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Cited by 8Effects of Radiation ExposureSpaceflight effects on biologyRadiation Therapy and Dosimetry

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Angiotensin converting enzyme (ACE) inhibitors as radiation countermeasures for long-duration space flights

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Moulder, John E., Cohen, Eric P., Medhora, Meetha, Fish, Brian L.·2022·Life Sciences in Space Research
DOI 10.1016/j.lssr.2022.04.005
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Abstract

Angiotensin converting enzyme (ACE) inhibitors are effective countermeasures to chronic radiation injuries in rodent models, and there is evidence for similar effects in humans. In rodent models ACE inhibitors are effective mitigators of radiation injury to kidney, lung, central nervous system (CNS) and skin, even when started weeks after irradiation. In humans, the best data for their efficacy as radiation countermeasures comes from retrospective studies of injuries in radiotherapy patients. We propose that ACE inhibitors, at doses approved for human use for other indications, could be used to reduce the risk of chronic radiation injuries from deep-space exploration. Because of the potential interaction of ACE inhibitors and microgravity (due to effects of ACE inhibitors on fluid balance) use might be restricted to post-exposure when/if radiation exposures reached a danger level. A major unresolved issue for this approach is the sparse evidence for the efficacy of ACE inhibitors after low-dose-rate exposure and/or for high-LET radiations (as would occur on long-duration space flights). A second issue is that the lack of a clear mechanism of action of the ACE inhibitors as mitigators makes obtaining an appropriate label under the Food and Drug Administration Animal Rule difficult.

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Metadata

Authors
Moulder, J. E., Cohen, E. P., Medhora, M., & Fish, B. L.
Affiliations
  • Medical College of Wisconsin (US)
  • NYU Langone Health (US)
Corresponding author
Cohen, Eric P.
ORCID
Venue
Life Sciences in Space Research
Publisher
Elsevier BV
Published
2022-11
Volume
35
Pages
60-68
ISSN
2214-5524 (ISSN-L)
DOI
10.1016/j.lssr.2022.04.005
OpenAlex
W4224252939
Cited by
8
References
3
Citations by year
2025: 4 · 2024: 1 · 2023: 2 · 2022: 1
FWCI
1.14
Type
journal article
Language
en
Open access
Licence
Locations
  • Life Sciences in Space Research (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (AI067734, AI101898, AI107276, AI107305, AI133594, AI81294)
  • U.S. Department of Veterans Affairs (BX003833)
  • Biomedical Advanced Research and Development Authority (HHSO100205000091)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
  • Health Sciences › Medicine › Physiology (medical) › Spaceflight effects on biology
  • Physical Sciences › Physics and Astronomy › Radiation › Radiation Therapy and Dosimetry
Keywords
ACE inhibitors, radiation countermeasures, chronic radiation injury, long-duration spaceflight, deep space exploration, microgravity, fluid balance, radiation-induced lung injury, radiation dermatitis, radiotherapy patients, low-dose-rate exposure, high-LET radiation, FDA Animal Rule, rodent models
MeSH terms
Angiotensin-Converting Enzyme Inhibitors, Animals, Captopril, Humans, Peptidyl-Dipeptidase A, Radiation Injuries, Retrospective Studies, Space Flight

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CoChat. (2026). Citation check: Angiotensin converting enzyme (ACE) inhibitors as radiation countermeasures for long-duration space flights. https://app.cochat.ai/papers/10.1016/j.lssr.2022.04.005
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Moulder, J. E., Cohen, E. P., Medhora, M., & Fish, B. L. (2022). Angiotensin converting enzyme (ACE) inhibitors as radiation countermeasures for long-duration space flights. Life Sciences in Space Research. https://doi.org/10.1016/j.lssr.2022.04.005