The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Assessment of microplastic-sorbed contaminant bioavailability through analysis of biomarker gene expression in larval zebrafish
Open accessAbstract
Microplastics (MPs) are prevalent in marine ecosystems. Because toxicants (termed here “co-contaminants”) can sorb to MPs, there is potential for MPs to alter co-contaminant bioavailability. Our objective was to demonstrate sorption of two co-contaminants with different physicochemistries [phenanthrene (Phe), log10Kow = 4.57; and 17α-ethinylestradiol (EE2), log10Kow = 3.67] to MPs; and assess whether co-contaminant bioavailability was increased after MP settlement. Bioavailability was indicated by gene expression in larval zebrafish. Both Phe and EE2 sorbed to MPs, which reduced bioavailability by a maximum of 33% and 48% respectively. Sorption occurred, but was not consistent with predictions based on co-contaminant physicochemistry (Phe having higher log10Kow was expected to have higher sorption). Contaminated MPs settled to the bottom of the exposures did not lead to increased bioavailability of Phe or EE2. Phe was 48% more bioavailable than predicted by a linear sorption model, organism-based measurements therefore contribute unique insight into MP co-contaminant bioavailability.
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“They documented genotoxicity, reproductive and behavioural effects in the fish D. rerio.”
From Studies of the Effects of Microplastics on Aquatic Organisms: What Do We Know and Where Should We Focus Our Efforts in the Future? (2018) · cites this paper as Sleight et al., 2017
In the citing paper
“Chen et al. (2017a) and Sleight et al. (2017) studied the interactions of MPs and the 17α-ethinylestradiol, a synthetic hormone which can function as an EDC.”
From Studies of the Effects of Microplastics on Aquatic Organisms: What Do We Know and Where Should We Focus Our Efforts in the Future? (2018) · cites this paper as Sleight et al., 2017
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Cites
Microplastics in the marine environment
Andrady, A. L. (2011) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2011.05.030 · Cited by 8,105 · cited 2×
“uPVC was selected as a model polymer because it is reported globally in themarine environment (Andrady, 2011), and because preliminary trials with unplasticized PVC showed that the MPs sank to the bottom.”
MethodLost at sea: where is all the plastic?
Thompson, R. C., Olsen, Y., Mitchell, R. P., Davis, A., Rowland, S. J., John, A. W. G., McGonigle, D., & Russell, A. E. (2004) · Science · doi:10.1126/science.1094559 · Cited by 7,765 · cited 1×
“A uPVC size of 200 – 250 μ m was selected and provided a high surface area for sorption (Teuten et al., 2009), is comparable with previous work (Bakir et al., 2012) and is representative of small MPs found in the environment (Thompson et al., 2004).”
ResultAccumulation of Microplastic on Shorelines Woldwide: Sources and Sinks
Browne, M. A., Crump, P., Niven, S. J., Teuten, E. L., Tonkin, A., Galloway, T. S., & Thompson, R. C. (2011) · Environmental Science & Technology · doi:10.1021/es201811s · Cited by 4,838
Eriksen, M., Lebreton, L. C. M., Carson, H. S., Thiel, M., Moore, C. J., Borerro, J. C., Galgani, F., Ryan, P. G., & Reisser, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111913 · Cited by 4,710 · cited 1×
“Plastic debris is present in numerous shapes and sizes and particles b 5 mm (MPs) in size are reported as the most abundant sizes detected in large-scale assessments of the oceans (Eriksen et al., 2014).”
BackgroundLong, E. R., MacDonald, D. D., Smith, S. L., & Calder, F. D. (1995) · Environmental Management · doi:10.1007/bf02472006 · Cited by 4,331 · cited 2×
“…of MPs and co-contaminants used in the present study were orders of magnitudes higher than what is found in the environment (Aris et al., 2014; Long et al., 1995; Lusher et al., 2014), and co-contaminant concentrations were deliberately tested at higher than environmentally relevant amounts.”
BackgroundTransport and release of chemicals from plastics to the environment and to wildlife
Teuten, E. L., Saquing, J. M., Knappe, D. R. U., Barlaz, M. A., Jonsson, S., Björn, A., Rowland, S. J., Thompson, R. C., Galloway, T. S., Yamashita, R., et al. (2009) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0284 · Cited by 2,938
Ingested plastic transfers hazardous chemicals to fish and induces hepatic stress
Rochman, C. M., Hoh, E., Kurobe, T., & Teh, S. J. (2013) · Scientific Reports · doi:10.1038/srep03263 · Cited by 2,169 · cited 3×
“One concern is the potential for MPs to transport harmful pollutants (termed here “ co-contaminants ” ) sorbed from marine environments (Holmes et al., 2012; Mato et al., 2001; Rochman et al., 2013a) into the food chain (Teuten et al., 2007).”
