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Cited by 3Effects of Radiation ExposureSpaceflight effects on biologyRadiation Therapy and Dosimetry

Armed Forces Radiobiology Research Institute/Uniformed Services University of the Health Sciences perspective on space radiation countermeasure discovery

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Singh, Vijay K., Seed, Thomas M·2022·Life Sciences in Space Research
DOI 10.1016/j.lssr.2022.09.004
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Abstract

There is a need to develop and deploy medical countermeasures (MCMs) in order to support astronauts during space missions against excessive exposures to ionizing radiation exposure. The radiation environment of extraterrestrial space is complex and is characterized by nearly constant fluences of elemental atomic particles (protons being a dominant particle type) with widely different energies and ionization potentials. Chronic exposure to such ionizing radiation carries both near- and long-term health risks, which are generally related to the relative intensity and duration of exposure. These radiation-associated health risks can be managed only to a limited extent by physical means, but perhaps they might be more effectively managed biomedically. The Armed Forces Radiobiology Research Institute/Uniformed Services University of the Health Sciences has a long history of researching and developing MCMs specifically designed to support terrestrial-based military missions involving a radiation-threat component. The development of MCMs for both low and high doses of radiation are major aims of current research, and as such can provide lessons learned for the development of countermeasures applicable to future space missions and its extraterrestrial radiation environment.

