Pagani, O., Coates, A. S., et al. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-1235-y · Cited by 63 · see citing works

Impact of the selective estrogen receptor modulator, tamoxifen, on neuronal outgrowth and survival following toxic insults associated with aging and Alzheimer's disease

O’Neill, K. E., Chen, S., & Brinton, R. D. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.01.014 · Cited by 57 · see citing works

A new approach to understanding the molecular mechanisms through which estrogens affect cognition

Frick, K. M., Fernandez, S. M., & Harburger, L. L. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.11.004 · Cited by 55 · see citing works

Estrogen, progestogen and tamoxifen increase synaptic density of the hippocampus of ovariectomized rats

Silva, I., Mello, L. E., Freymüller, E. H., Haidar, M. A., & Baracat, E. C. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01410-5 · Cited by 55 · see citing works

Effects of letrozole on hippocampal and cortical catecholaminergic neurotransmitter levels, neural cell adhesion molecule expression and spatial learning and memory in female rats

Aydin, M., Yılmaz, B., Alçin, E., Nedzvetsky, V. S., Şahin, Z., & Tuzcu, M. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.09.005 · Cited by 51 · see citing works

Spatiotemporal dynamics of the expression of estrogen receptors in the postnatal mouse brain

Sugiyama, N., Andersson, S., Lathe, R., Fan, X., Alonso‐Magdalena, P., Schwend, T., Nalvarte, I., Warner, M. N., & Gustafsson, J. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.118 · Cited by 49 · see citing works

Effects of Tamoxifen and Raloxifene on Memory and Other Cognitive Abilities: Cognition in the Study of Tamoxifen and Raloxifene

Legault, C., Maki, P. M., Resnick, S. M., Coker, L. H., Hogan, P. E., Bevers, T. B., & Shumaker, S. A. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.21.0716 · Cited by 49 · see citing works

Minireview: Estrogen Receptor-Initiated Mechanisms Causal to Mammalian Reproductive Behaviors

Pfaff, D. W., Waters, E. M., Khan, Q., Zhang, X., & Numan, M. (2011) · Endocrinology · doi:10.1210/en.2010-1007 · Cited by 48 · see citing works

Mechanisms of cerebrovascular protection: oestrogen, inflammation and mitochondria

DUCKLES, S. P., & Krause, D. N. (2010) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02184.x · Cited by 46 · see citing works

Effect of chronic estradiol, tamoxifen or raloxifene treatment on serotonin 5-HT1A receptor

Landry, M., & Paolo, T. D. (2003) · Molecular Brain Research · doi:10.1016/s0169-328x(03)00049-4 · Cited by 46 · see citing works

Ovarian Hormone Deficiency Reduces Intrinsic Excitability and Abolishes Acute Estrogen Sensitivity in Hippocampal CA1 Pyramidal Neurons

Wu, W., Adelman, J. P., & Maylie, J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6081-10.2011 · Cited by 45 · see citing works

Increased estrogen receptor β expression correlates with decreased spine formation in the rat hippocampus

Szymczak, S., Kalita, K. B., Jaworski, J., Mioduszewska, B., Savonenko, A. V., Markowska, A. L., Merchenthaler, I. J., & Kaczmarek, L. (2006) · Hippocampus · doi:10.1002/hipo.20172 · Cited by 45 · see citing works

Do aromatase inhibitors have adverse effects on cognitive function?

Phillips, K. A., Ribi, K., & Fisher, R. (2011) · Breast Cancer Research · doi:10.1186/bcr2806 · Cited by 45 · see citing works

Effects of repeated administration of chemotherapeutic agents tamoxifen, methotrexate, and 5-fluorouracil on the acquisition and retention of a learned response in mice

Walker, E. A., Foley, J. J., Clark‐Vetri, R., & Raffa, R. B. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2310-8 · Cited by 44 · see citing works

Endocrine therapy is associated with low performance on some estrogen-sensitive cognitive tasks in postmenopausal women with breast cancer

Lejbak, L., Vrbancic, M. I., & Crossley, M. (2010) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803391003596389 · Cited by 44 · see citing works

