A Controlled Study of Colonic Immune Activity and β7+ Blood T Lymphocytes in Patients With Irritable Bowel Syndrome
Open accessAbstract
Background & aims The mechanisms behind irritable bowel syndrome (IBS) are incompletely understood. Recently several studies have suggested a low-grade colonic inflammation as initiator of the gut dysfunctions recorded in this patient group. The aim of this study was to characterize the phenotype and homing properties of colonic and peripheral blood lymphocytes in patients with IBS.Methods Patients with IBS (n=33), defined by the Rome II criteria, were compared with UC patients (n=23) and control subjects (n=15) without gastrointestinal symptoms. Colonic and peripheral blood lymphocytes were analyzed by flow cytometry. Secretion of IFN-gamma from intestinal biopsies was determined by enzyme-linked immunosorbent assay, and immunohistochemical staining of colonic biopsies was performed.Results IBS patients displayed an increased frequency of peripheral blood CD4+ and CD8+ T cells expressing the gut homing integrin beta7. Accordingly, IBS and UC patients had an augmented frequency of lamina propria CD8+ T cells in the ascending colon as compared with control subjects. The frequency of intestinal T cells expressing integrin beta7+ was unaltered in IBS and UC patients, although the expression of mucosal addressin cell adhesion molecule-1+ endothelium, the ligand for integrin beta7, was increased in the ascending colon of IBS and UC patients as compared with control subjects.Conclusions Patients with IBS exhibit an enhanced immune activity in the gut and an increased frequency of integrin beta7+ T lymphocytes in the peripheral blood. Our data further support the hypothesis of IBS being at least partially an inflammatory disorder.
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Increased levels of CD4+ T helper cells were observed in the colon of patients with IBS in one study but not in another.
“Similarly, increased levels of CD4+ T helper cells were observed in the colon of patients with IBS in one study (46) but not in another (123), leaving the role for this T cell subtype in IBS unclear.”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [123]
Peripheral blood T cells from patients with IBS express elevated levels of integrin β7.
“Peripheral blood T cells from patients with IBS express elevated levels of integrin β7 (122, 123), which is important for homing of cells to the intestines.”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [123]
Levels of MAdCAM-1 are elevated on colonic endothelial cells in IBS, creating an environment for enhanced recruitment of CD4+ and CD8+ T cells to the intestines.
“Levels of MAdCAM-1, the ligand of integrin β7, are also elevated on colonic endothelial cells (123), creating an environment for enhanced recruitment of CD4+ and CD8+ T cells to the intestines of patients with IBS.”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [123]
Concentrations of cytotoxic CD8+ T cells may be elevated in the lamina propria of the colon of patients with IBS or PI-IBS, although this finding was disputed by others.
“Concentrations of cytotoxic CD8+ T cells, which comprise most of the intraepithelial T cell population (126) may also be elevated in the lamina propria of the colon of patients with IBS (46, 123) or PI-IBS (89) although this finding was disputed by others (36).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [123]
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- Authors
- Öhman, L., Isaksson, S., Lundgren, A., Simrén, M., & Sjövall, H.
- Affiliations
- University of Gothenburg (SE)
- Corresponding author
- Öhman, Lena
- Venue
- Clinical Gastroenterology and Hepatology
- Publisher
- Elsevier BV
- Published
- 2005-10
- Volume
- 3
- Issue
- 10
- Pages
- 980-986
- ISSN
- 1542-3565 (ISSN-L)
- OpenAlex
- W2166328424
- Cited by
- 98
- References
- 33
- Citations by year
- 2026: 1 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 5 · 2019: 5 · 2018: 2 · 2017: 5 · 2016: 4 · 2015: 5 · 2014: 9 · 2013: 10 · 2012: 10
- FWCI
- 3.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical Gastroenterology and Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- irritable bowel syndrome, beta7 integrin, MAdCAM-1, ulcerative colitis, IFN-gamma secretion, CD4+ T cells, CD8+ T cells, ascending colon
- MeSH terms
- Adult, Colitis, Ulcerative, Enzyme-Linked Immunosorbent Assay, Female, Flow Cytometry, Humans, Immunohistochemistry, Interferon-gamma, Intestinal Mucosa, Male, T-Lymphocytes, CD8-Positive T-Lymphocytes, Integrin beta Chains, Irritable Bowel Syndrome
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