Enzyme characteristics of recombinant poly(ADP-ribose) polymerases-1 of rat and human origin mirror the correlation between cellular poly(ADP-ribosyl)ation capacity and species-specific life span
Abstract
Poly(ADP-ribosyl)ation is a posttranslational modification, which is involved in many cellular functions, including DNA repair and maintenance of genomic stability, and has also been implicated in cellular and organismal ageing. We have previously reported that maximum poly(ADP-ribosyl)ation capacity in mononuclear blood cells is correlated with mammalian life span. Here we show that the difference between a long-lived and a short-lived species tested (i.e. man and rat) is directly mirrored by the enzymatic parameters of recombinant poly(ADP-ribose) polymerase-1 (PARP-1), i.e. substrate affinity and reaction velocity. In addition, we have characterized two human PARP-1 alleles and assign their activity difference to their respective initial velocity and not substrate affinity.
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PARP1 activity positively correlates with longevity across species.
“It has been observed that PARP1 activity positively correlates with longevity in different species (Bakondi et al., 2011; Beneke et al., 2010; Noren-Hooten et al., 2012)”
From A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline (2018) · cites this paper as Beneke et al., 2010
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- Authors
- Beneke, S., Scherr, A.-L., Ponath, V., Popp, O., & Bürkle, A.
- Affiliations
- University of Konstanz (DE)
- Corresponding author
- Beneke, Sascha
- Bürkle, Alexander
- Venue
- Mechanisms of Ageing and Development
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 131
- Issue
- 5
- Pages
- 366-369
- ISSN
- 0047-6374 (ISSN-L)
- OpenAlex
- W2064123757
- Cited by
- 36
- References
- 27
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 4 · 2014: 3 · 2013: 5 · 2012: 3
- FWCI
- 1.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mechanisms of Ageing and Development (publishedVersion)
- PubMed (publishedVersion)
- KOPS (University of Konstanz) (submittedVersion)
- Topics
- Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Keywords
- PARP1, poly(ADP-ribosyl)ation, enzyme kinetics, substrate affinity, reaction rate, aging, DNA repair, genome stability, blood mononuclear cells, rats
- MeSH terms
- Poly (ADP-Ribose) Polymerase-1, Alleles, Animals, Humans, Longevity, Poly(ADP-ribose) Polymerases, Protein Processing, Post-Translational, Recombinant Proteins, Species Specificity, Substrate Specificity, Rats
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