Administration of raloxifene reduces sensorimotor and working memory deficits following traumatic brain injury

Kokiko, O. N., Murashov, A. K., & Hoane, M. R. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.02.026 · Cited by 43 · see citing works

Recognizing menopause in women with amenorrhea induced by cytotoxic chemotherapy for endocrine-responsive early breast cancer

Torino, F., Barnabei, A., Vecchis, L. D., Appetecchia, M., Strigari, L., & Corsello, S. M. (2012) · Endocrine Related Cancer · doi:10.1530/erc-11-0199 · Cited by 42 · see citing works

Cognitive changes associated with endocrine therapy for breast cancer

Agrawal, K., Onami, S. H., Mortimer, J. E., & Pal, S. K. (2010) · Maturitas · doi:10.1016/j.maturitas.2010.07.004 · Cited by 41 · see citing works

Different expression of α and β mitochondrial estrogen receptors in the aging rat brain: Interaction with respiratory complex V

Álvarez‐Delgado, C., Mendoza-Rodríguez, C. A., Picazo, O., & Cerbón, M. A. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.01.015 · Cited by 41 · see citing works

Inhibition of oestrogen biosynthesis induces mild anxiety in C57BL/6J ovariectomized female mice

Meng, F., Ni, R., Zhang, Z., Zhao, J. J., Liu, Y.-J., & Zhou, J. (2011) · Neuroscience Bulletin · doi:10.1007/s12264-011-1014-8 · Cited by 40 · see citing works

Chronic exposure to estrogen and tamoxifen regulates synaptophysin and phosphorylated cAMP response element-binding (CREB) protein expression in CA1 of ovariectomized rat hippocampus

Sharma, K., Mehra, R. D., Dhar, P., & Vij, U. (2006) · Brain Research · doi:10.1016/j.brainres.2006.11.027 · Cited by 40 · see citing works

A priming role of local estrogen on exogenous estrogen-mediated synaptic plasticity and neuroprotection

Chamniansawat, S., & Chongthammakun, S. (2012) · Experimental & Molecular Medicine · doi:10.3858/emm.2012.44.6.046 · Cited by 39 · see citing works

Tamoxifen and toremifene impair retrieval, but not acquisition, of spatial information processing in mice

Chen, D., Wu, C., Shi, B., & Xu, Y.-M. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00782-1 · Cited by 39 · see citing works

Differential effects of ovarian steroids and raloxifene on serotonin 1A and 2C receptor protein expression in macaques

Henderson, J. A., & Bethea, C. L. (2008) · Endocrine · doi:10.1007/s12020-008-9087-5 · Cited by 39 · see citing works

Raloxifene blocks estradiol induction of the serotonin transporter and 5-hydroxytryptamine2A receptor in female rat brain

SUMNER, B. E. H., Grant, K. E., Rosie, R., Hegele-Hartung, C., Fritzemeier, K., & Fink, G. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.02.039 · Cited by 39 · see citing works

Onset of estrogen replacement has a critical effect on synaptic density of CA1 hippocampus in ovariectomized adult rats

Silva, I., Mello, L. E., Freymüller, E. H., Haidar, M. A., & Baracat, E. C. (2003) · Menopause The Journal of The North American Menopause Society · doi:10.1097/01.gme.0000064816.74043.e9 · Cited by 35 · see citing works

An assessment of agonist/antagonist effects of tamoxifen in the female mouse brain*1

McKenna, S. (1992) · Hormones and Behavior · doi:10.1016/0018-506x(92)90020-v · Cited by 33 · see citing works

Tamoxifen fails to affect central serotonergic tone but increases indices of anxiety in female rhesus macaques

Mook, D. M., Felger, J. C., Graves, F. C., Wallen, K., & Wilson, M. E. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2004.08.005 · Cited by 31 · see citing works

Relative Effects of Tamoxifen, Raloxifene, and Conjugated Equine Estrogens on Cognition

Espeland, M. A., Shumaker, S. A., Limacher, M., Rapp, S. R., Bevers, T. B., Barad, D. H., Coker, L. H., Gaussoin, S. A., Stefanick, M. L., Lane, D. S., et al. (2010) · Journal of Women's Health · doi:10.1089/jwh.2009.1605 · Cited by 30 · see citing works