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  71. Singh, V.K., Hanlon, B.K., Santiago, P.T., Seed, T.M., 2017b. A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: part III. Countermeasures under early stages of development along with 'standard of care' medicinal and procedures not requiring regulatory approval for use. Int. J. Radiat. Biol. 93, 885-906. https://doi.org/10.1080/ 09553002.2017.1332440. · DOI
  72. Singh, V.K., Hauer-Jensen, M., 2016. Gamma-tocotrienol as a promising countermeasure for acute radiation syndrome: Current status. Int. J. Mol. Sci. 17, e663. https://doi. org/10.3390/ijms17050663. · DOI
  73. Singh, V.K., Kulkarni, S., Fatanmi, O.O., Wise, S.Y., Newman, V.L., Romaine, P.L., Hendrickson, H., Gulani, J., Ghosh, S.P., Kumar, K.S., Hauer-Jensen, M., 2016b. Radioprotective efficacy of gamma-tocotrienol in nonhuman primates. Radiat. Res. 185, 285-298. https://doi.org/10.1667/RR14127. · DOI
  74. Singh, V.K., Newman, V.L., Seed, T.M., 2015. Colony-stimulating factors for the treatment of the hematopoietic component of the acute radiation syndrome (H-ARS): a review. Cytokine 71, 22-37. https://doi.org/10.1016/j.cyto.2014.08.003. · DOI
  75. Singh, V.K., Seed, T.M., 2017. A review of radiation countermeasures focusing on injury- specific medicinals and regulatory approval status: part I. Radiation sub-syndromes, animal models and FDA-approved countermeasures. Int. J. Radiat. Biol. 93, 851-869. https://doi.org/10.1080/09553002.2017.1332438. · DOI
  76. Singh, V.K., Seed, T.M., 2018. An update on sargramostim for treatment of acute radiation syndrome. Drugs Today (Barc) 54, 679-693. https://doi.org/10.1358/ dot.2018.54.11.2899370. · DOI
  77. Singh, V.K., Seed, T.M., 2019. The efficacy and safety of amifostine for the acute radiation syndrome. Expert Opin. Drug Saf. 18, 1077-1090. https://doi.org/ 10.1080/14740338.2019.1666104. · DOI
  78. Singh, V.K., Seed, T.M., 2020a. BIO 300: a promising radiation countermeasure under advanced development for acute radiation syndrome and the delayed effects of acute radiation exposure. Expert Opin. Investig. Drugs 29, 429-441. https://doi.org/ 10.1080/13543784.2020.1757648. · DOI
  79. Singh, V.K., Seed, T.M., 2020b. Pharmacological management of ionizing radiation injuries: current and prospective agents and targeted organ systems. Expert Opin. Pharmacother. 21, 317-337. https://doi.org/10.1080/14656566.2019.1702968. · DOI
  80. Singh, V.K., Seed, T.M., 2021a. Entolimod as a radiation countermeasure for acute radiation syndrome. Drug Discov. Today 26, 17-30. https://doi.org/10.1016/j. drudis.2020.10.003. · DOI
  81. Singh, V.K., Seed, T.M., 2021c. Repurposing pharmaceuticals previously approved by regulatory agencies to medically counter injuries arising either early or late following radiation exposure. Front. Pharmacol. 12, 624844 https://doi.org/ 10.3389/fphar.2021.624844. · DOI
  82. Singh, V.K., Seed, T.M., Cheema, A.K., 2021. Metabolomics-based predictive biomarkers of radiation injury and countermeasure efficacy: current status and future perspectives. Expert Rev. Mol. Diagn. 21, 641-654. https://doi.org/10.1080/ 14737159.2021.1933448. · DOI
  83. Soref, C.M., Hacker, T.A., Fahl, W.E., 2012. A new orally active, aminothiol radioprotector-free of nausea and hypotension side effects at its highest radioprotective doses. Int. J. Radiat. Oncol. Biol. Phys. 82, e701-e707. https://doi. org/10.1016/j.ijrobp.2011.11.038. · DOI
  84. Stewart, F.A., Akleyev, A.V., Hauer-Jensen, M., Hendry, J.H., Kleiman, N.J., Macvittie, T. J., Aleman, B.M., Edgar, A.B., Mabuchi, K., Muirhead, C.R., Shore, R.E., Wallace, W. H., 2012. ICRP publication 118: ICRP statement on tissue reactions and early and late effects of radiation in normal tissues and organs-threshold doses for tissue reactions in a radiation protection context. Ann. ICRP 41, 1-322. https://doi.org/ 10.1016/j.icrp.2012.02.001. · DOI · Paper page
  85. Suman, S., Datta, K., Chakraborty, K., Kulkarni, S.S., Doiron, K., Fornace Jr., A.J., Sree Kumar, K., Hauer-Jensen, M., Ghosh, S.P., 2013. Gamma tocotrienol, a potent radioprotector, preferentially upregulates expression of anti-apoptotic genes to promote intestinal cell survival. Food Chem. Toxicol. 60, 488-496. https://doi.org/ 10.1016/j.fct.2013.08.011. · DOI
  86. Tian, J., Pecaut, M.J., Slater, J.M., Gridley, D.S., 2010. Spaceflight modulates expression of extracellular matrix, adhesion, and profibrotic molecules in mouse lung. J. Appl. Physiol. 108 (1985), 162-171. https://doi.org/10.1152/japplphysiol.00730.2009. · DOI
  87. Turroni, S., Magnani, M., Kc, P., Lesnik, P., Vidal, H., Heer, M., 2020. Gut microbiome and space travelers' health: state of the art and possible pro/prebiotic strategies for long-term space missions. Front. Physiol. 11, 553929 https://doi.org/10.3389/ fphys.2020.553929. · DOI
  88. Virk, Z.M., Kuter, D.J., Al-Samkari, H., 2021. An evaluation of avatrombopag for the treatment of thrombocytopenia. Expert Opin. Pharmacother. 22, 273-280. https:// doi.org/10.1080/14656566.2020.1841748. · DOI

Cited by

Sorted by citations

Authors
Singh, V. K., & Seed, T. M.
Affiliations
Uniformed Services University of the Health Sciences (US)
Corresponding author
Singh, Vijay K.
ORCID
Singh, Vijay K.
Venue
Life Sciences in Space Research
Publisher
Elsevier BV
Published
2022-11
Volume
35
Pages
20-29
ISSN
2214-5524 (ISSN-L)
DOI
10.1016/j.lssr.2022.09.004
OpenAlex
W4295779068
Cited by
3
References
5
Citations by year
2024: 1 · 2023: 1 · 2022: 1
FWCI
0.43
Type
journal article
Language
en
Open access
Licence
Locations
  • Life Sciences in Space Research (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • Uniformed Services University of the Health Sciences (AFR-B2-11037, AFR‐B4‐10978)
  • Armed Forces Radiobiology Research Institute
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
  • Health Sciences › Medicine › Physiology › Spaceflight effects on biology
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Radiation Therapy and Dosimetry
Keywords
space radiation, medical countermeasures, ionizing radiation exposure, astronaut health risk, radiation protection, radiation biology, protons
MeSH terms
Academies and Institutes, Cosmic Radiation, Humans, Military Personnel, Radiation Dosage, Radiobiology, Space Flight, Astronauts

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