The DOI matches its Crossref record; 118 of the 119 references it cites were found in a registry or an index.
Shaping the stress response: Interplay of palatable food choices, glucocorticoids, insulin and abdominal obesity
Abstract
Activity of the hypothalamo-pituitary-adrenal (HPA) axis is regulated by a negative feedback loop that dampens central drive of the axis via the actions of the secreted glucocorticoids. Conversely, under conditions of chronic stress, glucocorticoids delivered centrally increase hypothalamic paraventricular nucleus (PVN) corticotrophin-releasing factor (CRF) expression and the response to restraint. However, HPA axis activity and PVN CRF mRNA expression under chronic stress conditions are often reduced, implying other indirect peripheral or extra-hypothalamic glucocorticoid actions. Glucocorticoids chronically increase palatable food intake, which increases abdominal fat depots and circulating insulin levels, both of which negatively correlate with PVN CRF mRNA expression and may in turn dampen the response to stress. Such an effect is dependent on food choices, rather than total calories ingested. Considering stress is omnipresent in the workplace, palatable food ingestion may represent a means to combat the feeling of stress which is ultimately maladaptive when unresolved.
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“Chronic high GCs and increases in insulin have synergistic effects on increasing HP food intake and abdominal fat deposition”
From Role of addiction and stress neurobiology on food intake and obesity (2018) · cites this paper as Warne, 2009
Citations
Cites
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1 of the 119 references couldn’t be matched to a known paper.
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Items 101–112 of 112
Predictors of self-rated health in a Manitoba First Nation community
Bombak, A. E. (2010) · Mspace (University of Manitoba) · Cited by 1
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Kitraki, E. (2011) · doi:10.1002/9781118083222.ch28
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Metadata
- Authors
- Warne, J. P.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Warne, James P.
- Venue
- Molecular and Cellular Endocrinology
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 300
- Issue
- 1-2
- Pages
- 137-146
- ISSN
- 0303-7207 (ISSN-L)
- OpenAlex
- W1967852835
- Cited by
- 112
- References
- 119
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 6 · 2022: 2 · 2021: 6 · 2020: 8 · 2019: 5 · 2018: 8 · 2017: 6 · 2016: 10 · 2015: 5 · 2014: 10 · 2013: 13 · 2012: 9
- FWCI
- 0.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular and Cellular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- hypothalamic-pituitary-adrenal axis, glucocorticoids, chronic stress, corticotropin-releasing factor, paraventricular nucleus, palatable food intake, food choice, insulin, abdominal obesity, stress response, restraint stress, negative feedback
- MeSH terms
- Animals, Corticotropin-Releasing Hormone, Eating, Food Preferences, Glucocorticoids, Humans, Hypothalamo-Hypophyseal System, Insulin, Obesity, Pituitary-Adrenal System, Stress, Physiological, Feedback, Physiological
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