Multimodal mechanoregulation strategies towards tissue regeneration
Open accessAbstract
Mechanical microenvironment of each tissue plays an important role in regulating its special cellular behaviors, such as morphology, proliferation, differentiation, and migration. Mechanical signals can direct lineage specification or promote cell migration towards injury sites and facilitate tissue repair. During tissue regeneration, mechanoregulation is also important due to the ability of providing an extracellular microenvironment that closely resembles the physiological state for cells. Currently, mechanoregulation strategies have been usually applied to promote tissue regeneration. However, the in vivo mechanical environment is highly complex, these single mechanical conditioning strategies cannot comprehensively replicate the mechanical microenvironment experienced by cells or tissues in the body, thereby hindering the achievement of efficient tissue regeneration. The proposal of multimodal mechanoregulation strategies offers promising avenues to address this limitation. Herein, we summarize the critical role of mechanical factors in promoting tissue regeneration and the current development of different multimodal mechanoregulation approaches. Furthermore, the complex mechanical microenvironment of various tissues such as bone, intervertebral disc and cardiac. Afterwards, the recent successful applications of multimodal mechanical strategies in regenerative therapies were reviewed. And we delineate the persisting challenges, potential resolutions, and emerging translational prospects for multimodal mechanoregulation strategies in regenerative medicine, providing a reference for further development of multimodal mechanoregulation approaches.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
An optimal biodegradable implant should degrade substantially only after fulfilling its mechanical role during fracture healing, necessitating a degradation rate that aligns with the bone healing process.
“Actually, an optimal biodegradable implant should degrade substantially only after fulfilling its mechanical role during the fracture healing period, necessitating a degradation rate that aligns with the bone healing process42–44.”
From Intelligence-responsive wettability switch coating on magnesium implants for treating osteoporotic fracture (2026) · cites this paper as [44]
The Clinical translation section discusses degradation of a PLLA scaffold and its acidic byproducts, but not when a fracture-fixation implant should lose mechanical support. Searches for fracture healing, implant degradation rate, and mechanical support found no passage linking degradation timing to bone healing. (LLM, conf=0.76)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Role of YAP/TAZ in mechanotransduction
Dupont, S., Morsut, L., Aragona, M., Enzo, E., Giulitti, S., Cordenonsi, M., Zanconato, F., Le Digabel, J., Forcato, M., Bicciato, S., et al. (2011) · Nature · doi:10.1038/nature10137 · Cited by 5,979 · see citing works
What low back pain is and why we need to pay attention
Hartvigsen, J., Hancock, M. J., Kongsted, A., Louw, Q., Ferreira, M. L., Genevay, S., Hoy, D., Karppinen, J., Pransky, G., Sieper, J., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)30480-x · Cited by 4,652 · see citing works
Extracellular matrix structure
Theocharis, A. D., Skandalis, S. S., Gialeli, C., & Karamanos, N. K. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.11.001 · Cited by 2,598 · see citing works
Chiu, J.-J., & Chien, S. (2011) · Physiological Reviews · doi:10.1152/physrev.00047.2009 · Cited by 2,280 · see citing works
Effects of extracellular matrix viscoelasticity on cellular behaviour
Chaudhuri, O., Cooper-White, J., Janmey, P. A., Mooney, D. J., & Shenoy, V. B. (2020) · Nature · doi:10.1038/s41586-020-2612-2 · Cited by 2,224 · see citing works
