The DOI matches its Crossref record; 326 of the 330 references it cites were found in a registry or an index.
Biological effects of space radiation and development of effective countermeasures
Open accessAbstract
As part of a program to assess the adverse biological effects expected from astronaut exposure to space radiation, numerous different biological effects relating to astronaut health have been evaluated. There has been major focus recently on the assessment of risks related to exposure to solar particle event (SPE) radiation. The effects related to various types of space radiation exposure that have been evaluated are: gene expression changes (primarily associated with programmed cell death and extracellular matrix (ECM) remodeling), oxidative stress, gastrointestinal tract bacterial translocation and immune system activation, peripheral hematopoietic cell counts, emesis, blood coagulation, skin, behavior/fatigue (including social exploration, submaximal exercise treadmill and spontaneous locomotor activity), heart functions, alterations in biological endpoints related to astronaut vision problems (lumbar puncture/intracranial pressure, ocular ultrasound and histopathology studies), and survival, as well as long-term effects such as cancer and cataract development. A number of different countermeasures have been identified that can potentially mitigate or prevent the adverse biological effects resulting from exposure to space radiation.
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“But their mechanisms and effects are not fully understood and their application in space flight is not yet mature.”
From Radiation environment for future human exploration on the surface of Mars: the current understanding based on MSL/RAD dose measurements (2021) · cites this paper as Kennedy (2014)
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“Even if candidate antioxidant cocktails have been proposed based on the scientific knowledge of their effects, their translation to the field, and specifically to astronauts, has not been successful47,53,54.”
From Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions (2021) · cites this paper as [47]
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Cited by
Sorted by citations
Space Radiation: The number one risk to astronaut health beyond low earth orbit
Chancellor, J., Scott, G., & Sutton, J. (2014) · Life · doi:10.3390/life4030491 · Cited by 455
Human Pathophysiological Adaptations to the Space Environment
Demontis, G. C., Germani, M. M., Caiani, E. G., Barravecchia, I., Passino, C., & Angeloni, D. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00547 · Cited by 354
Space radiation protection: Destination Mars
Durante, M. (2014) · Life Sciences in Space Research · doi:10.1016/j.lssr.2014.01.002 · Cited by 202
Limitations in predicting the space radiation health risk for exploration astronauts
Chancellor, J. C., Blue, R. S., Cengel, K. A., Auñón-Chancellor, S. M., Rubins, K. H., Katzgraber, H. G., & Kennedy, A. R. (2018) · npj Microgravity · doi:10.1038/s41526-018-0043-2 · Cited by 183
Self-citationLimitations in predicting the space radiation health risk for exploration astronauts
Chancellor, J. C., Blue, R. S., Cengel, K. A., Auñón-Chancellor, S. M., Rubins, K., Katzgraber, H. G., & Kennedy, A. R. (2018) · Civil War Book Review · Cited by 174
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Metadata
- Authors
- Kennedy, A. R.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Kennedy, Ann R.
- ORCID
- Kennedy, Ann R.
- Venue
- Life Sciences in Space Research
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 1
- Pages
- 10-43
- ISSN
- 2214-5524 (ISSN-L)
- PMC
- PMC4170231
- OpenAlex
- W2119240968
- Cited by
- 188
- References
- 330
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 15 · 2023: 15 · 2022: 19 · 2021: 33 · 2020: 23 · 2019: 15 · 2018: 17 · 2017: 9 · 2016: 9 · 2015: 11 · 2014: 3
- FWCI
- 7.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Life Sciences in Space Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (T32CA009677)
- National Aeronautics and Space Administration (NCC 9-58, NAG9-1517)
- National Space Biomedical Research Institute
- Topics
- Health Sciences › Medicine › Physiology (medical) › Spaceflight effects on biology
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Physical Sciences › Physics and Astronomy › Radiation › Radiation Therapy and Dosimetry
- Keywords
- space radiation, astronaut health, solar energetic particle events, radiation countermeasures, gene expression, programmed cell death, extracellular matrix remodeling, oxidative stress, bacterial translocation, immune activation, vomiting, coagulation, skin effect, fatigue, cardiac function, visual impairment, cataract, cancer risk, survival
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