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Cited by 5Effects of Radiation ExposureSpaceflight effects on biologyRadiation Therapy and Dosimetry

Inter-agency perspective: Translating advances in biomarker discovery and medical countermeasures development between terrestrial and space radiation environments

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DiCarlo, Andrea L., Carnell, Lisa S., Rios, Carmen I., Prasanna, Pataje G.·2022·Life Sciences in Space Research
DOI 10.1016/j.lssr.2022.06.004PMC PMC9832585
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Abstract

Over the past 20+ years, the U.S. Government has made significant strides in establishing research funding and initiating a portfolio consisting of subject matter experts on radiation-induced biological effects in normal tissues. Research supported by the National Cancer Institute (NCI) provided much of the early findings on identifying cellular pathways involved in radiation injuries, due to the need to push the boundaries to kill tumor cells while minimizing damage to intervening normal tissues. By protecting normal tissue surrounding the tumors, physicians can deliver a higher radiation dose to tumors and reduce adverse effects related to the treatment. Initially relying on this critical NCI research, the National Institute of Allergy and Infectious Diseases (NIAID), first tasked with developing radiation medical countermeasures in 2004, has provided bridge funding to move basic research toward advanced development and translation. The goal of the NIAID program is to fund approaches that can one day be employed to protect civilian populations during a radiological or nuclear incident. In addition, with the reality of long-term space flights and the possibility of radiation exposures to both acute, high-intensity, and chronic lower-dose levels, the National Aeronautics and Space Administration (NASA) has identified requirements to discover and develop radioprotectors and mitigators to protect their astronauts during space missions. In sustained partnership with sister agencies, these three organizations must continue to leverage funding and findings in their overlapping research areas to accelerate biomarker identification and product development to help safeguard these different and yet undeniably similar human populations - cancer patients, public citizens, and astronauts.

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Cited by

Sorted by citations

Authors
DiCarlo, A. L., Carnell, L. S., Rios, C. I., & Prasanna, P. G.
Affiliations
  • National Institutes of Health (US)
  • National Aeronautics and Space Administration (US)
Corresponding author
DiCarlo, Andrea L.
ORCID
Venue
Life Sciences in Space Research
Publisher
Elsevier BV
Published
2022-11
Volume
35
Pages
9-19
ISSN
2214-5524 (ISSN-L)
DOI
10.1016/j.lssr.2022.06.004
PMC
PMC9832585
OpenAlex
W4282825641
Cited by
5
References
6
Citations by year
2026: 1 · 2024: 1 · 2023: 1 · 2022: 2
FWCI
0.57
Type
journal article
Language
en
Open access
Licence
Locations
  • Life Sciences in Space Research (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion, cc-by)
Funders
  • Biological and Physical Sciences Division
  • National Cancer Institute
  • National Institute of Allergy and Infectious Diseases
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
  • Health Sciences › Medicine › Physiology › Spaceflight effects on biology
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Radiation Therapy and Dosimetry
Keywords
radiation effects, normal tissue radiation injury, biomarker discovery, radioprotective agents, space radiation, astronaut radiation protection, cancer radiotherapy
MeSH terms
Medical Countermeasures, Humans, Radiation Injuries, Space Flight, United States, Astronauts, National Institute of Allergy and Infectious Diseases (U.S.)

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