The DOI matches its Crossref record; 171 of the 171 references it cites were found in a registry or an index.
The PDGF/PDGFR pathway as a drug target
Abstract
Platelet-derived growth factors (PDGF) promotes cell proliferation, survival and migration, primarily of cells of mesenchymal origin. Dysfunction of PDGF signaling has been observed in a wide array of pathological conditions, such as cancer, fibrosis, neurological conditions and atherosclerosis. Reported abnormalities of the PDGF pathway include overexpression or amplification of PDGF receptors (PDGFRs), gain of function point mutations or activating chromosomal translocations. Current development of therapeutic drugs often aims at producing compounds that specifically target interaction between PDGFs and their receptors by specific DNA aptamers and ligand traps, or downregulate PDGFRs with blocking antibodies, or inhibit tyrosine kinase activity of PDGFRs with small molecules. In this review, we discuss some of the approaches taken to interfere with PDGF signaling, review a panel of existing therapeutic drugs, and consider clinically successful cases and remaining challenges.
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Metadata
- Authors
- Papadopoulos, N., & Lennartsson, J.
- Venue
- Molecular Aspects of Medicine
- Publisher
- Elsevier BV
- Published
- 2018-08
- Volume
- 62
- Pages
- 75-88
- ISSN
- 0098-2997 (ISSN-L)
- OpenAlex
- W2769616494
- Cited by
- 283
- References
- 171
- FWCI
- 6.50
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