Geometric cues for directing the differentiation of mesenchymal stem cells
Kilian, K. A., Bugarija, B., Lahn, B. T., & Mrksich, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903269107 · Cited by 1,841 · see citing works
Mechanical forces direct stem cell behaviour in development and regeneration
Vining, K. H., & Mooney, D. J. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.108 · Cited by 1,656 · see citing works
Piezo1, a mechanically activated ion channel, is required for vascular development in mice
Ranade, S. S., Qiu, Z., Woo, S., Hur, S. S., Murthy, S. E., Cahalan, S. M., Xu, J., Mathur, J., Bandell, M., Coste, B., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409233111 · Cited by 907 · see citing works
Cell–extracellular matrix mechanotransduction in 3D
Saraswathibhatla, A., Indana, D., & Chaudhuri, O. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00583-1 · Cited by 859 · see citing works
The Tissue-Engineered Vascular Graft—Past, Present, and Future
Pashneh‐Tala, S., MacNeil, S., & Claeyssens, F. (2015) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2015.0100 · Cited by 799 · see citing works
Fibroblast and myofibroblast activation in normal tissue repair and fibrosis
Younesi, F. S., Miller, A. E., Barker, T. H., Rossi, F. M. V., & Hinz, B. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00716-0 · Cited by 711 · see citing works
Vedadghavami, A., Minooei, F., Mohammadi, M. H., Khetani, S., Kolahchi, A. R., Mashayekhan, S., & Sanati‐Nezhad, A. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.07.028 · Cited by 544 · see citing works
Recent Advances in 3D Printing of Smart Scaffolds for Bone Tissue Engineering and Regeneration
Yuan, X., Zhu, W., Yang, Z., He, N., Chen, F., Han, X., & Zhou, K. (2024) · Advanced Materials · doi:10.1002/adma.202403641 · Cited by 353 · see citing works
Exercise-induced piezoelectric stimulation for cartilage regeneration in rabbits
Liu, Y., Dzidotor, G. K., Le, T. T., Vinikoor, T., Morgan, K. D., Curry, E. J., Das, R., McClinton, A., Eisenberg, E., Apuzzo, L. N., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abi7282 · Cited by 340 · see citing works
Tissue mechanics regulate brain development, homeostasis and disease
Barnes, J. M., Przybyla, L., & Weaver, V. M. (2017) · Journal of Cell Science · doi:10.1242/jcs.191742 · Cited by 313 · see citing works
Matrix viscoelasticity controls spatiotemporal tissue organization
Elósegui-Artola, A., Gupta, A., Najibi, A. J., Seo, B. R., Garry, R., Tringides, C. M., de Lázaro, I., Darnell, M., Gu, W., Zhou, Q., et al. (2022) · Nature Materials · doi:10.1038/s41563-022-01400-4 · Cited by 293 · see citing works
Matrix viscoelasticity promotes liver cancer progression in the pre-cirrhotic liver
Fan, W., Adebowale, K., Váncza, L., Li, Y., Rabbi, M. F., Kunimoto, K., Chen, D., Mozes, G., Chiu, D. K.-C., Li, Y., et al. (2024) · Nature · doi:10.1038/s41586-023-06991-9 · Cited by 263 · see citing works
Freeze Casting for Assembling Bioinspired Structural Materials
Cheng, Q., Huang, C., & Tomsia, A. P. (2017) · Advanced Materials · doi:10.1002/adma.201703155 · Cited by 250 · see citing works
Wang, L., Wang, C., Wu, S., Fan, Y., & Li, X. (2020) · Biomaterials Science · doi:10.1039/d0bm00269k · Cited by 237 · see citing works
Mechanical regulation of vascular growth and tissue regeneration in vivo
Boerckel, J. D., Uhrig, B. A., Willett, N. J., Huebsch, N., & Guldberg, R. E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107019108 · Cited by 230 · see citing works
Lamins at the crossroads of mechanosignalingPreprint
Osmanagic‐Myers, S., Dechat, T., & Foisner, R. (2015) · Genes & Development · doi:10.1101/gad.255968.114 · Cited by 230 · see citing works
Mechanical stretch induces hair regeneration through the alternative activation of macrophages
Chu, S., Chou, C., Huang, H.-D., Yen, M.-H., Hong, H.-C., Chao, P., Wang, Y.-H., Chen, P., Nian, S.-X., Chen, Y.-R., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09402-8 · Cited by 188 · see citing works