Hippocampal Estrogen Receptor-Alpha Splice Variant TADDI in the Human Brain in Aging and Alzheimer’s Disease

Александровна, И. Т., & Swaab, D. F. (2008) · Neuroendocrinology · doi:10.1159/000158573 · Cited by 26 · see citing works

Tamoxifen enhances choline acetyltransferase mRNA expression in rat basal forebrain cholinergic neurons

McMillan, P. J., LeMaster, A. M., & Dorsa, D. M. (2002) · Molecular Brain Research · doi:10.1016/s0169-328x(02)00195-x · Cited by 25 · see citing works

Estrogenic activity of tamoxifen and raloxifene on rat brain AMPA receptors

Cyr, M., Morissette, M., Landry, M., & Paolo, T. D. (2001) · Neuroreport · doi:10.1097/00001756-200103050-00021 · Cited by 25 · see citing works

The Mouse Primary Visual Cortex Is a Site of Production and Sensitivity to Estrogens

Jeong, J. K., Tremere, L. A., Burrows, K., Majewska, A. K., & Pinaud, R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020400 · Cited by 23 · see citing works

Tamoxifen disrupts consolidation and retrieval of morphine-associated contextual memory in male mice: interaction with estradiol

Esmaeili, B., Basseda, Z., Gholizadeh, S., Paydar, M. J., & Dehpour, A. R. (2009) · Psychopharmacology · doi:10.1007/s00213-008-1448-5 · Cited by 21 · see citing works

Effects of estrogen and estrogenic compounds on cognition in ovariectomized rats

Wu, J., Zhu, Y., & Wu, J. (2008) · Climacteric · doi:10.1080/13697130802162855 · Cited by 21 · see citing works

NO EFFECT OF DIFFERENT ESTROGEN RECEPTOR LIGANDS ON COGNITION IN ADULT FEMALE MONKEYS

Lacreuse, A., Wilson, M., & Herndon, J. (2008) · Physiology and Behavior · doi:10.1016/j.physbeh.2008.11.018 · Cited by 16 · see citing works

Sex Steroids and Acetylcholine Release in the Hippocampus

Mitsushima, D. (2010) · Vitamins and hormones · doi:10.1016/s0083-6729(10)82014-x · Cited by 15 · see citing works

Untitled work

(1997) · doi:10.1002/(sici)1096-9861(19971201)388:4

Prevalence of cognitive impairment following chemotherapy treatment for breast cancer: a systematic review and meta-analysis

Whittaker, A. L., George, R. P., & O'Malley, L. A. (2022) · Scientific Reports · doi:10.1038/s41598-022-05682-1 · Cited by 209 · see citing works

Impact of Cancer and Its Treatments on Cognitive Function: Advances in Research From the Paris International Cognition and Cancer Task Force Symposium and Update Since 2012

Joly, F., Giffard, B., Rigal, O., de Ruiter, M. B., Small, B. J., Dubois, M., Fel, J. L., Schagen, S. B., Ahles, T. A., Wefel, J. S., et al. (2015) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2015.06.019 · Cited by 185 · see citing works

Monitoring and optimising cognitive function in cancer patients: Present knowledge and future directions

Schagen, S. B., Klein, M., Reijneveld, J. C., Brain, E. G. C., Deprez, S., Joly, F., Scherwath, A., Schrauwen, W., & Wefel, J. S. (2014) · European Journal of Cancer Supplements · doi:10.1016/j.ejcsup.2014.03.003 · Cited by 105 · see citing works

Cancer and Dementia

Ganguli, M. (2015) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000086 · Cited by 99 · see citing works

Cognitive Function After the Initiation of Adjuvant Endocrine Therapy in Early-Stage Breast Cancer: An Observational Cohort Study

Ganz, P. A., Petersen, L., Castellon, S. A., Bower, J. E., Silverman, D. H. S., Cole, S. W., Irwin, M. R., & Belin, T. R. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2014.56.1662 · Cited by 97 · see citing works

