The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Menthacarin induces calcium ion influx in sensory neurons, macrophages and colonic organoids of mice
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In contrast, menthol increases calcium influx in mouse dorsal root ganglionic neurons, colonic organoids, and peritoneal macrophages through activation of transient receptor potential cation channel, subfamily A, member 1 (TRPA1) channels [22,23].”
From Plant-Derived Treatments for IBS: Clinical Outcomes, Mechanistic Insights, and Their Position in International Guidelines (2026) · cites this paper as [23]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Spiller, R. C., Jenkins, D., Thornley, J. P., Hebden, J. M., Wright, T., Skinner, M., & Neal, K. R. (2000) · Gut · doi:10.1136/gut.47.6.804 · Cited by 1,155
Activation of the mucosal immune system in irritable bowel syndrome
Chadwick, V. S., Chen, W., Shu, D., Paulus, B., Bethwaite, P., Tie, A., & Wilson, I. (2002) · Gastroenterology · doi:10.1053/gast.2002.33579 · Cited by 833
Role for protease activity in visceral pain in irritable bowel syndrome
Cenac, N., Andrews, C. N., Holzhausen, M., Chapman, K., Cottrell, G., Andrade-Gordon, P., Steinhoff, M., Barbara, G., Beck, P., Bunnett, N. W., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29255 · Cited by 591
Dunlop, S. P., Jenkins, D., & Spiller, R. C. (2003) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07542.x · Cited by 359
Irritable bowel syndrome: A clinical review
Soares, R. L. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i34.12144 · Cited by 266
Research works printed but not linked: 38
- Botschuijver, 2018, Reversal of visceral hypersensitivity in rat by Menthacarin((R)), a proprietary combination of essential oils from peppermint and caraway, coincides with mycobiome modulation, Neurogastroenterol. Motil., 30, 10.1111/nmo.13299 · DOI
- Adam, 2006, A combination of peppermint oil and caraway oil attenuates the post-inflammatory visceral hyperalgesia in a rat model, Scand. J. Gastroenterol., 41, 155, 10.1080/00365520500206442 · DOI
- Krueger, 2020, Peppermint and caraway oils have muscle inhibitory and pro-secretory activity in the human intestine in vitro, Neurogastroenterol. Motil., 32, 10.1111/nmo.13748 · DOI
- Goerg, 2003, Effect of peppermint oil and caraway oil on gastrointestinal motility in healthy volunteers: a pharmacodynamic study using simultaneous determination of gastric and gall-bladder emptying and orocaecal transit time, Aliment. Pharmacol. Ther., 17, 445, 10.1046/j.1365-2036.2003.01421.x · DOI
- Micklefield, 2000, Effects of peppermint oil and caraway oil on gastroduodenal motility, Phytother. Res., 14, 20, 10.1002/(SICI)1099-1573(200002)14:1<20::AID-PTR542>3.0.CO;2-Z · DOI
- Madisch, 2019, Effectiveness of Menthacarin on symptoms of irritable bowel syndrome, Wien Med. Wochenschr., 169, 149, 10.1007/s10354-018-0635-1 · DOI
- Rich, 2017, A randomized placebo-controlled trial on the effects of Menthacarin, a proprietary peppermint- and caraway-oil-preparation, on symptoms and quality of life in patients with functional dyspepsia, Neurogastroenterol. Motil., 29, 10.1111/nmo.13132 · DOI
- Drossman, 2006, The functional gastrointestinal disorders and the Rome III process, Gastroenterology, 130, 1377, 10.1053/j.gastro.2006.03.008 · DOI · Paper page
- Chey, 2015, Irritable bowel syndrome: a clinical review, JAMA, 313, 949, 10.1001/jama.2015.0954 · DOI · Paper page
- Bueno, 1999, Effects of inflammatory mediators on gut sensitivity, Can. J. Gastroenterol., 13, 42A
- Grundy, 2019, Visceral pain, Annu. Rev. Physiol., 81, 261, 10.1146/annurev-physiol-020518-114525 · DOI
- Barbara, 2007, Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndrome, Gastroenterology, 132, 26, 10.1053/j.gastro.2006.11.039 · DOI · Paper page
- de Jong, 2015, TRPM8 on mucosal sensory nerves regulates colitogenic responses by innate immune cells via CGRP, Mucosal Immunol., 8, 491, 10.1038/mi.2014.82 · DOI
- Engel, 2011, TRPA1 and substance P mediate colitis in mice, Gastroenterology, 141, 1346, 10.1053/j.gastro.2011.07.002 · DOI
- Lapointe, 2011, The role of TRPA1 in visceral inflammation and pain, Channels (Austin), 5, 525, 10.4161/chan.5.6.18016 · DOI
