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The tumour hypoxia induced non-coding transcriptome
Abstract
Recent investigations have highlighted the importance of the non-coding genome in regions of hypoxia in tumours. Such regions are frequently found in solid tumours, and are associated with worse patient survival and therapy resistance. Hypoxia stabilises the transcription factors, hypoxia inducible factors (HIF1α and HIF2α) which coordinate transcriptomic changes that occur in hypoxia. The changes in gene expression induced by HIF1α and HIF2α contribute to many of the hallmarks of cancer phenotypes and enable tumour growth, survival and invasion in the hypoxic tumour microenvironment. Non-coding RNAs, in particular microRNAs (miRNAs), which regulate mRNA stability and translation, and long-non-coding RNAs (lncRNAs), which have diverse functions including chromatin modification and transcriptional regulation, are also important in enabling the key hypoxia regulated processes. They have roles in the regulation of metabolism, angiogenesis, autophagy, invasion and metastasis in the hypoxic microenvironment. Furthermore, HIF1α and HIF2α expression and stabilisation are also regulated by both miRNAs and lncRNAs. Here we review the recent developments in the expression, regulation and functions of miRNAs, lncRNAs and other non-coding RNA classes in tumour hypoxia.
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“A large number of miRNAs have been identified from the field of cancer biology as being regulated by hypoxia, and mediate events such as cell proliferation, differentiation, invasion and metastasis that are relevant to placental biology (109, 499).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [109]
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Metadata
- Authors
- Choudhry, H., Harris, A. L., & McIntyre, A.
- Affiliations
- King Abdulaziz University (SA)
- University of Oxford (GB)
- University of Nottingham (GB)
- Corresponding author
- Harris, Adrian L.
- McIntyre, Alan
- Venue
- Molecular Aspects of Medicine
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 47-48
- Pages
- 35-53
- ISSN
- 0098-2997 (ISSN-L)
- OpenAlex
- W2264671620
- Cited by
- 120
- References
- 155
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 9 · 2023: 8 · 2022: 15 · 2021: 21 · 2020: 24 · 2019: 8 · 2018: 10 · 2017: 16 · 2016: 4
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Aspects of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Cancer Research UK (C602/A18974)
- Breast Cancer Research Foundation
- Deanship of Scientific Research (DSR), King Abdulaziz University, Saudi Arabia (G-1436-130-284)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Keywords
- tumor hypoxia, non-coding RNA, microRNA, long non-coding RNA, hypoxia-inducible factor, HIF-1α, HIF-2α, tumor microenvironment, treatment resistance, metastasis, angiogenesis, autophagy, cancer metabolism, gene expression regulation
- MeSH terms
- Endothelial PAS Domain-Containing Protein 1, Hypoxia, Gene Expression Regulation, Humans, Neoplasms, Neovascularization, Pathologic, MicroRNAs, Basic Helix-Loop-Helix Transcription Factors, Basic Helix-Loop-Helix Proteins, Hypoxia-Inducible Factor 1, alpha Subunit, Transcriptome, RNA, Long Noncoding
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