Xie, W., Wei, X., Kang, H., Jiang, H., Chu, Z., Lin, Y., Hou, Y., & Wei, Q. (2023) · Advanced Science · doi:10.1002/advs.202204594 · Cited by 178 · see citing works
3D microniches reveal the importance of cell size and shape
Bao, M., Xie, J., Piruska, A., & Huck, W. T. S. (2017) · Nature Communications · doi:10.1038/s41467-017-02163-2 · Cited by 177 · see citing works
Park‐Min, K., Lim, E., Lee, M. J., Park, S. H., Γιαννοπούλου, Ε., Yarilina, A., van der Meulen, M. C. H., Zhao, B., Smithers, N. N., Witherington, J. J., et al. (2014) · Nature Communications · doi:10.1038/ncomms6418 · Cited by 140 · see citing works
LeSavage, B. L., Zhang, D. H., Huerta-López, C., Gilchrist, A. E., Krajina, B. A., Karlsson, K., Smith, A. R., Karagyozova, K., Klett, K. C., Huang, M. S., et al. (2024) · Nature Materials · doi:10.1038/s41563-024-01908-x · Cited by 139 · see citing works
Biomaterial-induced pathway modulation for bone regeneration
Vermeulen, S., Birgani, Z. N. T., & Habibović, P. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121431 · Cited by 137 · see citing works
Role of macrophage in intervertebral disc degeneration
Dou, Y., Zhang, Y., Liu, Y., Sun, X., Liu, X., Li, B., & Yang, Q. (2025) · Bone Research · doi:10.1038/s41413-024-00397-7 · Cited by 127 · see citing works
Self-citationLi, Q., Kumar, A., Makhija, E., & Shivashankar, G. V. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.10.037 · Cited by 122 · see citing works
Iijima, H., Gilmer, G. G., Wang, K., Bean, A., He, Y., Lin, H., Tang, W., Lamont, D. N., Tai, C., Ito, A., et al. (2023) · Nature Communications · doi:10.1038/s41467-022-35359-2 · Cited by 117 · see citing works
Osteon: Structure, Turnover, and Regeneration
Chang, B., & Liu, X. (2021) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2020.0322 · Cited by 114 · see citing works
Liu, C., Yu, Q., Yuan, Z., Guo, Q., Liao, X., Han, F., Feng, T., Liu, G., Zhao, R., Zhu, Z., et al. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.07.031 · Cited by 109 · see citing works
Self-citationZhu, Y., Zhang, Q., Shi, X., et al. (2019) · Advanced Materials · doi:10.1002/adma.201804950 · Cited by 107 · see citing works
Sox9 Accelerates Vascular Aging by Regulating Extracellular Matrix Composition and Stiffness
Faleeva, M., Ahmad, S., Theofilatos, K., Lynham, S., Watson, G. C., Whitehead, M., Marhuenda, E., Iskratsch, T., Cox, S., & Shanahan, C. M. (2024) · Circulation Research · doi:10.1161/circresaha.123.323365 · Cited by 104 · see citing works
Liu, C., Zhu, C., Li, J., Zhou, P., Chen, M., Yang, H., & Li, B. (2015) · Bone Research · doi:10.1038/boneres.2015.12 · Cited by 101 · see citing works
Self-citationZhu, M., Zhang, H., Zhou, Q., Sheng, S., Gao, Q., Geng, Z., Chen, X., Lai, Y., Jing, Y., Xu, K., et al. (2025) · Advanced Materials · doi:10.1002/adma.202501254 · Cited by 101 · see citing works
Chu, G., Yuan, Z., Zhu, C., Zhou, P., Wang, H., Zhang, W., Cai, Y., Zhu, X., Yang, H., & Li, B. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.05.013 · Cited by 89 · see citing works
Self-citationStructure and mechanical function of the inter‐lamellar matrix of the annulus fibrosus in the disc
Tavakoli, J., Elliott, D. M., & Costi, J. J. (2016) · Journal of Orthopaedic Research® · doi:10.1002/jor.23306 · Cited by 88 · see citing works
Saffitz, J. E. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1341.030 · Cited by 85 · see citing works
Chen, Q., Zhang, X., Chen, K., Feng, C., Wang, D., Qi, J., Li, X., Zhao, X., Chai, Z., & Zhang, D. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c13641 · Cited by 85 · see citing works
Bioinspired structure of bioceramics for bone regeneration in load-bearing sites
Zhang, F., Chang, J., Lu, J., Lin, K., & Ning, C. (2007) · Acta Biomaterialia · doi:10.1016/j.actbio.2007.05.008 · Cited by 75 · see citing works