Chemotherapy-related changes in cognitive functioning

Schagen, S. B., & Wefel, J. S. (2013) · European Journal of Cancer Supplements · doi:10.1016/j.ejcsup.2013.07.007 · Cited by 74 · see citing works

How to Identify and Manage Cognitive Dysfunction After Breast Cancer Treatment

Lange, M., & Joly, F. (2017) · Journal of Oncology Practice · doi:10.1200/jop.2017.026286 · Cited by 70 · see citing works

Screening the ToxCast phase II libraries for alterations in network function using cortical neurons grown on multi-well microelectrode array (mwMEA) plates

Strickland, J. D., Martin, M. T., Richard, A. M., Houck, K. A., & Shafer, T. J. (2017) · Archives of Toxicology · doi:10.1007/s00204-017-2035-5 · Cited by 69 · see citing works

Post-treatment Neurocognition and Psychosocial Care Among Breast Cancer Survivors

Buchanan, N. D., Dasari, S. R., Rodriguez, J. L., Smith, J. L., Hodgson, M. E., Weinberg, C. R., & Sandler, D. P. (2015) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2015.08.013 · Cited by 64 · see citing works

Cancer related cognitive impairment: a downside of cancer treatment

Demos-Davies, K. M., Lawrence, J., & Seelig, D. M. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1387251 · Cited by 53 · see citing works

The Working Memory and Dorsolateral Prefrontal-Hippocampal Functional Connectivity Changes in Long-Term Survival Breast Cancer Patients Treated with Tamoxifen

Chen, X., He, X., Tao, L., Li, J., Wu, J., Zhu, C., Yu, F., Zhang, L., Zhang, J., Qiu, B., et al. (2017) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx008 · Cited by 49 · see citing works

Chemobrain in Breast Cancer: Mechanisms, Clinical Manifestations, and Potential Interventions

Onzi, G. R., D’Agustini, N., García, S. C., Guterres, S. S., Pohlmann, P. R., Rosa, D. D., & Pohlmann, A. R. (2022) · Drug Safety · doi:10.1007/s40264-022-01182-3 · Cited by 48 · see citing works

Cognitive impairment following hormone therapy: current opinion of research in breast and prostate cancer patients

Wu, L. M., & Amidi, A. (2016) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000251 · Cited by 47 · see citing works

Tamoxifen induces cellular stress in the nervous system by inhibiting cholesterol synthesis

Denk, F., Ramer, L. M., Erskine, E. L. K. S., Nassar, M. A., Bogdanov, Y., Signore, M., Wood, J. N., McMahon, S. B., & Ramer, M. S. (2015) · Acta Neuropathologica Communications · doi:10.1186/s40478-015-0255-6 · Cited by 44 · see citing works

Decision-making impairments in breast cancer patients treated with tamoxifen

Chen, X., Li, J., Chen, J., Li, D., Ye, R., Zhang, J., Zhu, C., Tian, Y., & Wang, K. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.07.005 · Cited by 44 · see citing works

Adjuvant ovarian function suppression and cognitive function in women with breast cancer

Phillips, K., Regan, M. M., Ribi, K., Francis, P. A., Puglisi, F., Bellet, M., Spazzapan, S., Karlsson, P., Budman, D. R., Zaman, K., et al. (2016) · British Journal of Cancer · doi:10.1038/bjc.2016.71 · Cited by 40 · see citing works

A four week randomised control trial of adjunctive medroxyprogesterone and tamoxifen in women with mania

Kulkarni, J., Berk, M., Wang, W., Mu, L., Scarr, E., Rheenen, T. E. V., Worsley, R., Gurvich, C., Gavrilidis, E., de Castella, A. R., et al. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.02.004 · Cited by 38 · see citing works

Long-term subjective cognitive functioning following adjuvant systemic treatment: 7–9 years follow-up of a nationwide cohort of women treated for primary breast cancer

Amidi, A., Christensen, S., Mehlsen, M. Y., Jensen, A. B., Pedersen, A. D., & Zachariae, R. H. (2015) · British Journal of Cancer · doi:10.1038/bjc.2015.243 · Cited by 36 · see citing works

