A Blueprint for Characterizing Senescence
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Given the heterogeneity of senescent cells, our knowledge of both the drivers and consequences of cellular senescence in tissues and organs remains limited, as is our understanding of how this process could be harnessed for human health. Here we identified five broad areas that would help propel the field forward.
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Combining single-cell transcriptomics and a senescent-cell enrichment sorting protocol overcame the technical limitation of senescent-cell scarcity.
“The technical limitation of senescent-cell scarcity3 was overcome by combining single-cell transcriptomics and a senescent-cell enrichment sorting protocol.”
From Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration (2023) · cites this paper as [3]
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NIH SenNet Consortium: Mapping Senescent Cells in the Human Body to Understand Health and DiseasePreprint
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Senescence And The Senescence Associated Secretory Phenotype In Salivary Hypofunction
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Single cell RNA sequencing: modern approaches and achievements
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- Authors
- Roy, A. L., Sierra, F., Howcroft, K., Singer, D. S., Sharpless, N., Hodes, R. J., Wilder, E. L., & Anderson, J. M.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Roy, Ananda L.
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2020-11
- Volume
- 183
- Issue
- 5
- Pages
- 1143-1146
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC8364378
- OpenAlex
- W3094877792
- Cited by
- 81
- References
- 15
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 17 · 2023: 25 · 2022: 18 · 2021: 13
- FWCI
- 8.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- cellular senescence, senescent cells, senescence heterogeneity, aging
- MeSH terms
- Clinical Trials as Topic, Humans, Models, Biological, Biomarkers, Cellular Senescence
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