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Cited by 731

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Etiology and Therapeutic Approach to Elevated Lactate Levels

Open access
Andersen, Lars W., Mackenhauer, Julie, Roberts, Jonathan C., Berg, Katherine M., Cocchi, Michael N., Donnino, Michael W.·2013·Mayo Clinic Proceedings
DOI 10.1016/j.mayocp.2013.06.012
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Abstract

Lactate levels are commonly evaluated in acutely ill patients. Although most commonly used in the context of evaluating shock, lactate can be elevated for many reasons. While tissue hypoperfusion is probably the most common cause of elevation, many other etiologies or contributing factors exist. Clinicians need to be aware of the many potential causes of lactate elevation as the clinical and prognostic importance of an elevated lactate varies widely by disease state. Moreover, specific therapy may need to be tailored to the underlying cause of elevation. The current review is based on a comprehensive PubMed search and contains an overview of the pathophysiology of lactate elevation followed by an in-depth look at the varied etiologies, including medication-related causes. The strengths and weaknesses of lactate as a diagnostic/prognostic tool and its potential use as a clinical endpoint of resuscitation will be discussed. The review ends with some general recommendations on management of patients with elevated lactate.

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Crossref · 10.1016/j.mayocp.2013.06.012

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Metadata

Authors
Andersen, L. W., Mackenhauer, J., Roberts, J. C., Berg, K. M., Cocchi, M. N., & Donnino, M. W.
Venue
Mayo Clinic Proceedings
Publisher
Elsevier BV
Published
2013-10
Volume
88
Issue
10
Pages
1127-1140
ISSN
0025-6196 (ISSN-L)
DOI
10.1016/j.mayocp.2013.06.012
OpenAlex
W2072945343
Cited by
731
References
6
FWCI
19.24
Type
journal article
Language
en
Open access
bronze

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.