Effects of Tibolone on the Central Nervous System: Clinical and Experimental Approaches

Pinto‐Almazán, R., Segura-Uribe, J. J., Farfán‐García, E. D., & Guerra‐Araiza, C. (2017) · BioMed Research International · doi:10.1155/2017/8630764 · Cited by 35 · see citing works

Effects of Endocrine Therapy on Cognitive Function in Patients with Breast Cancer: A Comprehensive Review

Haggstrom, L., Vardy, J. L., Carson, E., Segara, D., Lim, E., & Kiely, B. E. (2022) · Cancers · doi:10.3390/cancers14040920 · Cited by 39 · see citing works

Effect of physical exercise on cognitive function and brain measures after chemotherapy in patients with breast cancer (PAM study): protocol of a randomised controlled trial

Witlox, L., Schagen, S. B., de Ruiter, M. B., Geerlings, M. I., Peeters, P. H. M., Koevoets, E. W., van der Wall, E., Stuiver, M. M., Sonke, G. S., Velthuis, M. J., et al. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-028117 · Cited by 31 · see citing works

Impairment of the executive attention network in premenopausal women with hormone receptor-positive breast cancer treated with tamoxifen

Chen, X., Li, J., Zhang, J., He, X., Zhu, C., Zhang, L., Hu, X., & Wang, K. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.10.020 · Cited by 22 · see citing works

Adjuvant aromatase inhibitor treatment worsens depressive symptoms and sleep quality in postmenopausal women with localized breast cancer: A one-year follow-up study

García-Sánchez, J., Mafla-España, M. A., Torregrosa, M. D., & Cauli, O. (2022) · The Breast · doi:10.1016/j.breast.2022.11.007 · Cited by 19 · see citing works

Cognitive Impairment in Patients With Breast Cancer: Understanding the Impact of Chemotherapy and Endocrine Therapy

Ganz, P. A., & Dyk, K. V. (2020) · Journal of Clinical Oncology · doi:10.1200/jco.20.00336 · Cited by 18 · see citing works

Can Exercise Ameliorate Aromatase Inhibitor-Induced Cognitive Decline in Breast Cancer Patients?

Li, C., Zhou, C., & Li, R. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9341-9 · Cited by 17 · see citing works

Steroid receptor coactivator-1: A versatile regulator and promising therapeutic target for breast cancer

Zhang, Y., Duan, C., Bian, C., Xiong, Y., & Zhang, J. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.02.010 · Cited by 13 · see citing works

Older patients’ experience of living with cognitive impairment related to hormone therapy for breast cancer: A qualitative study

Tenda, Y., Miyashita, M., Yamada, A., Shimizu, C., Nakayama, K., Honma, N., Taira, N., & Sawaki, M. (2022) · European Journal of Oncology Nursing · doi:10.1016/j.ejon.2022.102115 · Cited by 10 · see citing works

The Effect of 17β-Estradiol and Its Analogues on Cognition in Preclinical and Clinical Research: Relevance to Schizophrenia

Sbisa, A. M., van den Buuse, M., & Gogos, A. (2017) · Springer eBooks · doi:10.1007/978-3-319-53126-7_26 · Cited by 8 · see citing works

Management of breast cancer in elderly patients

Vicini, E., Swaminathan, V., & Audisio, R. A. (2013) · Clinical Practice · doi:10.2217/cpr.13.73 · Cited by 6 · see citing works

Cognitive Impairment in Breast Cancer Survivors

MacKenzie, M. J., Zuniga, K. E., & McAuley, E. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800778-5.00019-0 · Cited by 6 · see citing works

Effects of tamoxifen on cognitive function in patients with primary breast cancer

Luijendijk, M. J., Buijs, S. M., Jager, A., Koolen, S. L. W., van der Wall, E., Schagen, S. B., & Mathijssen, R. H. J. (2024) · British Journal of Cancer · doi:10.1038/s41416-024-02914-1 · Cited by 5 · see citing works

Understanding the impact of breast cancer adjuvant endocrine therapy on cognitive function: a work in progress

