Smoking history and lung carcinoma: KRAS mutation is an early hit in lung adenocarcinoma development

Somatic mutations affect key pathways in lung adenocarcinoma

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Base-excision repair of oxidative DNA damage

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Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

Johnson, L., Mercer, K., Greenbaum, D., Bronson, R. T., Crowley, D., Tuveson, D. A., & Jacks, T. (2001) · Nature · doi:10.1038/35074129 · Cited by 1,179 · see citing works

Suppression of non-small cell lung tumor development by the let-7 microRNA family

Kumar, M. S., Erkeland, S. J., Pester, R. E., Chen, C. Y., Ebert, M. S., Sharp, P. A., & Jacks, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712321105 · Cited by 844 · see citing works

Frequency and Distinctive Spectrum of <i>KRAS</i> Mutations in Never Smokers with Lung Adenocarcinoma

Riely, G. J., Kris, M. G., Rosenbaum, D., Marks, J., Li, A., Chitale, D. A., Nafa, K., Riedel, E. R., Hsu, M., Pao, W., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0646 · Cited by 578 · see citing works

Growth rate of small lung cancers detected on mass CT screening.

Hasegawa, M., Sone, S., Takashima, S., et al. (2000) · British Journal of Radiology · doi:10.1259/bjr.73.876.11205667 · Cited by 562 · see citing works

Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung.

Rodenhuis, S., Slebos, R. J. C., Boot, A. J., Evers, S. G., Mooi, W. J., WAGENAAR, S. S., Bodegom, P. C. V., & Bos, J. L. (1988) · PubMed · Cited by 460 · see citing works

Activation of the Ki-ras protooncogene in spontaneously occurring and chemically induced lung tumors of the strain A mouse.

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Mutations of p53 and ras genes in radon-associated lung cancer from uranium miners

Vähäkangas, K., Metcalf, R. A., Welsh, J. A., et al. (1992) · The Lancet · doi:10.1016/0140-6736(92)90866-2 · Cited by 320 · see citing works

Stem cells are dispensable for lung homeostasis but restore airways after injury

Giangreco, A., Arwert, E. N., Rosewell, I. R., Snyder, J. C., Watt, F. M., & Stripp, B. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900668106 · Cited by 238 · see citing works

Evaluation of the potential effects of ingredients added to cigarettes. Part 2: Chemical composition of mainstream smoke

Rustemeier, K., Stabbert, R., Haussmann, H., et al. (2002) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(01)00085-0 · Cited by 232 · see citing works

Relationship between the formation of promutagenic adducts and the activation of the K-ras protooncogene in lung tumors from A/J mice treated with nitrosamines

Belinsky, S. A. (1990) · Lung Cancer · doi:10.1016/0169-5002(90)90262-k · Cited by 209 · see citing works

Volumetric Growth Rate of Stage I Lung Cancer prior to Treatment: Serial CT Scanning

Winer-Muram, H. T., Jennings, S. G., Tarver, R. D., et al. (2002) · Radiology · doi:10.1148/radiol.2233011026 · Cited by 155 · see citing works

K‐ras mutations in human adenocarcinoma of the lung: Association with smoking and occupational exposure to asbestos

Husgafvel‐Pursiainen, K., Hackman, P., Ridanpää, M., Anttila, S. L., Karjalainen, A., Partanen, T. J., Taikina-aho, O., Heikkilä, L. J., & Vainio, H. (1993) · International Journal of Cancer · doi:10.1002/ijc.2910530213 · Cited by 143 · see citing works

Disproportionate representation of KRAS gene mutation in atypical adenomatous hyperplasia, but even distribution of EGFR gene mutation from preinvasive to invasive adenocarcinomas

Sakamoto, H., Shimizu, J., Horio, Y., Ueda, R., Takahashi, T., Mitsudomi, T., & Yatabe, Y. (2007) · The Journal of Pathology · doi:10.1002/path.2165 · Cited by 129 · see citing works

c-K-ras and p53 mutations occur very early in adenocarcinoma of the lung

Li, Z. H. (1995) · Lung Cancer · doi:10.1016/0169-5002(95)96453-3 · Cited by 127 · see citing works

Distinctive Evaluation of Nonmucinous and Mucinous Subtypes of Bronchioloalveolar Carcinomas inEGFRand K-rasGene-Mutation Analyses for Japanese Lung Adenocarcinomas

Sakuma, Y., Matsukuma, S., Yoshihara, M., et al. (2007) · American Journal of Clinical Pathology · doi:10.1309/wvxfgaflaux48du6 · Cited by 125 · see citing works

Detection of c-Ki-ras gene mutation in paraffin sections of adenocarcinoma and atypical bronchioloalveolar cell hyperplasia of human lung

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Activated protooncogenes in human lung tumors from smokers.

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DNA Microarray Format for Detection and Subtyping of Human Papillomavirus

Klaassen, C. H. W., Prinsen, C., de Valk, H. A., et al. (2004) · Journal of Clinical Microbiology · doi:10.1128/jcm.42.5.2152-2160.2004 · Cited by 72 · see citing works

Increased frequency of K-ras mutations in lung neoplasms from female B6C3F1 mice exposed to ozone for 24 or 30 months

Sills, R. C., Hong, H. L. T., Greenwell, A., et al. (1995) · Carcinogenesis · doi:10.1093/carcin/16.7.1623 · Cited by 51 · see citing works

c-myc GENE ABNORMALITIES IN MUCOSA-ASSOCIATED LYMPHOID TISSUE (MALT) LYMPHOMAS

Peng, H., Diss, T. C., Isaacson, P. G., & Pan, L. (1997) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(199704)181:4 · Cited by 43 · see citing works

Detection of K-ras point mutations in sputum from patients with adenocarcinoma of the lung by point-EXACCT.