Varying mechanical forces drive sensory epithelium formation
Xia, M., Wu, M., Li, Y., Liu, Y., Jia, G., Lou, Y., Ma, J., Gao, Q., Xie, M., Chen, Y., et al. (2023) · Science Advances · doi:10.1126/sciadv.adf2664 · Cited by 66 · see citing works
Nerger, B. A., Kashyap, K., Deveney, B. T., Lou, J., Hanan, B. F., Liu, Q., Khalil, A. S., Lungjangwa, T., Cheriyan, M., Gupta, A., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2410806121 · Cited by 66 · see citing works
Dynamic hydrogels for biofabrication: A review
Xu, R., Ooi, H. S., Bian, L., Ouyang, L., & Sun, W. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123266 · Cited by 65 · see citing works
Huang, H., Wang, K., Liu, X., et al. (2025) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2024.12.011 · Cited by 57 · see citing works
Staruch, R. M. T., Glass, G. E., Rickard, R. F., Hettiaratchy, S. P., & Butler, P. E. M. (2016) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2016.0305 · Cited by 53 · see citing works
Zhu, Z., Yu, Q., Li, H., Han, F., Guo, Q., Sun, H., Zhao, H., Tu, Z., Liu, Z., Zhu, C., et al. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.05.005 · Cited by 53 · see citing works
Self-citationYu, Q., Han, F., Yuan, Z., Zhu, Z., Liu, C., Tu, Z., Guo, Q., Zhao, R., Zhang, W., Wang, H., et al. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.05.054 · Cited by 51 · see citing works
Self-citationOsteochondral regenerative engineering: challenges, state-of-the-art and translational perspectives
Barui, S., Ghosh, D., & Laurencin, C. T. (2022) · Regenerative Biomaterials · doi:10.1093/rb/rbac109 · Cited by 51 · see citing works
Park, J. H., Jo, S. B., Lee, J., Lee, H., Knowles, J. C., & Kim, H. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.06.003 · Cited by 49 · see citing works
Cimmino, C., Rossano, L., Netti, P. A., & Ventre, M. (2018) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2018.00190 · Cited by 48 · see citing works
A sonosensitive diphenylalanine-based broad-spectrum antimicrobial peptide
Zhang, X., Feng, X., Ma, L., Lei, J., Li, G., Zhang, W., Liang, H., Tong, B., Wu, D., Cao, Y., et al. (2025) · Nature Biomedical Engineering · doi:10.1038/s41551-025-01377-w · Cited by 48 · see citing works
Zhang, W., Liu, Y., & Kassab, G. S. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00423.2007 · Cited by 47 · see citing works
Ashinsky, B. G., Gullbrand, S. E., Bonnevie, E. D., Mandalapu, S. A., Wang, C., Elliott, D. M., Han, L., Mauck, R. L., & Smith, H. E. (2019) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2019.07.016 · Cited by 47 · see citing works
Endothelial discoidin domain receptor 1 senses flow to modulate YAP activation
Liu, J., Zhao, C., Xiao, X., Li, A., Liu, Y., Zhao, J., Fan, L., Liang, Z., Pang, W., Yao, W., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42341-z · Cited by 43 · see citing works
Engineering topography: effects on nerve cell behaviors and applications in peripheral nerve repair
Ma, Y., Gao, H., Wang, H., & Cao, X. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb00782c · Cited by 42 · see citing works
Tu, Z., Han, F., Zhu, Z., Yu, Q., Liu, C., Bao, Y., Li, B., & Zhou, F. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.05.034 · Cited by 42 · see citing works
Self-citationHan, F., Yu, Q., Chu, G., Li, J., Zhu, Z., Tu, Z., Liu, C., Zhang, W., Zhao, R., Mao, H., et al. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202200895 · Cited by 42 · see citing works
Self-citationEmanuel, K. S., van der Veen, A. J., Rustenburg, C. M. E., et al. (2017) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2017.10.010 · Cited by 41 · see citing works
Wang, X., Zhang, D., Peng, H., et al. (2023) · Biomaterials Advances · doi:10.1016/j.bioadv.2023.213638 · Cited by 41 · see citing works
Cellular modulation by the mechanical cues from biomaterials for tissue engineering.