Ganz, P. A. (2016) · British Journal of Cancer · doi:10.1038/bjc.2016.89 · Cited by 4 · see citing works

Assay of Calcium Transients and Synapses in Rat Hippocampal Neurons by Kinetic Image Cytometry and High-Content Analysis: An In Vitro Model System for Postchemotherapy Cognitive Impairment

McDonough, P. M., Prigozhina, N. L., Basa, R. C. B., & Price, J. H. (2017) · Assay and Drug Development Technologies · doi:10.1089/adt.2017.797 · Cited by 2 · see citing works

Association of Cancer History with Lifetime Risk of Dementia and Alzheimer’s Disease

Li, Y., Xu, X., Wang, P., Chen, X. M., Yang, Q., Sun, L., & Gao, X. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231223 · Cited by 2 · see citing works

Challenges of Endocrine Therapy in Breast Cancer

Mansouri, S., Teymourzadeh, A., Farahmand, L., & Majidzadeh‐A, K. (2017) · Springer eBooks · doi:10.1007/978-3-319-64550-6_17 · Cited by 2 · see citing works

WORK PERFORMANCE LIMITATIONS POST ANASTROZOLE TREATMENT FOR WOMEN WITH BREAST CANCER

Popelas, T. (2014) · D-Scholarship@Pitt (University of Pittsburgh)

Cognitive Function in Post-Menopausal Women with Breast Cancer Treated with Aromatase Inhibitors.

Clark, P. M. (2014) · Deep Blue (University of Michigan)

Older Patients’ Experience of Living With Cognitive Impairment Related to Hormone Therapy for Breast CancerPreprint

Tenda, Y., Miyashita, M., Yamada, A., Shimizu, C., Nakayama, K., Honma, N., Taira, N., & Sawaki, M. (2021) · Research Square · doi:10.21203/rs.3.rs-413974/v1

Imagens de tensores de difusão em mulheres com queixas cognitivas persistentes após quimioterapia para câncer de mama

Sanches, L. G. (2022) · doi:10.31744/pg2022.108588

Alteraciones cognitivas asociadas al tratamiento de hormonoterapia en pacientes con cáncer de mama: una revisión sistemática

Toader, I. D., & Cruzado, J. A. (2024) · Psicooncología · doi:10.5209/psic.94813

Cognitive Problems and Management in Breast Cancer

Çam, Y. (2024) · Springer eBooks · doi:10.1007/978-3-031-75480-7_21

Prévention des neuropathies périphériques induites par les chimiothérapies par une modulation pharmacologique des dérives des formes réactives de l'oxygène et des récepteurs muscariniques

Cerles, O. (2017) · doi:10.70675/5734b561zdbcez47fdz9079zd20120eca3be

Results From a Phase II Single-Arm Trial Evaluating the Safety and Efficacy of Anhydrous Enol-Oxaloacetate on Improving Cognitive Complaints in Breast Cancer Survivors

Ganz, P. A., Dyk, K. V., Crespi, C. M., Petersen, L., Sedrak, M. S., & Bower, J. E. (2026) · JCO oncology advances. · doi:10.1200/oa-26-00063

The effect of treatment interruptions during postoperative breast irradiation

Beşe, N., Sut, P., & Öber, A. (2006) · European Journal of Cancer Supplements · doi:10.1016/s1359-6349(06)80205-3

Optimal timing and duration of the use of an aromatase inhibitor (Al) in the adjuvant treatment of postmenopausal hormone receptor-positive (HR+) breast cancer (BC)

Cuzick, J. M. (2008) · European Journal of Cancer Supplements · doi:10.1016/s1359-6349(08)70562-7

Recent findings and future directions in breast cancer chemoprevention

Mamounas, E. P. (2005) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(05)80067-8

Cognitive changes associated with endocrine therapy for breast cancer

Agrawal, K., Onami, S. H., Mortimer, J. E., & Pal, S. K. (2010) · Maturitas · doi:10.1016/j.maturitas.2010.07.004 · Cited by 41 · see citing works

Neurological effects of endocrine therapy in the treatment of breast cancer

Ladan, B. P. (2015) · Utrecht University Repository (Utrecht University)