Somers, V. A., Pietersen, A. M., Theunissen, P. H. M. H., et al. (1998) · Journal of Clinical Oncology · doi:10.1200/jco.1998.16.9.3061 · Cited by 43 · see citing works

Detection of Infrequent and Multiple K-rasMutations in Human Tumors and Tumor-Adjacent Tissues

Keohavong, P., Zhu, D., Whiteside, T. L., et al. (1997) · Analytical Biochemistry · doi:10.1006/abio.1997.2100 · Cited by 33 · see citing works

The molecular progression of plutonium‐239–induced rat lung carcinogenesis: Ki‐ras expression and activation

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The activation of K-ras gene at an early stage of lung tumorigenesis in mice

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Cell type specificity of lung cancer associated with air pollution

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A critical appraisal of prognostic and predictive factors for common lung cancers

Thunnissen, E., Schuurbiers, O. C. J., & Bakker, M. A. D. (2006) · Histopathology · doi:10.1111/j.1365-2559.2006.02386.x · Cited by 23 · see citing works

Codon 12 Ki-ras mutation in non-small-cell lung cancer: comparative evaluation in tumoural and non-tumoural lung

Urban, T., Ricci, S., Lacave, R., et al. (1996) · British Journal of Cancer · doi:10.1038/bjc.1996.488 · Cited by 19 · see citing works

Microarray as a Model for Quantitative Visualization Chemistry

Prinsen, C., Klaassen, C. H. W., & Thunnissen, E. (2003) · Applied immunohistochemistry & molecular morphology · doi:10.1097/00129039-200306000-00014 · Cited by 19 · see citing works

EUELC project: a multi-centre, multipurpose study to investigate early stage NSCLC, and to establish a biobank for ongoing collaboration

Field, J. K., Liloglou, T., Niaz, A., et al. (2009) · European Respiratory Journal · doi:10.1183/09031936.00077809 · Cited by 17 · see citing works

A rapid, reliable method for detection of known point mutations: Point-EXACCT

Somers, V. A., Moerkerk, P. T. M., Murtagh, J. J., et al. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.22.4840 · Cited by 16 · see citing works

Mutational load distribution analysis yields metrics reflecting genetic instability during pancreatic carcinogenesis

Tarafa, G., Tuck, D. P., Ladner, D. P., Topazian, M. D., Brand, R. E., Deters, C. A., Moreno, V. R., Capellá, G., Lynch, H. T., Lizardi, P. M., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708250105 · Cited by 13 · see citing works

Validation of the Point-EXACCT method in non-small cell lung carcinomas

Somers, V. A., Leimbach, D. L., Theunissen, P. H. M. H., et al. (1998) · Clinical Chemistry · doi:10.1093/clinchem/44.7.1404 · Cited by 11 · see citing works

The Detection of Chemically Initiated Cells Having the Mutation of K-rasGene at an Early Stage of Lung Carcinogenesis in Mice

Yano, T., Yuasa, M., Murakami, A., et al. (1997) · Analytical Biochemistry · doi:10.1006/abio.1996.9902 · Cited by 10 · see citing works

Baseline human papillomavirus status of women with abnormal smears in cervical screening: a 5‐year follow‐up study in the Netherlands

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p53 gene mutations and 17p allelic deletions in hepatocellular carcinoma from Japan

Nose, H., Imazeki, F., Ohto, M., & Omata, M. (1993) · Cancer · doi:10.1002/1097-0142(19930715)72:2

Selective KRAS G12C inhibitors in non-small cell lung cancer: chemistry, concurrent pathway alterations, and clinical outcomes

Palma, G., Khurshid, F., Lu, K., Woodward, B., & Husain, H. (2021) · npj Precision Oncology · doi:10.1038/s41698-021-00237-5 · Cited by 72 · see citing works

Assessing the significance of KRAS G12C mutation: Clinicopathologic features, treatments, and survival outcomes in a real-world KRAS mutant non-small cell lung cancer cohort.

Cui, W., Franchini, F., Alexander, M., Officer, A., Wong, H., IJzerman, M. J., Desai, J., & Solomon, B. (2020) · Journal of Clinical Oncology · doi:10.1200/jco.2020.38.15_suppl.e19324 · Cited by 3 · see citing works

Lung Cancer and KRAS -Its Molecular Biology/Genetics and Therapeutic Strategy-

Koga, T., & Mitsudomi, T. (2022) · Haigan · doi:10.2482/haigan.62.188 · Cited by 1 · see citing works

Molecular profile of KRAS G12C-mutant colorectal and non-small-cell lung cancer

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127P RAS, RAF and NF1 oncogenic mutations in KRAS-mutated lung adenocarcinoma

Marinelli, D., Pisegna, S., Chiavassa, A., et al. (2022) · Annals of Oncology · doi:10.1016/j.annonc.2022.09.128

Molecular profile of KRAS G12C-mutant colorectal and non-small-cell lung cancer

Araujo, L. H., Souza, B. M., Leite, L. R., Parma, S. A. F., Lopes, N. P., Malta, F. S. V., & Freire, M. C. M. (2021) · BMC Cancer · doi:10.1186/s12885-021-07884-8 · Cited by 41 · see citing works