Cited by 188Spaceflight effects on biologyEffects of Radiation ExposureRadiation Therapy and Dosimetry

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Biological effects of space radiation and development of effective countermeasures

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Kennedy, Ann R.·2014·Life Sciences in Space Research

DOI 10.1016/j.lssr.2014.02.004PMC PMC4170231

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Abstract

As part of a program to assess the adverse biological effects expected from astronaut exposure to space radiation, numerous different biological effects relating to astronaut health have been evaluated. There has been major focus recently on the assessment of risks related to exposure to solar particle event (SPE) radiation. The effects related to various types of space radiation exposure that have been evaluated are: gene expression changes (primarily associated with programmed cell death and extracellular matrix (ECM) remodeling), oxidative stress, gastrointestinal tract bacterial translocation and immune system activation, peripheral hematopoietic cell counts, emesis, blood coagulation, skin, behavior/fatigue (including social exploration, submaximal exercise treadmill and spontaneous locomotor activity), heart functions, alterations in biological endpoints related to astronaut vision problems (lumbar puncture/intracranial pressure, ocular ultrasound and histopathology studies), and survival, as well as long-term effects such as cancer and cataract development. A number of different countermeasures have been identified that can potentially mitigate or prevent the adverse biological effects resulting from exposure to space radiation.

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Authors: Kennedy, A. R.
Affiliations: University of Pennsylvania (US)
Corresponding author: Kennedy, Ann R.
ORCID: Kennedy, Ann R.
Venue: Life Sciences in Space Research
Publisher: Elsevier BV
Published: 2014-04
Volume: 1
Pages: 10-43
ISSN: 2214-5524 (ISSN-L)
DOI: 10.1016/j.lssr.2014.02.004
PMC: PMC4170231
OpenAlex: W2119240968
Cited by: 188
References: 330
Citations by year: 2026: 8 · 2025: 11 · 2024: 15 · 2023: 15 · 2022: 19 · 2021: 33 · 2020: 23 · 2019: 15 · 2018: 17 · 2017: 9 · 2016: 9 · 2015: 11 · 2014: 3
FWCI: 7.11
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Life Sciences in Space Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (T32CA009677)
National Aeronautics and Space Administration (NCC 9-58, NAG9-1517)
National Space Biomedical Research Institute
Topics: Health Sciences › Medicine › Physiology (medical) › Spaceflight effects on biology
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
Physical Sciences › Physics and Astronomy › Radiation › Radiation Therapy and Dosimetry
Keywords: space radiation, astronaut health, solar energetic particle events, radiation countermeasures, gene expression, programmed cell death, extracellular matrix remodeling, oxidative stress, bacterial translocation, immune activation, vomiting, coagulation, skin effect, fatigue, cardiac function, visual impairment, cataract, cancer risk, survival

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Biological effects of space radiation and development of effective countermeasures

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