Cited by 266Gastrointestinal motility and disordersInfant Health and DevelopmentGut microbiota and health

Irritable bowel syndrome: A clinical review

Open access
Soares, Rosa LS·2014·World Journal of Gastroenterology

Abstract

Irritable bowel syndrome (IBS) remains a clinical challenge in the 21(st) century. It's the most commonly diagnosed gastrointestinal condition and also the most common reason for referral to gastroenterology clinics. Its can affect up to one in five people at some point in their lives, and has a significantly impact of life quality and health care utilization. The prevalence varies according to country and criteria used to define IBS. Various mechanisms and theories have been proposed about its etiology, but the biopsychosocial model is the most currently accepted for IBS. The complex of symptoms would be the result of the interaction between psychological, behavioral, psychosocial and environmental factors. The diagnosis of IBS is not confirmed by a specific test or structural abnormality. It is made using criteria based on clinical symptoms such as Rome criteria, unless the symptoms are thought to be atypical. Today the Rome Criteria III is the current gold-standard for the diagnoses of IBS. Secure positive evidence of IBS by means of specific disease marker is currently not possible and cannot be currently recommended for routine diagnosis. There is still no clinical evidence to recommend the use of biomarkers in blood to diagnose IBS. However, a number of different changes in IBS patients were demonstrated in recent years, some of which can be used in the future as a diagnostic support. IBS has no definitive treatment but could be controlled by non-pharmacologic management eliminating of some exacerbating factors such certain drugs, stressor conditions and changes in dietary habits.The traditional pharmacologic management of IBS has been symptom based and several drugs have been used. However, the cornerstone of its therapy is a solid patient physician relationship. This review will provide a summary of pathophysiology, diagnostic criteria and current and emerging therapies for IBS.

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Crossref · 10.3748/wjg.v20.i34.12144

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Authors
Soares, R. L.
Venue
World Journal of Gastroenterology
Published
2014
Volume
20
Issue
34
Pages
12144
ISSN
1007-9327 (ISSN-L)
OpenAlex
W2040223383
Cited by
266
References
271
Citations by year
2026: 12 · 2025: 15 · 2024: 16 · 2023: 38 · 2022: 26 · 2021: 28 · 2020: 24 · 2019: 23 · 2018: 21 · 2017: 22 · 2016: 24 · 2015: 16 · 2014: 1
FWCI
3.49
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • World Journal of Gastroenterology (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Health Professions › Pharmacy › Infant Health and Development
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
irritable bowel syndrome, Rome criteria, biopsychosocial model, IBS pathophysiology, IBS diagnosis, non-pharmacological treatment, pharmacotherapy, physician-patient relationship, quality of life, prevalence
MeSH terms
Combined Modality Therapy, Humans, Predictive Value of Tests, Risk Factors, Prevalence, Treatment Outcome, Irritable Bowel Syndrome

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