Wei, Q., Wang, S., Han, F., Wang, H., Zhang, W., Yu, Q., Liu, C., Ding, L., Wang, J., Yu, L., et al. (2021) · PubMed Central · doi:10.12336/biomatertransl.2021.04.001 · Cited by 41 · see citing works
Self-citationEffect of collagen fibre orientation on intervertebral disc torsion mechanics
Yang, B., & O’Connell, G. D. (2017) · Biomechanics and Modeling in Mechanobiology · doi:10.1007/s10237-017-0934-2 · Cited by 40 · see citing works
Liu, Z., Wang, H., Yuan, Z., et al. (2022) · Biofabrication · doi:10.1088/1758-5090/aca71f · Cited by 40 · see citing works
Liu, Y., Li, L., Li, X., Cherif, H., Jiang, S., Ghezelbash, F., Weber, M. H., Juncker, D., Li‐Jessen, N. Y. K., Haglund, L., et al. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.04.017 · Cited by 40 · see citing works
Yu, L., Cai, Y., Wang, H., et al. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.05.041 · Cited by 37 · see citing works
Approximating bone ECM: Crosslinking directs individual and coupled osteoblast/osteoclast behavior
Hwang, M. P., Subbiah, R., Kim, I. G., Lee, K. E., Park, J., Kim, S., & Park, K. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.06.052 · Cited by 36 · see citing works
Emerging role of Piezo ion channels in cardiovascular development
Shah, V., Patel, S., & Shah, J. (2021) · Developmental Dynamics · doi:10.1002/dvdy.401 · Cited by 36 · see citing works
Organoid-based tissue engineering for advanced tissue repair and reconstruction
Hsiung, N., Ju, Y., Yang, K. C., Pu, Y., Zeng, W., Zhao, H., Zou, P., Ye, J., Yi, K., & Wang, X. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102093 · Cited by 35 · see citing works
Han, K., Mao, M., Fu, L., Zhang, Y., Kang, Y., Li, D., & He, J. (2024) · Small · doi:10.1002/smll.202401561 · Cited by 34 · see citing works
Minimally Invasive Implantable Biomaterials for Bone Reconstruction
Han, F., Liu, Z., Wei, Q., Ding, L., Li, Y., Wang, J., Wang, H., Zhang, W., Yu, Y., Zhao, Y., et al. (2024) · Engineering · doi:10.1016/j.eng.2024.01.031 · Cited by 33 · see citing works
Self-citationEvolving biomaterials design from trial and error to intelligent innovation
Hang, R., Yao, X., Bai, L., & Hang, R. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.03.013 · Cited by 33 · see citing works
Damage analysis of human cortical bone under compressive and tensile loadings
Maghami, E., Moore, J. P., Josephson, T. O., et al. (2022) · Computer Methods in Biomechanics & Biomedical Engineering · doi:10.1080/10255842.2021.2023135 · Cited by 32 · see citing works
Lai, Q., Li, B., Chen, L., Zhou, Y., Bao, H., & Li, H. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.12.021 · Cited by 32 · cited 1× · see citing works
“66,67 For example, Chiang et al. controlled the stiffness of polyacrylamide gels from 0.9 kPa to 74.6 kPa by changing the concentration of acrylamide and N, N ′ -methylenebisacrylamide to investigate whether the biomechanical properties of skeletal muscle directly impact the myogenic program,…”
InfluentialSelf-citationLi, J., Liu, C., Guo, Q., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091799 · Cited by 31 · see citing works
Biomechanics of Macrophages on Disordered Surface Nanotopography
Huo, Z., Yang, W., Harati, J., Nene, A., Borghi, F., Piazzoni, C., Milani, P., Guo, S., Galluzzi, M., & Boraschi, D. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c04330 · Cited by 24 · see citing works
Altered extracellular matrix structure and elevated stiffness in a brain organoid model for disease
Zur, M. K., Bhattacharya, B., Solomonov, I., Dror, S. B., Savidor, A., Levin, Y., Prior, A., Sapir, T., Harris, T., Olender, T., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59252-w · Cited by 23 · see citing works
Wang, G., Yuan, Z., Li, Y., et al. (2023) · PubMed · doi:10.12336/biomatertransl.2023.01.005 · Cited by 23 · see citing works
Zhao, R., Yang, L., He, S., & Xia, T. (2022) · Experimental Cell Research · doi:10.1016/j.yexcr.2022.113230 · Cited by 22 · see citing works
Baka, T., Moore, J., Qin, F., Yurista, S. R., Zhang, A., He, H., Chambers, J. M., Croteau, D., Goel, R. K., Smith, H. R., et al. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf324 · Cited by 22 · see citing works
Microscale Interrogation of 3D Tissue Mechanics
