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Cited by 40Menopause: Health Impacts and TreatmentsEstrogen and related hormone effectsSexual function and dysfunction studies

Pulsed estrogen therapy improves postmenopausal quality of life: a 2-year placebo-controlled study

Nielsen, Therese F., Ravn, Pernille, Pitkin, Joan, Christiansen, Claus·2006·Maturitas
DOI 10.1016/j.maturitas.2005.04.003
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Abstract

Objective To investigate the effect of pulsed estrogen therapy S21400 (intranasal 17 beta-estradiol) on different quality of life (QoL) dimensions in early postmenopausal women treated with S21400 150 microg per day, S21400 300 microg per day, or placebo in a double blind, randomized, controlled 2-year study.Study design QoL was assessed based on the validated Women's Health Questionnaire designed for peri- and post-menopausal women. Three hundred and thirty-five healthy, early postmenopausal Danish women, 53 years of age in average, who completed one questionnaire at baseline and one under study treatment were included in the analysis set. All analyses were performed on an intention-to-treat basis.Results QoL improved significantly in both S21400 groups compared to placebo in the dimensions 'memory/concentration', 'vasomotor symptoms', 'sleep problems' and 'sexual behavior' (difference in mean change scores being respectively +7.9, +28.3, +9.9 and +10.8%, p < 0.001, between the S21400 300 microg and placebo group). There were no significant differences between actively treated groups and placebo in the dimensions 'anxiety/depressed mood' and 'well-being'.Conclusion Pulsed estradiol therapy had a pronounced effect not only on vasomotor symptoms but also a significant and clinically relevant improvement in several other QoL dimensions.

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Crossref · 10.1016/j.maturitas.2005.04.003

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  • Several studies comparing hormone therapy to placebo have found that hormone therapy improves perceived sleep quality and self-reported sleeping problems more than placebo.

    “Although several studies comparing HT to a placebo have found that HT improves perceived sleep quality and self-reported sleeping problems more than a placebo [112-123]”

    From Non-Pharmacological Treatment of Insomnia (2012) · cites this paper as [113]

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Authors
Nielsen, T. F., Ravn, P., Pitkin, J., & Christiansen, C.
Affiliations
  • Center for Clinical & Basic Research (DK)
  • Northwick Park Hospital (GB)
Corresponding author
Nielsen, Therese F.
ORCID
Venue
Maturitas
Publisher
Elsevier BV
Published
2006-01
Volume
53
Issue
2
Pages
184-190
ISSN
0378-5122 (ISSN-L)
DOI
10.1016/j.maturitas.2005.04.003
OpenAlex
W1967317262
Cited by
40
References
29
Citations by year
2026: 2 · 2025: 3 · 2023: 3 · 2022: 2 · 2021: 1 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 2
FWCI
1.66
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Maturitas (publishedVersion)
  • PubMed (publishedVersion)
  • University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
Keywords
estradiol, postmenopausal women, quality of life, vasomotor symptoms, hot flashes, sleep disorders, sexual behavior, memory and concentration, anxiety and depression, Women's Health Questionnaire
MeSH terms
Administration, Intranasal, Adult, Aged, Double-Blind Method, Estradiol, Female, Humans, Middle Aged, Pulsatile Flow, Quality of Life, Surveys and Questionnaires, Estrogen Replacement Therapy, Postmenopause

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