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Cited by 9

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Dual opposing actions of STW 5 on TRP receptors mediate neuronal desensitisation in vitro

Khalil, M., Zhang, Z., Abdel-Aziz, H., Rabini, S., Ammar, R.M., Reeh, P.W., Engel, M.A.·2020·Life Sciences
DOI 10.1016/j.lfs.2020.118112
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Research works printed but not linked: 43

  1. Keohane, 2006, Functional dyspepsia: the role of visceral hypersensitivity in its pathogenesis, World J. Gastroenterol., 12, 2672, 10.3748/wjg.v12.i17.2672 · DOI
  2. Rosen, 2014, Visceral hypersensitivity and electromechanical dysfunction as therapeutic targets in pediatric functional dyspepsia, World J Gastrointest Pharmacol Ther, 5, 122, 10.4292/wjgpt.v5.i3.122 · DOI
  3. Kuiken, 2005, Relationship between symptoms and hypersensitivity to rectal distension in patients with irritable bowel syndrome, Aliment. Pharmacol. Ther., 22, 157, 10.1111/j.1365-2036.2005.02524.x · DOI
  4. Rukwied, 2007, Potentiation of nociceptive responses to low pH injections in humans by prostaglandin E2, J. Pain, 8, 443, 10.1016/j.jpain.2006.12.004 · DOI
  5. Holzer, 2011, Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system, Pharmacol. Ther., 131, 142, 10.1016/j.pharmthera.2011.03.006 · DOI
  6. Akbar, 2010, Expression of the TRPV1 receptor differs in quiescent inflammatory bowel disease with or without abdominal pain, Gut, 59, 767, 10.1136/gut.2009.194449 · DOI
  7. S.M. Brierley, et al., TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity, J. Physiol.. 589(Pt 14) (2011) 3575–93, doi:https://doi.org/10.1113/jphysiol.2011.206789. · DOI
  8. Holzer, 2017, Visceral inflammation and immune activation stress the brain, Front. Immunol., 8, 1613, 10.3389/fimmu.2017.01613 · DOI · Paper page
  9. Liebregts, 2007, Immune activation in patients with irritable bowel syndrome, Gastroenterology, 132, 913, 10.1053/j.gastro.2007.01.046 · DOI · Paper page
  10. Jardin, 2017, TRPs in pain sensation, Front. Physiol., 8, 392, 10.3389/fphys.2017.00392 · DOI
  11. Abdel-Aziz, 2017, Evaluating the multitarget effects of combinations through multistep clustering of pharmacological data: the example of the commercial preparation Iberogast, Planta Med., 83, 1130
  12. Ottillinger, 2013, STW 5 (Iberogast(R))--a safe and effective standard in the treatment of functional gastrointestinal disorders, Wien Med Wochenschr, 163, 65, 10.1007/s10354-012-0169-x · DOI
  13. Stanghellini, 2016, Gastroduodenal Disorders, Gastroenterology, 150, 1380, 10.1053/j.gastro.2016.02.011 · DOI · Paper page
  14. Liu, 2004, The herbal preparation STW 5 (Iberogast) desensitizes intestinal afferents in the rat small intestine, Neurogastroenterol. Motil., 16, 759, 10.1111/j.1365-2982.2004.00576.x · DOI
  15. Mueller, 2018, Differential desensitisation of afferent nerve fibres by Iberis amara (STW 6) and Iberogast (STW 5) in the murine colon, Am J Phytomed Clin Ther., 6
  16. Muller, 2006, STW 5 (Iberogast) reduces afferent sensitivity in the rat small intestine, Phytomedicine, 13, 100, 10.1016/j.phymed.2006.03.014 · DOI
  17. Simmen, 2006, Binding of STW 5 (Iberogast) and its components to intestinal 5-HT, muscarinic M3, and opioid receptors, Phytomedicine, 13, 51, 10.1016/j.phymed.2006.03.012 · DOI
  18. Abdel-Aziz, 2007, Effect of a herbal preparation in a model of 5-HT3 receptor mediated ileal contraction in vitro, Gut, 56
  19. Forster, 2009, High concentrations of morphine sensitize and activate mouse dorsal root ganglia via TRPV1 and TRPA1 receptors, Mol. Pain, 5, 17, 10.1186/1744-8069-5-17 · DOI
  20. Mueller-Tribbensee, 2015, Differential contribution of TRPA1, TRPV4 and TRPM8 to colonic nociception in mice, PLoS One, 10, 10.1371/journal.pone.0128242 · DOI
  21. Obata, 2005, TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury, J. Clin. Invest., 115, 2393, 10.1172/JCI25437 · DOI · Paper page
  22. Story, 2003, ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures, Cell, 112, 819, 10.1016/S0092-8674(03)00158-2 · DOI
  23. Brand, 2002, Sensitization and desensitization to allyl isothiocyanate (mustard oil) in the nasal cavity, Chem. Senses, 27, 593, 10.1093/chemse/27.7.593 · DOI
