3D printed bone tissue regenerative PLA/HA scaffolds with comprehensive performance optimizations
Open accessAbstract
Polylactic acid/Hydroxyapatite (PLA/HA) composite was widely studied and applied in the field of biomaterials for its good processability, bioactivity, and mechanical properties. In addition to traditional preparation methods, additive manufacturing has also been adopted to prepare PLA/HA composites with customized geometries. This work combined the comprehensive optimized PLLA (L-polylactic acid)/nano-HA (nHA) composite with the low-cost and stable Fused deposition modeling (FDM) technology to successfully prepare PLLA/nHA porous bone repair scaffolds. The results showed that PLLA/nHA composite ink satisfied the smoothness of printing, and the accuracy also met the requirements of personalized bone repair application. The high loaded nHA scaffold had suitable compressive strength was significantly higher than those of pure HA ceramic scaffold and cancellous bone. Besides, in vitro bone-like apatite formation on the surface in the degradation process and in vivo evaluations further verified its good osteogenic property. Compared with other complex and cutting-edge 3D printing technologies, this study provides a low-cost, stable, simple and fast way to realize personalized printing of bone repair scaffolds, which is undoubtedly conductive to the improvement and rapid deployment of personalized biomaterials in clinical applications.
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One advantage of combining PLA with bioceramics is the possibility of additive manufacturing, enabling a high degree of personalization.
“One advantage of combining PLA with bioceramics is the possibility of additive manufacturing, enabling a high degree of personalization [169,188,189,190,191,192].”
From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [189]
One extensively studied combination is PLA combined with HAp, which can be processed using low-cost and stable fused deposition modeling (FDM) technology.
“One extensively studied combination is PLA combined with HAp, which can be processed using low-cost and stable fused deposition modeling (FDM) technology [189].”
From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [189]
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Accelerated in vitro degradation properties of polylactic acid/phosphate glass fibre composites
Felfel, R. M., Hossain, K. M. Z., Parsons, A. J., Rudd, C. D., & Ahmed, I. (2015) · Journal of Materials Science · doi:10.1007/s10853-015-8946-8 · Cited by 61 · see citing works
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- M.H. Bin Md Ansari, M.H. Irwan Bin Ibrahim, IOP Conf. Ser. Mater. Sci. Eng. 165 (2017).
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Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review
Vach Agocsova, S., Culenova, M., Birova, I., Omanikova, L., Moncmanova, B., Danisovic, L., Ziaran, S., Bakos, D., & Alexy, P. (2023) · Materials · doi:10.3390/ma16124267 · Cited by 98 · see citing works
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Self-citationMoghimi, N., Kamaraj, M., Zehtabi, F., Amin Yavari, S., Kohandel, M., Khademhosseini, A., & John, J. V. (2024) · Journal of Materials Chemistry B · doi:10.1039/d3tb02924g · Cited by 24 · see citing works
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- Authors
- Zhang, B., Wang, L., Song, P., Pei, X., Sun, H., Wu, L., Zhou, C., Wang, K., Fan, Y., & Zhang, X.
- Affiliations
- Sichuan University (CN)
- Corresponding author
- Wang, Kefeng
- Fan, Yujiang
- ORCID
- Venue
- Materials & Design
- Publisher
- Elsevier BV
- Published
- 2021-03
- Volume
- 201
- Pages
- 109490
- ISSN
- 0264-1275 (ISSN-L)
- OpenAlex
- W3123689080
- Cited by
- 285
- References
- 1
- Citations by year
- 2026: 34 · 2025: 57 · 2024: 67 · 2023: 56 · 2022: 52 · 2021: 19
- FWCI
- 14.49
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Materials & Design (publishedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Key Research and Development Program of China
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Engineering › Automotive Engineering › Additive Manufacturing and 3D Printing Technologies
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Keywords
- polylactic acid, hydroxyapatite, bone tissue engineering, bone scaffolds, fused deposition modeling, 3D printing, porous scaffolds, patient-specific implants, compressive strength, apatite formation, osteogenic activity, scaffold degradation, bioactivity (biomaterials)
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