BackgroundMethodPlastic Resin Pellets as a Transport Medium for Toxic Chemicals in the Marine Environment
Mato, Y., Isobe, T., Takada, H., Kanehiro, H., OHTAKE, C., & Kaminuma, T. (2000) · Environmental Science & Technology · doi:10.1021/es0010498 · Cited by 1,898 · cited 5×
“Phenanthrene [Phe, (log 10 of the octanol:water partition coef fi cient (log 10 K ow ) = 4.57 (Miller et al., 1985)] is a simple three ringed polycyclic aromatic hydrocarbon (PAH) that has been frequently reported as a co-contaminant sorbed to MPs (Mato et al., 2001).”
BackgroundInfluentialGregory, M. R. (2009) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0265 · Cited by 1,852 · cited 2×
“Plastic debris is accumulating in the environment on a global scale and the potential for negative effects on ecosystems has become a priority concern for environmental science and policy (Gregory, 2009).”
BackgroundPollutants bioavailability and toxicological risk from microplastics to marine mussels
Avio, C. G., Gorbi, S., Milan, M., Benedetti, M., Fattorini, D., d'Errico, G., Pauletto, M., Bargelloni, L., & Regoli, F. (2015) · Environmental Pollution · doi:10.1016/j.envpol.2014.12.021 · Cited by 1,413 · cited 2×
“Recently MPs have been shown to alter the bioavailability of pyrene and PCBs in vertebrates and invertebrates (Avio et al., 2015; Besseling et al., 2013; Oliveira et al., 2013; Rochman et al., 2013b).”
BackgroundMethod
Research works printed but not linked: 1
- Hansch, 1995, Exploring QSAR: fundamentals and applications in chemistry and biology, Am. Chem. Soc.
Cited by
Sorted by citations
Li, J., Liu, H., & Chen, J. P. (2017) · Water Research · doi:10.1016/j.watres.2017.12.056 · Cited by 2,432
“A few studies on larval and adult zebrafish showed that microplastics were first ingested, became accumulated, and consequently caused alternations in locomotion, intestinal damage, and change in metabolic profiles (Lu et al., 2016; Chen et al., 2017; Sleight et al., 2017; Lei et al., 2018).”
Backgroundde Sá, L. C., Oliveira, M., Ribeiro, F., Rocha, T. L., & Futter, M. N. (2018) · Science of The Total Environment · doi:10.1016/j.scitotenv.2018.07.207 · Cited by 1,316
Assessment of microplastics in freshwater systems: A review
Li, C., Busquets, R., & Campos, L. C. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.135578 · Cited by 1,005
“Recent investigations indicate that microplastics can alter the bioavailability of heavy metals in aquatic environments (Brennecke et al., 2016), PAHs (Karami et al., 2016; Oliveira et al., 2013), and PCBs (Sleight et al., 2017), thereby causing complex changes in physiological processes such as protein synthesis, ene…”
BackgroundAlimba, C. G., & Faggio, C. (2019) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2019.03.001 · Cited by 863
The potential of microplastics as carriers of metals
Godoy, V., Blázquez, G., Calero, M., Quesada, L., & Martín-Lara, M. Á. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.113363 · Cited by 678
Metadata
- Authors
- Sleight, V. A., Bakir, A., Thompson, R. C., & Henry, T. B.
- Affiliations
- British Antarctic Survey (GB)
- University of Portsmouth (GB)
- University of Plymouth (GB)
- Corresponding author
- Sleight, Victoria A.
- Venue
- Marine Pollution Bulletin
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 116
- Issue
- 1-2
- Pages
- 291-297
- ISSN
- 0025-326X (ISSN-L)
- OpenAlex
- W2579412410
- Cited by
- 190
- References
- 49
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 13 · 2023: 26 · 2022: 34 · 2021: 32 · 2020: 32 · 2019: 21 · 2018: 15 · 2017: 3
- FWCI
- 8.74
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Marine Pollution Bulletin (publishedVersion, cc-by)
- PubMed (publishedVersion)
- NERC Open Research Archive (Natural Environment Research Council) (acceptedVersion)
- Aberdeen University Research Archive (Aberdeen University) (submittedVersion)
- PEARL (University of Plymouth) (submittedVersion)
- Funders
- Natural Environment Research Council (NE/N006526/1, bas0100036)
- Topics
- Physical Sciences › Environmental Science › Pollution › Microplastics and Plastic Pollution
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
- Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
- Keywords
- microplastics, co-contaminants, contaminant sorption, bioavailability, phenanthrene, ethinyl estradiol, zebrafish larvae, gene expression biomarkers, octanol-water partition coefficient, marine pollution
- MeSH terms
- Animals, Biological Availability, Ethinyl Estradiol, Larva, Phenanthrenes, Plastics, Water Pollutants, Chemical, Zebrafish, Biomarkers, Gene Expression
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