  24. Jacquot, 2005, Trigeminal sensitization and desensitization in the nasal cavity: a study of cross interactions, Rhinology, 43, 93
  25. Allam, 2015, Mode of action of the herbal medicine STW 5 to evoke gastric relaxation, Gastroenterology, 148, S821, 10.1016/S0016-5085(15)32792-X · DOI
  26. Szolcsanyi, 1975, Functional and fine structural characteristics of the sensory neuron blocking effect of capsaicin, Naunyn Schmiedeberg’s Arch. Pharmacol., 287, 157, 10.1007/BF00510447 · DOI
  27. Szolcsanyi, 1990, Resiniferatoxin: an ultrapotent selective modulator of capsaicin-sensitive primary afferent neurons, J. Pharmacol. Exp. Ther., 255, 923, 10.1016/S0022-3565(25)23196-2 · DOI
  28. Allam, 2014, Effects of the herbal drug STW 5 and its individual components on human intestinal motility, Gastroenterology, 146, S82, 10.1016/S0016-5085(14)60296-1 · DOI
  29. Doihara, 2009, Molecular cloning and characterization of dog TRPA1 and AITC stimulate the gastrointestinal motility through TRPA1 in conscious dogs, Eur. J. Pharmacol., 617, 124, 10.1016/j.ejphar.2009.06.038 · DOI
  30. Penuelas, 2007, Contractile effect of TRPA1 receptor agonists in the isolated mouse intestine, Eur. J. Pharmacol., 576, 143, 10.1016/j.ejphar.2007.08.015 · DOI
  31. Koseki, 2012, Role of transient receptor potential ankyrin 1 in gastric accommodation in conscious guinea pigs, J. Pharmacol. Exp. Ther., 341, 205, 10.1124/jpet.111.189027 · DOI
  32. Malfertheiner, 2017, STW 5 (Iberogast) therapy in gastrointestinal functional disorders, Dig. Dis., 35, 25, 10.1159/000485410 · DOI · Paper page
  33. Mittler, 2011, Iberis Amara desensitizes colonic afferent nerve fibers in the mouse to 5-HT and low-threshold distension but not to Bradykinin and high-threshold distension, Gastroenterology, 140, S, 10.1016/S0016-5085(11)62228-2 · DOI
  34. Balemans, 2017, Transient receptor potential ion channel function in sensory transduction and cellular signaling cascades underlying visceral hypersensitivity, Am. J. Physiol. Gastrointest. Liver Physiol., 312, G635, 10.1152/ajpgi.00401.2016 · DOI
  35. Simmen, 2003, Relevance of the herbal combination of STW 5 for its binding affinity to the muscarinic M3 receptor, Archiv für Experimentelle Pathologie und Pharmakologie, 367, R22
  36. Kang, 2015, Spontaneous L-glutamate release enhancement in rat substantia gelatinosa neurons by (−)-carvone and (+)-carvone which activate different types of TRP channel, Biochem. Biophys. Res. Commun., 459, 498, 10.1016/j.bbrc.2015.02.135 · DOI
  37. Gonçalves, 2013, The monoterpene (−)-carvone: a novel agonist of TRPV1 channels, Cytometry Part A, 83A, 212, 10.1002/cyto.a.22236 · DOI
  38. Chen, 2014, Furanocoumarins are a novel class of modulators for the transient receptor potential vanilloid type 1 (TRPV1) channel, J. Biol. Chem., 289, 9600, 10.1074/jbc.M113.536862 · DOI
  39. Liu, 2013, TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain, Pain, 154, 2169, 10.1016/j.pain.2013.06.043 · DOI · Paper page
  40. Takaishi, 2016, Reciprocal effects of capsaicin and menthol on thermosensation through regulated activities of TRPV1 and TRPM8, J. Physiol. Sci., 66, 143, 10.1007/s12576-015-0427-y · DOI
  41. Harrington, 2011, A novel role for TRPM8 in visceral afferent function, Pain, 152, 1459, 10.1016/j.pain.2011.01.027 · DOI
  42. Ruparel, 2008, Homologous and heterologous desensitization of capsaicin and mustard oil responses utilize different cellular pathways in nociceptors, Pain, 135, 271, 10.1016/j.pain.2007.06.005 · DOI
  43. Akopian, 2007, Transient receptor potential TRPA1 channel desensitization in sensory neurons is agonist dependent and regulated by TRPV1-directed internalization, J. Physiol., 583, 175, 10.1113/jphysiol.2007.133231 · DOI

Cited by

Metadata

Authors
Khalil, M., Zhang, Z., Abdel-Aziz, H., Rabini, S., Ammar, R. M., Reeh, P. W., & Engel, M. A.
Venue
Life Sciences
Publisher
Elsevier BV
Published
2020-09
Volume
257
Pages
118112
ISSN
0024-3205
DOI
10.1016/j.lfs.2020.118112
Cited by
9
References
1
Language
en
Licence
Funders
  • Deutsche Forschungsgemeinschaft (SFB TRR 241/1 TP B05)
  • Friedrich-Alexander-Universität Erlangen-Nürnberg
  • Bayer Consumer Health (64295)

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