Zhang, J., Chada, N. C., & Reinhart‐King, C. A. (2019) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00412 · Cited by 21 · see citing works
Printability in Multi-material Projection-Based 3-Dimensional Bioprinting
He, C.-F., Qiao, T.-H., Ren, X.-C., et al. (2025) · Research · doi:10.34133/research.0613 · Cited by 21 · see citing works
Matrix mechanics regulates muscle regeneration by modulating kinesin-1 activity
Chiang, W.-Y., Yu, H. W., Wu, M.-C., Huang, Y.-M., Chen, Y., Lin, J., Liu, Y.-W., You, L., Chiou, A., & Kuo, J. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122551 · Cited by 20 · see citing works
Liu, Y., Cai, F., Liu, K., Liu, J., Zhang, X., & Yusufu, A. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.810723 · Cited by 20 · see citing works
Maghin, E., Carraro, E., Boso, D., Dedja, A., Giagante, M., Caccin, P., Barna, R.-A.-M., Bresolin, S., Cani, A., Borile, G., et al. (2022) · npj Regenerative Medicine · doi:10.1038/s41536-022-00222-x · Cited by 19 · see citing works
Sun, H., Wang, H., Zhang, W., Mao, H., & Li, B. (2022) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2022.11.004 · Cited by 19 · see citing works
Self-citationWang, H., Zhang, W., Cai, Y., Guo, Q., Pan, L., Chu, G., Chen, J., Yuan, Z., & Li, B. (2023) · Journal of Orthopaedic Research® · doi:10.1002/jor.25596 · Cited by 18 · see citing works
Self-citationMultiscale mechanical-adapted hydrogels for the repair of intervertebral disc degeneration
Cai, W., Yang, F., Yang, C., Liu, Y., Xu, H., Zhang, W., Li, B., Han, F., Luo, Z., & Liang, T. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.02.021 · Cited by 17 · see citing works
Self-citationChaudhary, S., Ghosal, D., Tripathi, P., & Kumar, S. (2023) · Biomaterials Science · doi:10.1039/d2bm01410f · Cited by 16 · see citing works
Sun, X., Guo, Y., Zheng, X., et al. (2024) · Advanced Materials · doi:10.1002/adma.202414161 · Cited by 16 · see citing works
Zhang, Y., Yang, J., Wan, W., et al. (2025) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2024.10.010 · Cited by 16 · see citing works
Fahad, M. A. A., Lee, H.-Y., Park, M., & Lee, B. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123264 · Cited by 16 · see citing works
Su, S., Wu, X., Li, B., Zhang, F., Zhang, K., Wang, H., Lin, Y., & Chen, J. (2025) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2025.01.013 · Cited by 15 · see citing works
Self-citationYu, C., Zhao, J., Cheng, F., et al. (2024) · Research · doi:10.34133/research.0336 · Cited by 14 · see citing works
Emerging Epigenetic Therapies for the Treatment of Cardiac Fibrosis
Garitano, N., Aguado‐Alvaro, L. P., & Pelacho, B. (2025) · Biomedicines · doi:10.3390/biomedicines13051170 · Cited by 13 · see citing works
Ma, Y., Liu, N., Shao, X., Shi, T., Lin, J., Liu, B., Shen, T., Guo, B., & Jiang, Q. Y. (2024) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2024.06.012 · Cited by 11 · see citing works
Baxter, A. L., Thrasher, A., Etnoyer-Slaski, J. L., & Cohen, L. L. (2023) · Frontiers in Pain Research · doi:10.3389/fpain.2023.1114633 · Cited by 10 · see citing works
The effects of matrix stiffness on immune cells in bone biology
Jiang, T., Zheng, M.-T., Li, R.-M., & Ouyang, N. (2024) · Mechanobiology in Medicine · doi:10.1016/j.mbm.2024.100046 · Cited by 10 · see citing works
Zhou, Z., Suo, Y., Bai, J., Lin, F., Gao, X. Y., Shan, H., Ni, Y., Zhou, X., Sheng, L., & Dai, J. (2023) · Aging and Disease · doi:10.14336/ad.2023.00205 · Cited by 10 · see citing works
Cimmino, C., Netti, P. A., & Ventre, M. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.933410 · Cited by 9 · see citing works
Atashipour, S. R., & Baqersad, J. (2023) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2023.106266 · Cited by 8 · see citing works
Zhang, Z., Han, R., Liu, Y., Yu, X., Wang, G., Bai, Y., Yang, R., Jin, T., & Zhang, X. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.164550 · Cited by 8 · see citing works
Garrido, C. A., Garske, D. S., Bucher, C. H., Amini, S., Duda, G. N., Schmidt‐Bleek, K., & Cipitria, A. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.07.063 · Cited by 8 · see citing works
Zhou, J., Wang, J., Li, J., et al. (2024) · JOR Spine · doi:10.1002/jsp2.1314 · Cited by 7 · see citing works
Mechanical environment for in vitro cartilage tissue engineering assisted by in silico models.
