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Anti-diabetic activities of phenolic compounds in muscadine against alpha-glucosidase and pancreatic lipase
Open accessAbstract
Inhibitory mode and anti-diabetic activities of the Carols muscadine extracts on the α-glucosidase and pancreatic lipase were investigated. The IC 50 values of the muscadine and its seed methanolic extracts against the α-glucosidase were 1.92 and 1.53 mg/mL, and those against the lipase were 34.41 and 8.63 mg/mL, respectively, which indicated the muscadine possessed the strong anti-diabetes activity. Particularly, the ethyl acetate (EtOAc) extract fractions exhibited the highest inhibitory activities against both enzymes. Since most of the phenolic compounds existed in the EtOAc fractions, it is suggested that phenolic compounds may be the main source against the α-glucosidase and pancreatic lipase. Twelve individual phenolics were identified by HPLC-MS. Ellagic acid and quercetin exhibited much stronger anti-diabetic activities among the selected phenolic standards. Besides, the extracts and the phenolic standards obeyed the competitive mode in their enzymatic inhibitions.
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Advances in flavonoid research since 1992
Harborne, J. B., & Williams, C. A. (2000) · Phytochemistry · doi:10.1016/s0031-9422(00)00235-1 · Cited by 3,956
Absorption, metabolism and health effects of dietary flavonoids in man
Hollman, P., & Katan, M. (1997) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(97)88045-6 · Cited by 609
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Podsędek, A., Majewska, I., Redzynia, M., Sosnowska, D., & Koziołkiewicz, M. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf5008264 · Cited by 266
Vilcacundo, R., Martínez-Villaluenga, C., & Hernández-Ledesma, B. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.06.024 · Cited by 264
Saleem, M., Tanvir, M., Akhtar, M. F., Iqbal, M., & Saleem, A. (2019) · Medicina · doi:10.3390/medicina55070353 · Cited by 72
Metadata
- Authors
- You, Q., Chen, F., Wang, X., Jiang, Y., & Lin, S.
- Venue
- LWT - Food Science and Technology
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 46
- Issue
- 1
- Pages
- 164-168
- ISSN
- 0023-6438 (ISSN-L)
- OpenAlex
- W2146990413
- Cited by
- 171
- References
- 2
- FWCI
- 4.47
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- You, Q., Chen, F., Wang, X., Jiang, Y., & Lin, S. (2012). Anti-diabetic activities of phenolic compounds in muscadine against alpha-glucosidase and pancreatic lipase. LWT - Food Science and Technology. https://doi.org/10.1016/j.lwt.2011.10.011
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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