- Lundgren, 2011, Intestinal epithelial stem/progenitor cells are controlled by mucosal afferent nerves, PLoS One, 6, 10.1371/journal.pone.0016295 · DOI
- See, 1990, The myenteric plexus regulates cell growth in rat jejunum, J. Auton. Nerv. Syst., 31, 219, 10.1016/0165-1838(90)90188-O · DOI
- Nilius, 2011, The transient receptor potential family of ion channels, Genome Biol., 12, 218, 10.1186/gb-2011-12-3-218 · DOI
- Khalil, 2019, Neuro-immune networks in gastrointestinal disorders, Visc. Med., 35, 52, 10.1159/000496838 · DOI
- Veiga-Fernandes, 2016, Neuro-immune interactions at barrier surfaces, Cell, 165, 801, 10.1016/j.cell.2016.04.041 · DOI
- Farmer, 2013, Gut pain & visceral hypersensitivity, Br. J. Pain, 7, 39, 10.1177/2049463713479229 · DOI
- Peier, 2002, A TRP channel that senses cold stimuli and menthol, Cell, 108, 705, 10.1016/S0092-8674(02)00652-9 · DOI · Paper page
- Andersson, 2004, TRPM8 activation by menthol, icilin, and cold is differentially modulated by intracellular pH, J. Neurosci., 24, 5364, 10.1523/JNEUROSCI.0890-04.2004 · DOI
- Gade, 2017, Extraction of menthol using different methods from peppermint oil, Int. J. Pharmtech Res., 10, 186, 10.20902/IJPTR.2017.10324 · DOI
- Khalil, 2016, Transient receptor potential melastatin 8 ion channel in macrophages modulates colitis through a balance-shift in TNF-alpha and interleukin-10 production, Mucosal Immunol., 9, 1500, 10.1038/mi.2016.16 · DOI
- Sabat, 2010, Biology of interleukin-10, Cytokine Growth Factor Rev., 21, 331, 10.1016/j.cytogfr.2010.09.002 · DOI · Paper page
- Tomoyose, 1998, Role of interleukin-10 in a murine model of dextran sulfate sodium-induced colitis, Scand. J. Gastroenterol., 33, 435, 10.1080/00365529850171080 · DOI
- Rozza, 2014, The gastroprotective effect of menthol: involvement of anti-apoptotic, antioxidant and anti-inflammatory activities, PLoS One, 9, 10.1371/journal.pone.0086686 · DOI
- Zhao, 2016, Transient receptor potential ankyrin 1 channel involved in atherosclerosis and macrophage-foam cell formation, Int. J. Biol. Sci., 12, 812, 10.7150/ijbs.15229 · DOI
- Kaji, 2012, Activation of TRPA1 by luminal stimuli induces EP4-mediated anion secretion in human and rat colon, Am. J. Physiol. Gastrointest. Liver Physiol., 302, G690, 10.1152/ajpgi.00289.2011 · DOI
- Alliger, 2020, Menthacarin attenuates experimental colitis, Phytomedicine, 10.1016/j.phymed.2020.153212 · DOI
- Kang, 2015, Spontaneous L-glutamate release enhancement in rat substantia gelatinosa neurons by (−)-carvone and (+)-carvone which activate different types of TRP channel, Biochem. Biophys. Res. Commun., 459, 498, 10.1016/j.bbrc.2015.02.135 · DOI
- Touska, 2011, A “cute” desensitization of TRPV1, Curr. Pharm. Biotechnol., 12, 122, 10.2174/138920111793937826 · DOI
- Sarria, 2011, TRPM8 acute desensitization is mediated by calmodulin and requires PIP(2): distinction from tachyphylaxis, J. Neurophysiol., 106, 3056, 10.1152/jn.00544.2011 · DOI
- Akopian, 2007, Transient receptor potential TRPA1 channel desensitization in sensory neurons is agonist dependent and regulated by TRPV1-directed internalization, J. Physiol., 583, 175, 10.1113/jphysiol.2007.133231 · DOI
- Kistner, 2016, Systemic desensitization through TRPA1 channels by capsazepine and mustard oil - a novel strategy against inflammation and pain, Sci. Rep., 6, 10.1038/srep28621 · DOI
- Khalil, 2020, Dual opposing actions of STW 5 on TRP receptors mediate neuronal desensitisation in vitro, Life Sci., 257, 10.1016/j.lfs.2020.118112 · DOI · Paper page
- Jacquot, 2005, Trigeminal sensitization and desensitization in the nasal cavity: a study of cross interactions, Rhinology, 43, 93
Cited by
Pastras, P., Aggeletopoulou, I., Bali, M., & Triantos, C. (2026) · Nutrients · doi:10.3390/nu18020183 · Cited by 1
Metadata
- Authors
- Zhang, Z., Engel, M. A., Koch, E., Reeh, P. W., & Khalil, M.
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 2021-01
- Volume
- 264
- Pages
- 118682
- ISSN
- 0024-3205
- Cited by
- 15
- References
- 5
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Funders
- Bayer Consumer Health (64295)
- Deutsche Forschungsgemeinschaft (SFB TRR 241/1 TP B05)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.