Jess, R. B., Ling, T., Xiong, Y., et al. (2023) · PubMed · doi:10.12336/biomatertransl.2023.01.004 · Cited by 7 · see citing works
Ying, J., Yu, H., Cheng, L., et al. (2023) · PubMed · doi:10.12336/biomatertransl.2023.03.005 · Cited by 7 · see citing works
Zhang, W., Wang, H., Chu, G., Yu, L., Han, F., Yu, Q., Wang, Y., & Li, B. (2023) · Applied Materials Today · doi:10.1016/j.apmt.2023.101751 · Cited by 7 · see citing works
Self-citationLiu, B., Song, G., Wang, Y., Song, C., Cao, Y., Tong, J., Wang, Y., Fan, X., Shi, N., Zhao, H., et al. (2025) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2025.05.004 · Cited by 6 · see citing works
Prolonged cyclical loading induces Haversian remodeling in mandibles of growing rabbits
Lad, S. E., Kowalkowski, H., Liggio, D. F., Ding, H., & Ravosa, M. J. (2023) · Journal of Experimental Biology · doi:10.1242/jeb.245942 · Cited by 5 · see citing works
Harnessing mechanobiology to enhance cell therapy
Ma, P., Qin, A., Winkler, T., et al. (2024) · Mechanobiology in Medicine · doi:10.1016/j.mbm.2024.100102 · Cited by 5 · see citing works
Michalek, A. J., Wood, I. M., Carranza, D. G., & Ferlito, L. (2025) · JOR Spine · doi:10.1002/jsp2.70084 · Cited by 4 · see citing works
Zhang, C., Jing, Y., Wang, J., et al. (2024) · PubMed · doi:10.12336/biomatertransl.2024.04.005 · Cited by 3 · see citing works
Mechanical forces pattern endocardial Notch activation via mTORC2-PKC pathwayPreprint
Mu, Y., Hu, S., Liu, X., Tang, X., Lin, J., & Shi, H. (2024) · eLife · doi:10.7554/elife.97268 · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Qi, G., Ma, T., Wang, Y., Chen, K., Yan, Y., Li, Z., Deng, N., Tseng, C., Li, B., Zheng, Y., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-72683-3 · Cited by 2 · see citing works
Self-citation
- Authors
- Yu, Q., Duan, Y., Zhu, Z., Ji, W., Zhu, C., & Li, B.
- Affiliations
- Soochow University (CN)
- Corresponding author
- Zhu, Caihong
- Li, Bin
- Venue
- Mechanobiology in Medicine
- Publisher
- Elsevier BV
- Published
- 2025-12
- Volume
- 3
- Issue
- 4
- Pages
- 100159
- ISSN
- 2949-9070 (ISSN-L)
- PMC
- PMC12552545
- OpenAlex
- W4415614737
- Cited by
- 8
- References
- 112
- Citations by year
- 2026: 8
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Mechanobiology in Medicine (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- National Natural Science Foundation of China (824B2075, U24A20670, 81925027, 32371414, 32130059)
- Graduate Research and Innovation Projects of Jiangsu Province (KYCX25_3488)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Keywords
- mechanoregulation, tissue regeneration, mechanical microenvironment, mechanobiology, bone regeneration, intervertebral disc regeneration, cardiac regeneration, cell migration, lineage specification, regenerative medicine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
