The DOI matches its Crossref record; 302 of the 302 references it cites were found in a registry or an index.
Brain aging mechanisms with mechanical manifestations
Open accessAbstract
Brain aging is a complex process that affects everything from the subcellular to the organ level, begins early in life, and accelerates with age. Morphologically, brain aging is primarily characterized by brain volume loss, cortical thinning, white matter degradation, loss of gyrification, and ventricular enlargement. Pathophysiologically, brain aging is associated with neuron cell shrinking, dendritic degeneration, demyelination, small vessel disease, metabolic slowing, microglial activation, and the formation of white matter lesions. In recent years, the mechanics community has demonstrated increasing interest in modeling the brain's (bio)mechanical behavior and uses constitutive modeling to predict shape changes of anatomically accurate finite element brain models in health and disease. Here, we pursue two objectives. First, we review existing imaging-based data on white and gray matter atrophy rates and organ-level aging patterns. This data is required to calibrate and validate constitutive brain models. Second, we review the most critical cell- and tissue-level aging mechanisms that drive white and gray matter changes. We focuse on aging mechanisms that ultimately manifest as organ-level shape changes based on the idea that the integration of imaging and mechanical modeling may help identify the tipping point when normal aging ends and pathological neurodegeneration begins.
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Cited by
Aging Hallmarks and Progression and Age-Related Diseases: A Landscape View of Research Advancement
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Metadata
- Authors
- Blinkouskaya, Y., Caçoilo, A., Gollamudi, T., Jalalian, S., & Weickenmeier, J.
- Venue
- Mechanisms of Ageing and Development
- Publisher
- Elsevier BV
- Published
- 2021-12
- Volume
- 200
- Pages
- 111575
- ISSN
- 0047-6374 (ISSN-L)
- OpenAlex
- W3201680702
- Cited by
- 258
- References
- 302
- FWCI
- 9.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Blinkouskaya, Y., Caçoilo, A., Gollamudi, T., Jalalian, S., & Weickenmeier, J. (2021). Brain aging mechanisms with mechanical manifestations. Mechanisms of Ageing and Development. https://doi.org/10.1016/j.mad.2021.111575
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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