The DOI matches its Crossref record; 252 of the 252 references it cites were found in a registry or an index.
Mechanistic Pathogenesis of Endothelial Dysfunction in Diabetic Nephropathy and Retinopathy
Open accessAbstract
Diabetic nephropathy (DN) and diabetic retinopathy (DR) are microvascular complications of diabetes. Microvascular endothelial cells are thought to be the major targets of hyperglycemic injury. In diabetic microvasculature, the intracellular hyperglycemia causes damages to the vascular endothelium, via multiple pathophysiological process consist of inflammation, endothelial cell crosstalk with podocytes/pericytes and exosomes. In addition, DN and DR diseases development are involved in several critical regulators including the cell adhesion molecules (CAMs), the vascular endothelial growth factor (VEGF) family and the Notch signal. The present review attempts to gain a deeper understanding of the pathogenesis complexities underlying the endothelial dysfunction in diabetes diabetic and retinopathy, contributing to the development of new mechanistic therapeutic strategies against diabetes-induced microvascular endothelial dysfunction.
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Metadata
- Authors
- Yang, J., & Liu, Z.
- Venue
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Published
- 2022-05-25
- Volume
- 13
- Pages
- 816400-816400
- ISSN
- 1664-2392 (ISSN-L)
- OpenAlex
- W4281485160
- Cited by
- 281
- References
- 252
- FWCI
- 28.88
- Type
- journal article
- Language
- en
- Open access
- gold
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- Yang, J., & Liu, Z. (2022). Mechanistic Pathogenesis of Endothelial Dysfunction in Diabetic Nephropathy and Retinopathy. Frontiers in Endocrinology. https://doi.org/10.3389/fendo.2022.816400
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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