Non-coding RNAs in human disease
Abstract
The relevance of the non-coding genome to human disease has mainly been studied in the context of the widespread disruption of microRNA (miRNA) expression and function that is seen in human cancer. However, we are only beginning to understand the nature and extent of the involvement of non-coding RNAs (ncRNAs) in disease. Other ncRNAs, such as PIWI-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs), transcribed ultraconserved regions (T-UCRs) and large intergenic non-coding RNAs (lincRNAs) are emerging as key elements of cellular homeostasis. Along with microRNAs, dysregulation of these ncRNAs is being found to have relevance not only to tumorigenesis, but also to neurological, cardiovascular, developmental and other diseases. There is great interest in therapeutic strategies to counteract these perturbations of ncRNAs.
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Dysregulation of miRNAs may contribute to the onset and/or progression of various diseases by regulating disease-associated genes.
“Growing evidence suggests that dysregulation of miRNAs may contribute to the onset and/or progression of various diseases by regulating disease-associated genes (Delay et al. 2012, Schonrock et al. 2012, Esteller 2011).”
From miR‐186 is decreased in aged brain and suppresses <scp>BACE</scp>1 expression (2016) · cites this paper as Esteller 2011
Small ncRNAs are involved in nearly all developmental and pathological processes in mammals.
“today small ncRNAs are believed to be involved in nearly all developmental and pathological processes in mammals (2–4)”
From A mouse tissue atlas of small noncoding RNA (2020) · cites this paper as [3]
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- Authors
- Esteller, M.
- Affiliations
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Corresponding author
- Esteller, Manel
- ORCID
- Esteller, Manel
- Venue
- Nature Reviews Genetics
- Published
- 2011-11-18
- Volume
- 12
- Issue
- 12
- Pages
- 861-874
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2070777085
- Cited by
- 4,825
- References
- 10
- Citations by year
- 2026: 132 · 2025: 212 · 2024: 265 · 2023: 337 · 2022: 431 · 2021: 468 · 2020: 463 · 2019: 418 · 2018: 375 · 2017: 368 · 2016: 337 · 2015: 299 · 2014: 288 · 2013: 270 · 2012: 152
- FWCI
- 16.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- non-coding RNA, microRNA, cancer, piRNA, small nucleolar RNA, ultraconserved elements, long intergenic non-coding RNA, disease, treatment options, carcinogenesis, neurological disorders, cardiovascular disease, developmental disorders
- MeSH terms
- Cardiovascular Diseases, Humans, Neoplasms, Nervous System Diseases, RNA, Untranslated, Molecular Targeted Therapy
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